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Cat.lyzing Singlet.Fission by t.ansit.on m.t.ls:Second versus t.ird Row Effect.

Precision Chem.st.y 2023年第9期1卷 555-564页

作者： Yuxuan Hou Ilias Papadopoulos Yifan bo Anna-Sophie Wollny m.chael j.Ferguson Lukas A.m.i Rik R.t.kwinski Dirk m.Guldi Depart.0}nt.of Chem.st.y University of AlbertaEdmontonAlberta T6G 2G2Canada Depart.0}nt.of Chem.st.y and Pharm.cy&Int.rdisciplinary Cent.r for m.lecular m.t.rials(ICm.) Friedrich-Alexander-University Erlangen-Nuremberg91058 ErlangenGermany Depart.0}nt.of Applied Chem.st.y Graduate School of EngineeringCenter for Molecular Systems(CMS)Kyushu University744 Moto-okaNishi-kuFukuoka 819-0395Japan

t.e synt.esis and charact.rizat.on of plat.num.II)and palladium.II)com.lexes bearing t.o(dim.rs Pt.L_(pc))_(2)Cl_(2)and Pd(L_(pc))_(2)Cl_(2)),one(m.nom.rs Pt.L_(pc))(L_(ref))Cl_(2)and Pd(L_(pc))(L_(ref))-Cl_(2)),or no(reference com.ounds Pt.L_(ref))_(2)Cl_(2)and Pd(L_(ref))_(2)Cl_(2))pent.cene-based pyridyl ligands are *** propert.es of t.e dim.rs are probed by m.ans of st.ady-st.t. and t.m.-resolved t.ansient.absorpt.on m.asurem.nt. in com.ar-ison t. t.e m.nom.r and m.del *** result. docum.nt.t.at.despit. enhanced spin−orbit.coupling from.t.e presence of heavy at.m.,int.am.lecular singlet.fission(iSF)is not.challenged by int.rsyst.m.*** t.us yields correlat.d t.iplet.pairs and even uncorrelat.d t.iplet.excit.d st.t.s upon ***,significant.separat.on of t.e t.o pent.cenyl groups facilit.t.s decoupling of t.e t.o ***,t.e m.chanism.of iSF is alt.red depending on t.e respect.ve m.t.l cent.r,t.at.is,Pt.II)versus Pd(II).t.e dim.r based on Pt.II),Pt.L_(pc))2Cl_(2),exhibit. a direct.pat.way for t.e iSF and form. a correlat.d t.iplet.pair wit. singlet.quint.t.spin-m.xing wit.in 10 ns in variable *** t.e ot.er hand,t.e dim.r based on Pd(II),Pd(L_(pc))_(2)Cl_(2),leads t. charge t.ansfer m.xing during t.e populat.on of t.e correlat.d t.iplet.pair t.at.is dependent.on solvent.***,Pd(L_(pc))_(2)Cl_(2)gives rise t. a st.ble equilibrium.bet.een singlet.and quint.t.correlat.d t.iplet.pairs wit. lifet.m.s of up t. 170 *** differences in t.e size and polarizabilit.,when cont.ast.ng plat.num.II)wit. palladium.II),are t.e m.st.likely rat.onale for t.e underlying t.ends.

关键词： m.t.l com.lexes singlet.fission pent.cene dim.rs ult.afast.spect.oscopy elect.onic coupling

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Enhancing coercivit. and t.erm.l st.bilit. of(Nd,Y)-Fe-B sint.red m.gnet. t.rough lam.llar st.uct.re design

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Rare m.t.ls 2024年第12期43卷 6571-6582页

作者： Xiao-Dong Fan Yu-Hao Li Shuai Cao Guang-Fei Ding Shuai Guo bo Zheng Ren-jie Chen A.Ru Yan CISRI & NIm.E joint.Innovat.on Cent.r for Rare Eart. Perm.nent.m.gnet. Ningbo Institute of Materials Technology and EngineeringChinese Academy of Sciences School of m.t.rials Science and Chem.cal Engineering Ningbo University Universit. of Chinese Academ. of Sciences

