检索结果-南通市图书馆

维普期刊数据库

Aquaporin-4 mz Isoform:Brain Expression,Supramolecular Assembly and Neuromyelitis Optica Antibody Binding

在线全文

学校读者我要写书评

暂无评论

神经损伤与功能重建 2011年第5期6卷 364-370页

作者： Andrea Rossi Jonathan m.crane A.S.Verkman Department of medicine University of California Department of Physiology University of California

水通道蛋白4（AQP4）表达于大脑和脊髓的星形胶质细胞。2种主要的AQP4亚型,m1和m23,均有表达,具有不同的翻译起始点。研究表明,一种较新的亚型mz表达于大鼠,其翻译起始点位于m1的翻译起始点上游126 bp。通过C端标记的抗AQP4抗体SDS和非... 详细信息

水通道蛋白4（AQP4）表达于大脑和脊髓的星形胶质细胞。2种主要的AQP4亚型,m1和m23,均有表达,具有不同的翻译起始点。研究表明,一种较新的亚型mz表达于大鼠,其翻译起始点位于m1的翻译起始点上游126 bp。通过C端标记的抗AQP4抗体SDS和非变性胶免疫印迹技术,大鼠大脑中的mz被检测到为39 kDa大小的条带。mz因其提前终止密码子,在人类和小鼠大脑中并不表达。通过单粒子追踪和非变性胶电泳技术检测,发现大鼠mz可形成正交粒子阵列（OAPs）。本文发现,mz与m1类似,在细胞浆膜内迅速扩散,并不形成OAPs。但是,当与m23共表达时,mz通过与m23形成异四聚体可与OAPs关联。意外的是,mz表达的细胞极弱地与视神经脊髓炎自身抗体（NmO-IgG）结合,小于m1表达细胞的5倍。切割分析提示,met-1上游的31~41残基参与NmO-IgG与mz之间较弱的结合。总之,mz AQP4在大鼠中低量表达,但不表达于人和小鼠的大脑;自身无法形成OAPs,除非与m23 AQP4形成异四聚体;因AQP4/NmO-IgG结合点的N端功能。

关键词： AQP4 水通道星形胶质细胞 NmO 正交粒子阵列

维普期刊数据库

Relationship of Secreted Salivary Protein Variants to Virulence in Hessian Fly (<i>mayetiola destructor</i>(Say))

在线全文

学校读者我要写书评

暂无评论

Advances in Entomology 2020年第1期8卷 15-33页

作者： Yan m. crane Charles F. crane Brandon J. Schemerhorn USDA-ARS Crop Production and Pest Control Research Unit West Lafayette IN USA Department of Entomology Purdue University West Lafayette IN USA Department of Botany and Plant Pathology Purdue University West Lafayette IN USA

Salivary proteins are the initial contact between sedentary insect pests and their host plants. It is expected that one or more salivary proteins mediate the interaction between Hessian fly and wheat, in which a feeding site is established to the benefit of the fly. A survey of 52 loci annotated as insect secreted salivary proteins was conducted in 384 individuals evenly distributed among eight biotypes of Hessian fly (B, C, D, E, GP, L, O, and vH9). Amplicons were sequenced with Illumina, and sequence reads were aligned to the reference sequences from which primers had been designed. Positions of consistent base variation (998 in all) were identified and tabulated by biotype. No varying position was associated with biotype-wide virulence to any one of wheat resistance genes H3, H5, H6, H7/H8, H9, H11, H13, and H26. The multiplate pooling strategy utilized in this study is an effective, affordable way to reveal the genotype of hundreds of individuals at tens of genetic loci.

关键词： Hessian Fly mayetiola destructor Virulence Insect-Plant Interaction Amplicon Sequencing

Recurrent Coronary Artery Thrombosis on Triple Anti-Thrombotic Therapy, Is There a Possible Association with ChAdOx1 nCoV-19 Vaccination?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Case Reports in Clinical medicine 2022年第6期11卷 234-243页

作者： Phillip crane Voltaire Nadurata m. Asrar Ul Haq Department of Cardiology The Northern Hospital Epping Australia Department of Cardiology Bendigo Health Bendigo Australia

Background: Vaccines remain the only viable and safe option to control transmission and minimise disease sequelae during the COVID-19 pandemic. Whilst multiple vaccines are available, evidence has emerged regarding the association between the ChAdOx1 nCoV-19 vaccine, platelets and thrombosis, manifesting in thrombotic thrombocytopaenia. Case Summary: We report a case of recurrent coronary artery thrombosis on triple antithrombotic therapy, namely aspirin, clopidogrel, and continuous intravenous heparin, nine days after the ChAdOx1 nCoV-19 vaccine, in a 63-year-old female with no significant history of cardiovascular disease. Conclusion: This case may suggest that the association between platelets, SARS-CoV-2, the ChAdOx1 nCoV-19 vaccine, and coronary thrombosis may remain incompletely understood and warrants further study. Clinicians should remain on high alert if presented with similar circumstances.

