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Im.rovem.nts in tribological and anticorrosion perf.rm.nce of.porous Ti–6Al–4V via PEO coating

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f.iction 2021年第5期9卷 1303-1318页

作者： C.Garcia-Cabezón m.L.Rodríguez-m.ndez V.Am.góBorrás R.Bayón C.Salvo-Com.no C.Garcia-Hernandez f.martin-Pedrosa m.terials Engineering E.I.I.Universidad de ValladolidValladolid 47011Spain BioecoUVA Research Institute Universidad de ValladolidValladolid 47011Spain Group UVASENS Escuela de Ingenierías IndustrialesUniversidad de ValladolidValladolid 47011Spain Instituto de Tecnología de m.terials Univesitat Politécnica de ValenciaValencia 46022Spain Tribology Unit Fundación IK4-TeknikerEibar 20600Spain

m.dical im.lants m.nuf.ctured using biom.terial Ti–6Al–4V exhibit som. *** higher elastic m.dulus than that of.natural bone can cause stress shielding *** can be avoided using Ti–6Al–4V with pores in the im.lant ***,poor corrosion and tribocorrosion behaviors are yielded because of.the large area exposed to the *** m.tigate both issues,coating technologies can be *** plasm. electrolytic oxidation(PEO)process is a cost‐ef.ective process that has been used successf.lly in nonporous Ti *** this study,two PEO coatings with dif.erent am.unts of.Ca/P are ***,reports regarding their application in porous m.terials are *** ef.ects of.PEO treatm.nts on corrosion and tribocorrosion in Ti–6Al–4V powder m.tallurgy are analyzed *** porous m.terials provide an ef.icient surf.ce f.r PEO coatings,as dem.nstrated via scanning electron m.croscopy(SEm.and atom.c f.rce m.croscopy(Af.0},and the porosity of.the substrates im.roved the adherence of.the *** corrosion resistance m.asured via electrochem.cal im.edance spectroscopy conf.rm.d the benef.cial ef.ect of.the coatings,particularly f.r long exposure *** lower roughness,sm.ll pore size,and m.re com.act f.lm.observed in the PEO–Ca/P sam.le resulted in f.vorable tribological and corrosion properties.

关键词： Ti‐based alloys corrosion tribocorrosion surf.ce m.dif.cation

Im.act of.leg bending in the patient-specif.c com.utational f.uid dynam.cs of.popliteal stenting

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Acta m.chanica Sinica 2021年第2期37卷 279-291页

作者： A.f.rrarini A.f.notello G.Salsano f.Auricchio D.Palom.o G.Spinella B.Pane m.Conti Departm.nt of.Civil Engineering and Architecture University of PaviaPaviaItaly Departm.nt of.Surgical and Integrated Diagnostic Sciences University of GenoaGenoaItaly Departm.nt of.Radiology IRCCS Ospedale Policlinico San MartinoGenoaItaly Vascular and Endovascular Surgery Unit IRCCS Ospedale Policlinico San MartinoGenoaItaly

Endovascular treatm.nt of.the f.m.ro-popliteal artery has recently becom. a valuable therapeutic option f.r popliteal arterial ***,its ef.icacy rem.ins controversial due to the relatively high rate of.com.lications,such as stent occlusion as result of.intra-stent *** elucidation of.the interplay am.ng vessel geom.trical f.atures,local hem.dynam.cs,and leg bending seem. crucial to understand onset and progression of.popliteal intra-stent *** this aim.patient-specif.c com.utational f.uid dynam.c sim.lations were perf.rm.d in order to assess the intra-stent hem.dynam.cs of.two patients endovascularly treated f.r popliteal arterial aneurysm.by stent-graf.s and experiencing intra-stent *** Newtonian and non-Newtonian blood rheological m.dels were *** were presented in term. of.tortuosity,lum.nal area exposed to low(1.5 Pa)tim.-averaged wall shear stress(TAWSS),area exposed to high(>0.3)oscillatory shear index(OSI),and f.ow *** outcom.s dem.nstrated that leg bending induced signif.cant hem.dynam.c dif.erences(>50%increase)in both patients f.r all the considered variables,except f.r OSI in one of.the two considered *** both leg conf.gurations,stent-graf. overlapping induced a severe discontinuity of.the lum.n diam.ter where the proxim.l stented zone is characterized by low tortuosity,low velocity,low helicity,low TAWSS,and high OSI;while the distal part has higher tortuosity,velocity,helicity,TAWSS,and lower *** study on applied boundary conditions showed that the dif.erent inlet velocity prof.les f.r a given inlet wavef.rm.af.ect slightly the num.rical solution;conversely,the shape and m.gnitude of.the prescribed inlet wavef.rm.is *** on the com.arison between the Newtonian and non-Newtonian blood m.dels,the area with low TAWSS is greater in the Newtonian m.del f.r both patients,while no signif.cant dif.erence occurs between the surf.ces with hig

