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Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： mackenzie m.Spicer Jianqi Yang daniel fu Alison N.deVore marisol Lauffer Nilufer S.Atasoy deniz Atasoy Rory A.Fisher department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in molecular medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural circuits and Behavior core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

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Advancements and challenges in Organic–Inorganic composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang Shichao cheng chuankai fu Geping Yin Liguang Wang Yongmin Wu Hua Huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China college of chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OIcSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OIcSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OIcSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OIcSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OIcSEs are summarized,and the challenges and perspectives on the future development of OIcSEs are also highlighted for constructing superior ASSLBs.

关键词： composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism characterization techniques

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Bacterial indole-3-propionic acid inhibits macrophage IL-1β production through targeting methionine metabolism

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Science china Life Sciences 2025年

作者： Ziyi Han Jian fu Aiyan Gong Wenkai Ren State Key Laboratory of Livestock and Poultry Breeding College of Animal Science South China Agricultural University Animal disease-resistant Nutrition Key Laboratory of Sichuan Province Sichuan Agricultural University china Institute of Veterinary drug control

The gut microbiota plays key roles in host health by shaping the host immune responses through their metabolites, like indole derivatives from tryptophan. However, the direct role of these indole derivatives in macrophage fate decision and the underlying mechanism remains unknown. Here, we found that bacterial indole-3-propionic acid(IPA) downregulates interleukin-1beta(IL-1β) production in m1 macrophages through inhibition of nuclear factor-kappa B(NF-κB) signaling. mechanistically, IPA binds specifically with methionine adenosyltransferase 2A(mAT2A) to promote S-adenosylmethionine(SAm) synthesis, which facilitates the dNA methylation of ubiquitin-specific peptidase 16(USP16, a deubiquitinase), and in turn promotes Toll-like receptor 4(TLR4) ubiquitination and NF-κB inhibition. furthermore,IPA administration attenuates sepsis in mouse models induced by lipopolysaccharides(LPS), showcasing its potential as a microbial-derived adjunct in alleviating inflammation. collectively, our findings reveal a newly found microbial metabolite-immune system regulatory pathway mediated by IPA.

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Gradient‑Layered mXene/Hollow Lignin Nanospheres Architecture design for Flexible and Stretchable Supercapacitors

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Nano-micro Letters 2025年第2期17卷 447-462页

作者： Haonan Zhang cheng Hao Tongtong fu dian Yu Jane Howe Kaiwen chen Ning Yan Hao Ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass materials NanJing Forestry UniversityNanjing 210037People’s Republic of China department of chemical Engineering and Applied chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada department of materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada college of materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)c_(2)T_(x) mXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the mXene layers with a bottom-up decreasing gradient,a multilayered porous mXene structure with smooth ion channels was constructed by reducing the overstacking of mXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and mXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for mXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres mXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

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Reversing anther thermotolerance by manipulating the cis-elements in the promoter of a high-temperature upregulated gene casein Kinase I in upland cotton

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Science china Life Sciences 2025年

作者： Yanlong Li Yinuo fu Yaoyao Li Rui Zhang Jing Yang Huanhuan ma Ling min Xianlong Zhang National Key Laboratory of crop Genetic Improvement Huazhong Agricultural University

High temperature (HT) stress causes male sterility,leading to reduced upland cotton ***,we identified a key gene,casein Kinase I (GhcKI),that negatively regulates male fertility in upland cotton under ***,conventional genetic manipulations of GhcKI would result in male sterility,hindering its utilization in breeding ***,we engineered quantitative variation for anther thermotolerance-related traits in upland cotton by creating weak promoter alleles of GhcKI genes,using cRISPR/cas9 and cRISPR/cpf1genome ***,we screened and identified two new upland cotton plant lines exhibiting a HT-tolerant phenotype with edited GhcKI promoters,and characterized their corresponding heat-tolerant allelic *** research revealed that the primary reason for the HT tolerance of the GhcKI promoter editing mutants is that the trans-acting factors GhmYB73 and GhmYB4,which positively regulate GhcKI expression under HT,failed to bind and activate the expression of ***,our study not only provides a rapid strategy to generate new beneficial alleles but also offers novel germplasm resources and molecular insights for crop HT tolerance breeding.

