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成人隐匿阴茎治疗的综述

中国美容整形外科杂志 2012年第5期23卷 I0012-I0017页

作者： Ivo A. Pestana Jason m. Greenfield mark Walsh Craig F. Donatucci Detlev Erdmann 冯爱娜陶凯魏峰高景恒张晨美国北卡罗来纳州达勒姆杜克大学医学中心外科部整形再造与口腔颌面外科泌尿外科沈阳军区总医院整形外科《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

背景与目的导致隐匿阴茎的原因很多，最常见的是肥胖、包皮环切术后或阴囊水肿。随着肥胖病日益增多，这种病症的发病率也必然增多。儿童先天性隐匿阴茎极为罕见，其结果也是转变成为成人隐匿阴茎。本文的目的旨在综述目前对于此类身心... 详细信息

背景与目的导致隐匿阴茎的原因很多，最常见的是肥胖、包皮环切术后或阴囊水肿。随着肥胖病日益增多，这种病症的发病率也必然增多。儿童先天性隐匿阴茎极为罕见，其结果也是转变成为成人隐匿阴茎。本文的目的旨在综述目前对于此类身心疾患的治疗策略。方法对有关隐匿阴茎治疗的文献进行综述，文献主要来源是1977年至2007年Pubmed中刊登的整形外科和泌尿外科文献。结果病态肥胖症和糖尿病是成人隐匿阴茎的危险因素。文献中介绍了多种复位和重建的手术方法，如原位缝合、z成形、植皮修复等，修复过程中均可能进行脂肪切除。最近的文献更多关注采用断层皮片和负压技术进行治疗，该技术有利于皮片成活，远期美观效果良好。结论隐匿阴茎临床少见，治疗困难，对于整形科和泌尿外科医师具有挑战性。潜在因素如病态肥胖和糖尿病的增加，提示这种疾病的发生率也将不断上升。没有某一特定的技术适用于所有患者，治疗时可以采用几种技术的联合。对于疑难重症患者，可以进行阴茎体断层皮片移植术、阴囊缩小术，并可辅助负压吸脂术或脂肪切除术。个体化治疗方法可以获得更高的修复成功率，并且达到满意的美观效果。

关键词：隐匿阴茎治疗方法综述成人泌尿外科医师外科文献病态肥胖症脂肪切除术

空间分辨力与管电流对CT结肠成像计算机辅助息肉检出影响的模型研究

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国际医学放射学杂志 2008年第5期31卷 402-402页

作者： S.H.Kim J.m.Lee C.I. Shin H.C.Kim J.G.Lee J.H.Kim 唐光健 Department of Radiology Institute of Radiation Medicine Seoul National University College of Medicine 28 Yongon-dong Chongno-gu Seoul 110-744 Korea.

目的前瞻性评价z轴分辨力与管电流对普通CT结肠成像计算机辅助诊断（CAD）系统在猪结肠模型的息肉检出中的影响。方法在14个猪结肠模型上制造了96个息肉。在16层CT上扫描获得CT结肠影像，扫描准直器宽0．75mm，采用10、50、100与160mAs... 详细信息

目的前瞻性评价z轴分辨力与管电流对普通CT结肠成像计算机辅助诊断（CAD）系统在猪结肠模型的息肉检出中的影响。方法在14个猪结肠模型上制造了96个息肉。在16层CT上扫描获得CT结肠影像，扫描准直器宽0．75mm，采用10、50、100与160mAs；螺矩为1．5。每扫描1mAs，CT影像重建厚度（ST）均为1．5mm，重建间隔（RI）为1．3mm。为评价z轴空间分辨力的影响，还对100mAs的CT扫描用不同的ST（原文为SI，可能有误）与RI组合进行重建（分别为1．0与0．7mm，3．0与2．0mm，3．0与3．0mm．5．0与5．0mm）。随后用CAD程序分析模型数据。

关键词： CT结肠成像计算机辅助诊断空间分辨力管电流模型息肉 CT扫描影像重建

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Fungal diversity notes 1–110:taxonomic and phylogenetic contributions to fungal species

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Fungal Diversity 2015年第3期72卷 1-197页