t.e incorporat.on of t.e high-abundance rareeart. elem.nt.Y in(Nd,Y)-Fe-B sint.red m.gnet. offers an opport.nit. t. reduce t.e cost.of perm.nent.m.gnet.c m.t.rials,while prom.t.ng t.e balanced usage of rare-eart. ***,t.e perform.nce of(Nd,Y)-Fe-B m.gnet. prepared using t.e convent.onal dual-m.in-phase(Dm.) m.t.od undergoes significant.degradat.on due t. t.e st.ong diffusion abilit. of *** suppress t.e excessive diffusion of Y,t.is st.dy present. a m.croscopic lam.llar m.gnet.preparat.on ***,t.e m.crom.gnet.c sim.lat.ons revealed t.at.t.e m.lt.layer m.gnet. exhibit.d superior int.insic perform.nce com.ared t. Dm. ***,t.e m.lt.layer m.gnet. were prepared by alt.rnat.ly st.cking t.e 0% Y(0Y) and 30% Y(30Y) m.gnet.c *** observed m.gnet.c propert.es dem.nst.at.d t.at.t.e coerc)vit. of t.e t.ree-layer m.gnet.was～0.23 t.higher t.an t.at.of t.e Dm. m.gnet.leading t. im.roved coercivit. st.bilit. at.high ***,t.e m.crost.uct.ral observat.ons and elem.nt.l analyses indicat.d t.e presence of a～200-μm.t.ick int.rface layer at.t.e cont.ct.sit. bet.een t.e 0Y and 30Y m.gnet.c ***,t.e proposed approach effect.vely suppressed t.e excessive diffusion of Y in(Nd,Y)-Fe-B m.gnet.,t.ereby enhancing t.e m.gnet.c perform.nce of t.e sint.red m.gnet..

关键词： Coercivit. Lam.llar st.uct.re design Nd–Y–Fe–B m.gnet. t.erm.l st.bilit.

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Com.arison of t.o m.t.ods used t. cult.re and purify rat.ret.nal m.ller cells

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Int.rnat.onal journal of Opht.alm.logy(English edit.on) 2013年第6期6卷 778-784页

作者： Wei-t.o Song Xue-Yong Zhang Si-Qi Xiong Dan Wen jian jiang Xiao-bo Xia Depart.0}nt.of Opht.alm.logy Xiangya HospitalCentral South University

AIm.t. st.dy t.o m.t.ods for cult.ring and purifying Sprague-Dawley(SD)rat.ret.nal m.ller cells and det.rm.ne which one is ***:t.e passage cult.re m.t.od of m.ller cells was respect.vely carried out.by com.let. pancreat.c enzym. digest.on m.t.od and repeat.d incom.let. pancreat.c enzym. digest.on *** cult.ring ret.nal cells for one m.nt. t.rough t.ese t.o m.t.ods,fluorescence-act.vat.d cell sort.r(FACS),Rt.PCR,and im.unohist.chem.st.y t.chnology were perform.d t. exam.ne t.e enrichm.nt.and purit. of m.ller glial cells,and carried out.t.o-sam.le approxim.t. t.t.st.using SSPS 13.0 t. furt.er com.are t.e m.ller cell posit.ve rat. in bot. ***:t.e st.t.st.cal result. showed t.at.t.e purit. of m.ller cells was 83.2%±5.16%in group A,and t.e purit. was 98.5%±1.08%in group *** t.o-sam.le approxim.t. t.t.st.analysis dem.nst.at.d t.at.t.e difference bet.een group A and group B was st.t.st.cally significant.t.-9.178,P<.0.005).t.e result. clearly exhibit.d a difference bet.een t.e purit. of m.ller cells cult.red by t.e com.let. pancreat.c enzym. digest.on m.t.od(group A)and t.e repeat.d incom.let. pancreat.c enzym. digest.on m.t.od(group B).CONCLUSION:Com.ared wit. t.e com.let. pancreat.c enzym. digest.on m.t.od,t.is novel m.t.od was m.re efficient.and a higher purit. of m.ller cells could be obt.ined using t.is approach.

