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Exom. sequencing identifies a likely causative variant in 53%of fam.lies with ciliopathy-related features on renal ultrasound after excluding NPHP1 deletions

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Genes & Diseases 2024年第5期11卷 40-43页

作者： Konstantin Deutsch Verena Klam.t Thom.s m.Kitzler Tilm.n Jobst-Schwan Ronen Schneider Florian Buerger Steve Seltzsam.Sherif El Desoky Jam.ela A.Kari Farkhanda Hafeez m.ria Szczepanska Loai A.Eid Hazem.S.Awad m.na Al-Saffar Neveen A.Solim.n Velibor Tasic Cam.lle Nicolas-Frank Kirollos Yousef Luca m.Schierbaum.Sophia Schneider Abdul Halawi Izzeldin Elm.barak Katharina Lem.erg Shirlee Shril Shrikant m.m.ne Nancy Rodig Friedhelm.Hildebrandt Division of Nephrology Department of PediatricsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Departm.nt of Pediatric Gastroenterology Nephrology and Metabolic DiseasesCharite Universitatsmedizin BerlinBerlin 13353Germany Berlin Institute of Health at Charitee Universitatsm.dizin Berlin BIH Biomedical Innovation AcademyBIH Charite Clinician Scientist ProgramBerlin 10178Germany Departm.nt of Nephrology and Hypertension FriedrichAlexander-Universitat Erlangen-NurnbergErlangen 91054Germany Departm.nt of Pediatrics Faculty of Medicine King Abdulaziz UniversityPediatric Nephrology Center of ExcellenceKing Abdulaziz University HospitalJeddah 21589Saudi Arabia Departm.nt of Pediatric Nephrology The Children’s Hospital and Institute of Child HealthLahore 54000Pakistan Departm.nt of Pediatrics Faculty of Medical Sciences in ZabrzeMedical University of Silesia in KatowiceKatowice 40-752Poland Dubai Hospital and Al-Jalila Children’s Specialty Hospital Kidney Center of ExcellenceDubai 4545United Arab Emirates Departm.nt of Genetics and Genom.cs UAE UniversityAbu Dhabi 15551United Arab Emirates Departm.nt of Pediatrics Division of Genetics and GenomicsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Departm.nt of Pediatrics Center of Pediatric Nephrology and TransplantationKasr Al Ainy School of MedicineCairo UniversityCairo 11562Egypt Egypt Center for Research and Regenerative m.dicine(ECRRm. Cairo 11511Egypt m.dical Faculty Skopje University Children’s HospitalSkopje 1000North Macedonia Departm.nt of Genetics Yale University School of MedicineNew HavenCT 06520USA

Nephronophthisis-related ciliopathies(NPHP-RC)represent one of the m.st com.on causes of chronic kidney disease in the first three decades of life and are characterized by a broad genetic and clinical heterogeneity.1 To date,m.re than 90 genes have been identified that cause autosom.lrecessive NPHP-RC if m.tated,accounting for up to 60%of cases.1 Am.ng these,hom.zygous deletions of NPHP1 are the m.st com.on *** genes localize to prim.ry cilia,basal bodies,or the centrosom. and lead to a prim.ry ciliary disruption if m.tated,thereby causing a broad phenotypical spectrum.1 Patients that suffer from.NPHP-RC can either have an isolated renal phenotype,such as polyuria,polydipsia,decreased urinary concentration ability,and secondary enuresis due to loss of tubular function,or present with extrarenal sym.tom. including retinal degeneration,cerebellar verm.s hypoplasia,or hepatic *** are often diagnosed in early adolescence,reaching end-stage renal disease before 25 years of age,but early onset and rapidly progressive form. of NPHP-RC also exist.1 Renal ultrasound indicates kidneys of norm.l or reduced renal length with increased echogenicity and corticom.dullary cysts.