作者： Jian Kui Liu Kevin D.Hyde E.B.Gareth Jones Hiran A.Ariyawansa Darbhe J.Bhat Saranyaphat Boonmee Sajeewa S.N.maharachchikumbura Eric H.C.mcKenzie Rungtiwa Phookamsak Chayanard Phukhamsakda Belle Damodara Shenoy mohamed A,Abdel-Wahab Bart Buyck Jie Chen K.W.Thilini Chethana Chonticha Singtripop Dong Qin Dai Yu Cheng Dai Dinushani ADaranagama Asha J.Dissanayake mingkwan Doilom melvina J.D’souza Xin Lei Fan Ishani DGoonasekara Kazuyuki Hirayama Sinang Hongsanan Subashini C.Jayasiri Ruvishika S.Jayawardena Samantha C.Karunarathna Wen Jing Li Ausana mapook Chada Norphanphoun Ka Lai Pang Rekhani H.Perera Derek Peršoh Umpava Pinruan Indunil CSenanayake Sayanh Somrithipol Satinee Suetrong Kazuaki Tanaka Kasun m.Thambugala Qing Tian Saowaluck Tibpromma Danushka Udayanga Nalin N.Wijayawardene Dhanuska Wanasinghe Komsit Wisitrassameewong Xiang Yu zeng Faten AAbdel-Aziz Slavomir Adamčík Ali H.Bahkali Nattawut Boonyuen Timur Bulgakov Philippe Callac Putarak Chomnunti Katrin Greiner Akira Hashimoto Valerie Hofstetter Ji Chuan Kang David Lewis Xing Hong Li Xing zhong Liu zuo Yi Liu misato matsumura Peter E.mortimer Gerhard Rambold Emile Randrianjohany Genki Sato Veera Sri-Indrasutdhi Cheng ming Tian Annemieke Verbeken Wolfgang von Brackel Yong Wang Ting Chi Wen Jian Chu Xu Ji Ye Yan Rui Lin zhao Erio Camporesi Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanChina Institute of Excellence in Fungal Research and School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Botany and microbiology King Saudi UniversityRiyadhSaudi Arabia manaaki Whenua Landcare Research Private Bag 92170AucklandNew Zealand Formerly Department of Botany Goa UniversityGoaIndia No.128/1–J Azad Housing SocietyCurcaGoa VelhaIndia muséum national d’histoire naturelle Dépt.Systématique etévolutionUMR 720575005 ParisFrance Institute of microbiology&Beijing Key Laboratory for Forest Pest Control Beijing Forestry UniversityPO Box 61Beijing 100083China Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesNo.9 of Shu Guang Hua Yuan Zhong LuHaidian DistrictBeijing 10097China The Key Laboratory for Silviculture and Conservation of ministry of Education Beijing Forestry UniversityBeijing 100083China mycology University of BayreuthUniversitätsstraße 3095440 BayreuthGermany The United Graduate School of Agricultural Sciences Iwate University18-8 Ueda 3 chomeMorioka 020-8550Japan Apple Experiment Station Aomori Prefectural Agriculture and Forestry Research Center24 FukutamiBotandairaKuroishiAomori 036-0332Japan Department of Plant Protection Agroscope Changins-Wadenswil Research Station ACWRte de Duiller1260 NyonSwitzerland Department of Botany and microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany Faculty of ScienceSohag UniversitySohagEgypt Institute of Botany Slovak Academy of SciencesDúbravskácesta 984523 BratislavaSlovakia Hirosaki University Bleakwood262 CR 3062NewtonTexas 75966USA Faculty of Agriculture and Life Sciences Hirosaki University3 Bunkyo-choHirosakiAomori

