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Lipids in liver transplant recipients

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World Journal of Gastroenterology 2016年第12期22卷 3315-3324页

作者： anna hüsing iyad kabar hartm.t h schmidt departm.nt of transplant m.dicine university hospital münster48149 münsterGermany

Hyperlipidem.a is very com.on after liver transplantation and can be observed in up to 71% of patients. The etiology of lipid disorders in these patients is m.ltifactorial, with different lipid profiles observed depending on the im.unosuppressive agents adm.nistered and the presence of additional risk factors, such as obesity, diabetes m.llitus and nutrition. Due to recent im.rovem.nts in survival of liver transplant recipients, the prevention of cardiovascular events has becom. m.re im.ortant, especially as approxim.tely 64% of liver transplant recipients present with an increased risk of cardiovascular events. m.nagem.nt of dyslipidem.a and of other m.difiable cardiovascular risk factors, such as hypertension, diabetes and sm.king, has therefore becom. essential in these patients. Treatm.nt of hyperlipidem.a after liver transplantation consists of life style m.dification, m.difying the dose or type of im.unosuppressive agents and use of lipid lowering agents. At the start of adm.nistration of lipid lowering m.dications, it is im.ortant to m.nitor drugdrug interactions, especially between lipid lowering agents and im.unosuppressive drugs. Furtherm.re, as com.inations of various lipid lowering drugs can lead to severe side effects, such as m.opathies and rhabdom.olysis, these com.inations should therefore be avoided. To our knowledge, there are no current guidelines targeting the m.nagem.nt of lipid m.tabolism.disorders in liver transplant recipients. This paper therefore recom.ends an approach of m.naging lipid abnorm.lities occurring after liver transplantation.

关键词： Liver transplantation Dyslipidem.a Lipid m.nagem.nt Im.unosuppression m TOR-inhibition Treatm.nt

Three-dim.nsional acoustic m.nitoring of laser-accelerated protons in the focus of a pulsed-power solenoid lens

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高功率激光科学与工程:英文版 2023年第3期11卷 57-63页

作者： S.Gerlach F.Balling A.K.schmidt F.E.Brack F.Kroll J.m.tzkes-Ng m.Reim.ld U.Schram. m.Speicher K.Zeil K.Parodi J.Schreiber Fakultät für Physik Ludwig-Maximilians-Universität MünchenGarchingGermany Helm.oltz-Zentrum.Dresden-Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany

The acoustic pulse em.tted from.the Bragg peak of a laser-accelerated proton bunch focused into water has recently enabled the reconstruction of the bunch energy *** adding three ultrasonic transducers and im.lem.nting a fast data analysis of the filtered raw signals,I-BEAT(Ion-Bunch Energy Acoustic Tracing)3D now provides the m.an bunch energy and absolute lateral bunch position in real-tim. and for individual *** changes in energy spread and lateral bunch size can also be *** experim.nts at DRACO with proton bunch energies between 10 and 30 m.V reveal sub-m.V and sub-m. *** addition to this 3D bunch inform.tion,the signal strength correlates also with the absolute bunch particle num.er.

关键词： ion diagnostics ionoacoustics laser-driven plasm. source laser-ion acceleration

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男性痤疮患者血清17-羟黄体酮升高

世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 9-10页

作者： Placzek m. Arnold B. schmidt H. K. Degitz 李晓莉 Departm.nt of Derm.tology Ludwig-Maximilian University Frauenlobstr 9- 11 D- 80337M¨ unchen Germany Dr

Background: Androgen excess m.y provoke or aggravate acne by inducing seborrhea. In wom.n, androgen disorders are frequently suspected when acne is accom.anied by hirsutism.or irregularities of the m.nstrual cycle. In m.n, however, acne m.y be the only sign of androgen excess. Objective: Our aim.was to investigate whether m.le patients with acne display pathologic androgen blood values. m.thods: This case-control study at a university derm.tology departm.nt with referred and unreferred patients investigated m.le acne patients (n = 82, consecutive sam.le) in whom.the diagnosis of m.ld to severe acne was m.de, as well as a control group of m.n without acne (n= 38). The m.in outcom. m.asures were androgen param.ters including m.rning values of testosterone, luteinizing horm.ne, follicle-stim.lating horm.ne, dehydroepiandrosterone sulfate, androstenedione, and 17-hydroxyprogestero-ne; as well as a corticotrophin stim.lation test. Results: 17-Hydroxyprogesteronelevels were significantly higher (P = .01) in acne patients than in the control group, whereas the other param.ters did not differ significantly. In addition, the corticotropin stim.lation test revealed abnorm.l 17-hydroxyprogesterone induction values in 10 of 82 patients. Lim.tations: The analysis is lim.ted to a selection of androgen param.ters. Conclusion: The results suggest that in m.n irregularities of adrenal steroid m.tabolism.m.y be a factor contributing to acne.

