检索结果-南通市图书馆

World Journal of Gastroenterology 2019年第28期25卷 3669-3683页

作者： Lynn H Gerber Ali A weinstein Rohini m.hta Zobair m.Younossi Departm.nt of m.dicine Beatty Center for Liver and Obesity Research Inova Health System Falls Church VA 22042 United States Center for the Study of Chronic Illness and Disability George Mason University Fairfax VA 22030 United States Beatty Center for Liver and Obesity Research Inova Health System Falls Church VA 22042 United States

The m.chanism. of fatigue in the group of people with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are protean. The liver is central in the pathogenesis of fatigue because it uniquely regulates m.ch of the storage, release and production of substrate for energy generation. It is exquisitely sensitive to the feedback controlling the uptake and release of these energy generation substrates. m.tabolic contributors to fatigue, beginning with the uptake of substrate from.the gut, the passage through the portal system.to hepatic storage and release of energy to target organs (m.scle and brain) are central to understanding fatigue in patients with chronic liver disease. Inflam.ation either causing or resulting from.chronic liver disease contributes to fatigue, although inflam.ation has not been dem.nstrated to be causal. It is this unique com.ination of factors, the nexus of m.tabolic abnorm.lity and the inflam.atory burden of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis that creates pathways to different types of fatigue. m.ny use the term. central and peripheral fatigue. Central fatigue is characterized by a lack of self-m.tivation and can m.nifest both in physical and m.ntal activities. Peripheral fatigue is classically m.nifested by neurom.scular dysfunction and m.scle weakness. Therefore, the distinction is often seen as a difference between intention (central fatigue) versus ability (peripheral fatigue). New approaches to m.asuring fatigue include the use of objective m.asures as well as patient reported outcom.s. These m.asures have im.roved the precision with which we are able to describe fatigue. The m.asures of fatigue severity and its im.act on usual daily routines in this population have also been im.roved, and they are m.re generally accepted as reliable and sensitive. Several approaches to evaluating fatigue and developing endpoints for treatm.nt have relied of biosignatures associated with fatigue. These have bee

关键词： Fatigue Chronic liver disease Non-alcoholic fatty liver diseases Nonalcoholic steatohepatitis m.asurem.nt Patient-reported outcom.s

Robotics in genital gender-affirm.ng surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plastic and Aesthetic Research 2023年第1期10卷 74-82页

作者： Brielle weinstein Henry Govekar Edward Cherullo Kristin m.Jacobs Loren Schechter Departm.nt of Surgery Division of Plastic and Reconstructive SurgeryRush University Medical CenterChicagoIL 60612USA Departm.nt of Surgery Division of Colorectal SurgeryRush University Medical CenterChicagoIL 60612USA Departm.nt of Urology Rush University Medical CenterChicagoIL 60612USA Departm.nt of Surgery Division of Plastic and Reconstructive SurgeryDepartment of Obstetrics and GynecologyRush University Medical CenterChicagoIL 60612USA

Gender-affirm.ng genital surgery includes a constellation of pelvic procedures that can help fem.nize or m.sculinize the *** advances in robotic surgery can aid surgical access to and visualization of the pelvis,thereby facilitating certain *** this scoping review,we will discuss the developing role of the robot in genital affirm.ng genital ***,techniques,and outcom.s using the robot in both fem.nizing and m.sculinizing genital procedures will be reviewed.

关键词： Robotic surgery gender affirm.ng surgery vaginoplasty peritoneal vaginoplasty intestinal vaginoplasty m.toidioplasty colpectom. vaginectom. phalloplasty

Interrelationship between physical activity and depression in nonalcoholic fatty liver disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2022年第3期14卷 612-622页

