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PIK3CA mutation in non-metastatic triple-negative breast cancer as a potential biomarker of early relapse:A case report

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World Journal of Clinical Oncology 2021年第8期12卷 702-711页

作者： Guillermo Arturo Valencia Patricia Rioja Zaida morante Jhajaira m Araujo Heberth Daniel Vallejos henry Guerra henry L Gomez Department of medical Oncology Instituto Nacional de Enfermedades NeoplásicasLima 15000Peru Escuela de medicina Humana Universidad Privada San Juan BautistaLima 15067Peru Department of medical Oncology Russian Scientific Center of Radiology and RadiotherapyKonkovo 117485MoscowRussia Department of Pathology Instituto Nacional de Enfermedades NeoplásicasLima 15000Peru

BACKGROUND Currently,the detection of PIK3CA mutations is of special interest in personalized medicine because it is frequently found in triple-negative breast cancer(TNBC).The PI3KCA mutation is an independent negative prognostic factor for survival in metastatic breast cancer,and its prognostic value in liquid biopsy as a biomarker of treatment and early relapse is under investigation,both for metastatic disease and neoadjuvant scenario with curative *** SUmmARY A 54-year-old female patient with TNBC clinical stage IIIA,who,after receiving neoadjuvant chemotherapy(based on anthracyclines and taxanes),surgery,radiotherapy,and adjuvant capecitabine,was detected with a PI3KCA mutation in tissue and peripheral blood(ctDNA in liquid biopsy).After 10 mo,the patient had disease relapse of left cervical node *** The detection of PIK3CA mutation in TNBC after neoadjuvant treatment might be associated with early relapse or rapid disease progression.

关键词： Triple-negative breast cancer PIK3CA mutation Liquid biopsy Early relapse Biomarker Case report

Squeeze casting of aluminum alloy A380: microstructure and tensile behavior

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China Foundry 2015年第5期12卷 367-374页

作者： Li Fang Xue-zhi Zhang Bo-jun Xiong henry Hu Xue-yuan Nie Jimi Tjong Department of mechanical Automotive & Materials Engineering University of Windsor 401 Sunset Ave. Ford Powertrain Engineering Research & Development Centre

A380 alloy with a relatively thick cross-section of 25 mm was squeeze cast using a hydraulic press with an applied pressure of 90 mPa. microstructure and tensile properties of the squeeze cast A380 were characterized and evaluated in comparison with the die cast counterpart. Results show that the squeeze cast A380 possesses a porosity level much lower than the die cast alloy, which is disclosed by both optical microscopy and the density measurement technique. The results of tensile testing indicate the improved tensile properties, specifically ultimate tensile strength(UTS: 215.9 mPa) and elongation(Ef: 5.4%), for the squeeze cast samples over those of the conventional high-pressure die cast part(UTS: 173.7 mPa, Ef: 1.0%). The analysis of tensile behavior shows that the squeeze cast A380 exhibits a high tensile toughness(8.5 mJ·m-3) and resilience(179.3 k J·m-3) compared with the die cast alloy(toughness: 1.4 mJ·m-3, resilience: 140.6 k J·m-3), despite that, during the onset of plastic deformation, the strain-hardening rate of the die cast specimen is higher than that of the squeeze cast specimens. The microstructure analyzed by the scanning electron microscopy(SEm) shows that both the squeeze and die cast specimens contain the primary α-Al, Al2 Cu, Al5 Fe Si phase and the eutectic Si phase. But, the Al2 Cu phase present in the squeeze cast alloy is relatively large in size and quantity. The SEm fractography evidently reveals the ductile fracture features of the squeeze cast A380 alloy.