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A dimension-Reduction Interval Analysis method for Uncertain Problems

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computer modeling in Engineering & Sciences 2017年第3期113卷 239-259页

作者： J.c.Tang c.m.fu State Key Laboratory of Advanced design and manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha City410082P.R.China college of mechanical Engineering University of South ChinaHengyang 421001P.R.China

In this paper,an efficient interval analysis method called dimension-reduction interval analysis(dRIA)method is proposed to calculate the bounds of response functions with interval variables,which provides a kind of solution method for uncertainty analysis problems of complex structures and ***,multi-dimensional function is transformed into multiple one-dimensional functions by extending dimension reduction method to the interval analysis ***,all the one-dimensional functions are transformed to standard quadratic form by second order Taylor expansion *** a result,the multi-dimensional function is approximately represented by the functions that each interval variable occurs once,and interval power arithmetic can be used to efficiently calculate the bounds of response functions in restricted ***,three numerical examples and an engineering application are investigated to demonstrate the validity of the proposed method.

关键词： Interval uncertainty interval analysis dimension-reduction method over estimation

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Engineering N3c vacancies in hierarchical porous carbon nitride nanosheets for room temperature ultradeep photocatalytic aerobic oxidative desulfurization

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Science china chemistry 2025年

作者： Yina Nie Weijie Yang Xin Wang Xiang Li Lele Wei Xiaolin Bai Lin Liu Feng fu Jun Wan college of chemistry & chemical Engineering Research Institute of Comprehensive Energy Industrial Technology Shaanxi Key Laboratory of Chemical Reaction Engineering Yan'an University Anhui Engineering Research center of carbon Neutrality College of Chemistry and Materials Science Anhui Normal University

The production of ultra-low sulfur clean fuels holds global significance for improving energy efficiency and reducing environmental pollution. Photocatalytic aerobic oxidative desulfurization（POdS） offers an attractive approach to efficiently remove refractory heterocyclic aromatic sulfur compounds under mild conditions. However, the sluggish charge dynamics,insufficient molecule activation, and slow mass transfer within photocatalysts restrict the overall desulfurization efficiency,hindering the widespread application of this technology. Herein, we developed a defective g-c3N4（m1U3cN） photocatalyst with bridged N3cvacancies and hierarchical porous structures to address these limitations. This catalyst not only demonstrates outstanding dibenzothiophene（dBT） removal efficiency of 99.6% for model oil with high conversion and selectivity but also achieves complete sulfur removal from gasoline as well as 96.7% sulfur removal for distilled diesel at room temperature,successfully achieving ultradeep aerobic oxidative desulfurization. The introduction of rich N3cvacancies and abundant micromeso-macroporous distribution in m1U3cN enhances kinetic efficiencies by promoting charge carrier separation, mass transfer,and molecular activation simultaneously; resulting in exceptional POdS performance. This work provides a collaborative strategy to overcome kinetic challenges in aerobic oxidative desulfurization via defect and structural engineering of the catalyst.

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胆道生态系统：全局视角下的胆道外科关键科学问题

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中华外科杂志 2025年第1期63卷 39-44页

作者：王向付静海军军医大学第三附属医院胆道二科上海海军军医大学国家肝癌科学中心上海

随着胆道外科现代诊疗体系的建立与科学研究范式的转变, 无论是良性还是恶性胆道疾病, 均已进入精准化、个体化、全程化及多学科协作的诊疗和研究阶段。然而胆道外科医师仍面临着两大困境:(1)外科技术在降低良性胆道疾病致残率、提高胆... 详细信息

随着胆道外科现代诊疗体系的建立与科学研究范式的转变, 无论是良性还是恶性胆道疾病, 均已进入精准化、个体化、全程化及多学科协作的诊疗和研究阶段。然而胆道外科医师仍面临着两大困境:(1)外科技术在降低良性胆道疾病致残率、提高胆道肿瘤患者生存率方面进入了瓶颈期;(2)对于"切胆保胆""如何减黄"等临床争议, 传统的临床研究似乎难以给出确切答案。借鉴系统生物学的理念, 作者提出了"胆道生态系统"的概念框架:胆管是丛林, 血管、淋巴管、神经和免疫系统是土壤, 干细胞是种子, 胆汁是河流, 肝细胞是河流的发源地。良恶性疾病具有动态转化的特征;不同部位的胆管构成"大"环境, 胆汁形成"小"环境, 不同细胞组成"微"环境;细胞亚群具有不同状态及多样性, 并受复杂分子信号网络的调控。作者据此进一步凝练了胆道外科的若干关键科学问题, 提出了优化研究范式的建议, 旨在从全局视角推动学科交叉融合, 推动胆道外科临床及转化研究。

