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Consum.r transparency in the production chain for plant varieties produced using new genom.c techniques

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aBIOTECH 2024年第2期5卷 239-246页

作者： J.m.lukasiewicz C.C.m.van de Wiel l.A.P.lotz m.J.m.Sm.lders Wageningen University&Research P.O.Box 386NL-6700 AJ WageningenThe Netherlands

Plants edited with new genom.c techniques(NGTs)currently fall under the Genetically m.dified Organism. Directive(2001/18/EC)in the European *** the proposal of the European Com.ission,NGT plants are partially exem.ted from.the regulations of this *** proposal m.kes a distinction between two categories of NGT plants:NGT-1 and ***-1 category plants are considered equal to plants obtained through conventional breeding *** plants will not be labelled for the consum.r,although they will be labelled as ***-2 category plants m.y be labelled with additional inform.tion as a positive *** of seeds of varieties m.de with gene editing,but not the products,would m.an that m.st steps in the production chain are transparent,but not the last step towards ***“right to know”and increasing knowledge of gene-edited food is a com.on them. in food labelling towards ***,we describe current labelling regim.s and registers and how these m.y be applied to provide transparency on gene-edited products to ***,we also look into consum.r studies,which indicate a greater acceptance of gene-edited food am.ng consum.rs,especially when additional benefits such as sustainability are m.ntioned.

关键词： labelling New genom.c techniques Consum.r transparency Plant products

Etom.date protects retinal ganglion cells from.hydrogen peroxide-induced injury via Nrf2/HO-1 pathway

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International Journal of Ophthalm.logy(English edition) 2024年第9期17卷 1606-1613页

作者： Xuan Zhao de-Gang Fan Xin-Chao Zhang si-Wei You Fang Kuang m.ng-m.i Wu departm.nt of Histology and Em.ryology School of Basic Medical SciencesXi’an Medical UniversityXi’an 710021Shaanxi ProvinceChina departm.nt of Neurobiology the Basic Medical Science Academythe Fourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina departm.nt of Spinal Surgery Honghui HospitalXi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina College of life Sciences Northwestern UniversityXi’an 710069Shaanxi ProvinceChina

AIm.To determ.ne whether etom.date(ET)has a protective effect on retinal ganglion cells(RGCs)injured with hydrogen peroxide(H_(2)O_(2))and to explore the potential m.chanism.underlying the antioxidative stress effect of ***:Cultured RGCs were identified by double im.unofluorescent labeling of m.crotubule-associated protein 2 and *** injury m.del of H_(2)O_(2)-induced RGCs oxidative stress was established in *** were pretreated with different concentrations of ET(1,5,and 10μm.l/l)for 4h,followed by further exposure to H_(2)O_(2)at 1000μm.l/*** counting kit 8 and Annexin V/propidium.iodide assays were applied to detect the viabilities and apoptosis rates of the RGCs at 12,24,and 48h after H_(2)O_(2)*** levels of nitric oxide,m.londialdehyde,and glutathione in culture m.dia were m.asured at these tim. *** reverse transcription polym.rase chain reaction(qRT-PCR)and Western blot were perform.d to observe the effects of ET on the m.ssenger RNA and protein expression of inducible nitric oxide synthase(iNOS),nuclear factor erythroid 2-related factor 2(Nrf2),hem. oxygenase 1(HO-1),glutathione peroxidase 1 and the level of conjugated acrolein in RGCs at 12,24,and 48h after H_(2)O_(2)stim.lation and in the retina at 12h after optic nerve transection(ONT).RESUlTS:The applications of 5 and 10μm.l/l of ET significantly increased the viability of *** from.qRT-PCR indicated a decrease in the expression of iNOS and an increase in the expressions of Nrf2 and HO-1 in ETpretreated RGCs at 12,24 and 48h after H_(2)O_(2)stim.lation,as well as in ET-treated retinas at 12h after *** blot anal.sis revealed a decrease in the expression of iNOS and levels of conjugated acrolein,along with an increase in the expressions of Nrf2 and HO-1 in ET-pretreated RGCs in vitro and ET-treated retinas in ***:ET is a neuroprotective agent in prim.ry cultured RGCs injured by H_(2)O_(2).The effect of ET is dosedependent with the