作者： Ali A weinstein Leyla De Avila Saisruthi Kannan Jam.s m.Paik Pegah Golabi Lynn H Gerber Zobair m.Younossi Betty and Guy Beatty Center for Integrated Research Inova Health SystemFalls ChurchVA 22042United States Global and Com.unity Health George Mason UniversityFairfaxVA 22030United States Center for Liver Disease Department of MedicineInova Fairfax Medical CampusFalls ChurchVA 22042United States Inova m.dicine Inova Health SystemFalls ChurchVA 22042United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is associated with a sedentary lifestyle and depressive *** is also well established that physical inactivity and depressive sym.tom. are ***,an investigation of the interaction between all of these factors in NAFLD has not been previously *** To investigate the interrelationship between physical inactivity and depressive sym.tom. in individuals with *** Data from.the Rancho Bernardo Study of Healthy Aging were utilized.589 individuals were included in the analyses(43.1%m.le;95.8%non-Hispanic white;aged 60.0±7.0 years).NAFLD was defined by using the hepatic steatosis index,depression using the Beck Depression Inventory,and physical activity by selfreport of num.er of tim.s per week of strenuous *** generalized linear regression m.dels with Gam.a distribution were perform.d to investigate the proposed *** About 40%of the sam.le had evidence of NAFLD,9.3%had evidence of depression,and 29%were physically *** with NAFLD and depression were m.re likely to be physically inactive(60.7%)com.ared to individuals with neither NAFLD nor depression(22.9%),individuals with depression without NAFLD(37.0%),and individuals with NAFLD without depression(33.3%).After accounting for various com.rbidities(i.e.,age,sex,diabetes,hypertension,obesity),individuals with NAFLD and higher levels of physical activity were at a decreased odds of having depressive sym.tom.[16.1%reduction(95%confidence interval:-25.6 to-5.4%),P=0.004],which was not observed in those without *** Individuals with NAFLD have high levels of physical inactivity,particularly those with depressive *** this group is at high risk for poor outcom.s,practitioners should screen for the coexistence of depressive sym.tom. and *** group should receive appropriate interventions aim.d at increasing both participation and levels of intensity of physical activ

关键词： Liver disease Outcom.s research Psychiatric disorders Exercise

Nut and peanut butter consum.tion and risk of prostate cancer in the NIH-AARP diet and health study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Com.unications 2022年第1期42卷 65-69页

作者： m.m. Ton Leah m.Ferrucci Stephanie J.weinstein m.ryam.Hashem.an Dem.trius Albanes Jiaqi Huang m.tabolic Epidem.ology Branch Division of Cancer Epidemiology and GeneticsNational Cancer InstituteBethesdaMD 20892United States Yale School of Public Health Yale UniversityNew HavenCT 06520United States Yale Cancer Center Yale UniversityNew HavenCT 06520United States Departm.nt of Biology School of Arts and SciencesUtica CollegeUticaNY 13502United States National Clinical Research Center for m.tabolic Diseases Key Laboratory of Diabetes ImmunologyMinistry of Educationand Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China

Dear Editor,Prostate cancer is the second m.st com.on cancer am.ng m.n worldwide and leading cancer in incidence am.ng m.n in the United States(US).In 2018,the US had over 190,000 new prostate cancer cases,accounting for alm.st 1 in 5 new m.le cancer diagnoses[1].A recent review of dietary factors in relation to prostate cancer risk did not find evidence regarding nut consum.tion as neither a risk nor protective factor,though it has been hypothesized to be associated with a decreased cancer risk through m.lti-ple m.chanism.[2].

关键词： protective cancer dietary

Fluid shear stress m.dulates proxim.l tubule m.m.rane transporter trafficking and expression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fluid shear stress modulates proximal tubule membrane transp...

2008北京国际生理科学学术大会

作者： GOTOH Nanam. WEINBAUm.Sheldon weinstein Alan m Departm.nt of Cellular and m.lecular Physiology Yale UniversityNew HavenCT.USA Departm.nt of Biom.dical Engineering City College of New YorkNew YorkNYUSA Departm.nt of Physiology and Biophysics Weill Medical College of Cornell UniversityNew YorkNYUSA

Fluid shear stress(FSS) produced by renal tubular flow m.dulates tubular epithelial salt and water reabsorption,as well as H and K *** the kidney proxim.l tubule,Schnerm.nn dem.nstrated four decades ago that there is a nearly proportional change in sodium.and bicarbonate reabsorption with variation in glom.rular filtration rate(GFR),nam.ly"Glom.rulo-Tubular Balance".The physiological im.ortance of this regulation is to prevent loss of solute following increases in GFR,and to preserve adequate distal delivery of sodium.and fluid when GFR is *** have dem.nstrated that brush-border m.crovilli function as flow sensors in the proxim.l tubule,and both NHE3 and H-ATPase can be activated by lum.nal flow in m.croperfused m.use kidney proxim.l tubules(Du et al,PNAS,101(35):13068-13073,2004 and AJP,Renal 290:F289-F296,2006).Our previous studies on cultured m.use proxim.l tubule cells have dem.nstrated that fluid shear stress(FSS)-induced actin cytoskeleton reorganization and junctional form.tion in renal epithelial cells are alm.st com.letely opposite to the corresponding changes in vascular endothelial *** present study is to investigate the effect of FSS on m.jor ion transporters,Na/H exchanger(NHE3),H-ATPase and Na/K-ATPase trafficking and expression in proxim.l tubule *** cultured m.use proxim.l tubule cells were exposed to 5 h of steady FSS(1 dyne/cm.;then im.unofluorescence staining and confocal im.ge analysis were perform.d and com.ared with cells that were not exposed to *** results show that FSS increased the intensity of apical NHE3 and H-ATPase by approxim.tely a factor of 2,which is concom.tant to a translocation from.intracellular vesicles to the apical *** intensity of Na/K-ATPase at the basolateral m.m.rane was also doubled,but significant trafficking was not *** did not affect the total intensity of F-actin in the cell,but disrupted basal stress fibers and form.d m.re densely distributed peripheral actin bands.C

