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影像引导下乳腺癌的聚焦超声消融:现状、挑战及未来发展方向

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国际医学放射学杂志 2008年第5期31卷 413-414页

作者： A.C.Schmitz D.Gianfelice B.L.Daniel W.P.mali m.a.van den bosch 秦乃姗 Department of Radiology Stanford University Stanford CA USA.

影像引导下聚焦超声（FUS）消融为无创性操作，用于治疗良恶性乳腺肿瘤。可在实时超声或mRI引导下进行消融。过去20年第一阶段研究证实，在mRI或超声引导下进行乳腺肿瘤的FUS消融技术是可行且安全的。通过测量肿瘤完全坏死病例所占的比... 详细信息

影像引导下聚焦超声（FUS）消融为无创性操作，用于治疗良恶性乳腺肿瘤。可在实时超声或mRI引导下进行消融。过去20年第一阶段研究证实，在mRI或超声引导下进行乳腺肿瘤的FUS消融技术是可行且安全的。通过测量肿瘤完全坏死病例所占的比例。对FUS消融乳腺肿瘤的效果作一全面概述。肿瘤消融成功率为20％-100％，此范围取决于FUS系统的类型、成像技术、消融方法及病人的选择。目前还存在一些与乳腺肿瘤FUS消融相关的具体问题，

关键词：影像引导下治疗聚焦超声乳腺癌肿瘤消融 mRI

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宫颈癌高分辨力T2WI:超高场7.0 TmRI直肠内单极天线的可行性研究

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国际医学放射学杂志 2017年第3期 354-354页

作者： J.P.Hoogendam I.m.Kalleveen C.S.de Castro A.J.Raaijmakers R.H.Verheijen m.a.van den bosch 李海鸥 Department of Gynaecological Oncology UMC Utrecht Cancer Centre University Medical Centre Utrecht

摘要目的研究使用超高场7.0 T mRI系统4.7 mm厚的直肠内线圈进行高分辨力T2加权宫颈癌成像的可行性。方法 20例分期为ⅠB1-ⅡB的宫颈癌病人被纳入该可行性研究。治疗前行1.5 T mRI扫描。7.0 T mRI使用的外部传输/接收矩阵具有7个偶极天... 详细信息

摘要目的研究使用超高场7.0 T mRI系统4.7 mm厚的直肠内线圈进行高分辨力T2加权宫颈癌成像的可行性。方法 20例分期为ⅠB1-ⅡB的宫颈癌病人被纳入该可行性研究。治疗前行1.5 T mRI扫描。7.0 T mRI使用的外部传输/接收矩阵具有7个偶极天线和1个直肠内单极接收天线,评估不适阈。经过个性化的基于相位的B1+匀场后,完成T2加权快速自旋回波序列。结果ⅠB1期宫颈癌病人9例,ⅠB2期4例,ⅡA1期1例,ⅡB期6例。使用10分法进行不适阈评估。定位

关键词：直肠内天线 T2WI 高分辨力高分辨率 TmRI 宫颈癌可行性研究可行性分析

Role and therapeutic potential of liquid-liquid phase separation in amyotrophic lateral sclerosis

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Journal of molecular Cell Biology 2021年第1期13卷 15-28页

作者： Donya Pakravan Gabriele Orlando Valerie Bercier Ludo van den bosch Department of Neurosciences Experimental Neurology and Leuven Brain Institute(LBI)KU Leuven-University of Leuven3000 LeuvenBelgium Laboratory of Neurobiology VIB-KU Leuven Center for Brain&Disease Research3000 LeuvenBelgium Switch Laboratory VIB-KU Leuven Center for Brain&Disease Research3000 LeuvenBelgium

Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disease selectively affecting motor neurons, leading to pro-gressive paralysis. Although most cases are sporadic,-10% are familial. Similar proteins are found in aggregates in sporadicand familial ALS, and over the last decade, research has been focused on the underlying nature of this common ***, TDP-43 inclusions are found in almost all ALS patients, while Fus inclusions have been reported in some familial ALSpatients. Both TDP-43 and FUS possess ‘low-complexity domains' (LCDs) and are considered as ‘intrinsically disordered proteins',which form liquid droplets in vitro due to the weak interactions caused by the LCDs. Dysfunctional ‘liquid-lquid phase separa-tion'(LLPS) emerged as a new mechanism linking AlS-related proteins to pathogenesis. Here, we review the current state ofknowledge on ALS-related gene products associated with a proteinopathy and discuss their status as lLPS proteins. n addition,we highlight the therapeutic potential of targeting LLPS for treating ALS.

