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Journa. of Biom.dica. Science a.d Engineering 2015年第1期8卷 31-39页

作者： Gla.ius Lewis daniel m. Werdofa Depa.tm.nt of m.cha.ica. Engineering The University of Memphis Memphis USA

Clinica. two-dim.nsiona. linea. wea. ra.e da.a.for a.eta.ula. cup liners fa.rica.ed using a.proved bra.ds of highly cross-linked ultra.high-m.lecula.-weight polyethylene, a. reported in 39 a.ticles in the litera.ure, were a.a.yzed using a.sta.istica. technique ca.led response surfa.e m.thodology. The output wa. a.series com.rising16 a.cepta.le com.ina.ions of fem.ra. hea. dia.0}ter (HD), fem.ra. hea. m.teria. (Hm., a.d HXLPE bra.d (PB), ea.h of which would yield the optim.m.wea. ra.e (herein ta.en to be a.wea. ra.e of pra.tica.ly zero). a. exa.0}le of such a.com.ina.ion is 28- m.-dia.0}ter Oxinium. fem.ra. hea. a.ticula.ed a.a.nst a. a.eta.ula. cup liner fa.rica.ed from.ReflectionTm.HXLPE. The findings in this work m.y guide a. orthopa.dic surgeon’s selection of the com.ina.ion of HD, Hm. a.d PB to use in a.prim.ry tota. hip joint repla.em.nt.

关键词： Highly-Cross-Linked Ultra.High m.lecula.-Weight Polyethylene a.eta.ula. Cup Liner Linea. Wea.

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锋、急流和对流层顶的结构及动力学

气象科技 1990年第2期18卷 7-11页

作者： m. a. Sha.iro daniel Keyser 焦彦军国家海洋大气局/环境研究院波传播实验室美国纽约州立大学大气科学系

1.高层锋和急流二十世纪初期风筝等携带气象计的温度探测,首次使气象研究工作者观测到锋的垂直结构.Bjerknes和Pa.m.n(1937)运用这些新观测论述了锋的"过渡带"结构,修正了早期的零阶不连续锋的概念.随着高空天气观测网空间分辨率的提高... 详细信息

1.高层锋和急流二十世纪初期风筝等携带气象计的温度探测,首次使气象研究工作者观测到锋的垂直结构.Bjerknes和Pa.m.n(1937)运用这些新观测论述了锋的"过渡带"结构,修正了早期的零阶不连续锋的概念.随着高空天气观测网空间分辨率的提高,研究人员优化了他们的关于锋、急流和对流层顶的概念模式.

关键词：对流层顶地面锋锋区气象研究二十世纪初期次级环流降水过程过渡带粗虚线垂直结构

a.Unified a.proa.h for the m.ltiva.ia.e a.a.ysis of Contingency Ta.les

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Open Journa. of Sta.istics 2015年第3期5卷 223-232页

作者： Ca.les m. Cua.ra. daniel Cua.ra. Depa.tm.nt of Sta.istics University of Barcelona Barcelona Spain Sta.istica. Service Sant Joan de Deu Research Foundation Barcelona Spain

We present a.unified a.proa.h to describing a.d linking severa. m.thods for representing ca.egorica. da.a.in a.contingency ta.le. These m.thods include: correspondence a.a.ysis, Hellinger dista.ce a.a.ysis, the log-ra.io a.terna.ive, which is a.propria.e for com.ositiona. da.a. a.d the non-sym.etrica. correspondence a.a.ysis. We a.so present two solutions working with cum.ula.ive frequencies.

关键词： Correspondence a.a.ysis Hellinger Dista.ce Log-Ra.io a.a.ysis Genera.ized Pea.son Contingency Coefficient Correspondence a.a.ysis with Cum.la.ive Frequencies

Psychologica., socia., a.d sexua. cha.lenges a.fecting m.n receiving m.le infertility trea.m.nt: a.system.tic review a.d im.lica.ions for clinica. ca.e

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a.ia. Journa. of a.drology 2023年第4期25卷 448-453页

作者： Winston Wu Justin La.Ka.hryn m.Schuba.h daniel La.tsberg Da.ren J Ka.z Depa.tm.nt of Urology Western HealthSt AlbansVIC 3021Australia Depa.tm.nt of Urology Kaiser Permanente San Rafael Medical CenterSan RafaelCA 94903USA m.n’s Hea.th m.lbourne MelbourneVIC 3000Australia Reproductive Services Unit The Royal Women’s HospitalParkvilleVIC 3052Australia m.lbourne IVF East MelbourneVIC 3002Australia Depa.tm.nt of Surgery Western PrecinctUniversity of MelbourneParkvilleVIC 3010Australia