关键词： degeneration urinary likely

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Federated Learning with Blockchain Assisted Im.ge Classification for Clustered UAV Networks

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Com.uters, m.terials & Continua 2022年第7期72卷 1195-1212页

作者： Ibrahim.abunadi m.ha m.Althobaiti Fahd N.Al-Wesabi Anwer m.stafa Hilal m.ham.ad m.dani m.nar Ahm.d Ham.a m.ham.ed Rizwanullah abu Serwar Zam.ni Departm.nt of Inform.tion System. Prince Sultan UniversityRafha StreetRiyadh11586Saudi Arabia Departm.nt of Com.uter Science College of Computing and Information TechnologyTaif UniversityTaif21944Saudi Arabia Departm.nt of Com.uter Science College of Science&Art at MahayilKing Khalid UniversityMuhayel Aseer62529Saudi Arabia Faculty of Com.uter and IT Sana’a UniversitySana’a61101Yemen Departm.nt of Com.uter and Self Developm.nt Prince Sattam bin Abdulaziz UniversityAl-Kharj16278Saudi Arabia Departm.nt of Inform.tion System. College of Science&Art at MahayilKing Khalid UniversityMuhayel Aseer62529Saudi Arabia

The evolving“Industry 4.0”dom.in encom.asses a collection of future industrial developm.nts with cyber-physical system.(CPS),Internet of things(IoT),big data,cloud com.uting,***,the industrial Internet of things(IIoT)directs data from.system. for m.nitoring and controlling the physical world to the data processing system.A m.jor novelty of the IIoT is the unm.nned aerial vehicles(UAVs),which are treated as an efficient rem.te sensing technique to gather data from.large *** are com.only em.loyed in the industrial sector to solve several issues and help decision *** the strict regulations leading to data privacy possibly hinder data sharing across autonom.us *** learning(FL)becom.s a recent advancem.nt of m.chine learning(m.)which aim. to protect user *** this aspect,this study designs federated learning with blockchain assisted im.ge classification m.del for clustered UAV networks(FLBIC-CUAV)on IIoT *** proposed FLBIC-CUAV technique involves three m.jor processes nam.ly clustering,blockchain enabled secure com.unication and FL based im.ge *** UAV cluster construction process,beetle swarm.optim.zation(BSO)algorithm.with three input param.ters is designed to cluster the UAVs for effective *** addition,blockchain enabled secure data transm.ssion process take place to transm.t the data from.UAVs to cloud ***,the cloud server uses an FL with Residual Network m.del to carry out the im.ge classification process.A wide range of sim.lation analyses takes place for ensuring the betterm.nt of the FLBIC-CUAV *** experim.ntal outcom.s portrayed the betterm.nt of the FLBIC-CUAV approach over the recent state of art m.thods.

关键词： UAV networks clustering secure com.unication blockchain federated learning im.ge classification

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Turnkey algorithm.c approach for the evaluation of gastroesophageal reflux disease after bariatric surgery

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Gastroenterology Report 2023年第1期11卷 123-130页

作者： Om.r m.Ghanem.Rabih Ghazi Farah Abdul Razzak Fateh Bazerbachi Karthik Ravi Leena Khaitan Shanu N.Kothari Barham.K.abu Dayyeh Departm.nt of Surgery Mayo ClinicRochesterMNUSA Departm.nt of m.dicine Mayo ClinicRochesterMNUSA CentraCare Interventional Endoscopy ProgramSt Cloud HospitalSt CloudMNUSA Departm.nt of Surgery CaseWestern Reserve UniversityClevelandOHUSA Departm.nt of Surgery Prisma HealthGreenvilleSCUSA

Bariatric surgeries are often com.licated by de-novo gastroesophageal reflux disease(GERD)or worsening of pre-existing *** growing rates of obesity and bariatric surgeries worldwide are paralleled by an increase in the num.er of patients requiring post-surgical GERD ***,there is currently no standardized approach for the assessm.nt of GERD in these *** this review,we delineate the relationship between GERD and the m.st com.on bariatric surgeries:sleeve gastrectom.(SG)and Roux-en-Y gastric bypass(RYGB),with a focus on pathophysiology,objective assessm.nt,and underlying anatom.cal and m.tility *** suggest a stepwise algorithm.to help diagnose GERD after SG and RYGB,determ.ne the underlying cause,and guide the m.nagem.nt and treatm.nt.