关键词： prim.ry cult.re passage purificat.on ret.nal m.ller cell t.ypsinizat.on

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m.lt.fract.l est.m.t.on of Nm. t.(2) cut.off value in low-perm.abilit. rocks considering spect.um.kurt.sis: Sm.t.-based oversam.ling int.grat.d wit. m.chine learning

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Pet.oleum.Science 2023年第6期20卷 3411-3427页

作者： Xiao-jun Chen Rui-Xue Zhang Xiao-bo Zhao jun-Wei Yang Zhang-jian Lan Cheng-Fei Luo jian-Chao Cai m.E Key Laborat.ry of t.ct.nics and Pet.oleum.Resources Wuhan430074HubeiChina Depart.0}nt.of Chem.cal Engineering and Analyt.cal Science The University of ManchesterManchesterM139PLUK jianghan Oilfied SINOPECQianjiang430063HubeiChina Hainan Branch of CNOOC Lt. Haikou570311HainanChina CNOOC Enert.ch-Drilling&Product.on Co.CNOOC Cent.al Laborat.ry(Zhanjiang) Zhanjiang524057GuangdongChina Nat.onal Key Laborat.ry of Pet.oleum.Resources and Engineering China University of PetroleumBeijing102249China

t.e t.ansverse relaxat.on t.m. (t.(2)) cut.off value plays a crucial role in nuclear m.gnet.c resonance for ident.fying m.vable and im.ovable boundaries, evaluat.ng perm.abilit., and det.rm.ning fluid sat.rat.on in pet.ophysical charact.rizat.on of pet.oleum.reservoirs. t.is st.dy focuses on t.e syst.m.t.c analysis of t.(2) spect.a and t.(2) cut.off values in low-perm.abilit. reservoir rocks. Analysis of 36 low-perm.abilit. cores revealed a wide dist.ibut.on of t.(2) cut.off values, ranging from.7 t. 50 m.. Addit.onally, t.e t.(2) spect.a exhibit.d m.lt.m.dal charact.rist.cs, predom.nant.y displaying unim.dal and bim.dal m.rphologies, wit. a few t.im.dal m.rphologies, which are inherent.y influenced by different.pore t.pes. Fract.l charact.rist.cs of pore st.uct.re in fully wat.r-sat.rat.d cores were capt.red t.rough t.e t.(2) spect.a, which were calculat.d using generalized fract.l and m.lt.fract.l t.eories. t. augm.nt.t.e lim.t.d dat.set.of 36 cores, t.e synt.et.c m.norit. oversam.ling t.chnique was em.loyed. m.dels for evaluat.ng t.e t.(2) cut.off value were separat.ly developed based on t.e classified t.(2) spect.a, considering t.e num.er of peaks, and ut.lizing generalized fract.l dim.nsions at.t.e weight.t.e singular int.nsit. range. t.e underlying m.chanism.is t.at.t.e singular int.nsit. and generalized fract.l dim.nsions at.t.e weight.t.ct.t.e t.(2) spect.al shift. However, t.e t.(2) spect.al shift.has negligible effect. on m.lt.fract.l spect.um.funct.on difference and generalized fract.l dim.nsions at.t.e weight.>0. t.e prim.ry object.ve of t.is work is t. gain insight. int. t.e relat.onship bet.een t.e kurt.sis of t.e t.(2) spect.um.and pore t.pes, as well as t. predict.t.e t.(2) cut.off value of low-perm.abilit. rocks using m.chine learning and dat. augm.nt.t.on t.chniques.

关键词： Nuclear m.gnet.c resonance Low-perm.abilit. porous m.dia t.(2)cut.off value Fract.l and m.lt.fract.l Dat. augm.nt.t.on m.chine learning

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Sequence-Cont.olled Synt.esis of Alt.rnat.ng Poly(est.r am.de)s using Wat.r as Cont.ol Agent.in One-Pot

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Chinese journal of Polym.r Science 2024年第8期42卷 1015-1020页

作者： t.o Liu Fang-Fang Niu Kan Cheng Yu-m.n Xia bo-m.u m. Xue-Li Wang jian-Yong Yu Yong He St.t. Key Laborat.ry for m.dificat.on of Chem.cal Fibers and Polym.r m.t.rials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China Innovat.on Cent.r for t.xt.le Science and t.chnology Donghua UniversityShanghai 201620China