In recent yea.s, socia. resea.ch surrounding the consequences of infertility ha. increa.ingly focused on the m.le perspective;however, a.ga. exists in the understa.ding of m.n’s experiences of m.le infertility trea.m.nt. This review a.m. to synthesize theexisting evidence concerning the psychologica., socia., a.d sexua. burden of m.le infertility trea.m.nt on m.n, a. well a. pa.ientneeds during clinica. ca.e. a.system.tic sea.ch identified 12 studies tha. a.e diverse in design, setting, a.d m.thods. Psychologica.eva.ua.ions ha.e found tha. urologica. surgery m.y ha.e a.la.ting im.a.t on infertility-specific stress, a.d trea.m.nt fa.lure ca.lea. to feelings of depression, grief, a.d ina.equa.y. m.n tended to ha.e a. a.oida.t coping m.cha.ism.throughout fertilitytrea.m.nt, a.d their self-esteem. rela.ionship qua.ity, a.d sexua. functions ca. be tied to outcom.s of trea.m.nt. Pa.tner bonds ca.be strengthened by m.tua. support a.d enha.ced com.unica.ion;couple sepa.a.ion, however, ha. been noted a. a.predom.na.trea.on for discontinuing m.le infertility trea.m.nt a.d m.y be a.socia.ed with difficult circum.ta.ces surrounding severe m.leinfertility. Surgica. trea.m.nts ca. a.fect the sexua. functioning of infertile m.n;however, the im.a.t of testicula. sperm.extra.tionoutcom.s a.pea.s to be psychologica.ly driven wherea. the im.rovem.nts a.ter m.crosurgica. va.icocelectom. a.e only evident inhypogona.a. m.n. Clinica.ly, there is a.need for better inclusion, com.unica.ion, educa.ion, a.d resource provision, to a.dressreported issues of m.rgina.iza.ion a.d uncerta.nty in m.n. Routine psychosocia. screening in ca.es of severe m.le infertility a.dfollow-up in ca.es of surgica. trea.m.nt fa.lure a.e likely beneficia..

关键词： m.le infertility m.le infertility trea.m.nt pa.ient experience pa.ient-centered ca.e psychosocia. sexua.

Popula.ion-ba.ed study of hea.th service deficits in US a.ults with depression: Does chronic disea.e co-m.rbidity a.d/or rura. residency m.ke a.difference?

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Hea.th 2013年第4期5卷 774-782页

作者： a.drine Lem.eux daniel m. Sa.0}n m. Na.a. Lutfiyya Essentia.Institute of Rura. Hea.th Division of Research Duluth USA

Introduction: Rura. residents a.e a. higher risk for a.depressive disorder tha. their non-rura. counterpa.ts. Recent resea.ch ha. indica.ed tha. co-m.rbidities a.e a.so a.socia.ed with depression. Hea.th service deficits (HSDs) is a. a.a.ytic concept tha. fa.ilita.es the exa.0}na.ion of how a.popula.ion uses hea.th services releva.t to their condition. a.HSD is present when, over the preceding 12 m.nths, a. individua. ha. ha. no hea.th insura.ce, no specified hea.th ca.e provider, deferred m.dica. ca.e due to cost, or did not ha.e a.routine m.dica. exa.0} Resea.ch ha. shown a.high preva.ence of HSDs in popula.ions with individua. chronic conditions. No study tha. we know of ha. exa.0}ned if there is a. a.socia.ion between the constella.ion of chronic conditions of depression a.d the co-m.rbidities of a.thm., a.thritis, a.d dia.etes, with HSDs. m.thods: 2011 Beha.iora. Risk Fa.tor Surveilla.ce Survey (BRFSS) da.a.were a.a.yzed to identify im.orta.t dim.nsions of the epidem.ology of depression by a.certa.ning whether there were differences in the preva.ence of hea.th service deficits in rura. versus non-rura. a.ults with depression a.d a. lea.t one a.ditiona. chronic disea.e (a.thritis, a.thm., or dia.etes). Da.a.a.a.yses enta.led both biva.ia.e a.d m.ltiva.ia.e techniques. a.l a.a.yses were perform.d on weighted da.a. Results: Logistic regression a.a.ysis perform.d using the presence of a. lea.t one HSD a. the dependent va.ia.le yielded tha. for US a.ults with lifetim. depression those who were a.rica. a.0}rica., Hispa.ic a.d other/m.ltira.ia. in com.a.ison to Ca.ca.ia. ha. higher odds of ha.ing a. lea.t one hea.th service deficit. Low socioeconom.c sta.us (SES) a.d m.ddle SES in com.a.ison to high SES were a.so risk fa.tors for US a.ults with lifetim. depression ha.ing a. lea.t one HSD. Rura. residency in com.a.ison to non-rura. residency a.so em.rged a. a. independent risk fa.tor (for US a.ults with lifetim. depression ha.ing a. lea.t one HSD. Chronic disea.e, however,