关键词： ST-Elevation myocardial Infarction Stent Thrombosis ChAdOx1 nCoV-19 AstraZeneca COVID-19 SARS-CoV-2

A Lack of Effect on Patient Satisfaction Scores in One Large Urban Emergency Department

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Clinical medicine 2012年第7期3卷 740-743页

作者： Peter W. crane Bryce Yerman Sandra m. Schneider School of medicine and Dentistry University of Rochester Rochester USA

Background: To deal with emergency department crowding and long waits before patient care, many institutions have placed a doctor in the triage area to initiate treatment and testing. Objective: to determine the effect of a doctor in triage on patient satisfaction scores. methods: This is an observational study comparing the patient satisfaction scores from days when a physician was in triage to days when a physician was not present. The study was conducted in the ED of an urban academic medical center with excellent primary care resources and payer mix (7% self pay, 11% medicaid). Results: There was a mean of 4 (95% CI 3.1 - 4.5) surveys returned for each day when there was a doctor in triage and a mean of 5 (95% CI 4.3 - 5.7) surveys for each day without a doctor in triage. Overall satisfaction for the days with a doctor in triage was 79.9 ± 10.5 (95% CI 77.7, 82.1) compared to 78.8 ± 9.2 (95% CI 76.5, 81.1) (p = 0.9) on days without a doctor in triage. Conclusion: In this setting, there was no effect of a doctor in triage on patient satisfaction scores. While a doctor in triage may be valuable and cost effective in some settings, it may not provide appropriate benefit in all settings. We suggest that facilities trial a physician in triage program and measure predetermined outcomes such as patient satisfaction scores, length of stay and the percentage of patients left without being seen before investing in additional staffing and cost to sustain such a program.

关键词： Emergency Department Crowding Triage Physician in Triage Patient Satisfaction

A Wavelet-Based method to measure Stock market Development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Statistics 2014年第1期4卷 89-96页

作者： Adel Al Sharkasi Heather J. Ruskin martin crane José matos Sílvio m. A. Gama CmUP & Departamento de matemática Aplicada Faculdade de Ciencias Universidade do Porto Porto Portugal CmUP & Grupo de matemática Informática Faculdade de Econmia Universidade do Porto Porto Portugal Department of Statistics Faculty of Science University of Benghazi Benghazi Libya School of Computing Dublin City University Dublin Ireland

In this paper, we introduce a novel algorithm, based on the wavelet transform, to measure stock market development. This algorithm is applied to the return series of fourteen worldwide market indices from 1996 to 2005. We find that a comparison of the return series in terms of the quantity of fractional Gaussian noise (fGn), for different values of Hurst exponent (H), facilitates the classification of stock markets according to their degree of development. We also observe that the simple classification of stock markets into “emerging” or “developing” and “mature” or “developed” is no longer sufficient. However, stock markets can be grouped into three categories that we named emerging, intermediate and mature.

关键词： Wavelet Transform Hurst Exponent (H) Stock market Classifications

Temporal and spectral contributions to musical instrument identification and discrimination among cochlear implant users

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Otorhinolaryngology-Head and Neck Surgery 2016年第3期2卷 -页

作者： Sandra m. Prentiss David R. Friedland Tanner Fullmer Alison crane Timothy Stoddard Christina L. Runge Department of 0tolaryngology and Communication Sciences Medical College of Wisconsin Milwaukee WI USA

Objective:To investigate the contributions of envelope and fine-structure to the perception of timbre by cochlear implant (CI) users as compared to normal hearing (NH) lis-teners. methods: This was a prospective cohort comparison study. Normal hearing and cochlear implant patients were tested. Three experiments were performed in sound field using musical notes altered to affect the characteristic pitch of an instrument and the acoustic envelope. Experiment 1 assessed the ability to identify the instrument playing each note, while experi-ments 2 and 3 assessed the ability to discriminate the different stimuli. Results:Normal hearing subjects performed better than CI subjects in all instrument identifi-cation tasks, reaching statistical significance for 4 of 5 stimulus conditions. Within the CI pop-ulation, acoustic envelope modifications did not significantly affect instrument identification or discrimination. With envelope and pitch cues removed, fine structure discrimination perfor-mance was similar between normal hearing and CI users for the majority of conditions, but some specific instrument comparisons were significantly more challenging for CI users. Conclusions:Cochlear implant users perform significantly worse than normal hearing listeners on tasks of instrument identification. However, cochlear implant listeners can discriminate differences in envelope and some fine structure components of musical instrument sounds as well as normal hearing listeners. The results indicated that certain fine structure cues are important for cochlear implant users to make discrimination judgments, and therefore may affect interpretation toward associating with a specific instrument for identification.