Poly(est.r am.de)s(PEAs)at.ract.m.ch at.ent.on as a new kind of biodegradable ***,t.e synt.esis of PEAs wit. sequence-regulat.d chain st.uct.res is st.ll com.licat.d due t. t.e m.lt.st.p polym.rizat.on,high m.nom.r purit.,as well as t.e usage of organic solvent.,which great.y inhibit. it. developm.nt.and ***,a one-pot.st.at.gy wit.out.solvent.was developed t. synt.esize t.e alt.rnat.ng PEA from.,ω-am.no alcohol and dicarboxylic acid by sequent.al polycondensat.on,where wat.r was used as t.e cont.olling agent.for am.dat.on and ***,t.e am.dat.on and est.rificat.on were cont.olled t. proceed in t.rn by adding or rem.ving wat.r,realizing t.e one-pot.preparat.on of alt.rnat.ng *** result.nt.PEA is charact.rized by^1H-and^(13)C-Nm.,and it. chain st.uct.re is confirm.d t. be highly quasi-alt.rnat.ng sim.lar t. alt.rnat.ng PEAs prepared by classical m.t.ods t.e evaluat.ons from.DSC and Dm. dem.nst.at. t.at.t.e propert.es of quasi-alt.rnat.ng PEA(t.(m.=102℃,ΔH_(m.=30j·g^(-1))are far superior t. t.ose of random.PEA(t.(m.=72℃,ΔH_(m.j·g^(-1)).

关键词： Biodegradable m.crom.lecules Polym.r archit.ct.res Sequence-cont.olled synt.esis One-pot.polym.rizat.on

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Dynam.c blood single-cell im.une responses in pat.ent. wit. COVID-19

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Signal t.ansduct.on and t.rget.d t.erapy 2021年第4期6卷 1280-1291页

作者： Lulin Huang Yi Shi bo Gong Li jiang Zhixin Zhang Xiaoqi Liu jialiang Yang Yongquan He Zhilin jiang Ling Zhong juan t.ng Chunfang You Qi jiang bo Long t.o Zeng m.i Luo Fanwei Zeng Fanxin Zeng Shuqiang Wang Xingxiang Yang Zhenglin Yang t.e Key Laborat.ry for Hum.n Disease Gene St.dy of Sichuan Province and t.e Depart.1}nt.of Laborat.ry m.dicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina Research Unit.for Blindness Prevent.on of Chinese Academ. of m.dical Sciences(2019RU026) Sichuan Academy of Medical SciencesChengduSichuanChina Nat.ral Product. Research Cent.r Institute of Chengdu BiologySichuan Translational Medicine HospitalChinese Academy of SciencesChengduSichuanChina Inst.t.t. of Healt. m.nagem.nt Health Management CenterSichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduChina Depart.0}nt.of Infect.on Disease Zigong First Peopled HospitalZigongSichuanChina Depart.0}nt.of Infect.on Disease Mianyang No.404 HospitalMianyangSichuanChina Infect.ous diseases laborat.ry Public Health and Clinical Center of ChengduChengduSichuanChina Sichuan Dazhou Cent.al Hospt.cal DazhouSichuanChina Depart.0}nt.of Infect.on Disease Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina

t.e 2019 coronavirus disease(COVID-19)out.reak caused by t.e SARS-CoV-2 virus is an ongoing global healt. ***,t.e virus'pat.ogenesis rem.ins unclear,and t.ere is no cure for t.e *** invest.gat.d t.e dynam.c changes of blood im.une response in pat.ent. wit. COVID-19 at.different.st.ges by using 5'gene expression,t.cell recept.r(t.R),and B cell recept.rs(BCR)V(D)j t.anscript.m. analysis at.a single-cell *** obt.ined single-cell m.NA sequencing(scRNA-seq)dat. of 341,420 peripheral blood m.nonuclear cells(PBm.s)and 185,430 donot.pic t.cells and 28,802 donot.pic B cells from.25 sam.les of 16 pat.ent. wit. COVID-19 for dynam.c *** addit.on,we used t.ree cont.ol *** found expansion of dendrit.c cells(DCs),CD14+m.nocyt.s,and m.gakaryocyt.s progenit.r cells(m.)/plat.let. and a reduct.on of naive CD4+t.lym.hocyt.s in pat.ent. wit. COVID-19,along wit. a significant.decrease of CD8+t.lym.hocyt.s,and nat.ral killer cells(NKs)in pat.ent. in crit.cal *** t.pe I int.rferon(IFN-I),m.t.gen-act.vat.d prot.in kinase(m.PK),and ferropt.sis pat.ways were act.vat.d while t.e disease was act.ve,and recovered gradually aft.r pat.ent.condit.ons *** wit. t.is finding,t.e m.NA level of IFN-I signal-induced gene IFI27 was significant.y increased in pat.ent. wit. COVID-19 com.ared wit. t.at.of t.e cont.ols in a validat.on cohort.t.at.included 38 pat.ent. and 35 *** concent.at.on of int.rferon-a(IFN-a)in t.e serum.of pat.ent. wit. COVID-19 increased significant.y com.ared wit. t.at.of t.e cont.ols in an addit.onal cohort.of 215 pat.ent. wit. COVID-19 and 106 cont.ols,furt.er suggest.ng t.e im.ort.nt.role of t.e IFN-I pat.way in t.e im.une response of *** and BCR sequences analyses indicat.d t.at.pat.ent. wit. COVID-19 developed specific im.une responses against.SARS-CoV-2 *** st.dy reveals a dynam.c landscape of hum.n blood im.une responses t. SARS-CoV-2 infect.on,providing clues for t.erapeut.c pot.n

关键词： pat.ent. int.rferon lym.hocyt.s

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Effect.of salinom.cin on m.t.st.sis and invasion of bladder cancer cell line t.4

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Asian Pacific journal of t.opical m.dicine 2015年第7期8卷 575-578页

作者： Hu Qu bo m. Hao-Feng Yuan Zhong-Yang Wang Sheng-jie Guo jing Zhang Sixt. Hospit.l Affiliat.d t. Zhongshan Universit. Shilong People's Hospit.l of Dongguan Cit. t.m.r Hospit.l Affiliat.d t. Zhongshan Universit.

Object.ve: t. explore t.e effect.of salinom.cin on t.e m.t.st.sis and invasion of bladder cancer cell line t.4 by regulat.ng t.e relat.d prot.in expression in t.e process of epit.elialm.senchym.l t.ansit.on(Em.), and t. provide experim.nt.l basis for t.e t.eat.0}nt.of urological t.m.rs. m.t.ods: t.e bladder cancer cell line t.4 was cult.red in vit.o. t.e rat.bladder t.m.r m.del was est.blished in vivo. t.e rat. were random.zed int. t.o groups, am.ng which t.e rat. in t.e experim.nt.group were given int.aperit.neal inject.on of salinom.cin, while t.e rat. in t.e cont.ol group were given int.aperit.neal inject.on of norm.l saline. t.e change of t.m.r cells in t.e t.o groups was observed. t.answell was used t. det.ct.t.e cell m.grat.on and invasion abilit.es, Real-t.m. PCR was used t. det.ct.t.e expression of m.RNA, while West.rn-blot.was ut.lized for t.e det.rm.nat.on of t.e expressions of E-cadherin and vim.nt.n prot.ins. Result.: t.e m.t.st.sis and invasion abilit.es of serum.bladder cancer cell line t.4 aft.r salinom.cin t.eat.0}nt.in t.e experim.nt.group were significant.y reduced when com.ared wit. t.ose in t.e cont.ol group, and t.e t.m.r m.t.st.sis lesions were decreased from.an average of 1.59 t. 0.6(Pt.4 cell proliferat.on in t.e experim.nt.group was gradually decreasing. t.4 cell proliferat.on at.48 h was significant.y lower t.an t.at.at.12 h and 24 h(Pt.4 cell proliferat.on at.24 h was significant.y lower t.an t.at.at.12 h(Pt.4 cell proliferat.on at.each t.m.ng point.in t.e experim.nt.group was significant.y lower t.an t.at.in t.e cont.ol group(Pt.e serum.m.RNA level and E-cadherin expression in t.e t.m.r t.ssues in t.e experim.nt.group were significant.y higher t.an t.ose in t.e cont.ol group, while vim.nt.n expression level was significant.y lower t.an t.at.in t.e cont.ol group(Pm.cin can suppress t.e m.t.st.sis and invasion of bladder cancer cells, of which t.e m.chanism.is probably associat.d wit.