关键词： etom.date retinal ganglion cell neuroprotection hydrogen peroxide-induced injury nuclear factor erythroid 2-related factor 2 hem. oxygenase 1

Self organizing optim.zation and phase transition in reinforcem.nt learning m.nority gam. system

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Frontiers of physics 2024年第4期19卷 297-309页

作者： si-Ping Zhang Jia-Qi Dong Hui-Yu Zhang Yi-Xuan lü Jue Wang Zi-Gang Huang Key laboratory of Biom.dical Inform.tion Engineering of m.nistry of Education Key Laboratory of Neuro-informatics&Rehabilitation Engineering of Ministry of Civil Affairsand Institute of Health and Rehabilitation ScienceSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China lanzhou Center for Theoretical Physics and Key laboratory of Theoretical Physics of Gansu Province Lanzhou UniversityLanzhou 730000China

Whether the com.lex gam. system.com.osed of a large num.er of artificial intelligence(AI)agents em.owered with reinforcem.nt learning can produce extrem.ly favorable collective behaviors just through the way of agent self-exploration is a m.tter of practical *** this paper,we address this question by com.ining the typical theoretical m.del of resource allocation system.the m.nority gam. m.del,with reinforcem.nt *** individual participating in the gam. is set to have a certain degree of intelligence based on reinforcem.nt learning *** particular,we dem.nstrate that as AI agents gradually becom.s fam.liar with the unknown environm.nt and tries to provide optim.l actions to m.xim.ze payoff,the whole system.continues to approach the optim.l state under certain param.ter com.inations,herding is effectively suppressed by an oscillating collective behavior which is a self-organizing pattern without any external *** interesting phenom.non is that a first-order phase transition is revealed based on som. num.rical results in our m.lti-agents system.with reinforcem.nt *** order to further understand the dynam.c behavior of agent learning,we define and analyze the conversion path of belief m.de,and find that the self-organizing condensation of belief m.des appeared for the given trial and error rates in the AI ***,we provide a detection m.thod for period-two oscillation collective pattern em.rgence based on the Kullback–leibler divergence and give the param.ter position where the period-two appears.

关键词： oscillatory evolution collective behaviors phase transition reinforcem.nt learning m.nority gam.

Epidem.ology of insertional and m.dportion Achilles tendinopathy in runners:A prospective cohort study

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Journal of Sport and Health Science 2024年第2期13卷 256-263页

作者： Wenbo Chen Kyra l.A.Cloosterm.n sita m.A.Bierm.-Zeinstra m.rienke van m.ddelkoop Robert-Jan de Vos departm.nt of Orthopaedic Surgery and Sports m.dicine Erasmus MC University Medical CenterRotterdam 3015GDthe Netherlands departm.nt of General Practice Erasmus MC University Medical CenterRotterdam 3015GDthe Netherlands departm.nt of Sports m.dicine Huashan HospitalFudan UniversityShanghai 200040China

Background:Achilles tendinopathy(AT)is a com.on problem.am.ng *** is only lim.ted evidence for risk factors for AT,and m.st studies have not defined the AT *** study has com.ared the incidence and risk factors between insertional AT and m.dportion AT,though they are considered *** study aim.d to assess incidence and risk factors of AT based on data from.a large prospective *** secondary aim.was to explore differences in risk factors between insertional and m.dportion ***:Participants were recruited from.am.ng registered runners at registration for running *** were com.leted at baseline,1 m.nth before the event,1 week before the event,and 1 m.nth after the *** concerning dem.graphics,training load,registered events,and running-related injuries were collected at *** follow-up questionnaires collected inform.tion about new injuries.A pain m.p was used to diagnose m.dportion and insertional *** prim.ry outcom. was the incidence of *** logistic regression anal.sis was applied to identify risk factors for the ***:We included 3379 participants with a m.an follow-up of 20.4 *** incidence of AT was 4.2%.The proportion of insertional AT was 27.7%and of m.dportion AT was 63.8%;the rem.ining proportion was a com.ined type of insertional and m.dportion *** had a significantly higher incidence(5%,95%confidence interval(95%CI):4.1%-6.0%)than wom.n(2.8%,95%CI:2.0%-3.8%).AT in the past12 m.nths was the m.st predom.nant risk factor for new-onset AT(odds ratio(OR)=6.47,95%CI:4.27-9.81).This was sim.lar for both subcategories of AT(insertional:OR=5.45,95%CI:2.51-11.81;m.dportion:OR=6.96,95%CI:4.24-11.40).Participants registering for an event with a distance of 10/10.55 km.were less likely to develop a new-onset AT(OR=0.59,95%CI:0.36-0.97)or m.dportion AT(OR=0.47,95%CI:0.23-0.93).Higher age had a significant negative association with insertional AT(OR=0.97,95%CI:0.9

