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患有动静脉畸形的儿童和青年纳米氧化铁增强mRI后脑铁评估：病例对照研究

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国际医学放射学杂志 2021年第1期44卷 108-108页

作者： m.iv N.N.Ng S.Nair Y.Zhang J.Lavezo S.H.Cheshier 李佳佳

摘要氧化铁纳米粒子是mR成像的替代对比剂,钆沉积引起了安全问题,但目前尚不清楚纳米氧化铁是否也会沉积在脑组织中。目的研究儿童和青年纳米氧化铁增强后多

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Physical-Chemical Characterization of Nanodispersed Powders Produced by a Plasma-Chemical Technique

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Plasma Science and Technology 2007年第3期9卷 273-279页

作者： m.GEORGIEVA G.VISSOKOV iv.GRANCHAROV Department of Technology of Inorganic Substances University of Chemical Technology and Metallurgy8St.Kliment Ohridski Blvd.1756 SofiaBulgaria

This article presents a review on the physical-chemical properties and characteristics of plasma-chemically produced nanodispersed powders （NDP）, such as metals, oxides, nitrides, carbides, and catalysts. The plasma-chemical preparatior~ of the powders was carried out in thermal plasma （TP） created by means of high-current electric arcs, plasma jets, high-frequency （HF） discharges, etc. We also discuss certain properties and characteristics of the NDPs, which are determined largely by the conditions of preparation.

关键词： plasma-chemical treatment nitrides thermodynamic analysis

High-Temperature Thermodynamic Investigation of Nano-Dispersed Nitrides Obtained in Thermal Plasma

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Plasma Science and Technology 2007年第2期9卷 174-176页

作者： m. GEORGIEVA G. VISSOKOV iv. GRANCHAROV L. BRAKALOV Department of Technology of Inorganic Substances University of Chemical Technology andMetal|urgy 8 K. Okhridski Blvd. 1756 Sofia Bulgaria

The nitrides of transient metals have a high hardness, thermal stability, remarkable wear resistance in aggressive chemical mediums, melted metals and alloys, high corrosion resistance, and low coefficient of electric resistance. Under the conditions of low-temperature argon plasma （LTP）, thermodynamic investigations were conducted in the process of obtaining of A1N, TiN and Si3N4 in a temperature range of 1000 K to 6000 K. To investigate the thermodynamic possibility of obtaining nitrides, a computer model was used which provided the equilibrium composition of gaseous and solid phases at different temperatures. The conditions for chemical equilibrium of the system were based on the minimization of Gibbs＇ energy.

关键词： plasma-chemical treatment nitrides thermodynamic analysis

The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease

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Neural Regeneration Research 2017年第3期12卷 380-384页

作者： Kerri J.Kinghorn Amir m.Asghari Jorge iván Castillo-Quan Institute of Healthy Ageing and Department of Genetics Evolution and EnvironmentUniversity College LondonLondonUK Institute of Neurology University College LondonLondonUK Department of Basic and Clinical Neuroscience King's College LondonMaurice Wohl Clinical Neuroscience InstituteLondonUK London Central&West Unscheduled Care Collaborative St.Charles Centre for Health and WellbeingExmoor Street StCharles HospitalLondonUK Research Division Joslin Diabetes CenterBostonMAUSA Department of Genetics and Harvard Stem Cell Institute Harvard Medical SchoolBostonMAUSA