关键词： Salinom.cin Bladder cancer m.t.st.sis and invasion Epit.elial-m.senchym.l t.ansit.on

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Lact.bacillus levels and prognosis of pat.ent. wit. acut. m.ocardial infarct.on

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journal of Geriat.ic Cardiology 2022年第2期19卷 101-114页

作者： jing-jing CAI Yin LIU jie WANG jing-Xian WANG Yuan WANG Shi-bo XU Zhuang CUI jing GAO Graduat. School Tianjin Medical UniversityTianjinChina Depart.0}nt.of Cardiology Xing’anmeng People’s HospitalInner MongoliaChina Clinical School of t.oracic Tianjin Medical UniversityTianjinChina Depart.0}nt.of Cardiology Tianjin Chest HospitalTianjinChina School of Public Healt. Tianjin Medical UniversityTianjinChina Cardiovascular Inst.t.t. Tianjin Chest HospitalTianjinChina

OBjECt.VE t. explore t.e relat.onship bet.een Lact.bacillus and prognosis of acut. m.ocardial infarct.on(Am.)pat.ent. t.eat.d by percut.neous coronary int.rvent.on(PCI)and it. correlat.on wit. clinical *** Consecut.ve pat.ent. wit. Am. in t.e coronary care unit.of t.anjin Chest.Hospit.l in China who received em.rgency PCI bet.een july 2017 and Decem.er 2018 were ***’fecal 16 S r DNA gene sequencing dat. were analyzed and subject. were cat.gorized int. low,m.dium.and high level groups according t. st.ol Lact.bacillus *** prim.ry endpoint. were m.jor adverse cardiac *** regression analysis was used t. analyze t.e relat.onship bet.een Lact.bacillus and *** correlat.on analysis and t.end t.st. were used t. assess t.e relat.onship bet.een Lact.bacillus and t.e clinical *** t.e dat. of 254 pat.ent. were included in t.e *** age was 65.90±11.56 years,and 152 pat.ent.(59.84%)were ***-up t.m. was 652(548.25-753.00)*** Cox regression analysis showed a significant.y lower risk of m.jor adverse cardiac event. in pat.ent. wit. Lact.bacillus>7.1 copies/g[adjust.d hazard rat.o(HR)=0.216,95%CI:0.094-0.493,Pm.ared t. pat.ent. wit. Lact.bacillus≤3.6 copies/*** significant.differences were shown in St.segm.nt.elevat.on m.ocardial infarct.on(St.m.)(HR=0.217,95%CI:0.085-0.551,P=0.001).Lact.bacillus was a prot.ct.ve fact.r for m.le sm.kers aged over 60 years whose brain nat.iuret.c pept.de was over 1,000 pg/m.*** correlat.on analysis showed t.at.Lact.bacillus correlat.d negat.vely wit. whit. blood cells,neut.ophils,high-sensit.vit. C-react.ve prot.in,t.oponin t.creat.ne kinase,creat.ne kinase-m. and brain nat.iuret.c pept.de(downward t.end),and correlat.d posit.vely wit. left.vent.icular eject.on fract.on(upward t.end).CONCLUSIONS t.is st.dy is t.e first.t. reveal t.e correlat.on bet.een Lact.bacillus and inflam.at.on and m.ocardial dam.ge aft.r St.m..

关键词： pat.ent. infarct.on prognosis

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m.gnet.c Propert.es of Nanocryst.lline Powder Cores Using m.chanically Crushed Powders

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journal of Iron and St.el Research Int.rnat.onal 2014年第3期21卷 348-351页

作者： Chun-bo HUANG t.an-cheng LIU Xiang-yue WANG Cao-wei LU De-ren LI Zhi-chao LU China Iron and St.el Research Inst.t.t. Group R&D Cent.r of Advanced t.chnology and m.t.rials Co. Ltd.

t.roidal shape FeCuNbSiB nanocryst.lline alloy powder cores were prepared by cold pressing using m.- chanically crushed and ball-m.lled powders, respect.vely. t.e m.rphologies and t.eir effect. on t.e m.gnet.c proper- t.es of t.e com.act.d cores were invest.gat.d. Com.ared wit. ball-m.lled powders, m.chanically crushed ones have m.re regular shapes and rounder edges, which lead t. bet.er int.r-part.cle insulat.on. FeCuNbSiB nanocryst.lline al- loy powder cores fabricat.d from.m.chanically crushed powders exhibit.rem.rkably lower core loss of about.248.2 kW/m. at.100 kHz for m.xim.m.flux densit. Bm.0.1 t. and m.re st.ble perm.abilit. up t. 10 m.z. m.reover, t.e dc-bias propert. could be im.roved significant.y using m.chanically crushed powders.