关键词：胆道疾病胆道肿瘤胆道生态系统普通外科学范式转变多组学技术

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A discrete Flux Scheme for Aerodynamic and Hydrodynamic Flows

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communications in computational Physics 2011年第5期9卷 1257-1283页

作者： S.c.fu R.m.c.So W.W.F.Leung mechanical Engineering department Hong Kong Polytechnic UniversityHung HomKowloonHong Kong School of mechanical Engineering Purdue UniversityWest LafayetteIN 47907-2088USA Research Institute of Innovative Products&Technologies Hong Kong Polytechnic UniversityHung HomKowloonHong Kong

The objective of this paper is to seek an alternative to the numerical simulation of the Navier-Stokes equations by a method similar to solving the BGK-type modeled lattice Boltzmann *** proposed method is valid for both gas and liquid flows.A discrete flux scheme(dFS)is used to derive the governing equations for two distribution functions;one for mass and another for thermal *** equations are derived by considering an infinitesimally small control volume with a velocity lattice representation for the distribution *** zero-order moment equation of the mass distribution function is used to recover the continuity equation,while the first-order moment equation recovers the linear momentum *** recovered equations are correct to the first order of the Knudsen number(Kn);thus,satisfying the continuum ***,the zero-order moment equation of the thermal energy distribution function is used to recover the thermal energy *** aerodynamic flows,it is shown that the finite difference solution of the dFS is equivalent to solving the lattice Boltzmann equation(LBE)with a BGK-type model and a specified equation of *** formulated,the dFS can be used to simulate a variety of aerodynamic and hydrodynamic *** of classical aeroacoustics,compressible flow with shocks,incompressible isothermal and non-isothermal couette flows,stratified flow in a cavity,and double diffusive flow inside a rectangle are used to demonstrate the validity and extent of the *** good to excellent agreement with known analytical and/or numerical solutions is obtained;thus lending evidence to the dFS approach as an alternative to solving the Navier-Stokes equations for fluid flow simulations.

关键词： Aerodynamics hydrodynamics lattice Boltzmann equation

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A Lattice Boltzmann and Immersed Boundary Scheme for model Blood Flow in constricted Pipes:Part 1-Steady Flow

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communications in computational Physics 2013年第6期14卷 126-152页

作者： S.c.fu W.W.F.Leung R.m.c.So department of mechanical Engineering The Hong Kong Polytechnic UniversityHung HomHong Kong

Hemodynamics is a complex problem with several distinct characteristics;fluid is non-Newtonian,flow is pulsatile in nature,flow is three-dimensional due to cholesterol/plague built up,and blood vessel wall is *** order to simulate this type of flows accurately,any proposed numerical scheme has to be able to replicate these characteristics correctly,efficiently,as well as individually and *** the equations of the finite difference lattice Boltzmann method(FdLBm)are hyperbolic,and can be solved using cartesian grids locally,explicitly and efficiently on parallel computers,a program of study to develop a viable FdLBm numerical scheme that can mimic these characteristics individually in any model blood flow problem was *** present objective is to first develop a steady FdLBm with an immersed boundary(IB)method to model blood flow in stenoic artery over a range of Reynolds *** resulting equations in the FdLBm/IB numerical scheme can still be solved using cartesian grids;thus,changing complex artery geometry can be treated without resorting to grid *** FdLBm/IB numerical scheme is validated against known data and is then used to study Newtonian and non-Newtonian fluid flow through constricted *** investigation aims to gain insight into the constricted flow behavior and the non-Newtonian fluid effect on this behavior.

关键词： Finite difference method lattice Boltzmann method immersed boundary method blood flow constricted pipe

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