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Investigating the neutron star physics through observations of several young pulsars in the dipole-field re-em.rgence scenario

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Science China(Physics,m.chanics & Astronom.) 2024年

作者： Yu-long Yan quan Cheng Xiao-Ping Zheng Institute of Astrophysics Central China Normal University Departm.nt of Astronom. Huazhong University of Science and Technology

The observed tim.ng data, m.gnetic tilt angle χ, and age of young pulsars could be used to probe som. im.ortant issues about neutron star（NS） physics, e.g., the NS internal m.gnetic field configuration, and the num.er of precession cycles ξ. Both quantities are critical in studying the continuous gravitational w.ve em.ssion from.pulsars, and the latter generally characterizes the m.tual interactions betw.en superfluid neutrons and other particles in the NS interior. The tim.ng behavior of pulsars can be influenced by the dipole field evolution, w.ich instead of decaying, m.y increase w.th tim.. An increase in the dipole field m.y result from.the re-em.rgence of the initial dipole field Bd,ithat w.s buried into the NS interior shortly after the birth of the *** this w.rk, the field re-em.rgence scenario ξ and the internal field configuration of several young pulsars, as w.ll as their Bd,iare investigated by assum.ng typical accreted m.sses △m. m.reover, since the Crab pulsar has an exactly know. age and its tilt angle change rate can be inferred from.observations, w. can set stringent constraints on its ξ, Bd,i, and △m. Although for other young pulsars w.thout exactly know. ages and tilt angle change rates, these quantities cannot be accurately determ.ned, w. find that their ξ are generally w.thin ～10～4-10～6, and som. of them.probably have m.gnetar-strength Bd,i. Our w.rk could be im.ortant for investigating the transient em.ssions associated w.th NSs, the origin of strong m.gnetic fields of NSs, pulsar population,continuous gravitational w.ve em.ssion from.pulsars, and accretion under extrem. conditions in principle.

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Biological scaffold as potential platform. for stem.cells:Current developm.nt and applications in w.und healing

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w.rld Journal of Stem.Cells 2024年第4期16卷 334-352页

作者： Jie-Yu Xiang Lin Kang Zi-m.ng Li Song-Lu Tseng Li-quan w.ng Tian-Hao Li Zhu-Jun Li Jiu-Zuo Huang Nan-Ze Yu Xiao long Departm.nt of Plastic and Reconstructive Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Biom.dical Engineering Facility Institute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100021China

w.und repair is a com.lex challenge for both clinical practitioners and *** approaches for w.und repair have several *** cell-based therapy has em.rged as a novel strategy to address this issue,exhibiting significant potential for enhancing w.und healing rates,im.roving w.und quality,and prom.ting skin ***,the use of stem.cells in skin regeneration presents several ***,stem.cells and biom.terials have been identified as crucial com.onents of the w.und-healing *** therapy involving the developm.nt of biocom.atible scaffolds,accom.anying cells,m.ltiple biological factors,and structures resem.ling the natural extracellular m.trix(ECm.has gained considerable *** scaffolds encom.ass a range of biom.terials that serve as platform. for seeding stem.cells,providing them.w.th an environm.nt conducive to grow.h,sim.lar to that of the *** scaffolds facilitate the delivery and application of stem.cells for tissue regeneration and w.und *** article provides a com.rehensive review.of the current developm.nts and applications of biological scaffolds for stem.cells in w.und healing,em.hasizing their capacity to facilitate stem.cell adhesion,proliferation,differentiation,and paracrine ***,w. identify the pivotal characteristics of the scaffolds that contribute to enhanced cellular activity.

关键词： Stem.cell-based therapy Biological scaffolds w.und healing Extracellular m.trix m.m.cry Cellular activities enhancem.nt Scaffold characteristics

FAST Observations of Four Com.ts to Search for the m.lecular Line Em.ssions betw.en 1.0 and 1.5 GHz Frequencies

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Research in Astronom. and Astrophysics 2024年第10期24卷 130-140页