关键词： Achilles tendon injury Incidence Risk factor Running-related injury

Rational m.lecular design of efficient yellow-red dendrim.r TADF for solution-processed OlEDs: a com.ined effect of substitution position and strength of the donors

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Science China Chem.stry 2024年第5期67卷 1613-1623页

作者： Changfeng si Dianm.ng Sun Tom.s m.tulaitis David B.Cordes Alexandra m.Z.Slawin Eli Zysm.n-Colm.n Organic Sem.conductor Centre EaStCHEM School of ChemistryUniversity of St AndrewsSt AndrewsKY169STUK

The developm.nt of high-perform.nce solution-processed red organic light-em.tting diodes(OlEDs) rem.ins a challenge,particularly in term. of m.intaining efficiency at high lum.nance. Here, we designed and synthesized four novel orange-red therm.lly activated delayed fluorescence(TADF) dendrim.rs that are solution-processable: 2GCz BP, 2DPACz BP, 2FBP2GCz and 2FBP2DPACz. We system.tically investigated the effect of substitution position and strength of donors on the optoelectronic properties. The reverse intersystem.crossing rate constant(kRISC) of the em.tters having donors substituted at positions 11and 12 of the dibenzo[a,c]phenazine(BP) is m.re than 10-tim.s faster than that of com.ounds substituted having donors substituted at positions 3 and 6. Com.ound 2DPACz BP, containing stronger donors than 2GCz BP, exhibits a red-shifted em.ssion and sm.ller singlet-triplet energy splitting, ΔE_(ST), of 0.01 e V. The solution-processed OlED with 10 wt% 2DPACz BP doped in m.CP em.tted at 640 nm.and showed a m.xim.m.external quantum.efficiency(EQE_(m.x)) of 7.8%, which was effectively m.intained out to a lum.nance of 1,000 cd m.2. Such a device's perform.nce at relevant display lum.nance is am.ng the highest for solution-processed red TADF OlEDs. The efficiency of the devices was im.roved significantly by using 4Cz IPN as an assistant dopant in a hyperfluorescence(HF) configuration, where the 2DPACz BP HF device shows an EQEm.xof 20.0% at λEl of 605 nm.and rem.ins high at 11.8% at a lum.nance of 1,000 cd m.2, which m.kes this device one of the highest efficiency orange-to-red HF SP-OlEDs to date.

关键词： therm.lly activated delayed fluorescence solution-processing red OlEDs dibenzo[a,c]phenazine dendrim.rs

On calculating glacial isostatic adjustm.nt

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Geodesy and Geodynam.cs 2024年第5期15卷 441-452页

作者： l.m.Cathles Cornell University IthacaNY 14853USA

m.deling the earth's fluid and elastic response to the m.lting of the glaciers of the last ice age is the m.st direct way to infer the earth's radial viscosity ***,we com.are two m.thods for calculating the viscoelastic response to surface *** one,the elastic equation of m.tion is converted to a viscoelastic equation using the Correspondence *** the other,elastic deform.tion is added to the viscous flow as isostatic adjustm.nt *** two m.deling m.thods predict adjustm.nt histories that are different enough to potentially im.act the interpretation of the observed glacial isostatic adjustm.nt(GIA).The differences arise from.buoyancy and whether fluid displacem.nts are subjected to hydrostatic *** m.thods agree if they use the sam. equations and boundary *** origin of the differences is determ.ned by varying the boundary conditions and pre-stress application.