Gaucher disease（GD）,the commonest lysosomal storage disorder,results from the lack or functional deficiency of glucocerebrosidase（GCase） secondary to mutations in the GBA1 *** is an established association between GBA1 mutations and Parkinson＇s disease（PD）,and indeed GBA1 mutations are now considered to be the greatest genetic risk factor for *** lysosomal-autophagic degradation of cellular proteins,including α-synuclein（α-syn）,is implicated in the pathogenesis of PD,and there is increasing evidence for this also in GD and *** we have recently shown in a Drosophila model lacking neuronal GCase,that there are clear lysosomal-autophagic defects in association with synaptic loss and *** addition,we demonstrated alterations in mechanistic target of rapamycin complex 1（mTORC1） signaling and functional rescue of the lifespan,locomotor defects and hypersensitivity to oxidative stress on treatment of GCase-deficient flies with the mT OR inhibitor ***,a number of other recent studies have shown autophagy-lysosomal system（ALS） dysfunction,with specific defects in both chaperone-mediated autophagy（CmA）,as well as macroautophagy,in GD and GBA1-PD model *** we discuss the possible therapeutic benefits of inhibiting mT OR using drugs such as rapamycin to reverse the autophagy defects in GD and PD.

关键词： Gaucher disease Parkinson's disease Drosophila autophagy lysosome glucocerebrosidase GBA

Symmetric carbon tetramers forming spin qubits in hexagonal boron nitride

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npj Computational materials 2023年第1期9卷 407-416页

作者： Zsolt Benedek Rohit Babar Ádám Ganyecz Tibor Szilvási Örs Legeza Gergely Barcza Viktor ivády Strongly Correlated Systems Lendület Research Group Wigner Research Centre for PhysicsPO Box 49H-1525 BudapestHungary mTA-ELTE Lendület“momentum”NewQubit Research Group Pázmány PéterSétány 1/A1117 BudapestHungary Department of Chemical and Biological Engineering The University of AlabamaTuscaloosaAL 35487USA Institute for Advanced Study Technical University of MunichLichtenbergstrasse 2a85748 GarchingGermany Department of Physics of Complex Systems Eötvös Loránd UniversityEgyetem tér 1-3H-1053 BudapestHungary Department of Physics Chemistry and BiologyLinköping UniversitySE-58183 LinköpingSweden

Point defect quantum bits in semiconductors have the potential to revolutionize sensing at atomic ***,vacancy-related defects are at the forefront of high spatial resolution and low-dimensional *** the other hand,it is expected that impurity-related defect structures may give rise to new features that could further advance quantum sensing in low ***,we study the symmetric carbon tetramer clusters in hexagonal boron nitride and propose them as spin qubits for *** utilize periodic-DFT and quantum chemistry approaches to reliably and accurately predict the electronic,optical,and spin properties of the studied *** show that the nitrogen-centered symmetric carbon tetramer gives rise to spin state-dependent optical signals with strain-sensitive intersystem crossing ***,the weak hyperfine coupling of the defect to their spin environments results in a reduced electron spin resonance linewidth that can enhance sensitivity.

关键词： hexagonal boron quantum

NO-ARBITRAGE SYmmETRIES

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Acta mathematica Scientia 2022年第4期42卷 1373-1402页

作者： iván DEGANO Sebastián FERRANDO Alfredo GONZáLEZ Departamento de matemática.Facultad de Ciencias Exactas y Naturales Universidad Nacional de Mar del Plata 7600Argentina Department of mathematics Ryerson University350 Victoria St.TorontoOntario M5B 2K3Canada

The no-arbitrage property is widely accepted to be a centerpiece of modern financial mathematics and could be considered to be a financial law applicable to a large class of(idealized) *** paper addresses the following basic question:can one characterize the class of transformations that leave the law of no-arbitrage invariant?We provide a geometric formalization of this question in a non probabilistic setting of discrete time-the so-called trajectorial *** paper then characterizes,in a local sense,the no-arbitrage symmetries and illustrates their meaning with a detailed *** context makes the result available to the stochastic setting as a special case.