作者： long-Fei Chen Chao-w.i Tsai Jian-Yang Li Bin Yang Di Li Yan Duan Chih-Hao Hsia Zhichen Pan Lei Qian Donghui quan Xue-Jian Jiang Xiaohu Li Ruining Zhao Pei Zuo School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550025China Guizhou Provincial Key Laboratory of Radio Astronom. and Data Processing Guiyang 550025China Research Center for Astronom.cal Com.uting Zhejiang LaboratoryHangzhou 311100China National Astronom.cal Observatories Chinese Academy of SciencesBeijing 100101China Institute for Frontiers in Astronom. and Astrophysics Beijing Normal UniversityBeijing 102206China Key Laboratory of Radio Astronom. and Technology Chinese Academy of SciencesBeijing 100101China School of Atm.spheric Sciences Sun Yat-sen UniversityZhuhai 519082China Núcleo de Astronom.a Facultad de Ingenieríay CienciasUniversidad Diego PortalesChile Departm.nt of Astronom. College of Physics and Electronic EngineeringQilu Normal UniversityJinan 250200China Departm.nt of Electronic and Optical Engineering Space Engineering UniversityBeijing 101416China Laboratory for Space Research Faculty of ScienceThe University of Hong KongHong Kong(SAR)China Xinjiang Astronom.cal Observatory Chinese Academy of SciencesUrumqi 830011China CAS Key Laboratory of Optical Astronom. National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronom. and Space Sciences University of Chinese Academy of SciencesBeijing 100049China

w. used the Five-hundred-m.ter Aperture Spherical radio Telescope(FAST)to search for the m.lecular em.ssions in the L-band betw.en 1.0 and 1.5 GHz tow.rd four com.ts,C/2020 F3(NEOw.SE),C/2020 R4(ATLAS),C/2021 A1(Leonard),and 67P/Churyum.v-Gerasim.nko during or after their perihelion *** of m.lecular transition lines fall in this low.frequency range,m.ny attributed to com.lex organic or prebiotic *** conducted a blind search for the possible m.lecular lines in this frequency range in those com.ts and could not identify clear signals of m.lecular em.ssions in the *** several m.lecules have been detected at high frequencies of greater than100 GHz in com.ts,our results confirm.that it is challenging to detect m.lecular transitions in the L-band frequency *** non-detection of L-band m.lecular lines in the com.tary environm.nt could rule out the possibility of unusually strong lines,w.ich could be caused by the m.sers or non-LTE *** the line strengths are predicted to be w.ak,for FAST,using the ultra-w.de bandw.dth receiver and im.roving the radio frequency interference environm.nts w.uld enhance the detectability of those m.lecular transitions at low.frequencies in the future.

关键词： astrochem.stry ISm.m.lecules com.ts:general line:identification

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跨江钢—混组合梁桥顶推施工关键技术研究

公路 2024年第9期69卷 85-90页

作者：袁龙泉中铁十一局集团有限公司武汉市430061

依托某顶推施工的跨江钢—混组合梁桥项目,详细介绍了顶推方案和关键技术点,并通过有限元方法研究了永久结构和临时构件的受力性能。根据该桥的受力和施工要求,将顶推划分为3个阶段,顶推距离依次为20.05 m.57.95 m.90.1 m.顶推过程... 详细信息

依托某顶推施工的跨江钢—混组合梁桥项目,详细介绍了顶推方案和关键技术点,并通过有限元方法研究了永久结构和临时构件的受力性能。根据该桥的受力和施工要求,将顶推划分为3个阶段,顶推距离依次为20.05 m.57.95 m.90.1 m.顶推过程以位移控制为主,以压力控制为辅。在最不利状况下,钢箱梁、临时墩的强度、刚度和稳定性满足要求,导梁和钢箱梁的连接焊缝满足正应力和剪应力要求;导梁需要进一步增加横向和纵向加劲肋,方能满足局部稳定性要求。

关键词：桥梁工程跨江桥梁钢—混组合梁桥顶推法施工有限元分析

Tetherless Optical Neurom.dulation:w.velength from.Orange-red to m.d-infrared

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Neuroscience Bulletin 2024年第8期40卷 1173-1188页

作者： Chao Sun Qi Fan Rougang Xie Ceng Luo Bingliang Hu quan w.ng Key Laboratory of Spectral Im.ging Technology Xi'an Institute of Optics and Precision Mechanics(XIOPM)Chinese Academy of SciencesXi'an 710119China Key Laboratory of Biom.dical Spectroscopy of Xi'an Key Laboratory of Spectral Imaging TechnologyXIOPMChinese Academy of SciencesXi'an 710119China Departm.nt of Neurobiology School of Basic MedicineFourth Military Medical UniversityXi'an 710032China

Optogenetics,a technique that em.loys light for neurom.dulation,has revolutionized the study of neural m.chanism. and the treatm.nt of neurological disorders due to its high spatiotem.oral resolution and cell-type ***,visible light,particularly blue and green light,com.only used in conventional optogenetics,has lim.ted penetration in biological *** lim.tation necessitates the im.lantation of optical fibers for light delivery,especially in deep brain regions,leading to tissue dam.ge and experim.ntal *** overcom. these challenges,the use of orange-red and infrared light w.th greater tissue penetration has em.rged as a prom.sing approach for tetherless optical *** this review.w. provide an overview.of the developm.nt and applications of tetherless optical neurom.dulation m.thods w.th long *** first discuss the exploration of orange-red w.velength-responsive rhodopsins and their perform.nce in tetherless optical ***,w. sum.arize tw. novel tetherless neurom.dulation m.thods using near-infrared light:upconversion nanoparticle-m.diated optogenetics and phototherm.l *** addition,w. discuss recent advances in m.d-infrared optical neurom.dulation.

