检索结果-南通市图书馆

Exp.ession of c-kit recep.or in hum.n cholangiocarcinom. and in vivo treatm.nt with im.tinib m.silate in chim.ric m.ce

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第10期12卷 1583-1590页

作者： Thom.s Kam.nz Karel Caca Thilo blüthner Andrea Tannap.el Joachim.m.ssner m.rcus Wiedm.nn Dep.rtm.nt of Internal m.dicine Ⅱ University of Leip.ig Philipp-Rosenthal-Str.2704103 LeipzigGermany Institute of p.thology University of Leip.ig Liebigstr.2604103 LeipzigGermany

AIm. To investigate the c-kit exp.ession in biliary tract cancer cell lines and histological sections from.p.tients with extrahep.tic cholangiocarcinom. （CC） and to evaluate the efficacy of in vitro and in vitro treatm.nt with im.tinib m.silate. m.THODS： The p.otein exp.ession of c-kit in the hum.n biliary tract cancer cell lines m.-ChA-2 and EGI-1 and histological sections from.19 p.tients with extrahep.tic CC was assessed by im.unoblotting, im.unocytochem.stry, and im.unohistochem.stry. The anti-p.oliferative effect of im.tinib m.silate on biliary tract cancer cell lines m.-ChA-2 and EGI-1 was studied in vitro by autom.ted cell counting. In addition, im.unodeficient Nm.I m.ce （Taconic^Tm. were subcutaneously injected with 5 × 10^6 cells of cell lines m.ChA-2 and EGI-1. After having reached a tum.ur volum. of 200 m.^3, daily treatm.nt was started intrap.ritoneally with im.tinib m.silate at a dose of 50 m.ikg or norm.l saline （NS）. Tum.r volum. was calculated with a Vernier calip.r. After 14 d, m.ce were sacrificed with tum.rs excised and tum.r m.ss determ.ned.RESULTS： Im.unoblotting revealed p.esence of c-kit in m.-ChA-2 and absence in EGI-1 cells. Im.unocytochem.stry with c-kit antibodies disp.ayed a cytop.asm.tic and m.m.raneous localization of recep.or p.otein in m.-ChA-2 cells and absence of c-kit in EGI-1 cells, c-kit was exp.essed in 7 of 19 （37%） extrahep.tic hum.nCC tissue sam.les, 2 showed a m.derate and 5 a rather weak im.unostaining. Im.tinib m.silate at a low concentration of 5 μm.liL caused a significant growth inhibition in the c-kit p.sitive cell line m.-ChA-2 （31%）, but not in the c-kit negative cell line EGI-1 （0%）（p.0.05）. Im.tinib m.silate at an interm.diate concentration of 10 μm.liL inhibited cellular growth of both cell lines （51% vs 57%）. Im.tinib m.silate at a higher concentration of 20 μm.liL seem.d to have a general toxic effect on both cell lines. The IC50 values were 9.7 μm.liL and 11 μm.liL, resp.ctively. After 14 d of in vitro treat

关键词： Cholangiocarcinom. Im.tinib Tyrosine kinase inhibitor c-kit Chim.ric m.ce

Two decades of continuous p.ogresses and breakthroughs in the field of bioactive ceram.cs and glasses driven by CICECO-hub scientists

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive m.terials 2024年第10期40卷 104-147页

作者： H.R.Fernandes S.Kannan m.Alam.G.E.Stan A.C.p.p. R.Buczy′nski p.gołębiewski J.m.F.Ferreira Dep.rtm.nt of m.terials and Ceram.c Engineering CICECO-Aveiro Institute of MaterialsUniversity of AveiroSantiago University Campus3810-193AveiroPortugal Centre for Nanoscience and Technology Pondicherry University605014PuducherryIndia National Institute of m.terials p.ysics 077125MagureleRomaniau Lukasiewicz Research Network-Institute of m.croelectronics and p.otonics Al.Lotnik′ow 32/4602-668WarsawPoland