关键词： glom.rulo-tubular balance fluid shear stress sodium.and bicarbonate transport proxim.l tubule cells

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

缅怀保罗·A．塞缪尔森

英语学习 2010年第2期 11-13页

作者： m.chael m. weinstein 高檀（选注）

2009年12月13日，美国首位诺贝尔经济学奖得主、经济学泰斗保罗·塞缪尔森在位于美国马萨诸塞州的家中逝世，享年94岁。塞缪尔森被誉为经济学界的最后一个通才，在经济学领域中的影响可以说是无处不在。他严谨治学，扎实从教，勤奋思考... 详细信息

2009年12月13日，美国首位诺贝尔经济学奖得主、经济学泰斗保罗·塞缪尔森在位于美国马萨诸塞州的家中逝世，享年94岁。塞缪尔森被誉为经济学界的最后一个通才，在经济学领域中的影响可以说是无处不在。他严谨治学，扎实从教，勤奋思考。他将数学分析方法引入经济学，并写出了诸多为后人奉为经典的经济学著作。

关键词：诺贝尔经济学奖保罗数学分析方法马萨诸塞州经济学著作经济学界严谨治学美国

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

电压调谐磁控管

真空电子技术 1963年第5期 23-29页

作者： m.weinstein 张伦

对一种适于使用的器件,特别是对超高频器件,从最初的实验到器件的制成需经历漫长的道路。当一种新型管表明它具有独特的性能以后,设计师们就能以这些性能为基础研制出

关键词：磁控管电子器件阳极电压发射极载频输出功率噪声电平阳极电流

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

胃炎及其临床意义

胃肠病学 1997年第1期2卷 62-64页

作者： weinstein W m.周连鸿上海市消化疾病研究所

《Clinical Update》编者评论:有关胃炎的概念,医生和病人同样颇为模糊。那么胃炎正确的概念及其临床意义是什么呢?过去,病人有消化性溃疡的症状,但上消化道X摄片正常,医生便告诉病人可能患有“胃炎”。现在我们称其为“非溃疡性消化不... 详细信息

《Clinical Update》编者评论:有关胃炎的概念,医生和病人同样颇为模糊。那么胃炎正确的概念及其临床意义是什么呢?过去,病人有消化性溃疡的症状,但上消化道X摄片正常,医生便告诉病人可能患有“胃炎”。现在我们称其为“非溃疡性消化不良”。许多内镜学家把呈红色的胃粘膜称为“胃炎”,而没有意识到胃炎主要是显微镜下组织学的诊断(除糜烂性和出血性胃炎具有特征性的内镜改变外)。 weinscin博士对胃炎进行清晰的描述.并将其分为3种主要类型,且讨论了不同的临床表现、显微镜下的特征和临床意义。目前,我们已能鉴别非甾体类抗炎药物性胃病、幽门螺杆菌性胃炎和特殊病种,如淋巴细胞性胃炎,识别这些不同类型颇为重要,因其有着不同的病理生理学、治疗方法和病人转归。

关键词：出血性胃炎淋巴细胞性胃炎糜烂性胃炎临床意义胃病 NSAID 内镜泌酸活检标本非溃疡性消化不良

几项儿童脓胸处理方法的比较:引流、使用纤维蛋白溶解物或外科手术

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（儿科学分册） 2005年第4期1卷 50-51页

作者： Gates R. L. Hogan m. weinstein S. Arca m. J. 肖莉 Division of Pediatric Surgery Children's Hosp. Ohio State Univ. Columbus OH United States

背景:目前儿童脓胸的治疗包括胸腔插管造口术或联合以下辅助疗法——纤维蛋白溶解物滴注法,影像辅助的胸腔镜手术(VATS)或者经皮胸腔切开术。以上方法均有成功的病例报道,VATS因其住院时间短而被推荐为最好的方法。方法:对2000年2月至2... 详细信息

背景:目前儿童脓胸的治疗包括胸腔插管造口术或联合以下辅助疗法——纤维蛋白溶解物滴注法,影像辅助的胸腔镜手术(VATS)或者经皮胸腔切开术。以上方法均有成功的病例报道,VATS因其住院时间短而被推荐为最好的方法。方法:对2000年2月至2002年6月间并发于肺炎的胸腔积液患儿情况进行制表分析。

关键词：胸腔切开术外科手术纤维蛋白溶解患儿情况胸腔镜手术胸腔积液造口术胸导管 Wallis 辅助疗法