This paper is a compilation of notes on 110 fungal taxa,including one new family,10 new genera,and 76 new species,representing a wide taxonomic and geographic *** new family,Paradictyoarthriniaceae is introduced based on its distinct lineage in Dothideomycetes and its unique *** family is sister to Biatriosporaceae and *** new genera are Allophaeosphaeria(Phaeosphaeriaceae),Amphibambusa(Amphisphaeriaceae),Brunneomycosphaerella(Capnodiales genera incertae cedis),Chaetocapnodium(Capnodiaceae),Flammeascoma(Anteagloniaceae),multiseptospora(Pleosporales genera incertae cedis),Neogaeumannomyces(magnaporthaceae),Palmiascoma(Bambusicolaceae),Paralecia(Squamarinaceae)and Sarimanas(melanommataceae).The newly described species are the Ascomycota Aliquandostipite manochii,Allophaeosphaeria dactylidis,***,Alternaria cesenica,Amphibambusa bambusicola,Amphisphaeria sorbi,Annulohypoxylon thailandicum,Atrotorquata spartii,Brunneomycosphaerella laburni,Byssosphaeria musae,Camarosporium aborescentis,***,***,Chaetocapnodium siamensis,Chaetothyrium agathis,Colletotrichum sedi,Conicomyces pseudotransvaalensis,Cytospora berberidis,***,Diaporthe thunbergiicola,Diatrype palmicola,Dictyosporium aquaticum,***,***,Didymella cirsii,Dinemasporium nelloi,Flammeascoma bambusae,Kalmusia italica,***,Keissleriella sparticola,Lauriomyces synnematicus,Leptosphaeria ebuli,Lophiostoma pseudodictyosporium,***,Lophiotrema eburnoides,montagnula graminicola,multiseptospora thailandica,myrothecium macrosporum,Natantispora unipolaris,Neogaeumannomyces bambusicola,Neosetophoma clematidis,***,Oxydothis atypica,Palmiascoma gregariascomum,Paraconiothyrium nelloi,***,Paradictyoarthrinium tectonicola,Paralecia pratorum,Paraphaeosphaeria spartii,Pestalotiopsis digitalis,***,***,Phaeoisaria pseudoclematidis,Phragmocapnias philippinensis,Pseudocamarosporium cotinae,Pseudocercospora tam

关键词： Ascomycota Basidiomycota Global Taxonomy Initiative Phylogeny Taxonomy

高原子序数元素CT影像对比:模拟成像研究与临床适应证

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国际医学放射学杂志 2016年第3期 301-301页

作者： P.F.Fitz Gerald R.E.Colborn P.m.Edic J.W.Lambert A.S.Torres P.J.Bonitatibus Jr 蓝星 Radiation Systems Lab.GE Global Research One Research Circle

摘要目的在临床相关成像条件下,比较不同对比剂的CT影像对比度。材料与方法相等质量浓度(每毫升溶液中所含活性成分的克数)的7种对比剂,包括碘、钡、钆、钽、镱、金、铋,配置成水溶液。依据活性元素主导X线的衰减的标准来选择复合物。... 详细信息

摘要目的在临床相关成像条件下,比较不同对比剂的CT影像对比度。材料与方法相等质量浓度(每毫升溶液中所含活性成分的克数)的7种对比剂,包括碘、钡、钆、钽、镱、金、铋,配置成水溶液。依据活性元素主导X线的衰减的标准来选择复合物。在80、100、120和140 k V CT下用修改后的32 cm CT剂量指数模型。为模拟更大的体积,我们分别使用

关键词： CT

Alignment of solid targets under extreme tight focus conditions generated by an ellipsoidal plasma mirror

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matter and Radiation at Extremes 2019年第2期4卷 30-35页

作者： Deepak Kumar michal Smid Sushil Singh Alexander Soloviev Hannes Bohlin Konstantin Burdonov Gashaw Fente Alexander Kotov Livia Lancia Vit Leedl Sergey makarov michael morrissey Sergey Perevalov Denis Romanovsky Sergey Pikuz Ryousuke Kodama David Neely Paul mcKenna Tomas Lastovicka mikhail Starodubtsev Stefan Weber motoaki Nakatsutsumi Julien Fuchs ELI Beamlines Institute of Physics5.kvetna 83525241 Dolni BrezanyCzech Republic Institute of Applied Physics of the Russian Academy of Sciences(IAP RAS) 46 Ulyanov Street603950 Nizhny NovgorodRussia LULI-CNRS Ecole PolytechniqueCEA:Universite Paris-SaclayUPMC Univ Paris 06:Sorbonne UniversitiesF-91128 Palaiseau CedexFrance Research Center Toptec Institute of Plasma PhysicsSobotecka 166051101 TurnovCzech Republic Joint Institute for High Temperatures Russian Academy of Science(JIHT RAS) Moscow 125412Russia Division of Electrical Electronic and Information EngineeringGraduate School of EngineeringOsaka UniversityOsakaJapan Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Department of Physics SUPA University of StrathclydeGlasgow G40NGUnited Kingdom European XFEL GmbH Holzkoppel 422869 SchenefeldGermany

The design of ellipsoidal plasma mirrors(EPms)for the PEARL laser facility is *** EPms achieve a magnification of 0.32 in focal spot size,and the corresponding increase in focused intensity is expected to be about *** and implementing such focusing optics for short-pulse(ms paves the way for their use in future high-power facilities,where they can be used to achieve intensities beyond 1023W/cm^(2).A retro-imaging-based target alignment system is also described,which is used to align solid targets at the output of the ellispoidal mirrors(with a numerical aperture of 0.75 in this case).