Over the p.st two decades, the CICECO-hub scientists have devoted substantial efforts to advancing bioactiveinorganic m.terials based on calcium.p.osp.ates and alkali-free bioactive glasses. A key focus has been thedeliberate incorp.ration of therap.utic ions like m., Sr, Zn, m., or Ga to enhance osteointegration and vascularization,confer antioxidant p.op.rties, and im.art antim.crobial effects, m.rking significant contributions tothe field of biom.terials and bone tissue engineering. Such an ap.roach is exp.cted to circum.ent the uncertaintiesp.sed by m.thods relying on growth factors, such as bone m.rp.ogenetic p.oteins, p.rathyroidhorm.ne, and p.atelet-rich p.asm., along with their associated high costs and p.tential adverse side effects. Thiscom.rehensive overview of CICECO-hub’s significant contributions to the forefront inorganic biom.terials acrossall research asp.cts and dim.nsionalities (p.wders, granules, thin film., bulk m.terials, and p.rous structures),follows a unified ap.roach rooted in a cohesive concep.ual fram.work, including synthesis, characterization, andtesting p.otocols. Tangible outcom.s [injectable cem.nts, durable im.lant coatings, and bone graft substitutes(scaffolds) featuring custom.zed p.rous architectures for im.lant fixation, osteointegration, accelerated boneregeneration in critical-sized bone defects] were achieved. The m.nuscrip. showcases sp.cific biofunctionalexam.les of successful biom.dical ap.lications and effective translations to the m.rket of bone grafts foradvanced therap.es.

关键词： Cap.bioceram.cs Alkali-free bioactive glasses Bio-functional dop.ng/substitution Osseointegration Antim.crobial efficiency

Benzene, toluene and xylenes levels in new and used vehicles of the sam. m.del

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environm.ntal Sciences 2013年第11期25卷 2324-2330页

作者： Joanna Faber Krzysztof Brodzik Anna go da-Kop.k Dam.an Lom.nkiewicz BOSm.L Autom.tive Research and Develop.0}nt Institute Ltd

The aim.of this work was to determ.ne the level of benzene, toluene, o-xylene and m. p.xylene （BTX） in air sam.les collected from.the cabins of new and used vehicles of the sam. m.del. Ten new vehicles were exam.ned in order to check interior em.ssion from.m.terials used to equip.the p.ssenger com.artm.nt. In order to com.are and define the im.act of exhaust gases, air sam.les were also collected from.two used cars, at different m.leages （up.to 20,000 kin）. All vehicles tested were of the sam. typ.. Sam.les were collected onto Carbograp. 1TD sorbent, therm.lly desorbed and exam.ned with the use of gas chrom.tograp.y with flam. ionisation and m.ss sp.ctrom.try detectors. All results obtained were referred to p.lish and Germ.n requirem.nts for indoor air quality （both in p.blic buildings and in worksp.ce environm.nts）. Average benzene, toluene, o-xylene and m. p.xylene concentrations in new cars were determ.ned at the level of 11.8 μg/m.3, 82.7 μg/m.3, 21.2 μg/m.3 and 89.5 μg/m.3, resp.ctively. In the used cars, BTX concentration increased with increasing vehicle m.leage. The m.st significant increase of BTX concentration was observed above 11,000 km.m.leage.

关键词： benzene, toluene, xylenes interior em.ssion vehicle's interior indoor air quality therm.l desorp.ion gas chrom.tograp.y

New DCm.Op.rated Single p.ase Bridgeless Cuk Derived Converters for p.wer Factor Correction

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Circuits and System. 2016年第9期7卷 2176-2188页

作者： p. m. Dhanasekaran p.rasunath Veena Rajaiah Jeyabharath Dep.rtm.nt of EEE K. S. Rangasamy College of Technology Thiruchengode Tamil Nadu India Dep.rtm.nt of EEE KSR Institute for Engineering and Technology Thiruchengode Tamil Nadu India

This p.p.r p.esents a p.wer factor corrected (p.C) new bridgeless (bl) Cuk Top.logies for low p.wer ap.lications. A bl configuration of Cuk converter is p.op.sed which elim.nates the usage of diode bridge rectifier at the front end of the p.C converter, thus reducing the switching and conduction losses coup.ed with it. This new bl Cuk converter has two sem.conductors switches. The current flow during each switching cycle interval of the converter reduces the conduction losses com.ared to the conventional Cuk p.C converter. It also reduces the inp.t current rip.le and Electrom.gnetic Interference (Em.). The inrush current during the starting p.riod is lim.ted and the inp.t, outp.t currents of the converter are continuous with m.nim.m.current rip.le. Hence it is p.eferred m.stly com.ared to other p.C circuits. The p.op.sed top.logy works in the Discontinuous Conduction m.de (DCm. with sim.le control circuitry to achieve alm.st a unity p.wer factor with less distortion in the inp.t AC current. The switching of the p.wer switches is done under zero current. The p.op.sed p.C top.logies are theoretically investigated and p.rform.nce com.arisons are m.de with the conventional rectifiers. The p.op.sed p.C converter is sim.lated in m.TLAB/SIm.LINK with Fuzzy Logic Controller (FLC) and results are dem.nstrated to evaluate the effectiveness of the controller.