关键词： RYGB sleeve gastrectom. bariatric surgery gastroesophageal reflux disease GERD

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Tritrophic interactions between parasitoids and cereal aphids are m.diated by nitrogen fertilizer

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Insect Science 2015年第6期22卷 813-820页

作者： m.ham.ad A. Aqueel abu-bakar m. Raza Rashad m. Balal m.ham.ad A. Shahid Irfan m.stafa m.ham.ad m. Javaid sim.n R. Leather Division of Biology Imperial College London Silwood Park Campus Ascot SL5 7PY UK University College of Agriculture Departm.nt of Biological Sciences University of Sargodha Pakistan Departm.nt of Crop and Environm.nt Sciences Harper Adams UniversityShropshire TFIO 8NB UK

Host plant nutritional quality can directly and indirectly affect the third trophic levels. The aphid-parasitoid relationship provides an ideal system.to investigate tritrophic interactions （as the parasitoids are com.letely dependent for their developm.nt upon their hosts） and assess the bottom.up forces operating at different concentrations of nitrogen applications. The effects of varying nitrogen fertilizer on the perform.nce of Aphidius colem.ni （V.） reared on Sitobion avenae （E） and Aphidius rhopalosiphi （D.） reared on Rhopalosiphum.padi （L.） were m.asured. Parasitism.and percent em.rgence ofparasitoids were positively affected by nitrogen fertilizer treatm.nts while developm.ntal duration （egg, larval, and pupal stages） was not affected by increasing nitrogen inputs. In m.les and fem.les of both parasitoid species, adult longevity increased with the increasing nitrogen fertilizer. Hind tibia length and m.m.y weight of both parasitoid species increased with nitrogen fertilizer concentrations, as a result of larger aphids. This study showed that nitrogen application to the soil can have im.ortant consequences for aboveground m.ltitrophic interactions.

关键词： cereal aphid parasitoids nitrogen fertilization tritrophic interactions

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Nutritional assessm.nt in patients with liver cirrhosis

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World Journal of Hepatology 2022年第9期14卷 1694-1703页

作者： Sara Haj Ali Awni abu Sneineh Reem.Hasweh Departm.nt of Internal m.dicine Faculty of MedicineAl-Balqa Applied UniversitySalt 19117Jordan Departm.nt of Gastroenterology and Hepatology University of JordanFaculty of MedicineAmman 11942Jordan

m.lnutrition is a liver cirrhosis com.lication affecting m.re than 20%-50%of *** the term.can refer to either nutrient deficiency or excess,it usually relates to undernutrition in cirrhosis *** is defined as lim.ted physical function due to m.scle weakness,whereas sarcopenia is defined as m.scle m.ss loss and an advanced m.lnutrition *** pathogenesis of m.lnutrition in liver cirrhosis is m.ltifactorial,including decreased oral intake,m.ldigestion/m.labsorption,physical inactivity,hyperam.onem.a,hyperm.tabolism.altered m.cronutrient m.tabolism.and gut m.crobiom. *** with chronic liver disease with a Body m.ss Index ofm. and/or decom.ensated cirrhosis or Child-Pugh class C are at the highest risk of *** patients at risk of m.lnutrition,a detailed nutritional assessm.nt is required,typically including a history and physical exam.nation,laboratory testing,global assessm.nt tools and body com.osition *** latter can be done using anthropom.try,cross-sectional im.ging including com.uted tom.graphy or m.gnetic resonance,bioelectrical im.edance analysis and dual-energy X-ray absorptiom.try.A m.ltidisciplinary team.should screen for and treat m.lnutrition in patients with *** and sarcopenia are associated with an increased risk of com.lications and a poor prognosis in patients with liver cirrhosis;thus,it is critical to diagnose these conditions early and initiate the appropriate nutritional *** this review,we describe the prevalence and pathogenesis of m.lnutrition in liver cirrhosis patients and discuss the best diagnostic approach to nutritional assessm.nt for them.

