Interrelationship between physical activity and depression in nonalcoholic fatty liver disease

作     者：Ali A Weinstein Leyla De Avila Saisruthi Kannan James M Paik Pegah Golabi Lynn H Gerber Zobair M Younossi 

作者机构：Betty and Guy Beatty Center for Integrated ResearchInova Health SystemFalls ChurchVA 22042United States Global and Community HealthGeorge Mason UniversityFairfaxVA 22030United States Center for Liver DiseaseDepartment of MedicineInova Fairfax Medical CampusFalls ChurchVA 22042United States Inova MedicineInova Health SystemFalls ChurchVA 22042United States 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2022年第14卷第3期

页      面：612-622页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：Supported by Betty and Guy Beatty Center for Integrated Research 

主　　题：Liver disease Outcomes research Psychiatric disorders Exercise 

摘      要：BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is associated with a sedentary lifestyle and depressive *** is also well established that physical inactivity and depressive symptoms are ***,an investigation of the interaction between all of these factors in NAFLD has not been previously *** To investigate the interrelationship between physical inactivity and depressive symptoms in individuals with *** Data from the Rancho Bernardo Study of Healthy Aging were utilized.589 individuals were included in the analyses(43.1%male;95.8%non-Hispanic white;aged 60.0±7.0 years).NAFLD was defined by using the hepatic steatosis index,depression using the Beck Depression Inventory,and physical activity by selfreport of number of times per week of strenuous *** generalized linear regression models with Gamma distribution were performed to investigate the proposed *** About 40%of the sample had evidence of NAFLD,9.3%had evidence of depression,and 29%were physically *** with NAFLD and depression were more likely to be physically inactive(60.7%)compared to individuals with neither NAFLD nor depression(22.9%),individuals with depression without NAFLD(37.0%),and individuals with NAFLD without depression(33.3%).After accounting for various comorbidities(i.e.,age,sex,diabetes,hypertension,obesity),individuals with NAFLD and higher levels of physical activity were at a decreased odds of having depressive symptoms[16.1%reduction(95%confidence interval:-25.6 to-5.4%),P=0.004],which was not observed in those without *** Individuals with NAFLD have high levels of physical inactivity,particularly those with depressive *** this group is at high risk for poor outcomes,practitioners should screen for the coexistence of depressive symptoms and *** group should receive appropriate interventions aimed at increasing both participation and levels of intensity of physical activ