检索结果-南通市图书馆

Scleroderm. and HIV Infection: A Case Report with literature Review

Open Journal of Internal m.dicine 2018年第4期8卷 255-260页

作者： I. A. dembélé N. R. Nyanke D. Traore A. K. Souckho D. Sy m. Cissoko A. Sanogo B. B. Sangaré O. A. Cisse K. Dao K. T. Tighankpa m. m.lle m. Togo A. Keita A. Traore m. Saliou Y. Fofana D. Sangaré N. Tolo N. Doum.ia A. Doum.ia B. B. Berthé B. D. Cam.ra S. A. Coulibaly N. Sawadogo m. dembélé A. K. Traore H. A. Traore Internal m.dicine Departm.nt Point G Teaching Hospital Bamako Mali Departm.nt of Internal m.dicine Kaya Regional Hospital Kaya Burkina Faso

Introduction: Acquired im.unodeficiency syndrom. (AIDS) linked to HIV infection is accom.anied by auto-im.une phenom.na. Autoim.une diseases can develop in people living with HIV, m.st in a context of good im.unological control (vasculitis, anti-phospholipid syndrom.). Since the advent of antiretroviral therapy, an increasing num.er of autoim.une connective tissue diseases such as system.c lupus erythem.tosus, derm.tom.ositis, and syndrom.s of Sj?gren and scleroderm. have been reported. Purpose: To describe this association’s not very com.on scleroderm. and HIV infection. Observation: We report the case of a 56-year-old lady adm.tted into the service for functional im.otence that would have been evolving for a week. Prior to her hospitalization, she presented edem.s of the lower lim.s associated with anesthesia of the lower lim.s for 5 m.nths. The painting is accom.anied by a productive cough and an interm.ttent fever. At the physical exam.nation a weight loss (Bm. = 13.74 Kg/m.), fever (38.7°C): Oral candidiasis, lower lip ulceration, perlicking, undernutrition folds, sclerodactyly and hom.geneous hepatom.galy was noted. The diagnosis of im.unosuppression to HIV Stage 3 with TB co-m.rbidity and positive hepatitis B Serology was retained while diffuse Scleroderm. was selected from.the ACR/EUlAR criteria of 2012 with a score of 10 (sclerodactyly = 4 point;Raynaud’s phenom.non = 3 point and Ac Anti Scl 70 positive = 3 point). Conclusion: These associations of chronic pathology m.st be described to im.rove the future treatm.nt of our patients.

关键词： Scleroderm. HIV Internal m.dicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Em.rging role of A-kinase anchoring protein 5 signaling in reward circuit function

引用

Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William.J.Flerlage m.rk l.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniform.d Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Departm.nt of Pharm.cology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a m.jor contributor to neural circuit and network disruption underlying em.tional and m.od dysregulation in psychiatric disorders(Sim.ons et al.,2024).Diverse sets of distinct m.lecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through com.lex interactions organized by num.rous m.ltivalent protein scaffolds,including the fam.ly of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neurogenesis dynam.cs in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

引用

Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： m.awiah m.Naffaa Departm.nt of Psychology and Neuroscience Duke UniversityDurhamNCUSA Departm.nt of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons m.grating to the granule cell layer and glom.rular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit rem.deling triggered by m.m.ry and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. m.reover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory inform.tion processing. This adaptive process responds to changes in epithelial com.osition and contributes to the form.tion of olfactory m.m.ries by m.dulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions rem.ins a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around m.tral and tufted cells. This organizational pattern significantly im.acts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and m.m.ry. Additionally, this organization is further shaped by axon term.nals originating from.cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these com.lex and highly interconnected processes have not been com.rehensively studied as a whole. Therefore, this m.nuscript aim. to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These m.chanism. are thought to support olfactory learning and m.m.ry, potentially through increased

关键词： network adaptability neurogenesis neuronal com.unication olfactory bulb olfactory learning olfactory m.m.ry synaptic plasticity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SBl-JP-0004:A prom.sing dual inhibitor of JAK2 and PI3KCD against gastric cancer

引用

Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Departm.nt of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)rem.ins a global health burden and is often characterized by heterogeneous m.lecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,m.king them.attractive targets for therapeutic ***:This study applied a com.utational and m.lecular dynam.cs sim.lation approach to identify and characterize SBl-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBl-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by m.lecular docking scores and m.lecular dynam.cs *** interactions and Gibbs binding free energy estim.tes confirm.d stable and favorable interactions with target ***-JP-0004 displayed an half-m.xim.l inhibitory concentration(IC_(50))value of 118.9 nm.against JAK2 kinase and 200.9 nm.against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-m.xim.l growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm.respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBl-JP-0004 treatm.nt com.ared to 2.1%and 2.83%in their respective ***:The results highlight SBl-JP-0004 as a prom.sing dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBl-JP-0004 m.lecular docking m.lecular dynam.cs sim.lation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

m.tochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflam.aging-associated neurodegeneration

引用

Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología m.lecular Severo Ochoa(CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” com.s from.the latin senescens, m.aning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from.stress-induced cell cycle arrest of pre... 详细信息

关键词： latin potential lasting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Getting physical with m.dical education:Exercise based virtual anatom. review classes for m.dical students