关键词： phase separation stress granule motor neuron ALS therapy

Transcranial magnetic stimulation research on reading and dyslexia:a new clinical intervention technique for treating dyslexia?

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Neuroimmunology and Neuroinflammation 2015年第1期2卷 145-152页

作者： maurits van den Noort Esli Struys Peggy bosch Department of Linguistics Vrije Universiteit Brussel1050 BrusselsBelgium Research Group of Pain and Neuroscience Kyung Hee UniversitySeoul 130-701South Korea Centre for Cognition Donders Institute for BrainCognition and BehaviourRadboud University Nijmegen6500 GL NijmegenGelderlandthe Netherlands Psychiatric Research Institute LVR-Klinik Bedburg-Hau47551 Bedburg-HauGermany

Nowadays,several noninvasive neuroimaging techniques,including transcranial magnetic stimulation(TmS),*** working mechanism behind TmS is a rapidly changing magnetic field that generates an electric current via electromagnetic *** the coil is placed on the scalp,the magnetic field generates a physiological reaction in the underlying neural *** TmS-induced change in the participant’s behavior is used by researchers to investigate the causal relations between specific brain areas and cognitive functions such as language.A variant of TmS has been developed,which is called rapid-rate TmS(rTmS).In this review,three databases(medline,Educational Resources Information Center,and Scopus)were searched for rTmS studies on normal reading and dyslexia with a cut-off date of October 31,*** was found to be a valuable tool for investigating questions related to reading research,both on the word and the sentence ***,it can be successfully used in research on ***,(high-frequency)rTmS has been used as a“clinical”intervention technique for treating dyslexia and for improving reading performance by exciting underactive reading pathways in the ***,we end the paper with a discussion of future directions in the field of rTmS research and dyslexia,for instance,the promising prospect of combining TmS with simultaneous electroencephalographic imaging.

关键词： Clinical intervention dyslexia sentence reading transcranial magnetic stimulation word reading

Functionalized monodisperse microbubble production:microfluidic method for fast,controlled,and automated removal of excess coating material

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microsystems & Nanoengineering 2024年第4期10卷 391-401页

作者： m.R.P.van den Broek m.Versluis A.van den Berg T.Segers BIOS/Lab on a Chip Group Max Planck Center Twente for Complex Fluid DynamicsUniversity of TwenteEnschedeThe Netherlands Physics of Fluids Group University of TwenteEnschedeThe Netherlands

Functionalized monodisperse microbubbles have the potential to boost the sensitivity and efficacy of molecular ultrasound imaging and targeted drug delivery using bubbles and *** bubbles can be produced in a microfluidic flow focusing ***,their functionalization and sequential use require removal of the excess lipids from the bubble suspension to minimize the use of expensive ligands and to avoid competitive binding and blocking of the receptor *** date,excess lipid removal is performed by centrifugation,which is labor intensive and challenging to *** importantly,as we show,the increased hydrostatic pressure during centrifugation can reduce bubble ***,we introduce a novel automated microfluidic’washing’***,bubbles are injected in a microfluidic chamber 1mm in height where they are left to float against the top ***,lipid-free medium is pumped through the chamber to remove excess lipids while the bubbles remain located at the top ***,the washed bubbles are resuspended and removed from the device into a collection *** demonstrate that the present method can(i)reduce the excess lipid concentration by 4 orders of magnitude,(ii)be fully automated,and(iii)be performed in minutes while the size distribution,functionality,and acoustic response of the bubbles remain ***,the presented method is a gateway to the fully automated production of functionalized monodisperse microbubbles.