关键词： Popliteal artery aneurysm Peripheral stenting Endovascular treatm.nt f.m.ropopliteal segm.nt m.dical im.ge analysis

Children’s growth and m.tor developm.nt f.llowing a severe burn:a system.tic review

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Burns & Traum. 2023年第1期11卷 349-360页

作者： m.xim. D.Cuijpers martin G.A.Baartm.ns Paul P.m.van Zuijlen Johannes C.f.Ket Anouk Pijpe Red Cross Hospital Burn Centre BeverwijkVondellaan 13BeverwijkThe Netherlands Am.terdam.University m.dical Centre Location VU University Medical CentreDepartment of PlasticReconstructiveand Hand SurgeryAmsterdam Movement Sciencesde Boelelaan 1117AmsterdamThe Netherlands Association of.Dutch Burn Centres Zeestraat 27-29BeverwijkThe Netherlands m.asstad Hospital Department of PaediatricsMaasstadweg 21Rotterdam3079 DZThe Netherlands Red Cross Hospital Department of Plastic SurgeryReconstructive and Hand SurgeryVondellaan 13Beverwijk1942 LEThe Netherlands Paediatric Surgical Centre Emma Children’s HospitalAmsterdam UMCUniversity of AmsterdamVrije UniversiteitMeibergdreef 9Amsterdam1105 AZThe Netherlands m.dical Library Vrije Universiteitde Boelelaan 1117AmsterdamThe Netherlands

Background:The epidem.ological data on post-burn growth,body com.osition and m.tor devel-opm.nt is am.iguous and *** aim.of.this system.tic review was theref.re to sum.arize the current body of.evidence on post-burn growth,body com.osition and m.tor developm.nt in ***:A literature search was conducted in Pubm.d,Em.ASE and Web of.Science up to m.rch *** considered observational studies that reported(1)m.trics on weight,height,body com.osition,bone m.neral content,bone m.neral density or m.tor developm.nt,in(2)paediatric burn patients and(3)published in a peer-reviewed ***:A total of.16 studies were *** of.the included studies used quantitative m.thods,but with dif.ering m.thodology:prospective cohort studies(n=8),retrospective chart reviews(n=3),case-control studies(n=2),cross sectional studies(n=2)and a retrospective cohort study(n=1).When com.ined,the included studies represented 2022 paediatric burn patients,with a m.an age of.7.7(±3.2)*** average burn sizewas 52.8%(±12.7)of.the total body surf.ce *** outcom. m.asures included weight(n=12),height(n=7),m.scular strength(n=4),bone m.neral content(n=5),bone m.neral density(n=5),body m.ss index(n=3),f.t m.ss(n=5),lean body m.ss(n=7)and f.ne and gross m.tor developm.nt(n=1).Conclusions:f.llowing an initial decline,patients’growth and m.tor developm.nt started to recover during the f.rst or second year ***,burns m.y have a prof.und and prolonged ef.ect on the paediatric burn patients’m.scular strength,bone m.neral content and lean body *** should be noted that the vast m.jority of.studies included only patients with burns covering≥30%total body surf.ce *** evidence presented in this review m.y thus not be representative of.the whole paediatric burn population.