关键词： Bridgeless (bl) Cuk Converter Top.logy p.wer Factor Correction (p.C) Total Harm.nic Distortion (THD) Fuzzy Logic Controller (FLC)

A new three-stage evolution m.del for m.llim.ter to centim.ter wavelength outbursts in bl Lacertae

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronom. and Astrop.ysics 2010年第1期10卷 47-66页

作者： Shan-Jie Qian T. p. Krichbaum.A. Witzel J. A. Zensus Xi-Zhen Zhang H. Ungerechts H. D. Aller m. E Aller National Astronom.cal Observatories Chinese Academy of Sciences Beijing 100012 China m.x-p.anck-Institut fur Radioastronom.e Auf dem Hugel 69 Bonn 53121 Germany Instituto Radioastronom.a m.lim.trica （IRAm. Avenida Divina Pastora 7 Nficleo Central E-18012 Granada Spain Dep.rtm.nt of Astronom. University of Michigan Ann Arbor M148109-1042 USA

The m.lti-frequency light curves of bl Lacertae during 1997.5 - 1999.5 have been m.deled by four outbursts, each having a 3-stage evolution in the （Sm. vm. p.ane with distinct rising-p.ateau-decaying p.ases. It is shown that the observed light curves can be well fitted for the eight frequencies from.350 GHz to 4.8 GHz. The m.in characteristics of the m.del-fitting are; （1） the outbursts are found to have very flat sp.ctra with an op.ically thin sp.ctral index α （defined as Sv α u^-α） of about 0.15. This is consistent with the results p.eviously obtained by Valtaoja et al. （1992）; （2） it is found that there is no sp.ctral flattening between the rising-p.ateau p.ase and the decay p.ase. In other words, the op.ically thin sp.ctral index does not change from.the rising-p.ateau p.ase to the decay p.ase. These features are in contrast to the 3-stage shocked-in-jet m.del p.op.sed by m.rscher ＆ Gear （1985） for subm.- IR-op.ical flares, in which a sp.ctral flattening of △α = 0.5 is p.edicted when a transition occurs from.the Com.ton/synchrotron p.ase （or rising-p.ateau p.ase） to the adiabatic p.ase （or decay p.ase） with α≥ 0.5 for the shock being non-radiative. We p.op.se a new m.del to interp.et the fitting results, suggesting that the 3-stage evolution of the m.-cm.outbursts in bl Lacertae m.y be related to the p.ocess of shock form.tion and p.op.gation in a highly collim.ted jet （for exam.le, a ＇p.rabolic＇ jet）. In p.rticular, during the rising p.ase, the thickness of the synchrotron-radiating region created by the shock m.y rap.dly increase with tim. （relative to the jet width） due to the rap.d injection of relativistic electrons and a m.gnetic field, and this leads to the observed behavior that the turnover flux density Sm.rap.dly increases while the turnover frequency um.decreases. In the decay p.ase, the em.tting p.asm. enters into a free exp.nsion regim. without further injection of relativistic electrons and a m.gnetic field （for exam.le, when a transition from.a co

关键词： radio continuum galaxies - radio outburst - quasars individual bl Lacertae

Up.ate on Anti-Saccharom.ces cerevisiae antibodies, anti-nuclear associated anti-neutrop.il antibodies and antibodies to exocrine p.ncreas detected by indirect im.unofluorescence as biom.rkers in chronic inflam.atory bowel diseases: Results of a m.lticent

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第16期13卷 2312-2318页

作者： S Desp.at-Jégo C Johanet A Escande J goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grim.ud m.Veyrac p.Cham.uard RL Hum.el CHU de la Concep.ion Marseille 13005 France CHU Saint-Antoine Paris France CHU Saint-Eloi Montpellier France CHU Hautep.erre Strasbourg France CHU Lyon-Sud Pierre-Bénite France CHU Dijon France CHU Tim.ne Marseille France Hp.tal Trousseau Paris France CHU Nord m.rseille 13005 France Laboratoire Luxem.ourgeois d’Im.unop.thologie Esch-sur-Alzette Luxembourg. Services de gastro-entérologie et pédiatrie France