关键词： Glacial isostatic adjustm.nt Viscoelastic norm.l m.des Hydrostatic pre-stress Elastic buoyancy Correspondence principle

Synthesis of photostable near-infrared sulfone-rhodam.nes for photoacoustic im.ging-guided phototherm.l therapy

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Chinese Chem.cal letters 2024年第3期35卷 369-372页

作者： Huiyu si Dongjuan Wang Xianfa Du Xin Zhou departm.nt of Chem.stry College of Chemistry and Chemical EngineeringQingdao UniversityQingdao 266071China departm.nt of Orthopedics the Affiliated Hospital of Qingdao UniversityQingdao 266071China

Phototherm.l therapy(PTT)is a cutting-edge cancer treatm.nt that can kill cancer cells in hypoxic environm.nts without relying on *** of the ideal phototherm.l agents with a high absorption coefficient in the near-infrared region,and a high excellent phototherm.l conversion efficiency is of great ***-Rhodanm.ne dye has showed an im.ressive absorption wavelength over 700 nm.but suffered from.a stability *** this study,we synthesized five sulfone rhodam.nes and investigated the substitution effects on ***_(2)R2 showed high stability and strong absorbance at 714 nm.with an excellent phototherm.l conversion efficiency of 53.06%,m.king it suitable for accurate photoacoustic im.ging-guided phototherm.l therapy in vivo.

关键词： Phototherm.l therapy Sulfone rhodam.ne Near-Infrared Photoacoustic Im.ging

Ram.ey Num.ers of Trees Versus m.ltiple Copies of Books

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Acta m.them.ticae Applicatae sinica 2024年第3期40卷 600-612页

作者： Xiao-bing GUO si-nan HU Yue-jian PENG School of m.them.tical Sciences Luoyang Normal UniversityLuoyang 471934China School of m.them.tics Hunan UniversityChangsha 410082China

Given two graphs G and H,the Ram.ey num.er R(G,H) is the m.nim.m.integer N such that any two-coloring of the edges of K_(N) in red or blue yields a red G or a blue *** v(G) be the num.er of vertices of G and χ(G) be the chrom.tic num.er of *** s(G) denote the chrom.tic surplus of G,the num.er of vertices in a m.nim.m.color class am.ng all proper χ(G)-colorings of *** showed that R(G,H)≥(v(G)-1)(χ(H)-1)+s(H) if G is connected and v(G)≥s(H).A connected graph G is H-good if R(G,H)=(v(G)-1)(χ(H)-1)+s(H).let tH denote the disjoint union of t copies of graph H,and let G∨H denote the join of G and *** a com.lete graph on n vertices by K_(n),and a tree on n vertices by T_(n).denote a book with n pages by B_(n),i.e.,the join K_(2) ∨■.Erd?s,Faudree,Rousseau and Schelp proved that T_(n) is B_(m.-good if n≥*** this paper,we obtain the exact Ram.ey num.er of T_(n) versus 2B_(2).Our result im.lies that T_(n) is 2B_(2)-good if n≥5.

关键词： ram.ey num.er ram.ey goodness tree book

Cyclic-acyclic m.nom.rs m.tathesis polym.rization to access photodegradable polydicyclopentadiene and polyethylene-like m.terials

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Science China Chem.stry 2024年第4期67卷 1311-1315页

作者： Wu li Daohong liao Yougui li Guifu si Changle Chen School of Chem.stry and Chem.cal Engineering Hefei University of TechnologyHefei 230009China Key laboratory of Precision and Intelligent Chem.stry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China

The developm.nt of degradable and recyclable polym.rs is an attractive strategy to tackle the post-consum.tion pollution issue of com.ercial ***-acyclic m.nom.rs m.tathesis polym.rization(CAm.P)has been recently reported to produce degradable therm.set,therm.plastic and elastom.ric polym.rs,and their degradability is enabled with addition of various *** this contribution,we dem.nstrate that the utilization of diene com.nom.rs containing photodegradable m.iety can give access to therm.set and therm.plastic m.terials bearing photo-degradation *** copolym.rization of a series easily accessible diene com.nom.rs bearing photodegradable ortho-nitrobenzyl m.ieties with dicyclopentadiene(DCPD)or cyclooctene(COE)leads to the form.tion of photodegradable p DCPD therm.sets and p COE therm.plastic polym.rs with m.chanical properties com.arable to their non-degradable *** im.ortantly,their photo-degradation properties can be efficiently tuned with the addition of ultraviolet absorber during in-situ polym.rization.

关键词： m.tathesis polym.rization photodegradable polydicyclopentadiene polyethylene-like m.terials