关键词： squeeze casting aluminum alloy A380 microstructure tensile properties fracture behavior

Report of the restudy of the defined global stratotype of the base of the Silurian System

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Episodes 2008年第3期31卷 315-318页

作者： Jiayu Rong michael melchin S. henry Williams Tatyana N. Koren Jacques Verniers SKL Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences 210008 Nanjing PRC Department of Geology St. Francis Xavier University Antigonish NS B2G 2W5 Canada Petro-Canada Oil and Gas 150 - 6th Avenue SW Calgary AB T2P 3E3 Canada All Russian Geological Research Insfitute-VSEGEI Sredny pr. 74 199026 St. Petersburg Russia Research Unit Palaeontology Ghent University Krijgslaan 281/S 8 2000 Ghent Belgium

The Global Stratotype Section and Point （GSSP） for the base of the Silurian System was defined in 1985. Since that time, a number of researchers have suggested that this section has serious deficiencies for use as a GSSP. As a result, in 2000, the Subcommission on Silurian Stratigraphy （SSS） proposed undertaking a formal restu@ of this GSSP, which was subsequently approved by the International Commission of Stratigraphy （ICS）. The result of this restudy was the formal proposal that the current GSSP, at 1.6 m above the base of the Birkhill Shale, at Dob＇s Linn, Scotland, should be maintained as the same locality and stratigraphic level, but the bios- tratigraphical definition of the boundary should be revised. The previously defined, basal Silurian grapto- lite zone, the Parakidograptus acuminatus Zone, should be subdivided into a lower Akidograptus ascensus Zone and a higher E acuminatus Zone. The base of the A. ascensus Zone, marked by the first appearance of A. ascensus, should be regarded as the biostratigraphic mark for the base of the Silurian. This proposal has now been formally approved by the SSS and ICS, and ratified by International Union of Geological Sciences. This is the first GSSP to undergo formal restudy and redefini- tion, and the proposal also included a recommended procedure for restudy of GSSPs.

关键词：全球层形志留纪地质学研究项目

EXTENSION OF RANGE IN RADIAL ORDER IN DETECTION AND mODE CLASSIFICATION OF SOLAR LOW-DEGREE GRAVITY mODES

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Science China mathematics 1990年第7期33卷 854-866页

作者： henry A.HILL 顾益民Department of Physics University of Arizona Tucson AZ 85721 USA Department of Physics University of Arizona Tucson AZ 85721 USA

The 1979 differential radius observations of the Sun have been reexamined for additional evidence of gravity modes (g-modes) beyond that reported by Hill and to classify the modes for which evidence has been obtained. The basic criteria employed in the mode detection and classification procedure are extensions of the criteria introduced by Hill. The properties of the 31 multiplets classified by Hill are used as the starting point in the work reported here. Statistically significant evidence of additional g-modes has been found and the number of classified multiplets is extended from 31 to 53. The degrees and radial orders of the 53 multiplets are respectively l=1, n=47,…, 7; l=2, n=6,…, 13, 15 and 16; l=3, n=7,…, 20; l=4, n=7,…, 20; and l=5, n=16,…, 26. The m=0 eigenfrequencies are measured with an accuracy of ≈0.02 μHz and the multiplet structure linear in angular order m is measured with an accuracy of ≈0.01 μHz.

关键词： Sun: oscillations Sun: internal structure.

Long-Term Cropping System, Tillage, and Poultry Litter Application Affect the Chemical Properties of an Alabama Ultisol

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Pedosphere 2019年第2期29卷 180-194页

作者： Zhongqi HE Irenus A.TAZISONG Xinhua YIN Dexter B.WATTS Zachary N.SENWO henry Allen TORBERT United States Department of Agriculture-Agricultural Research Service(USDA-ARS) Southern Regional Research Center Department of Biological and Environmental Sciences Alabama A&M University Department of Plant Sciences University of Tennessee United States Department of Agriculture-Agricultural Research Service(USDA-ARS) National Soil Dynamics Laboratory