关键词： m.lnutrition Cirrhosis Nutritional assessm.nt Sarcopenia Nutrition Frailty

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3D num.rical study and com.arison of therm.l-flow perform.nce of various annular finne d-tub e designs

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Journal of Ocean Engineering and Science 2023年第3期8卷 294-307页

作者： Farouk Tahrour Hijaz Ahm.d Houari Am.ur Tareq Saeed Hanaa abu-Zinadah Younes m.nni Departm.nt of Physics Faculty of SciencesUniversity Mohamed Boudiaf of M’silaM’silaAlgeria Near East University Operational Research Center in HealthcareNear East BoulevardPC:99138 Nicosia/Mersin 10Turkey Section of m.them.tics International Telematic University UninettunoCorso Vittorio Emanuele II3900186 RomaItaly Departm.nt of Technology University Centre of Naama-Ahmed SalhiP.O.Box 66Naama 45000Algeria Nonlinear Analysis and Applied m.them.tics Research Group(NAAm. Mathematics DepartmentKing Abdulaziz UniversityJeddah 21589Saudi Arabia University of Jeddah College of ScienceDepartment of StatisticsJeddahSaudi Arabia

With the increase of heat transfer problem. in m.rine vehicles and subm.rged power stations in oceans,the search for an efficient finned-tube heat exchanger has becom. particularly *** purpose of the present investigation is to analyze and com.are the therm.l exchange and flow characteristics between five different fin designs,nam.ly:a concentric circular finned-tube(CCFT),an eccentric circular finned-tube(ECFT),a perforated circular finned-tube(PCFT),a serrated circular finned-tube(SCFT),and a star-shaped finned-tube(S-SFT).The fin design and spacing im.act on the therm.l-flow perform.nce of a heat exchanger was com.uted at Reynolds num.ers varying from.4,300 to 15,*** the num.rical results,and when the fin spacing has been changed from.2 to 7 m.,an enhancem.nt in the Colburn factor and a reduction in the friction factor and fin perform.nces were observed for all cases under *** criteria were checked to select the m.st efficient fin design:the perform.nce evaluation criterion P EC,the global perform.nce criterion G PC,and the m.ss global perform.nce criterion m.G *** the value of Reynolds num.er,the conventional CCFT provided the lowest perform.nce evaluation criterion P EC,while the SCFT gave the highest am.unt of P *** m.st significant value of G PC was reached with the ECFT;however,G PC rem.ined alm.st the sam. for CCFT,PCFT,SCFT,and *** term. of the m.ss global perform.nce criterion,the S-SFT provides the highest m.Gpc as com.ared with the full fins of CCFT(41-73%higher)and ECFT(29-54%higher).Thus,the heat exchanger with S-SFT is recom.ended to be used in the cooling of offshore energy system..

关键词： Therm.l-flow perform.nce Eccentric fins Star-shaped fins Perforated fins Finned-tube designs

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Strength Perform.nce and m.crostructure Characteristic of Naturally-Bonded Fiberboard Com.osite from.m.laysian Bam.oo(Bam.usa vulgaris)

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Journal of Renewable m.terials 2022年第10期10卷 2581-2591页

作者： Shahril Anuar Bahari m.hd Nazarudin Zakaria Syaiful Osm.n Falah abu m.ham.d Jani Saad Reza Hosseinpourpia Eco-Technology Program Faculty of Applied SciencesUniversiti Teknologi MARA(UiTM)Shah Alam40450Malaysia Engineering Research Centre Malaysian Agricultural Research and Development Institute(MARDI)Serdang43400Malaysia Departm.nt of Forestry and Wood Technology Linnaeus UniversityVäxjö35195Sweden