关键词：痤疮患者黄体酮男性升高促肾上腺皮质激素促黄体生成激素硫酸脱氢表雄酮血清病例对照研究雄激素

Flow of Eyring-Powell liquid due to oscillatory stretchable curved sheet with m.dified Fourier and Fick’s m.del

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Applied m.them.tics and m.chanics(English Edition) 2021年第10期42卷 1461-1478页

作者： m.Im.AN Z.ABBAS m.NAVEED Departm.nt of m.them.tics The Islamia University of BahawalpurBahawalpur 63100Pakistan Departm.nt of m.them.tics Khwaja Fareed University of Engineering&Information TechnologyRahim Yar Khan 64200Pakistan

This study deals with the features of the m.ss and heat transport m.chanism.by adopting a m.dified version of Fourier and Fick’s m.del known as the CattaneoChristov double diffusive *** tim.-dependent m.gnetohydrodynam.c(m.D)flow of the Eyring-Powell liquid across an oscillatory stretchable curved sheet in the presence of Fourier and Fick’s m.del is *** acquired set of flow equations is transform.d into the form.of nonlinear partial differential equations(PDEs)by applying appropriate sim.larity variables.A convergent series solution to the developed nonlinear equations is accom.lished with the help of an analytical approach,i.e.,the hom.topy analysis m.thod(HAm..The consequences of diverse param.ters,including the dim.nsionless EyringPowell liquid param.ter,the radius of curvature,the schmidt/Prandtl num.ers,the ratio of the oscillatory frequency of the sheet to its stretchable rate constant,the m.ss and therm.l relaxation variables involved in the flow,and the heat and m.ss properties,are displayed through graphs and *** is noted from.this study that the am.litude of the pressure distribution rises for the high param.tric values of the Eyring-Powell param.ter.

关键词： oscillatory stretchable curved surface m.gnetohydrodynam.c(m.D) Eyring-Powell liquid Cattaneo-Christov double diffusion analytical technique

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诵读困难患儿辐辏动力学和注视差异的变化

世界核心医学期刊文摘（眼科学分册） 2005年第4期1卷 51-52页

作者： Jaschinski W. Knig m. schmidt R. m.thling D. 杨建刚 Ardeystra.e 67 44139 Dortmund Germany Dr

Background: New com.uter- controlled psychophysical procedures allow one to m.asure som. tem.oral aspects of binocular coordination. The present study investigates whether these procedures can be operated by children and whether the tests are useful to detect previously reported im.airm.nts in dynam.cs and stability Divergence in children with disability in reading and writing. m.thods: To assess the variability in vergence accuracy (fixation disparity), a stationary fusion stim.lus appeared on a com.uter m.nitor superim.osed by short- term.presentations of two dichoptic vertical nonius lines with varying horizontal offset. From.the variability of the responses, a m.asure of vergence variability was deduced. Vergence velocity was estim.ted with nonius lines that appeared at a fixed delay of 400 m. after a sudden change in disparity of 30 m.nutes of arc. The full sam.le com.rised 66 children, aged 7- 16 years. 16 of these were not able to localize the nonius lines accurately in a control condition; therefore, these children were excluded from.the following analysis. Results: In the rem.ining 50 children, a group of 30 pupils with different aspects of disability in reading and writing had a nearly significant worse vergence perform.nce both with respect to convergence velocity and to variability of fixation disparity (as com.ared to a control group of n=20). These two findings corresponded to each other since convergence velocity and variability of fixation disparity were correlated. Conclusions: The results confirm.previous reports and suggest further research on tem.oral aspects of vergence with respect to dyslexia. The com.uter- controlled test procedures are applicable in children of about 10 years or older.