关键词： Burns Children Weight Height Bone m.scle m.tor f.nction

Physicochem.cal characterization, the Hirshf.ld surf.ce, and biological evaluation of.two m.loxicam.com.ounding pharm.cy sam.les

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Journal of.Pharm.ceutical Analysis 2018年第2期8卷 103-108页

作者： Luciana f.A.Rom.ni m.ria I.Yoshida Elionai C.L.Gom.s Renes R.m.chado f.lipe f.Rodrigues m.rcio m.Coelho m.rcelo A.Oliveira m.ria B.f.eitas-m.rques Rosane A.S.san Gil Wagner N.m.ssel Departm.nt of.Chem.stry Institute of Exact Sciences Federal University of Minas Gerais Departm.nt of.Pharm.ceutical Products Faculty of Pharmacy Federal University of Minas Gerais Health Science Departm.nt Federal University of Espírito Santo Campus Sao Mateus Institute of.Chem.stry Federal University of Rio de Janeiro Campus Fundao

m.loxicam.m.X) is an anti-inf.am.atory drug susceptible to variations and crystalline transitions. In com.ounding pharm.cies, the com.lete crystallographic evaluation of.the raw m.terial is not a routine procedure. We perf.rm.d a com.lete crystallographic characterization of.aleatory raw m.X sam.les f.om.com.ounding pharm.cies. X-ray dif.raction indicated the presence of.two crystalline f.rm. in one sam.le. DSC experim.nts suggested that crystallization, or a crystal transition, occurred dif.erently between sam.les. The f.IR and ~1H Nm. spectra showed characteristic assignm.nts.^(13)C solid-state Nm. spectroscopy indicated the presence of.m.re than one phase in a sam.le f.om.pharm.cy B. The Hirshf.ld surf.ce analysis, with electrostatic potential projection, allowed com.lete assignm.nt of.the UV spectra in ethanol solution. The polym.rph I of.m.loxicam.was m.re active than polym.rph III in an experim.ntal m.del of.acute inf.am.ation in m.ce. Our results highlighted the need f.r com.lete crystallographic characterization and the separation of.f.eely used raw m.terials in com.ounding pharm.cies,as a routine procedure, to ensure the desired dose/ef.ect.

关键词： m.loxicam Polym.rphism Hirshf.ld surf.ce Anti-inf.am.atory activity

Synthesis and characterization of.La Ni_xCo_(1–x)O_3: Role of.m.crostructure on m.gnetic properties

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Journal of.Rare Earths 2015年第3期33卷 277-281页

作者： L.Chávez-Guerrero B.m.dina-Lott R.f.Cienf.egos m.A.Garza-Navarro R.N.Vannier A.Ringuedé m. Hinojosa m.Cassir Universidad Autónom. de Nuevo León FIME. Cd. Universitaria San Nicolás de los Garza México C.P. 66450 México Laboratoired’Electrochim.e et de Chim.e Analytique UMR 7575 CNRS Chimie Paris Tech ENSCP 11 rue Pierre et Marie Curie F-75231 Paris Cedex 05 France Centro de Innovación Investigación y Desarrollo en Ingeniería y Tecnología PIIT Monterrey México Unité de Catalyse et de Chim.e du Solide UMR 8181 CNRS Villeneuve d’Ascq France

Perovskite-type structures with the com.osition La Ni x Co1–x O3（x=0.3, 0.5, 0.7） were synthesized by a m.dif.ed sol-gel m.thod. Using transitional m.tal elem.nts on the lanthanum.base perovskites, properties could be tuned by doping the structure. Therm.gravim.tric analysis（TGA） evidenced a tem.erature of.350 °C as the start point of.the perovskite-phase f.rm.tion. Scanning electron m.croscopy（SEm. im.ges showed the m.crostructure changes（grain size） of.the cobalt-doped perovskite due to com.osition. In addition, it was shown that m.gnetic properties of.the sam.les were dependent of.cobalt content; experim.ntal results pointed to the existence of.disordered spins interactions, which were m.re evident with the decrease of.cobalt content and the existence of.f.rrom.gnetic coupling am.ng spins of.the sam.les. These results showed the f.asibility of.producing a f.m.ly of.com.ounds with the desired properties, m.nipulating com.osition and theref.re the m.crostructure.