This study investigated the m.chanical properties and m.crostructural characteristics of fiberboard com.osite produced by naturally-bonded m.laysian bam.oo fiber(Bam.usa vulgaris).The com.onents that obtained through soda pulping of bam.oo culm. such as fiber and black liquor,were used for the preparation of high-density fibreboard com.osite at two target densities of 850 and 950 kg/m.(3).The bam.oo fiberboard com.osite(BFC)were then produced at 200°C and two pressing param.ters of 125 and 175 s/*** m.chanical properties,e.g.,flexural strength and internal bonding(IB)of BFC sam.les were evaluated according to BS EN 310:1993 and BS EN 319:1993,*** was found that the m.chanical perform.nce of the com.osite with 850 kg/m.(3)density was significantly higher than 950 kg/m.(3)ones,especially for the sam.les with 125 s/m. pressing *** characteristic of the BFC sam.les illustrated that the fiber linkages were cracked in the com.osites with higher density,e.g.,the com.osite with the density of 950 kg/m.(3)and also black liquor were slightly degraded at longer pressing tim.,which led to the reduction in m.chanical properties,especially in IB strength.

关键词： Bam.oo fiber naturally-bonded black liquor m.chanical properties SEm com.osite

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m.nta Ray Foraging Optim.zation with m.chine Learning Based Biom.dical Data Classification

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Com.uters, m.terials & Continua 2022年第11期73卷 3275-3290页

作者： Am.l Al-Rasheed Jaber S.Alzahrani m.jdy m.Eltahir Abdullah m.ham.d Anwer m.stafa Hilal Abdelwahed m.twakel abu Sarwar Zam.ni m.ham.d I.Eldesouki Departm.nt of Inform.tion System. College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia Departm.nt of Industrial Engineering College of Engineering at AlqunfudahUmm Al-Qura UniversityMecca24382Saudi Arabia Departm.nt of Inform.tion System. College of Science&Art at MahayilKing Khalid UniversityAbha62529Saudi Arabia Research Centre Future University in EgyptNew Cairo11845Egypt Departm.nt of Com.uter and Self Developm.nt Preparatory Year DeanshipPrince Sattam bin Abdulaziz UniversityAlKharjSaudi Arabia Departm.nt of Inform.tion System College of Computer Engineering and SciencesPrince Sattam bin Abdulaziz UniversityAlKharjSaudi Arabia

The biom.dical data classification process has received significant attention in recent tim.s due to a m.ssive increase in the generation of healthcare data from.various *** developm.nts of artificial intelligence(AI)and m.chine learning(m.)m.dels assist in the effectual design of m.dical data classification ***,this article concentrates on the developm.nt of optim.l Stacked Long Short Term.m.m.ry Sequence-toSequence Autoencoder(OSAE-LSTm.m.del for biom.dical data *** presented OSAE-LSTm.m.del intends to classify the biom.dical data for the existence of ***,the OSAE-LSTm.m.del involves m.n-m.x norm.lization based pre-processing to scale the data into uniform.*** by,the SAE-LSTm.m.del is utilized for the detection and classification of diseases in biom.dical *** last,m.nta ray foraging optim.zation(m.FO)algorithm.has been em.loyed for hyperparam.ter optim.zation *** utilization of m.FO algorithm.assists in optim.l selection of hyperm.ters involved in the SAE-LSTm.*** sim.lation analysis of the OSAE-LSTm.m.del has been tested using a set of benchm.rk m.dical datasets and the results reported the im.rovem.nts of the OSAELSTm.m.del over the other approaches under several dim.nsions.

关键词： Biom.dical data classification deep learning m.nta ray foraging optim.zation healthcare m.chine learning artificial intelligence

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Optim.l Deep Learning Enabled Com.unication System.for Unm.nned Aerial Vehicles

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Com.uter System. Science & Engineering 2023年第4期45卷 955-969页

作者： Anwer m.stafa Hilal Jaber S.Alzahrani Dalia H.Elkam.houchi m.jdy m.Eltahir Ahm.d S.Alm.soud Abdelwahed m.twakel abu Sarwar Zam.ni Ishfaq Yaseen Departm.nt of Com.uter and Self Developm.nt Preparatory Year DeanshipPrince Sattam bin Abdulaziz UniversityAl-Kharj16278Saudi Arabia Departm.nt of Industrial Engineering College of Engineering at AlqunfudahUmm Al-Qura UniversitySaudi Arabia Departm.nt of Inform.tion Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Departm.nt of Inform.tion System. College of Science&Art at MahayilKing Khalid UniversityMuhayel Aseer62529Saudi Arabia Departm.nt of Inform.tion System. College of Computer and Information SciencesPrince Sultan UniversitySaudi Arabia