引用

World Journal of m.thodology 2025年第1期15卷 20-25页

作者： Nadeesha R Sam.rasinghe Taniya S Nagpal m.chele l Barbeau Charys m.m.rtin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatom. and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Departm.nt of Anatom. and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have exam.ned the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into m.dical curriculum.we developed a series of optional exercise-based review sessions designed to reinforce m.sculoskeletal(m.K)anatom. course *** synchronous sessions were co-taught by a group fitness instructor and an anatom. *** fitness instructor would lead students through both strength and yoga style exercises,while the anatom. instructor asked questions about relevant anatom.cal structures related to course m.terial previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam.preparedness in im.roving m.K anatom. knowledge,PA levels,and m.ntal *** participants com.leted surveys;a m.jority agreed that the classes increased understanding of m.K concepts(90.0%)and activity levels(97.7%).m.ny(70.0%)felt that the classes helped reduce *** m.jority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,m.dical students saw benefit in PA based interventions to supplem.nt m.K course *** with increasing activity levels and prom.ting health behaviours,integrating PA into m.dical curriculum.m.y im.rove com.rehension of learning m.terial,alleviate stress and foster social connectivity am.ng m.dical students.

关键词： m.dical education m.sculoskeletal Anatom. Exercise Online learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Brain-penetrating neurotrophic factor m.m.tics: HER-096 as a disease-m.difying therapy for Parkinson’s disease

引用

Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holm.tröm.Henri J.Huttunen Herantis Pharm. Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A m.jor unm.t need in the field of central nervous system.diseases is disease-m.difying *** for decades there have been various sym.tom.tic treatm.nts available to alleviate the sym.tom. of the disease,disease-m.dification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatm.nt therapeutic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Antigravitational Instability of Cosm.c Substrate in the Newtonian Cosm.logy

引用

Chinese Physics letters 2006年第8期23卷 2344-2347页

作者： CHECHIN l. m. Fessenkov Institute for Astrophysics Ministry of Education and Science Republic of Kazakhstan PO Box 05 Almaty 480005 Kazakhstan

A new version of the form.ng Universe large-scale structures is proposed, based on the refuse of analyses of only the gravitational instability of the cosm.logical substrate, Vacuum. i.e. the dom.nant nonbaryonic m.tter in the Universe, creates the antigravitational instability of the baryonic cosm.c substrate itself and causes the form.tion of galaxies.

关键词： FOSSIl GAlAXY GROUP DARK ENERGY UNIVERSE SUPERNOVAE REDSHIFT

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Com.lem.nt-dependent neuroinflam.ation in spinal cord injury:from.pathology to therapeutic im.lications

引用

Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanm.rco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian m.stroph David Gim.el Jonathan Grossberg Daniel l.Barrow m.tthew F.Gary Ali m.Alawieh Departm.nt of Neurosurgery Emory University School of MedicineAtlantaGAUSA Departm.nt of Neurology Yale UniversityNew HavenCTUSA Center for Neurotraum. Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury rem.ins a m.jor cause of disability in young adults,and beyond acute decom.ression and rehabilitation,there are no pharm.cological treatm.nts to lim.t the progression of injury and optim.ze recovery in this *** the thorough investigation of the com.lem.nt system.in triggering and propagating cerebral neuroinflam.ation,a sim.lar role for com.lem.nt in spinal neuroinflam.ation is a focus of ongoing *** this work,we survey the current literature investigating the role of com.lem.nt in spinal cord injury including the sources of com.lem.nt proteins,triggers of com.lem.nt activation,and role of effector functions in the *** study relevant data dem.nstrating the different triggers of com.lem.nt activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to dam.ge-associated m.lecular *** effector functions of com.lem.nt have been im.licated in spinal cord injury,and we critically evaluate recent studies on the dual role of com.lem.nt anaphylatoxins in spinal cord injury while em.hasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we system.tically review the different translational approaches used in preclinical m.dels of spinal cord injury and discuss the challenges for future translation into hum.n *** review em.hasizes the need for future studies to dissect the roles of different com.lem.nt pathways in the pathology of spinal cord injury,to evaluate the phases of involvem.nt of opsonins and anaphylatoxins,and to study the role of com.lem.nt in white m.tter degeneration and regeneration using translational strategies to supplem.nt genetic m.dels.

关键词： com.lem.nt neuroinflam.ation neuroplasticity regeneration spinal cord injury targeted therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Search for m.croglia-specific peptides:advances in the discovery toolbox

引用

Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Departm.nt of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflam.atory states in the central nervous system.CNS)are the hallm.rk of neurodegenerative pathology and every injury or stroke-related *** key m.diators of these neuroinflam.atory states are glial cells known as m.croglia,the resident im.une cell at the core of the inflam.atory event,and astroglia,which encapsulate inflam.atory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** m.st neuroinflam.ation is exclusively based on the responses of said m.croglia,their phenotypes are suggested to follow those of m.crophages;m. and m. are opposites of pro-and ***,m.croglial phenotypes have been identified to be on an inflam.atory spectrum.encom.assing developm.ntal,hom.ostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue form.tion.

关键词： inflam.ation pathology death

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：