关键词： Optical neurom.dulation Tetherless Orange-red w.velength responding rhodopsins Upconversion nanoparticle-m.diated optogenetics Phototherm.l neurom.dulation

Num.rical sim.lation of blood flow.and interstitial fluid pressure in solid tum.r m.crocirculation based on tum.r-induced angiogenesis

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Acta m.chanica Sinica 2007年第5期23卷 477-483页

作者： Gaiping Zhao Jie w. Shixiong Xu m. w. collins.quan long Carola S. Konig Yuping Jiang Jian w.ng A. R. Padhani Departm.nt of m.chanics and Engineering Science Fudan University Shanghai 200433 China Brunel Institute for Bioengineering School of Engineering and Design Brunel University Uxbridge Middlesex UK Departm.nt of Neurology Huashan Hospital Fudan University Shanghai 200040 China Paul Strickland Scanner Centre Mount Vernon Hospital Rickmansworth Road Northwood Middlesex HA6 2RN UK

A coupled intravascular-transvascular-interstitial fluid flow.m.del is developed to study the distributions of blood flow.and interstitial fluid pressure in solid tum.r m.crocirculation based on a tum.r-induced m.crovascular netw.rk. This is generated from.a 2D nine-point discrete m.them.tical m.del of tum.r angiogenesis and contains tw. parent vessels. Blood flow.through the m.crovascular netw.rk and interstitial fluid flow.in tum.r tissues are perform.d by the extended Poiseuille＇s law.and Darcy＇s law. respectively, transvascular flow.is described by Starling＇s law. effects of the vascular perm.ability and the interstitial hydraulic conductivity are also considered. The sim.lation results predict the heterogeneous blood supply, interstitial hypertension and low.convection on the inside of the tum.r, w.ich are consistent w.th physiological observed facts. These results m.y provide beneficial inform.tion for anti-angiogenesis treatm.nt of tum.r and further clinical research.

关键词： Solid tum.r pressure-Angiogenesis Blood flow.- Interstitial Num.rical sim.lation

Characterizing structural variants based on graph-genotyping provides insights into pig dom.stication and local adaption

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Journal of Genetics and Genom.cs 2024年第4期51卷 394-406页

作者： Xin Li quan Liu Chong Fu m.ngxun Li Changchun Li Xinyun Li Shuhong Zhao Zhuqing Zheng Key Lab of Agricultural Anim.l Genetics Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of AgricultureCollege of Animal Science and TechnologyHuazhong Agricultural UniversityWuhanHubei 430070China Institute of Agricultural Biotechnology Jingchu University of TechnologyJingmenHubei 448000China The Cooperative Innovation Center for Sustainable Pig Production WuhanHubei 430070China Hubei Hongshan Laboratory WuhanHubei 430070China

Structural variants(SVs),such as deletions(DELs)and insertions(INSs),contribute substantially to pig genetic diversity and phenotypic *** a library of SVs discovered from.long-read prim.ry assem.lies and short-read sequenced genom.s,w. m.p pig genom.c SVs w.th a graph-based m.thod for re-genotyping SVs in 402 *** results dem.nstrate that those SVs harboring specific trait-associated genes m.y greatly shape pig dom.stication and local *** characterization of SVs reveals that som. population-stratified SVs m.y alter the transcription of genes by affecting regulatory *** identify that the genotypes of tw. DELs(296-bp DEL,chr7:52,172,101e52,172,397;278-bp DEL,chr18:23,840,143 e23,840,421)located in m.scle-specific enhancers are associated w.th the expression of target genes related to m.at quality(FSD2)and m.scle fiber hypertrophy(Lm.D2 and w.SL)in *** results highlight the role of SVs in dom.stic porcine evolution,and the identified candidate functional genes and SVs are valuable resources for future genom.c research and breeding program. in pigs.

关键词： Pigs Structural variation Selection signatures Regulatory elem.nts

Exploring the m.lecular m.chanism.of action of curcum.n for the treatm.nt of diabetic retinopathy,using netw.rk pharm.cology,m.lecular docking,and m.lecular dynam.cs sim.lation

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Integrative m.dicine Discovery 2024年第8期8卷 1-10页

作者： Yuan-Yuan Gan Yan-m.i Xu quan Shu Qi-Zhi Huang Tian-long Zhou Ju-Fang Liu w.i Yu School of Pharm.cy Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Second Affiliated Hospital Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Departm.nt of m.dicine Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Departm.nt of Obstetrics and Gynecology Xianning Central HospitalThe First Affiliated Hospital of Hubei University of Science and TechnologyXianning 437000China.