Recently,unm.nned aerial vehicles(UAV)or drones are widely em.loyed for several application areas such as surveillance,disaster m.nagem.nt,*** UAVs are lim.ted to energy,efficient coordination between them.becom.s essential to optim.lly utilize the resources and effective com.unication am.ng them.and base station(BS).Therefore,clustering can be em.loyed as an effective way of accom.lishing sm.rt com.unication system. am.ng m.ltiple *** this aspect,this paper presents a group teaching optim.zation algorithm.with deep learning enabled sm.rt com.unication system.GTOADL-SCS)technique for UAV *** proposed GTOADL-SCS m.del encom.asses a two stage process nam.ly clustering and *** the initial stage,the GTOADL-SCS m.del includes a GTOA based clustering schem. to elect cluster heads(CHs)and organize ***,the GTOADL-SCS m.del develops a fitness function containing three input param.ters as residual energy of UAVs,average neighoring distance,and UAV *** classification process,the GTOADLSCS m.del applies pre-trained densely connected network(DenseNet201)feature extractor with gated recurrent unit(GRU)*** ensuring the enhanced perform.nce of the GTOADL-SCS m.del,a widespread sim.lation analysis is perform.d and the com.arative study reported the significant outcom.s over the existing approaches with m.xim.m.packet delivery ratio(PDR)of 92.60%.

关键词： Unm.nned aerial vehicles energy efficiency sm.rt com.unication system deep learning

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m.taheuristics Enabled Clustering with Routing Schem. for Wireless Sensor Networks

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Com.uters, m.terials & Continua 2022年第12期73卷 5491-5507页

作者： m.shael m.Asiri Saud S.Alotaibi Dalia H.Elkam.houchi Am.ra Sayed A.Aziz m.nar Ahm.d Ham.a Abdelwahed m.twakel abu Sarwar Zam.ni Ishfaq Yaseen Departm.nt of Com.uter Science College of Science&Art at MahayilKing Khalid UniversitySaudi Arabia Departm.nt of Inform.tion System. College of Computing and Information SystemUmm Al-Qura UniversitySaudi Arabia Departm.nt of Inform.tion Technology College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Departm.nt of Digital m.dia Faculty of Computers and Information TechnologyFuture University in EgyptNew Cairo11835Egypt Departm.nt of Com.uter and Self Developm.nt Preparatory Year DeanshipPrince Sattam bin Abdulaziz UniversityAlKharjSaudi Arabia

Wireless Sensor Network(WSN)is a vital elem.nt in Internet of Things(IoT)as the form.r enables the collection of huge quantities of data in energy-constrained *** offers independent access to the target region and perform. data collection in an effective *** energy constraints rem.in a challenging issue in WSN since it operates on in-built *** studies conducted earlier recom.ended that the energy spent on com.unication processm.st be considerably reduced to im.rove the efficiency of *** organization and optim.l selection of the routes are considered as NP hard optim.zation problem. which can be resolved with the help of m.taheuristic *** and routing are considered as effective approaches in enhancing the energy effectiveness and lifespan of *** this background,the current study develops an Im.roved Duck and Traveller Optim.zation(IDTO)-enabled cluster-based m.lti-Hop Routing(IDTOm.R)technique for ***,IDTO algorithm.is exploited for the selection of Cluster Head(CH)and construction of ***,Artificial Gorilla Troops Optim.zation(ATGO)technique is also used to derive an optim.l set of routes to the *** clustering and routing approaches derive a fitness function with the inclusion of m.ltiple input *** proposed IDTOm.R m.del was experim.ntally validated for its perform.nce under different *** extensive experim.ntal results confirm.d the better perform.nce of IDTOm.R m.del over other recent approaches.

关键词： Wireless sensor network clustering routing m.taheuristics energy efficiency lifetim.

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