关键词： No arbitrage symmetry convexity preserving maps non-probabilistic markets

Involvement of glucose transporter overexpression in the protection or damage after ischemic stroke

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Neural Regeneration Research 2022年第4期17卷 783-784页

作者： iván Alquisiras-Burgos Penélope Aguilera Laboratorio de Patología Vascular Cerebral Instituto Nacional de Neurología y Neurocirugía Manuel Velasco SuárezInsurgentes Sur#3877Col.La FamaTlalpanCiudad de MéxicoMéxico

Cerebral ischemia and resultant energy collapse:The ischemic stroke is a complex neurological condition that can be devastating for patients and their *** disease is the second leading cause of death worldwide and is characterized by a sudden decrease in cerebral blood flow due to major blood vessel *** stroke generates two damaged zones with distinctive metabolic *** first is the ischemic core,the region directly irrigated by the occluded artery.A reduction to less than 20%of the baseline blood flow levels defines the area;therefore,depletion of glucose and adenosine triphosphate(ATP)cause an irreversible failure in the energy metabolism that leads to loss of ionic homeostasis,acidosis,and *** second is the region surrounding the ischemic core,called the penumbra,characterized by significantly depressed tissue perfusion that is barely sufficient to support basal oxygen,glucose,and ATP levels.

关键词： metabolism damage homeostasis

Heparan sulfate proteoglycans as possible diagnostic molecular tools with therapeutic potential in Alzheimer′s disease

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Neural Regeneration Research 2021年第7期16卷 1404-1405页

作者： iván Fernández-Vega Laura Lorente-Gea Carla martín Luis m.Quirós Department of Pathology Hospital Universitario Central de Asturias/Biobank of Principality of AsturiasHealth Research Institute of the Principality of AsturiasOviedoSpain Department of Pathology Hospital Universitario de Araba-Txagorritxu/Biobanco Vasco para la Investigación(O+eHun)Brain BankHospital UniversitarioVitoriaSpain Instituto Universitario Fernández-Vega OviedoSpain Department of Functional Biology University of OviedoSpain

Importance of dementia and Alzheimer's disease(AD): On Earth, there is a "country" that we call Dementia with around 50 million inhabitants and an estimated global economic cost of US $1 trillion(Wimo et al., 2017).AD may contribute to 60–70% of cases, with other major forms of dementia being vascular dementia, dementia with Lewy bodies and a group of diseases that contribute to frontotemporal ***, the boundaries between different forms of dementia are indistinct and mixed forms often co-exist, which are only confirmed after postmortem neuropathological studies(Fernandez-Vega et al., 2015).

关键词： al. diseases Alzheimer

Hazards and Landscape Changes(Degradations) on Hungarian Karst mountains Due to Natural and Human Effects

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Journal of mountain Science 2013年第1期10卷 16-28页

作者： móga JNOS Kiss KLAUDIA Szabó mRIA Kériné Borsodi ANDREA Kéri ANDRS mari LSZLó Knáb móNIKA iván VERONIKA Geography and Earth Science Institute Etvs Loránd University Biology Institute Etvs Loránd University

In order to study the karstological processes within the karst ecological system,the geohazards and degradation of karst landscapes on the karst areas of the Bakony mountains(Hungary),we investigated the abiotic elements of the environment,soil and cover deposits,erosion soil decay;the changes in the quantity and quality of karst waters:contamination at swallow holes,contamination of karst springs;and the biogenic factors:surface vegetation coverage by the corine land cover method,plant-ecological examinations,qualification of surface waters with the help of biological water *** recognized that the increasing human activities during the past few centuries have had significant impact on the investigated landscapes of karst areas because of their spatial *** the scope of our research we concluded that the landscape changes due to natural and human effects can vary strongly on the different karst *** differences can arise from the climatic and geomorphologic situation,the coverlayer's qualities,etc.,but primarily from the different utilization of the investigated karst areas(*** intensity,characteristics and territorial extension of utilization).On the spot investigation we detected traces of new and fast geomorphological processes(gully formation,landslides,collapses,new sinkhole development) and landforms(sinkholes,gullies,swallow holes),which are clear evidences of the effect of climatic changes.

关键词： Karst landscape Geological hazards Soil erosion Limestone mountain