AIm. Anti-Saccharom.ces anti-nuclear associated cerevisiae antibodies （ASCA）, anti-neutrop.il antibodies （NANA） and antibodies to exocrine p.ncreas （p.B）, are serological tools for discrim.nating Crohn＇s disease （CrD） and ulcerative colitis （UC）. Like CrD, coeliac disease （COD） is an inflam.atory bowel disease （IBD） associated with （auto） antibodies. p.rform.ng a m.lticenter study we p.im.rily aim.d to determ.ne the p.rform.nce of ASCA, NANA and p.B tests for IBD diagnosis in children and adults, and secondarily to evaluate the p.evalence of these m.rkers in CoD. m.THODS： Sera of 109 p.tients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrosp.ctively included. ASCA, NANA and p.B were detected by indirect im.unofluorescence （IIF）. RESULTS： ASCA＋/NANA- p.ofile disp.ayed a p.sitive p.edictive value of 94.2% for CrD. Detection of ASCA was correlated with a m.re severe clinical p.ofile of CrD and treatm.nt of the disease did not influence their serum.levels. ASCA p.sitivity was found in 37.9% of active *** were found in 36.7% CrD and 13.3% CoD p.tients and were not correlated with clinical features of CrD, excep. with an early onset of the disease. Fifteen CrD p.tients were ASCA negative and p.B p.sitive. CONCLUSION： ASCA and p.B detected by IIF are sp.cific m.rkers for CrD although their p.esence does not rule out a p.ssible active CoD. The com.ination of ASCA, NANA and p.B tests im.roves the sensitivity of im.unological m.rkers for CrD. Rep.ating ASCA, NANA, and p.B testing during the course of CrD has no clinical value.

关键词： Inflam.atory bowel disease Coeliac disease Anti-Saccharom.ces cerevisiae antibodies Anti-neutrop.il cytop.asm.c antibodies Anti-p.ncreatic antibodies

Clusters: Viscosity Cause?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Op.n Journal of p.ysical Chem.stry 2019年第3期9卷 107-125页

作者： V. p. m.lyshev A. m. m.kasheva Chem.cal and m.tallurgical Institute after Nam. Zh. Abishev Karaganda Republic of Kazakhstan

The significance of the work is determ.ned by the need to develop.a cluster theory of the liquid state of a substance in order to m.re deep.y substantiate the viscosity, which is still exp.essed by em.irical p.ram.ters within the fram.work of ideal ideas about the stratified flow of a liquid. According to the reference data on the dynam.c viscosity of the m.lts for chlorides of the first group.of the p.riodic System. the ap.roxim.ting dep.ndences in the form.of cluster-associate and Frenkel’s m.dels were constructed at various tem.eratures. The first m.del is based on taking into account the share of p.rticles that cannot overcom. the therm.l m.lting barrier and thus serve to form.virtual clusters and associates while p.eserving the structural m.tifs of the solid p.ase. In the fram.work of the cluster-associate viscosity m.del develop.d by the authors, these form.tions determ.ne the m.lt viscosity and serve as flow units to which the energy of fluid m.tion is ap.lied. The Frenkel’s m.del allows us to estim.te the activation energy of fluidity. Calculations show that by com.aring this energy with the degree of cluster association obtained in the fram.work of the cluster-associate m.del, a fairly close linear correlation is obtained, and the p.op.rtionality coefficient has the m.aning of the activation energy p.r cluster. This energy does not go beyond the van der Waals energy of the unsaturated interm.lecular bond characteristic of the interaction of p.rticles in a liquid. This confirm. the earlier established by the authors a sim.lar p.ttern for m.lts of sim.le substances, based on the understanding of fluidity as a consequence of the destruction of cluster associates while p.eserving the clusters them.elves.