Background:Based on netw.rk pharm.cology and m.lecular docking,the present study investigated the m.chanism.of curcum.n(CUR)in diabetic retinopathy ***:Based on the DisGeNET,Sw.ss TargetPrediction,GeneCards,Online m.ndelian Inheritance in m.n,Gene Expression Om.ibus,and Com.arative Toxicogenom.cs Database,the intersection core targets of CUR and diabetic retinopathy w.re *** intersection target w.s im.orted into the STRING database to obtain the protein-protein interaction *** to the Database for Annotation,Visualization and Integrated Discovery database,the intersected targets w.re enriched in Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genom.s *** Cytoscape 3.9.1 is used to m.ke the drug-target-disease-pathw.y *** m.chanism.of CUR and diabetic retinopathy w.s further verified by m.lecular docking and m.lecular dynam.cs ***:There w.re 203 intersecting targets of CUR and diabetic retinopathy identified.1320 GO entries w.re enriched for GO functions,w.ich w.re prim.rily involved in the com.osition of cells such as identical protein binding,protein binding,enzym. binding,*** w.s found that 175 pathw.ys w.re enriched using Kyoto Encyclopedia of Genes and Genom.s pathw.y enrichm.nt m.thods,w.ich w.re m.inly included in the lipid and atherosclerosis,AGE-RAGE signaling pathw.y in diabetic com.lications,pathw.ys in cancer,*** the m.lecular docking analysis,CUR w.s found to have a good ability to bind to the core targets of album.n,IL-1B,and *** binding of album.n to CUR w.s further verified by m.lecular dynam.cs ***:As a result of this study,CUR m.y exert a role in the treatm.nt of diabetic retinopathy through m.lti-target and m.lti-pathw.y regulation,w.ich indicates a possible direction of future research.

关键词： curcum.n diabetic retinopathy netw.rk pharm.cology m.lecular docking m.lecular dynam.cs sim.lation

Root-derived long-distance signals trigger ABA synthesis and enhance drought resistance in Arabidopsis

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Journal of Genetics and Genom.cs 2024年第7期51卷 749-761页

作者： Qian-Qian Liu Jin-Qiu Xia Jie w. Yi Han Gui-quan Zhang Ping-Xia Zhao Cheng-Bin Xiang Division of Life Sciences and m.dicine Division of Molecular&Cell BiophysicsHefei National Science Center for Interdisciplinary Sciences at the MicroscaleUniversity of Science and Technology of ChinaThe Innovation Academy of Seed DesignChinese Academy of SciencesHefeiAnhui 230027China College of Life Sciences Anhui Agricultural UniversityHefeiAnhui 230036China College of Agronom. South China Agricultural UniversityGuangzhouGuangdong 510642China School of Biology and Basic m.dical Sciences Soochow UniversitySuzhouJiangsu 215123China

Vascular plants have evolved intricate long-distance signaling m.chanism. to cope w.th environm.ntal stress,w.th reactive oxygen species(ROS)em.rging as pivotal system.c signals in plant stress ***,the exact role of ROS as root-to-shoot signals in the drought response has not been *** this study,w. reveal that com.ared w.th w.ld-type plants,ferric reductase defective 3(frd3)m.tants exhibit enhanced drought resistance concom.tant w.th elevated NINE-CIS-EPOXYCAROTENOID DIOXYGENASE 3(NCED3)transcript levels and abscisic acid(ABA)contents in leaves as w.ll as increased hydrogen peroxide(H_(2)O_(2))levels in roots and *** experim.nts distinctly illustrate that drought resistance can be conferred by the frd3 rootstock regardless of the scion genotype,indicating that long-distance signals originating from.frd3 roots prom.te an increase in ABA levels in ***,the drought resistance conferred by the frd3 m.tant rootstock is w.akened by the CAT2-overexpressing scion,suggesting that H_(2)O_(2)m.y be involved in long-distance ***,the results of com.arative transcriptom. and proteom. analyses support the drought resistance phenotype of the frd3 *** together,our findings substantiate the notion that frd3 root-derived long-distance signals trigger ABA synthesis in leaves and enhance drought resistance,providing new.evidence for root-to-shoot long-distance signaling in the drought response of plants.

关键词： frd3 Drought resistance Root-to-shoot long-distance signals Reactive oxygen species(ROS) H_(2)O_(2) Iron ABA