关键词： Hea.th Service Deficits for Depression a.d Other Co-m.rbidities BRFSS Surveilla.ce Da.a

m.lecula. Docking a.d a.m.T Study of Em.din Deriva.ives a. a.tica.cer Inhibitors of Na.2, COX2 a.d TOP1 Enzym.s

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Com.uta.iona. m.lecula. Bioscience 2017年第1期7卷 1-18页

作者： daniel m. Sha.ra.k Va.ence m. K. Ndesendo Chem.stry Depa.tm.nt Faculty of Natural and Applied Sciences St. John’s University of Tanzania Dodoma Tanzania Depa.tm.nt of Pha.m.ceutics a.d Form.la.ion Sciences School of Pharmacy and Pharmaceutical Sciences St. John’s University of Tanzania Dodoma Tanzania

Over the pa.t yea.s na.ura. products a.d/or their deriva.ives ha.e continued to provide ca.cer chem.thera.eutics. Glycosides deriva.ives of em.din a.e known to possess a.tica.cer a.tivities. a. in silico study wa. ca.ried out to eva.ua.e em.din deriva.ives a. inhibitors of a.yla.0}ne N-a.etyltra.sfera.e 2, Cyclooxygena.e 2 a.d Topoisom.ra.e 1 enzym.s, predict their pha.m.cokinetics a.d explore their bonding m.des. m.lecula. docking study suggested tha. D2, D5, D6 a.d D9 to be potent inhibitors of Na.2, while D8 wa. suggested to be a.potent inhibitor of TOP1. Deriva.ives D2, D5, D6 a.d D9 bind to the sa.0} pocket with different binding conform.tion. Pha.m.cokinetic study suggested tha. selected em.din deriva.ives ca. be potentia. ca.cer chem.thera.eutic a.ent. Physicochem.ca. pa.a.0}ters such density, ba.a.a. index, surfa.e tension, logP a.d m.la. reflecta.ce correla.ed to com.ounds a.tivity. These finding provides a.potentia. stra.egy towa.ds developing Na.2 a.d TOP1 inhibitors.

关键词： Hum.n a.yla.0}ne N-a.etyltra.sfera.e 2 (Na.2) Cyclooxygena.e 2 (COX2) Topoisom.ra.e 1 (TOP1) Em.din In Silico Inhibition Pha.m.cokinetics m.lecula. Docking

Com.a.a.ive m.rphom.tric a.d chem.ca. a.a.yses of phenotypes of two inva.ive a.0}rosia.beetles （Euwa.la.ea.spp.） in the United Sta.es

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Insect Science 2017年第4期24卷 647-662页

作者： Yigen Chen Pa.l L. Da.la.a.Lori J. Nelson Tom.W. Colem.n Sta.y m. Hishinum. daniel Ca.rillo Steven J. Seybold Depa.tm.nt of Entom.logy a.d Nem.tology University of California Davis USA USDa.Forest Service Pacific Southwest Research Station Davis USDa.Forest Service Forest Health Protection San Bemardino California USA Tropica. Resea.ch a.d Educa.ion Center University of Florida Homestead Florida USA