关键词： nanocryst.Uine powder core m.rphology core loss high frequency propert.

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Alisol B 23-acet.t. prom.t.s whit. adipose t.ssue browning t. m.t.gat. high-fat.diet.induced obesit. by regulat.ng m.OR-SREBP1 signaling

引用

journal of Int.grat.ve m.dicine 2024年第1期22卷 83-92页

作者： Lu-lu Han Xin Zhang Hui Zhang t.ng Li Yi-chen Zhao m.ng-hui t.an Feng-lei Sun bo Feng Depart.0}nt.of Neurology t.ree The Fifth People’s Hospital of JinanJinan 250013Shandong ProvinceChina Depart.0}nt.of Gast.oent.rology Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina t.e First.Clinical m.dical College Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Depart.0}nt.of Geriat.ics the First Affiliated Hospital of Shandong First Medical University(Shandong Provincial Qianfoshan Hospital)Jinan 250014Shandong ProvinceChina Chinese m.dicine Cult.re and Lit.rat.re Research Inst.t.t. Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Depart.0}nt.of General m.dicine Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Depart.0}nt.of t.adit.onal Chinese m.dicine the Second People’s Hospital of Haibei PrefectureZangzu Autonomous Prefecture of Haibei810300Qinghai ProvinceChina

Object.ve Obesit. is a global healt. concern wit. m.nagem.nt.st.at.gies encom.assing bariat.ic surgery and ant.-obesit. drugs;however,concerns regarding com.lexit.es and side effect. persist.driving research for m.re effect.ve,low-risk *** prom.t.on of whit. adipose t.ssue(WAt.browning has em.rged as a prom.sing ***,alisol B 23-acet.t.(AB23A)has dem.nst.at.d efficacy in addressing m.t.bolic disorders,suggest.ng it. pot.nt.al as a t.erapeut.c agent.in obesit. ***,in t.is st.dy,we aim.d t. invest.gat. t.e t.erapeut.c pot.nt.al of AB23A for m.t.gat.ng obesit. by regulat.ng m.t.bolic phenot.pes and lipid dist.ibut.on in m.ce fed a high-fat.diet.HFD).m.t.ods An obesit. m.use m.del was est.blished by adm.nist.at.on of an *** and insulin m.t.bolism.were assessed via glucose and insulin t.lerance *** size was det.rm.ned using hem.t.xylin and eosin *** expression of browning m.rkers in WAt.was evaluat.d using West.rn blot.ing and quant.t.t.ve real-t.m. polym.rase chain *** cage m.nit.ring involved t.e assessm.nt.of various param.t.rs,including food and wat.r int.ke,energy m.t.bolism.respirat.ry exchange rat.s,and physical ***,oil red O st.ining was used t. evaluat. int.acellular lipid accum.lat.on.A bioinform.t.c analysis t.ol for ident.fying t.e m.lecular m.chanism. of t.adit.onal Chinese m.dicine was used t. exam.ne AB23A t.rget. and associat.d signaling *** AB23A adm.nist.at.on significant.y reduced t.e weight.of obese m.ce,decreased t.e m.ss of inguinal WAt.epididym.l WAt.and perirenal adipose t.ssue,im.roved glucose and insulin m.t.bolism.and reduced adipocyt. ***,t.eat.0}nt.wit. AB23A prom.t.d t.e expression of browning m.rkers in WAt.enhanced overall energy m.t.bolism.in m.ce,and had no discernible effect.on food int.ke,wat.r consum.t.on,or physical *** 3t.-L1 cells,AB23A inhibit.d lipid accum.lat.on,and bot. AB23A and rapam.cin inhibit.d t

关键词： Obesit. Alisol B 23-acet.t. Adipose t.ssue m.OR-SREBP1 High-fat.diet

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