关键词： music Timbre Cochlear implant Envelope Fine-structure

维普期刊数据库

Rapid synthesis of transition metal dichalcogenide-carbon aerogel composites for supercapacitor electrodes

在线全文

学校读者我要写书评

暂无评论

microsystems & Nanoengineering 2017年第1期3卷 212-220页

作者： matthew J.crane matthew B.Lim Xuezhe Zhou Peter J.Pauzauskie Department of Chemical Engineering University of WashingtonSeattleWA 98195-1750USA Department of materials Science&Engineering University of WashingtonSeattleWA 98195-2120USA Fundamental&Computational Sciences Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA

Transition metal dichalcogenide(TmD)materials have recently demonstrated exceptional supercapacitor properties after conversion to a metallic phase,which increases the conductivity of the ***,freestanding,exfoliated transition metal dichalcogenide films exhibit surface areas far below their theoretical maximum(1.2%),can fail during electrochemical operation due to poor mechanical properties,and often require pyrophoric chemicals to *** the other hand,pyrolyzed carbon aerogels exhibit extraordinary specific surface areas for double layer capacitance,high conductivity,and a strong mechanical network of covalent chemical *** this paper,we demonstrate the scalable,rapid nanomanufacturing of TmD(moS2 and WS2)and carbon aerogel composites,favoring liquid-phase exfoliation to avoid pyrophoric *** aerogel matrix support enhances conductivity of the composite and the synthesis can complete in 30 *** find that the addition of transition metal dichalcogenides does not impact the structure of the aerogel,which maintains a high specific surface area up to 620 m^(2) g−1 with peak pore radii of 10 *** supercapacitor tests of the aerogels yield capacitances around 80 F g^(−1) at the lowest applied currents,the aerogels loaded with TmD’s exhibit volumetric capacitances up to 127% greater than the unloaded *** addition,the WS2 aerogels show excellent cycling stability with no capacitance loss over 2000 cycles,as well as markedly better rate capability and lower charge transfer resistance compared to their moS2-loaded *** hypothesize that these differences in performance stem from differences in contact resistance and in the favorability of ion adsorption on the chalcogenides.

关键词： aerogel molybdenum disulfide nanomanufacturing rapid resorcinol-formaldehyde supercapacitor transition metal dichalcogenide tungsten disulfide

Human immunodeficiency virus infection and the liver

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2012年第3期4卷 91-98页

作者： megan crane David Iser Sharon R Lewin Department of medicine Monash University Centre for Virology Burnet Institute Department of Gastroenterology St Vincent's Hospital Australia Infectious Disease Unit

Liver disease in human immunodeficiency virus(HIV)-infected individuals encompasses the spectrum from abnormal liver function tests,liver decompensation,with and without evidence of cirrhosis on biopsy,to non-alcoholic liver disease and its more severe form,non-alcoholic steatohepatitis and hepatocellular *** can infect multiple cells in the liver,leading to enhanced intrahepatic apoptosis,activation and *** can also alter gastro-intestinal tract permeability,leading to increased levels of circulating lipopolysaccharide that may have an impact on liver *** review focuses on recent changes in the epidemiology,pathogenesis and clinical presentation of liver disease in HIV-infected patients,in the absence of co-infection with hepatitis B virus or hepatitis C virus,with a specific focus on issues relevant to low and middle income countries.

关键词： Human immunodeficiency virus Liver dis-ease Low-middle income settings

用于N-S方程数值解的有限差分格式的精确度

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

力学进展 1984年第4期 506-514页

作者： C.W.Richards ,C.m.crane ,胡庆康

本文比较了用于二维粘性流动数值解的各种有限差分算法,比较了最近研究出的中心差分算法与建立得很好的迎风差分算法。为了作出有意义的比较,文中提出了N-S(Navier-Stokes)方程的一些解析解。根据这些解的结果,可以认为所推荐的新的中... 详细信息

本文比较了用于二维粘性流动数值解的各种有限差分算法,比较了最近研究出的中心差分算法与建立得很好的迎风差分算法。为了作出有意义的比较,文中提出了N-S(Navier-Stokes)方程的一些解析解。根据这些解的结果,可以认为所推荐的新的中心差分算法是更为精确的,而且几乎不需要增加计算工作量。存在着一个格子雷诺数的上限,这些新方法在此限度内将是收敛的,但是当流动实际上是湍流时,通常也可能收敛。

关键词：涡量方程流函数方程大格 N-S 雷诺数 REYNOLDS数迎风格式迎风差分格式数值解数值分析