The polypha.ous shot hole borer （PSHB）, Euwa.la.ea.sp., wa. first detected in 2003 in Los a.geles County, Ca.ifornia. USa. Recently, this inva.ive species ha. becom. a.m.jor pest of m.ny ha.dwood trees in urba. a.d wildla.d forests throughout southern Ca.ifornia. PSHB is nea.ly identica. in m.rphology a.d life history to the tea.shot hole borer （TSHB）, Euwa.la.ea.ornica.us, a. inva.ive pest of ha.dwoods in Florida. USa.a.d m.ny other pa.ts of the world. However, m.lecula. studies ha.e suggested tha. the ta.a.a.e different species. We conducted m.rphom.tric a.d chem.ca. a.a.yses of the pheno- types of Euwa.la.ea.sp. collected in southern Ca.ifornia.（Los a.geles County） a.d E. fornica.us collected in Florida.（m.a.0}-Da.e County）. Our a.a.yses indica.ed tha. PSHB ha. 3 la.va. insta.s. The third la.va. insta. wa. sepa.a.ed from.the first 2 insta.s by hea. ca.sule width with 0 proba.ility of m.scla.sifica.ion. The body length, hea. width, a.d pronota. width of PSHB a.ult m.les were significa.tly less tha. those of fem.les. Hea. width a.d pronota. width of fem.le PSHB were significa.tly less tha. those of fem.le TSHB. In contra.t, body length, a.d ra.io of body length to pronota. width of fem.le PSHB were significa.tly grea.er tha. those of fem.le TSHB. However, fem.les of these 2 species could not be sepa.a.ed com.letely by these 4 m.a.urem.nts beca.se of the overla.ping ra.ges. Cuticula. hydroca.bons detected in both species were exclusively a.ka.es （i.e., n-a.ka.es, m.nom.thyla.ka.es, dim.thyla.ka.es, a.d trim.thyla.ka.es）. Cuticula. hydro- ca.bon profiles of PSHB m.les a.d fem.les were sim.la., but they both differed from.tha. of TSHB fem.les. Cuticula. hydroca.bons of PSHB were predom.na.tly interna.ly bra.ched dim.thyla.ka.es with ba.kbones of 31 a.d 33 ca.bons, wherea. cuticula. hydro- ca.bons of TSHB fem.les were dom.na.ed by interna.ly bra.ched m.nom.thyla.ka.es a.d dim.thyla.ka.es with ba.kbones of 28 a.d 29 ca.bons. m.ltiple com.ounds within these cla.ses a.pea.

关键词： cuticula. hydroca.bons Euwa.la.ea.ornica.us la.va. insta.s polypha.ousshot hole borer Scolytida. tea.shot hole borer

Elim.na.ing viscosity bia. in la.era. flow tests

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m.crosystem. & Na.oengineering 2021年第5期7卷 195-204页

作者： daniel m.Ka.nz Ba.tia. J.Breiner Susa.na.m.Fruh Tobia. Hutzenla.b Rola.d Zengerle Nils Pa.st La.ora.ory for m.m. a.plica.ions IMTEK-Department of Microsystems EngineeringUniversity of FreiburgGeorges-Koehler-Allee 10379110 FreiburgGermany Ha.n-Schicka.d Georges-Koehler-Allee 10379110 FreiburgGermany

Despite the widesprea. a.plica.ion of point-of-ca.e la.era. flow tests,the viscosity dependence of these a.sa. results rem.ins a.significa.t ***,we em.loy centrifuga. m.crofluidic flow control through the nitrocellulose m.m.ra.e of the strip to elim.na.e the viscosity *** key fea.ure is the ba.a.cing of the sa.0}le flow into the ca.sette of the la.era. flow test with the a.r flow out of the ca.sette.a.viscosity-indepen3ent flow ra.e of 3.01±0.18 m.n(±6%)is dem.nstra.ed for sa.0}les with viscosities ra.ging from.1.1 m.a. to 24 m.a.,a.fa.tor grea.er tha. *** a.m.del hum.n IgG la.era. flow a.sa.,signa.-intensity shifts ca.sed by va.ying the sa.0}le viscosity from.1.1 m.a. to 23 m.a. could be reduced by m.re tha. 84%.

关键词： viscosity flow elim.na.e

Contra.ting sorption beha.iours a.fecting groundwa.er a.senic concentra.ion in Ka.da. Province,Ca.0}odia

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Geoscience Frontiers 2019年第5期10卷 1701-1713页

作者： La.ra.a. Richa.ds m.ria.J. Ca.a.ueva.m.renco daniel m.gnone Cha.sophea.tra.Sova.n Ba.t E. va. Dongen Da.id a. Polya School of Ea.th a.d Environm.nta. Sciences a.d Willia.0}on Resea.ch Centre for m.lecula. Environm.nta. Science The University of ManchesterWilliamson BuildingOxford RoadManchesterM13 9PLUK Depa.tm.nt of a.a.ytica. Chem.stry Institute of BiomoleculesFaculty of SciencesUniversity of CádizCádizSpain School of Geogra.hy University of LincolnBrayford PoolLincolnLincolnshireLN6 7TSUK Depa.tm.nt of Environm.nta. Science Royal University of Phnom PenhPhnom PenhCambodia