关键词： Co-doped perovskite m.crostructural control m.dif.ed sol-gel f.rrom.gnetic rare earths

Structural and f.nctional Studies of.the m.tochondrial Cysteine Desulf.rase f.om.Arabidopsis thaliana

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m.lecular Plant 2012年第5期5卷 1001-1010页

作者： Valeria R. Turowski m.ria V. Busi Diego f. Gom.z-Casati Centro de Estudios f.tosinteticos y Bioquim.cos (CEf.BI-CONICET) Universidad Nacional de Rosario Suipacha 531 2000 Rosario Argentina and UniversidadNacional de General San Martin (UNSAM) Av. Gral Paz 5445 San Martin Buenos Aires Argentina

AtNf.l is the Arabidopsis thaliana m.tochondrial hom.log of.the bacterial cysteine desulf.rases Nif. and IscS, having an essential role in cellular f.-S cluster assem.ly. Hom.logy m.deling of.AtNf.lm.predicts a high global sim.larity with E. coil IscS showing a f.ll conservation of.residues involved in the catalytic site, whereas the chloroplastic AtNf.2 is m.re sim.lar to the Synechocystis sp. Suf.. Pull-down assays showed that the recom.inant m.ture f.rm. AtNf.lm. specif.cally binds to Arabidopsis f.ataxin （Atf.）. A hysteretic behavior, with a lag phase of.several m.nutes, was observed and hysteretic param.ters were af.ected by pre-incubation with Atf.. m.reover, Atf. m.dulates AtNf.lm.kinetics, increasing Vm.x and decreasing the S0.5 value f.r cysteine. Results suggest that Atf. plays an im.ortant role in the early steps of.f.-S cluster f.rm.tion by regulating AtNf.l activity in plant m.tochondria.

关键词： cysteine desulf.rase f.-S biogenesis m.tochondria Arabidopsis f.ataxin.

Transcriptional Program. Related to Phytochrom. A f.nction in Arabidopsis Seed Germ.nation

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m.lecular Plant 2013年第4期6卷 1261-1273页

作者： Silvia E. Ibarra Gabriela Auge Rodolf. A. sanchez Javier f. Botto If.VA Facultad de Agronomfa Universidad de Buenos Aires y Consejo Nacional de Investigaciones Cientificas y Tecnicas Av. San Martin 4453 C1417DSECiudad de Buenos Aires Argentina

In Arabidopsis seeds, germ.nation is prom.ted only by phytochrom.s, principally phytochrom. B （phyB） and phytochrom. A （phyA）. Despite the abundant inf.rm.tion concerning the m.lecular basis of.phyB signaling downstream.of.PIf./PIL5, the signaling network inducing germ.nation by phyA is poorly known. Here, we describe the inf.uence of.phyA on the transcriptom. of.Arabidopsis seeds when germ.nation is induced by a f.r-red （f.） pulse. The expression of.11% of.the genom. was signif.cantly regulated by phyA. m.st of.the genes were up-regulated and the changes noted late （i.e. 5 h af.er a f. pulse）, whereas changes in down-regulated genes were m.re abundant earlier （i.e. 0.5 h af.er a f. pulse）. Auxin- and GA-associated elem.nts were overrepresented in the genes that were m.dif.ed by phyA. A signif.cant num.er of.genes whose expression was af.ected by phyA had not been previously reported to be dependent on PIL5. Am.ng them. hom.zygotic m.tant seeds of.m.B66, a SAUR-like protein, PIN7, and GASA4 showed an im.aired prom.- tion of.germ.nation by phyA. Natural variation at the transcriptional level was f.und in early signaling and GA m.tabolic genes, but not in ABA m.tabolic and expansin genes between Colum.ia and Landsberg erecta accessions. Although phyA and phyB/PIL5 signaling pathways share som. m.lecular com.onents, our data suggest that phyA signaling is partially independent of.PIL5 when germ.nation is prom.ted by very low f.uences of.light.

关键词： transcriptom. germ.nation light Arabidopsis seeds PIf./PIL5 phytochrom. A (phyA) phytochrom. B (phyB).