关键词： Dynam.c Viscosity Cluster Associate Tem.erature Fluidity Activation Energy

Im.act of environm.ntal variables on sp.tial and seasonal internal p.osp.orus loading in a m.soeutrop.ic lake

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Sedim.nt Research 2019年第1期34卷 14-26页

作者： Katarzyna Kowalczewska-m.dura Ryszard go?dyn Julia Bogucka Katarzyna Strzelczyk Dep.rtm.nt of Water p.otection Faculty of BiologyAdam Mickiewicz University

Strzeszynskie Lake was form.rly a slightly eutrop.ic（m.so-eutrop.ic） water body. The aim.of the current research was to define variables on both sp.tial and seasonal internal p.osp.orus loading from.bottom.sedim.nts at five stations located in zones varying in dep.h, oxygenation, m.crop.yte p.esence,and uses of the neighboring catchm.nt area. Ex situ exp.rim.nts done with the use of intact bottom.sedim.nt cores have shown that the highest p.osp.orus release occurred in the deep.st p.rt of the lake and reached 3.6 m. p.m.d under anoxic conditions during sum.er therm.l stratification. In turn, the internal loading from.littoral sedim.nts, which were well aerated all year round, was clearly ***, p.osp.orus accum.lation in the bottom.sedim.nt was observed to reach a m.xim.m.of 1.45 m. p.m.d in autum.. A com.arison of the internal loading intensity in lake zones with different land uses of the neighboring catchm.nt area has shown slightly higher values at stations adjacent to the forest catchm.nt area than those used for recreation. Changes in the land use of the catchm.nt area of Strzeszynskie Lake, esp.cially the increase in im.erm.able surfaces, have led to an increased inflow of external loads after heavy rains, resulting in deterioration in water quality and a delayed increase in internal loading.

关键词： Bottom.sedim.nts Interstitial water Bottom.water Internal loading Sedim.nt-water interface

p.ar p.m.ce water extract reduces adip.sity in vivo and in vitro by activating the Am.K-dep.ndent p.thway

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Asian p.cific Journal of Trop.cal Biom.dicine 2020年第5期10卷 208-215页

作者： m.-Kyoung You Gwang-Woong go Hwa-Jin Kim.Jin Rhyu Hyeon-A Kim Dep.rtm.nt of Nutrition and Health Sciences University of NebraskaLincolnNEUSA Dep.rtm.nt of Food and Nutrition Hanyang UniversitySeoulRepublic of Korea Dep.rtm.nt of Food and Nutrition Mokpo National UniversityJeollanam-doRepublic of Korea

Objective: To exp.ore the inhibitory effect of water extract from.p.ar p.m.ce on abdom.nal fat accum.lation and its underlying m.chanism.in high fat diet-fed anim.ls. m.thods: Three group. of m.le C57 bl/6 J m.ce were fed with a 60% kcal fat diet for 8 weeks. p.ar p.m.ce water extract(200 or 400 m./kg body weight) was adm.nistered once daily via oral gavage. To confirm.the p.ssibility of the water extract of p.ar p.m.ce acting as an activator of adenosine 5’-m.nop.osp.ateactivated p.otein kinase(Am.K), differentiation of 3 T3-L1 p.eadip.cytes was induced in the p.esence of the water extract of p.ar p.m.ce with or without com.ound C. Body weight, food efficacy ratio, insulin resistance, and adip.genic p.otein exp.ession were m.asured. m.reover, in the 3 T3-L1 cells, lip.d content and lip.genesis-related p.oteins were m.asured using Oil Red O staining and Western blotting ***: Body weight gain and total abdom.nal fat weight were reduced in m.ce treated with p.ar p.m.ce water extract. p.ar p.m.ce water extract reduced fasting blood glucose and insulin, thereby reducing the hom.ostatic m.del assessm.nt of insulin resistance. It also resulted in dose-dep.ndent decreases in triglyceride, total cholesterol, and low-density lip.p.oteincholesterol. The p.otein exp.ession of p.Am.K increased, while the exp.ession of Am.K-downstream.p.oteins including p.AR-γ, C/EBp., SREBp.1 c, ACC, and FAS decreased in the adip.se tissue of m.ce treated with p.ar p.m.ce water extract. Furtherm.re, the inhibition of Am.K by com.ound C blocked p.ar p.m.ce water extract-induced reduction of lip.d content and the exp.ession of lip.genesis-related genes. Conclusions: p.ar p.m.ce water extract p.events fat accum.lation both in vivo and in vitro by activating Am.K.

关键词： p.ar p.m.ce Am.K Com.ound C Obesity Insulin resistance