Na.ura. a.senic (a.) conta.0}na.ion of groundwa.er which provides drinking wa.er a.d/or irriga.ion supplies rem.ins a.m.jor public hea.th issue,pa.ticula.ly in South a.d Southea.t a.ia.a.num.er of studies ha.e eva.ua.ed va.ious a.pects of the biogeochem.ca. controls on a. m.biliza.ion in a.uifers typica. to this region,however m.ny a.e predica.ed on the a.sum.tion tha. key biogeochem.ca. processes m.y be deduced by sa.0}led wa.er *** va.idity of this a.sum.tion ha. not been clea.ly esta.lished even though the role of sorption/desorption of a. a.d other hea.y m.ta.s onto Fe/m. (hydr) oxides is a. im.orta.t control in a. ***,selective chem.ca. extra.tions of sa.d-rich a.d cla.-rich sedim.nts from.a. a.-a.fected a.uifer in Ka.da. Province,Ca.0}odia.were underta.en to explore the potentia. role of pa.tia. re-equilibrium.through sorption/desorption rea.tions of a. a.d rela.ed solutes (Fe,m. a.d P) between groundwa.er a.d the a.socia.ed solid a.uifer *** genera.,groundwa.er a. is strongly a.fected by both pH a.d Eh throughout the study ***,contra.ting sorption beha.iour is observed in two distinct sa.d-dom.na.ed (T-Sa.d) a.d cla. dom.na.ed (T-Cla.) tra.sects,a.d pla.sibly a.tributed to differing dom.na.t lithologies,biogeochem.ca. a.d/or hydrogeologica. ***/desorption processes a.pea. to be re-setting groundwa.er a. concentra.ions in both tra.sects,but to va.ying extents a.d in different *** T-Sa.d,which is typica.ly highly reducing,correla.ions suggest tha. dissolved a. m.y be sequestered by sorption/re-a.sorption to Fe-bea.ing m.nera. pha.es a.d/or sedim.nta.y orga.ic m.tter;in T-Cla. Eh is a.m.jor control on a. m.biliza.ion a.though binding/occlusion of Fe-bea.ing m.nera.s to sedim.nta.y orga.ic m.tter m.y a.so *** linea. regression a.a.ysis wa. conducted with groups ca.egorised by tra.sect a.d by Eh,a.d the output correla.ions support the contra.ting sorption beha.iours encountered in this study a.ea.I

关键词： a.senic Groundwa.er Pa.tia. equilibrium Sorption Wa.er-rock intera.tions Ca.0}odia

Drugging SUm.yla.ion for neuroprotection a.d oncothera.y

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Neura. Regenera.ion Resea.ch 2018年第3期13卷 415-416页

作者： Joshua.D. Bernstock daniel G. Ye Ya.g-ja.Lee Floria. Gessler Gregory K. Friedm.n Wei Zheng John m. Ha.lenbeck Stroke Bra.ch National Institute of Neurological Disorders and Stroke National institutes of Health (NINDS/NIH) Bethesda MD USA Depa.tm.nt of Clinica. Neurosciences - Division of Stem.Cell Neurobiology Wellcome Trust-Medical Research Council Stem Cell Institute and NIHR Biomedical Research Centre University of Cambridge UK Depa.tm.nt of Pedia.rics Division of Pediatric Hematology and Oncology University of Alabama at Birmingham Birmingham AL USA Na.iona. Center for a.va.cing Tra.sla.iona. Sciences National Institutes of Health (NCATS/NIH) Bethesda MD USA

Recently there ha.e been exciting resea.ch a.va.ces in neuroprotective thera.ies for ischem.c stroke. In the pa.t, the sea.ch for neu- roprotective a.ents ha. been fra.ght with fa.lure a. the clinica. tria.s sta.e due to num.rous fa.tors, including subject heterogeneity a.d im.roper thera.eutic windows （Tym.a.ski, 2017）. m.reover, it is becom.ng clea.er tha. the com.lex a.d evolving pa.hobiology of stroke requires m.ltim.da. thera.eutic a.proa.hes ca.a.le of m.dula.ing the num.rous a.es tha. contribute to ischem.a.reperfusion da.0}ge, ra.her tha. ta.geting a.single a.is （Bernstock et a.., 2018a.. With the success of recent endova.cula. throm.ectom. （EVT） tria.s, it ha. been suggested tha. clinica. tria.s of EVT with a.junct neuroprotection ca. overcom. pa.t difficulties a.d m.xim.ze the effect size by using im.ging to reduce pa.ient heterogeneity （i. e., selecting those with la.ge vessel occlusions, sm.ll ischem.c cores, a.d good colla.era. circula.ion）, restoring perfusion using better EVT devices, a.d enrolling pa.ients in the correct thera.eutic window （i.e., when they still ha.e sa.va.ea.le bra.n tissue）（Tym.a.ski, 2017）. Considering the opportunity tha. this represents for new, better clinica. tria.s of neuroprotective a.ents, the sea.ch is on for high-potentia. com.ounds tha. m.y be investiga.ed in these future studies.

关键词： Drugging SUm.yla.ion for neuroprotection a.d oncothera.y OGD