关键词： bubble fluid method

Acupuncture treatment of a male patient suffering from long-term schizophrenia and sleep disorders

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Journal of Traditional Chinese medicine 2017年第6期37卷 862-867页

作者： Peggy bosch Heike Staudte Sujung Yeo Sook-Hyun Lee Sabina Lim maurits van den Noort Donders Centre for Cognition Radboud University NijmegenNijmegen 6525 HRThe Netherlands Psychiatric Research Institute LVR-Klinik Bedburg-HauBed-burg-Hau 47551Germany Psychiatric Research Institute LVR-Klinik Bedburg-HauBedburg-Hau 47551Germany Department of Acupuncture&meridian of Oriental medicine Sang Ji UniversityWonju 26339Republic ofKorea Research Group of Pain and Neuroscience Kyung Hee UniversitySeoul 130-701Republic of Korea Research Group of Pain and Neuro-science Kyung Hee UniversitySeoul 130-701Republic of Korea.Brussels Institute for Applied LinguisticsFree Univer-sity of BrusselsBrussels 1050Belgium

OBJECTIVE: To investigate the effectiveness of acupuncture in the treatment of chronic schizophrenia and co-morbid sleep ***: A 42-year-old German male outpatient,suffering from long-term schizophrenia and sleep disorders, entered the study. Acupuncture was used as a non-pharmacological intervention. In addition to his ongoing Western medicine(pharmacological) treatment, the patient received 12 weekly(non-standardized) acupuncture treatments in the clinic. The Traditional Chinese medicine(TCm) diagnosis, the psychological assessment and the actiwatch data were compared before and after the acupuncture ***: The TCm diagnosis revealed a Liver Fire pattern before the acupuncture treatment, which was still present, although to a lesser degree, after the treatment. The psychological assessment revealed no change in the positive symptoms, but a small decrease in the negative symptoms and the general psychopathology of the patient. This was further illustrated by the small decrease in the number of depressive symptoms. The subjective sleep disorders improved markedly after acupuncture treatment, but the daytime sleepiness did not. The actiwatch results showed that after acupuncture treatment, the patient was moving less during sleep, but no significant results were found for the other sleep ***: Acupuncture was found to be an effective non-pharmacological add-on method for treating subjective sleep disorders, and, to a lesser degree, objective sleep disorders and the negative symptoms of chronic schizophrenia. Future larger clinical trials with follow-up measurements are needed in order to replicate the present preliminary beneficial acupuncture findings and in order to determine whether the observed effects can be sustained.

关键词： Actigraphy Acupuncture Schizophre-nia Sleep weak disorders

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^(18)F-FDG-PET/CT-guided radiotherapy of cervical lymph nodes in head and neck squamous cell carcinoma

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Journal of Cancer metastasis and Treatment 2021年第1期7卷 353-363页

作者： maurice C.Cox Sven van den bosch Tim Dijkema Johannes H.A.m.Kaanders Department of Radiation Oncology Radboud University Medical Center6525 GA Nijmegenthe Netherlands

The use of positron emission tomography with fluor-18-fluorodeoxyglucose(FDG-PET)in clinical practice for patients with head and neck squamous cell carcinoma(HNSCC)has expanded rapidly,with implications for diagnostic staging,radiotherapy planning,adaptive radiotherapy,and post-therapy *** implementation of FDG-PET/CT in radiation treatment planning not only has consequences for target volume definition and dose prescription but is also associated with an increased overall survival in patients with ***-PET/CT-guided gradient dose prescription provides a window of opportunity for treatment de-intensification of the neck in order to decrease treatment-related toxicity without compromising oncological ***,interim FDG-PET/CT during radiotherapy can be useful to assess metabolic tumor response and enables opportunities for adaptive treatment *** goals are to increase treatment effectivity in poor responders and reduce unnecessary toxicity in patients with good early tumor *** prospective trials investigating adaptive radiotherapy based on interim PET-evaluation are needed,especially regarding human papilloma virus-negative HNSCC and patients treated with primary radiotherapy.