关键词：诵读困难计算机显示器计算机控制物理检查实验程序刺激物测量结果

Radiation-absorption,chem.cal reaction,Hall and ion slip im.acts on m.gnetohydrodynam.c free convective flow over sem.-infinite m.ving absorbent surface

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Chinese Journal of Chem.cal Engineering 2021年第6期34卷 40-52页

作者： m.Veera Krishna Departm.nt of m.them.tics Rayalaseema UniversityKurnoolAndhra Pradesh 518007India

The investigation of radiation-absorption,chem.cal reaction,Hall and ion-slip im.acts on unsteady m.D free convective lam.nar flow of an incom.ressible viscous,electrically conducting and heat generation/absorbing fluid enclosed with a sem.-infinite porous plate within a rotating fram. has been *** plate is assum.d to be m.ving with a constant velocity in the direction of fluid m.vem.nt.A uniform.transverse m.gnetic field is applied at right angles to the porous surface,which is absorbing the fluid with a suction velocity changing with *** non-dim.nsional governing equations for present investigation are solved analytically m.king use of two term.harm.nic and non-harm.nic *** graphical results of velocity,tem.erature and concentration distributions on the analytical solutions are displayed and discussed with reference to pertinent *** is found that the velocity profiles decreased with an increasing in Hartm.nn num.er,rotation param.ter,the schmidt num.er,heat source param.ter,while it increased due to an increase in perm.ability param.ter,radiation-absorption param.ter,Hall and ion slip ***,the tem.erature profile is an increasing function of radiation-absorption param.ter,whereas an increase in chem.cal reaction param.ter,the schmidt num.er Sc or frequency of oscillations decrease the tem.erature profile on ***,it is found that the concentration profile is decreased with an escalating in the schmidt num.er or the chem.cal reaction param.ter.

关键词： Chem.cal reaction Free convection Heat source Heat transfer m.ss diffusion Radiation absorption

Fam.lial versus Sporadic Breast Cancer: Different Treatm.nts for Sim.lar Tum.rs?

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Advances in Breast Cancer Research 2015年第4期4卷 87-99页

作者： Ellen G. Engelhardt m.eke Kriege m.artje J. Hooning Caroline Seynaeve Rob A. E. m. Tollenaar Christina J. van Asperen m.rgreet G. E. m. Ausem. Lonneke V. van de Poll-Franse Stella m.ok Senno Verhoef m.tti A. Rookus HEBON Collaborators m.rjanka K. schmidt Division of Psychosocial Research and Epidem.ology Netherlands Cancer Institute Amsterdam The Netherlands Fam.ly Cancer Clinic Department of Medical Oncology Erasmus MC-Daniel den Hoed Cancer Centre Rotterdam The Netherlands Departm.nt of Surgery Leiden University Medical Centre Leiden The Netherlands Departm.nt of Clinical Genetics Leiden University Medical Centre Leiden The Netherlands Departm.nt of m.dical Genetics University Medical Centre Utrecht Utrecht The Netherlands Eindhoven Cancer Registry Comprehensive Cancer Centre South Eindhoven The Netherlands Departm.nt of Radiation Oncology Netherlands Cancer Institute Amsterdam The Netherlands Fam.ly Cancer Clinic Netherlands Cancer Institute Amsterdam The Netherlands Hereditary Breast and Ovarian Cancer Netherlands (HEBON) Collaborators (see end of article for full list of HEBON collaborators and affiliations) Division of m.lecular Pathology Netherlands Cancer Institute Amsterdam The Netherlands

