Numerical simulation of blood flow and interstitial fluid pressure in solid tumor microcirculation based on tumor-induced angiogenesis

作     者：Gaiping Zhao Jie Wu Shixiong Xu M. W. Collins Quan Long Carola S. Konig Yuping Jiang Jian Wang A. R. Padhani 

作者机构：Department of Mechanics and Engineering Science Fudan University Shanghai 200433 China Brunel Institute for Bioengineering School of Engineering and Design Brunel University Uxbridge Middlesex UK Department of Neurology Huashan Hospital Fudan University Shanghai 200040 China Paul Strickland Scanner Centre Mount Vernon Hospital Rickmansworth Road Northwood Middlesex HA6 2RN UK 

出 版 物：《Acta Mechanica Sinica》 (力学学报（英文版）)

年 卷 期：2007年第23卷第5期

页      面：477-483页

核心收录：

学科分类：071011[理学-生物物理学] 0710[理学-生物学] 07[理学] 0802[工学-机械工程] 0701[理学-数学] 0801[工学-力学（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：The project supported by the National Natural Science Foundation of China(10372026) 

主　　题：Solid tumor pressure Angiogenesis Blood flow   Interstitial Numerical simulation 

摘      要：A coupled intravascular-transvascular-interstitial fluid flow model is developed to study the distributions of blood flow and interstitial fluid pressure in solid tumor microcirculation based on a tumor-induced microvascular network. This is generated from a 2D nine-point discrete mathematical model of tumor angiogenesis and contains two parent vessels. Blood flow through the microvascular network and interstitial fluid flow in tumor tissues are performed by the extended Poiseuille＇s law and Darcy＇s law, respectively, transvascular flow is described by Starling＇s law; effects of the vascular permeability and the interstitial hydraulic conductivity are also considered. The simulation results predict the heterogeneous blood supply, interstitial hypertension and low convection on the inside of the tumor, which are consistent with physiological observed facts. These results may provide beneficial information for anti-angiogenesis treatment of tumor and further clinical research.