Sustainable agricultural practices have been steadily increasing in the last couple of decades. These management practices frequently involve cover crops, less or no-tillage, and organic fertilization. In this study, we evaluated the effects of cropping systems,tillage and no-tillage, and the application of poultry litter(PL) on selected soil physicochemical properties and soil test nutrients. Soil samples were collected from the topmost surface(0–5 cm) and subsurface(5–10 cm) layers. The general effect trend was PL application > no-tillage > cover crop > cropping type. There were more statistically significant(P ≤ 0.05) correlations between the 18 soil attributes at the topmost surface than at the subsurface. This could be due to the accumulation of external C inputs and nutrients by crop residues and PL application as well as the retaining effects of no-tillage on less mobile nutrient components. Because of their high mobility and volatile nature, total nitrogen(N), ammonia-N(NH_4^+-N), and nitrate-N(NO_3^--N) levels varied greatly(high standard deviations), showing no consistent patterns among the treatments. Compared to the soybean cropping system, corn, especially with the wheat cover crop, contributed more to the total carbon(C) and sulfur(S) in the topmost surface soils(0–5 cm). Poultry litter application greatly increased pH, cation exchange capacity(CEC), base saturation, magnesium(mg), phosphorus(P), calcium(Ca),sodium(Na), potassium(K), manganese(mn), copper(Cu), and zinc(Zn) in both soil layers. Contrast comparisons revealed that PL application had more of an effect on these soil chemical properties than no-tillage and cropping systems. These results will shed light on developing better nutrient management practices while reducing their runoff potentials.

关键词： conventional tillage cover crop mehlich-3 extraction no-tillage nutrient management practice organic fertilization soil attributes soil test nutrients

间断或持续PTH刺激对骨及间充质干细胞的不同分化作用

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中华医学杂志 2018年第10期98卷 781-787页

作者：张瀶曦 Deepak H. Balani Sophia Trinh henry m. Kronenberg 母义明解放军总医院内分泌科北京100853 Endocrine Unit Massachusetts General Hospital and Harvard Medical School Boston 02114 USA

目的探讨不同甲状旁腺素（PTH）给药情况下及撤药后，骨及间充质干细胞的不同分化作用机制。方法6周龄雄性C57/BL6J小鼠，基因型为SOX9－creERT/Td－Tomato/Osteocalcin－GFP，分为间断PTH刺激及撤药组（PTH 500 μg·kg^－1·d^－1，... 详细信息

目的探讨不同甲状旁腺素（PTH）给药情况下及撤药后，骨及间充质干细胞的不同分化作用机制。方法6周龄雄性C57/BL6J小鼠，基因型为SOX9－creERT/Td－Tomato/Osteocalcin－GFP，分为间断PTH刺激及撤药组（PTH 500 μg·kg^－1·d^－1，皮下注射）、持续PTH刺激及撤药组（PTH泵，80 μg·kg^－1·d^－1，速度0.25 μl/h，皮下埋入）、空白对照组及撤药对照组，共6组，每组8只。分别于给药2周及撤药2周时观察小鼠血清中钙离子浓度及骨密度，并取小鼠胫骨骨骼分别进行病理及免疫荧光染色。结果间断PTH刺激组血清钙离子浓度一过性升高，达（1.36±0.03）mmol/L。持续PTH泵刺激组血清中钙离子浓度逐渐升高，48 h达高峰[（2.33±0.03）mmol/L]，2周后恢复正常（1.12～1.27 mmol/L）。PTH刺激2周后，间断组[（0.047±0.002）g/cm2]和持续组[（0.046±0.001）g/cm2]骨密度均高于对照组[（0.044±0.001）g/cm2]，但间断组和持续组差异无统计学意义。停药2周后，三组间BmD差异无统计学意义。股骨病理可见间断组骨皮质不明显，大量的骨小梁增生，伴少量纤维组织增生；持续PTH刺激大片纤维组织增生，尤以骨皮质内侧显著，撤药后纤维化消失。间断PTH刺激后骨细胞和成骨细胞明显升高，撤药后明显下降；衬里细胞数量骤减，撤药后有所增加；破骨细胞给药及撤药后差异均无统计学意义。持续PTH刺激破骨细胞增多，衬里细胞骤减，撤药后破骨细胞和衬里细胞增加，成骨细胞减少。腓骨干骺端免疫荧光显示，间断PTH刺激组大量未分化的Td－tomato间充质干细胞，撤药后较前明显减少。持续PTH组少量未分化的Td－tomato间充质干细胞增生，撤药后较前减少。结论间断PTH刺激可通过增加未分化的间充质干细胞和成骨细胞数量，将衬里细胞转换为骨细胞和成骨细胞，进而促进骨生成；持续PTH刺激可使少量未分化的间充质干细胞、成骨细胞和骨细胞增生，伴大量纤维化增生和破骨细胞数量骤增，最终可能导致代谢性骨病，撤药后衬里细胞明显增加，或有利于代谢性骨病的缓解。

关键词：甲状旁腺素间充质干细胞骨成骨细胞破骨细胞

A world of art 2nd ed.