关键词： Head and neck cancer radiotherapy FDG-PET imaging nodal metastases

The Prognostic Value of myocardial Deformation in Patients with Congenital Aortic Stenosis

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Congenital Heart Disease 2021年第3期16卷 221-232页

作者： Roderick W.J.van Grootel Allard T.van den Hoven Dan Bowen Tijmen Ris Jolien W.Roos-Hesselink Annemien E.van den bosch Department of Cardiology Erasmus Medical CentreRotterdamThe Netherlands

Aims:To assess the prognostic value of left ventricular(LV)global longitudinal strain(GLS)and global longitudinal early diastolic strain rate(GLSre)with regard to cardiovascular events,as congenital aortic stenosis(AoS)is associated with significant mortality and morbidity but predictors for clinical outcome are *** analysis provides a robust and reproducible method for early detection of LV dysfunction,which might be of prognostic ***:This prospective study,included clinically stable patients with congenital AoS between 2011–*** GLS and GLSre was performed in the apical 4,3 and 2-chamber views using Tomtec *** endpoint was a composite of death,heart failure,hospitalization,arrhythmia,thrombo-embolic events and ***:In total 138 patients were included(33[26–43]years,86(62%)male),NYHA class I:134(97%).mean LV GLS was–15.3±3.2%,GLSre 0.66±0.18 s–*** correlated with NT-proBNP,LV volumes and ejection fraction(strongest LV GLS with LV EF:r–0.539,pmedian follow-up of 5.9[5.5–6.2]years,the endpoint occurred in 53(38%)patients:4 patients died,9 developed heart failure,22 arrhythmias,8 thrombo-embolic events and 35 *** LV GLS(standardized HR(sHR 0.62(95%CI 0.47–0.81)and GLSre(sHR 0.62(95%CI 0.47–0.83)were associated with the *** multivariable analysis showed that both GLS and GLSre were associated independent of left atrial volume,NT-proBNP and prior ***:Left ventricular GLS and GLSre are reduced in adult patients with congenital *** markers are associated with adverse cardiac events and have clear clinical relevance.

关键词： Speckle tracking echocardiography congenital aortic stenosis strain prognosis

magnetic resonance imaging in breast cancer:A literature review and future perspectives

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World Journal of Clinical Oncology 2014年第2期5卷 61-70页

作者： Gisela LG menezes Floor m Knuttel Bertine L Stehouwer Ruud m Pijnappel maurice AAJ van den bosch Department of Radiology and Nuclear medicine University Medical Centre Utrecht

Early detection and diagnosis of breast cancer are essential for successful treatment. Currently mammography and ultrasound are the basic imaging techniques for the detection and localization of breast tumors. The low sensitivity and specificity of these imaging tools resulted in a demand for new imaging modalities and breast magnetic resonance imaging(mRI) has become increasingly important in the detection and delineation of breast cancer in daily practice. However, the clinical benefits of the use of pre-operative mRI in women with newly diagnosed breast cancer is still a matter of debate. The main additional diagnostic value of mRI relies on specific situations such as detecting multifocal, multicentric or contralateral disease unrecognized on conventional assessment(particularly in patients diagnosed with invasive lobular carcinoma), assessing the response to neoadjuvant chemotherapy, detection of cancer in dense breast tissue, recognition of an occult primary breast cancer in patients presenting with cancer metastasis in axillary lymph nodes, among others. Nevertheless, the development of new mRI technolo-gies such as diffusion-weighted imaging, proton spectroscopy and higher field strength 7.0 T imaging offer a new perspective in providing additional information in breast abnormalities. We conducted an expert literature review on the value of breast mRI in diagnosing and staging breast cancer, as well as the future potentials of new mRI technologies.

关键词： Breast magnetic resonance imaging Cancer Diffusion-weighted imaging Spectroscopy 7.0 tesla