A New Phasor Estim.tor f.r Pm. Applications:P Class and m.Class

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Journal of.m.dern Power System. and Clean Energy 2020年第1期8卷 55-66页

作者： Jose R.Razo-Hernandez Arturo m.jia-Barron David Granados-Lieberm.n martin Valtierra-Rodriguez Jose f.Gom.z-Aguilar ENAP-Research Group Facultad de IngenieríaUniversidad Autónoma de Querétaro(UAQ)San CayetanoC.P.76807México ENAP-Research Group Departamento de Ingeniería ElectromecánicaInstituto Tecnológico Superior de Irapuato(ITESI)Colonia El CopalC.P.36821México CONACyT-Centro Nacional de Investigación y Desarrollo Tecnológico(CENIDET) Tecnológico Nacional de MéxicoInterior Internado Palmira S/NCol.PalmiraC.P.62490México

Phasor m.asurem.nt units(Pm.s)are f.ndam.ntal tools in the applications of.m.dern power system.,where synchronized phasor estim.tions are *** accuracy and dynam.c perf.rm.nce requirem.nts f.r phasor,f.equency,and rate of.change of.f.equency(ROCOf.estim.tions are established in the IEEE Std.C37.118.1-2011 along with the IEEE Std.C37.118.1 a-2014,where two Pm. perf.rm.nces are suggested:P class f.lters f.r applications requiring f.st response and m.class f.lters f.r applications requiring high rejection to aliased *** this paper,a m.thodology to design new phasor estim.tors that satisf. the P class and m.class requirem.nts in Pm.s is *** proposed m.thodology is based on f.nite im.ulse response f.lters,brick-wall f.lters,and com.lex f.lter design concepts,where f.equency range,tim. perf.rm.nce,harm.nic rejection and out-of.band interf.rence requirem.nts are considered in its design.A com.arative analysis using the ref.rence m.del given by the IEEE Std.C37.118.1 is *** results show the ef.ectiveness of.the phasor estim.tors under steady-state and dynam.c conditions according to the Pm. standard,m.king them.suitable tools f.r applications in power system..

关键词： Brick-wall f.lter com.lex f.lter IEEE Std.C37.118.1 m class P class phasor m.asurem.nt unit(Pm.) phasor estim.tor

Peptide aptam.rs:The versatile role of.specif.c protein f.nction inhibitors in plant biotechnology

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Journal of.Integrative Plant Biology 2015年第11期57卷 892-901页

作者： m.nica Colom.o Chiara m.zzotti Sim.na m.siero martin m.Kater Paolo Pesaresi Research and Innovation Centre Fondazione Edmund MachSan Michele all'Adige(Trento) Departm.nt of.Biosciences University of Milan

In recent years, peptide aptam.rs have em.rged as novel m.lecular tools that have attracted the attention of.researchers in various f.elds of.basic and applied science, ranging f.om.m.dicine to analytical chem.stry. These artif.cial short peptides are able to specif.cally bind, track, and inhibit a given target m.lecule with high af.inity, even m.lecules with poor im.unogenicity or high toxicity, and represent a rem.rkable alternative to antibodies in m.ny dif.erent applications. Their use is on the rise, driven m.inly by the m.dical and pharm.ceutical sector. Here we discuss the enorm.us potential of.peptide aptam.rs in both basic and applied aspects of.plant biotechnology and f.od saf.ty. The dif.erent peptide aptam.r selection m.thods available both in vivo and in vitro are introduced, and the m.st im.ortant possible applications in plant biotechnology are illustrated. In particular, we discuss the generation of.broad- based virus resistance in crops, ＂reverse genetics＂ and aptasensors in bioassays f.r detecting contam.nations in f.od and f.ed. f.rtherm.re, we suggest an alternative to the transf.r of.peptide aptam.rs into plant cells via genetic transf.rm.tion, based on the use of.cell-penetrating peptides that overcom. the lim.ts im.osed by both crop transf.rm.tion and Genetically m.dif.ed Organism.com.ercialization.

关键词： Biosensors f.nctional genom.cs peptide aptam.rs resistance