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A world of art

1997年

作者： Sayre henry m.

来源：畅想之星图书光盘版（南... 评论

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纵向再探学前儿童心理理论发展模式

心理学报 2009年第8期41卷 706-714页

作者：方富熹 henry m. Wellman 刘玉娟刘国雄亢蓉中国科学院心理研究所北京100101 美国密执安大学人类发育发展中心中央教育科学研究所北京100088 南京师范大学教育科学学院南京210097 山东轻工业学院济南250353

本文作者前不久完成的一项横断设计研究中,以自编的心理理论量表测查比较了中美两国3～5岁儿童的有关发展。量表包括五项任务:(1)不同的愿望;(2)知与不知;(3)不同的信念;(4)内容错误信念和(5)伪装的情绪。研究发现两种不同文化群体儿童... 详细信息

本文作者前不久完成的一项横断设计研究中,以自编的心理理论量表测查比较了中美两国3～5岁儿童的有关发展。量表包括五项任务:(1)不同的愿望;(2)知与不知;(3)不同的信念;(4)内容错误信念和(5)伪装的情绪。研究发现两种不同文化群体儿童对上述任务的理解均表现出稳定一致的发展次序,两者的次序大致相同但具有重要差别:我国儿童的理解次序如从易到难排列如上所列,这一次序与美国儿童的差别在于我国儿童先理解"知与不知",然后是"不同的信念",而美国儿童则恰好相反。这一研究结果对了解不同文化儿童心理理论的发展次序是十分有意义的,但问题是经由横断设计的量表研究所确立的发展次序能否准确地描述个体儿童的纵向进展呢?为此本研究使用了相同的测量工具对参加过横断研究的北京3岁儿童(时间1)在他们4岁(时间2)和5岁(时间3)时进行了焦点追踪研究。研究结果表明,随着测查时间的延伸,个体儿童的作业成绩不仅逐步提高,而且这种提高符合量表任务的发展次序。通过应用格特曼(Guttman)和雷氏(Rasch)测量模型对这一结果的分析,再一次证实我国个体儿童的有关发展次序与欧美文化儿童的发展次序大致相同并且有重要的差别。本研究的结果不仅能为横断研究中个别差异的研究提供有用的工具,而且深化了人们对心理理论发展机制的认识,即把心理理论的发展看作是在一定的文化环境影响下不断扩展和深化的概念建构过程。但对这一推论仍有待进一步证实。

关键词：心理理论量表纵向研究发展次序学前儿童

Robotics in genital gender-affirming surgery

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Plastic and Aesthetic Research 2023年第1期10卷 74-82页

作者： Brielle Weinstein henry Govekar Edward Cherullo Kristin m.Jacobs Loren Schechter Department of Surgery Division of Plastic and Reconstructive SurgeryRush University Medical CenterChicagoIL 60612USA Department of Surgery Division of Colorectal SurgeryRush University Medical CenterChicagoIL 60612USA Department of Urology Rush University Medical CenterChicagoIL 60612USA Department of Surgery Division of Plastic and Reconstructive SurgeryDepartment of Obstetrics and GynecologyRush University Medical CenterChicagoIL 60612USA

Gender-affirming genital surgery includes a constellation of pelvic procedures that can help feminize or masculinize the *** advances in robotic surgery can aid surgical access to and visualization of the pelvis,thereby facilitating certain *** this scoping review,we will discuss the developing role of the robot in genital affirming genital ***,techniques,and outcomes using the robot in both feminizing and masculinizing genital procedures will be reviewed.

关键词： Robotic surgery gender affirming surgery vaginoplasty peritoneal vaginoplasty intestinal vaginoplasty metoidioplasty colpectomy vaginectomy phalloplasty