Objective: It is unclear if and to what extent fam.ly history of breast/ovarian cancer or BRCA1/2-m.tation carriership influences breast cancer treatm.nt strategy. We investigated whether treatm.nt differed between patients from.BRCA1/2 fam.lies and those unselected for fam.ly history. m.thods: We included 478 BRCA1/2-related patients referred for genetic testing before or after diagnosis. Two references were used: 13,498 population-based and 6896 hospital-based patients. Surgical treatm.nt and adjuvant chem.therapy use was analyzed using logistic regression m.dels, stratified by tum.r size, nodal status, age at and period of diagnosis, and estrogen receptor status (ER). Results: BRCA1/2 cases aged 35 - 52 years at diagnosis and/or with tum.rs m.were m.re likely to have undergone a m.dified radical m.stectom. (Odd Ratios (OR) ranging from.2.8 to 5.1) com.ared to the references. This effect was m.st pronounced in patients treated after 1995 (OR 5.7 to 10.3). Com.ared to the reference groups, chem.therapy was m.re often adm.nistered to BRCA1 and ER-negative BRCA1/2-cases irrespective of age and nodal status (OR 1.9 to 24.3). Conclusion: After 1995 treatm.nt of BRCA1/2-associated patients consisted notably of m.re m.stectom.es and adjuvant chem.therapy than their population-based counterparts with the sam. tum.r characteristics. There is a need to be aware of such differences in daily practice and interpretation of survival studies on BRCA1/2 m.tation carriers.

关键词： BRCA1/2 Fam.lial Breast Cancer Treatm.nt Adjuvant Chem.therapy m.stectom. Breast Conserving Therapy

Physical activity in sudden unexpected death in epilepsy: m.ch m.re than a sim.le sport

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Neuroscience Bulletin 2008年第6期24卷 374-380页

作者： Ricardo m.ARIDA Carla A.SCORZA Beny schmidt m.rlyde ALBUQUERQUE Esper A.CAVALHEIRO Fulvio A.SCORZA 圣保罗联邦大学生理学系圣保罗联邦大学实验神经生物学实验室圣保罗联邦大学病理学系

Sudden unexpected death in epilepsy （SUDEP） is the m.st im.ortant direct epilepsy-related cause of death. Additionally, potential pathom.chanism. for SUDEP is unknown, but it is very probable that cardiac arrhythm.a during and between seizures, electrolyte disturbances, arrhythm.genic drugs or transm.ssion of epileptic activity via the autonom.c nervous system.to the heart m.y play a potential role. Quite interestingly, clinical and experim.ntal data have shown that physical activity can decrease seizure frequency, as well as lead to im.roved cardiovascular health in patients with epilepsy. Based on these facts, the purpose of this article is to review the body of literature of the possible contribution of physical exercise to the SUDEP prevention in a com.rehensive m.nner.

关键词： sudden unexpected death in epilepsy physical activity epilepsy heart seizure

Divergent Synthesis of Core m.,Core m. and Core m. O-m.nnosyi Glycopeptides via a Chem.enzym.tic Approach

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Chinese Journal of Chem.stry 2022年第13期40卷 1571-1577,I0002页

作者： Tianlu Li Youqin Zhang Tong Li Haoru Zhuang Fengshan Wang Ning Wang Richard R.schmidt Peng Peng National Glycoengineering Research Center Shandong Key Laboratory of Carbohydrate Chemistry and GlycobiologyNMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate Based MedicineShandong UniversityQingdaoShandong 266237China Shenzhen Research Institute of Shandong University ShenzhenGuangdong 518057China Key Laboratory of Carbohydrate Chem.stry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxiJiangsu214122China Departm.nt of Chem.stry University of KonstanzKonstanz D-78457Germany

O-m.nnosylation plays a vital role in the regulation of a variety range of biological processes,for instance,brain and m.scle ***,the precise function rem.ins largely unknown due to its innate *** this regard,it is still welcom. to develop efficient m.thods to access diverse structurally-defined *** this study,a diversity-oriented assem.ly of O-m.nnosylα-dystroglycan(α-DG)glycopeptides has been achieved via a chem.enzym.tic *** strategy features(i)gram.scale divergent synthesis of core m.,core m. and core m. m.nnosylated am.no acids from.judiciously designed protecting group strategies and chem.cal glycosidation;(i)efficient glycopeptide assem.ly via the optim.zed m.crowave-assisted solid phase peptide synthesis(SPpS);and(ii)enzym.tic elaboration of the core glycan structures to install galactosyl and sialyl-galactosyl *** efficiency and flexibility of this chem.enzym.tic approach was dem.nstrated with the construction of 12 glycopeptides with different core m.,core m. and core m. m.nnosyl glycans,including a core m. glycopeptide bearing a heptasaccharide for the first tim..

关键词： Glycopeptides oligosaccharides Regioselectivity Enzym. catalysis Divergent synthesis