关键词： beyond mirror extreme

Biochemical composition and nutritional value in the muscle of yellowback seabream Dentex tumifrons（Temminck ＆ Schlegel,1843）,wild-caught in the East China Sea,China

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Biochemical composition and nutritional value in the muscle ...

Biochemical composition and nutritional value in the muscle of yellowback seabream Dentex tumifrons(Temminck & Schlegel,1843),wild-caught in the East China Sea

中国工程院第77场工程科技论坛·2008水产科技论坛—...

作者： XIA L J~1,LU J X~1,HOU J L~1,zHONG J S~2,XIN J~3,LIU m~(3,*) (1.Key and Open Laboratory of marine and Estuarine Fisheries,ministry of Agriculture of China,East China Sea Fisheries Research Institute,Chinese Academy of Fisheries Science,Shanghai,200090,China 2.College of Aqua -life Science and Technology,Shanghai Fisheries University,Shanghai,200090,China 3.marine Fisheries Research Institute of zhejiang Province,zhoushan,316100,China 4.Swire Institute of marine Science and Division of Ecology & Biodiversity,School of Biological Sciences,University of Hong Kong,Pokfulam Road,Hong Kong SAR)

＜正＞Biochemical composition and nutritional value in the muscle of wild-caught Dentex tumifrons in the East China Sea were determined,evaluated and compared with another three maricultured sparids,Acanthopagrus schlegilii schlegilii,Pagrus major and Rhabdosargus *** muscle of *** consisted of 18.30%crude protein and 0.47%crude lipid;crude protein was higher and crude lipid lower than *** schlegilii,*** and *** the muscle of ***, the total essential amino acids（EAA）required by humans comprised 42.88%of total amino acids,higher than *** schlegilii,*** and *** first limiting amino acid （s）was Threonine（Thr）based on the amino acid score（AAS）,and were methionine（met）and Cysteine（Cys）based on the chemical score（CS）.The EAA index was *** 19 fatty acids were *** acid（EPA）and docosahexaenoic acid（DHA）contributed to 22.65%of the total fatty acids with 17.25%from *** composition and nutritional value in the muscle of wild-caught Dentex tumifrons provide information on food quality and nutritive requirement and composition of the species,which will help to develop resembling feeds for its mariculture.

关键词： amino acid Dentex tumifrons fatty acid nutritive evaluation Sparidae

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Biochemical composition and nutritional value in the muscle ...

FAIR Principles:Interpretations and Implementation Considerations

中国工程院第77场工程科技论坛·2008水产科技论坛——渔业现代化与可持续发展

作者： XIA L J~1,LU J X~1,HOU J L~1,zHONG J S~2,XIN J~3,LIU m~4 (1.Key and Open Laboratory of marine and Estuarine Fisheries,ministry of Agriculture of China,East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Shanghai 200090,China 2.College of Aqua-life Science and Technology,Shanghai Fisheries University,Shanghai 200090,China 3.marine Fisheries Research Institute of zhejiang Province,zhoushan 316100,China 4.Swire Institute of marine Science and Division of Ecology & Biodiversity, School of Biological Sciences,University of Hong Kong,Pokfulam Road,Hong Kong SAR)

Biochemical composition and nutritional value in the muscle of wild-caught Dentex tumifrons in the East China Sea were determined,evaluated and compared with other three maricultured sparids, Acanthopagrus schlegilii schlegilii,Pagrus major and Rhabdosargus *** muscle of *** consisted of 18.30%crude protein and 0.47%crude lipid;the centent of crude protein was higher and crude lipid lower than those of *** schlegilii,*** and *** muscle of ***, the total essential amino acids(EAA)required by humans comprised 42.88%of total amino acids,higher than that of *** schlegilii,*** and *** first limiting amino acid (s)was Threonine(Thr)based on the amino acid score(AAS),and were methionine(met)and Cysteine(Cys)based on the chemical score(CS).The EAA index was *** 19 fatty acids were *** acid(EPA)and docosahexaenoic acid(DHA)contributed to 22.65%of the total fatty acids with 17.25%from *** composition and nutritional value in the muscle of wild-caught Dentex tumifrons provide information on food quality and nutritive requirement and composition of the species,which will help to develop resembling feeds for its mariculture.

关键词： amino acid Dentex tumifrons fatty acid nutritive evaluation Sparidae

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Data Intelligence 2020年第1期2卷 10-29,293-302,322页

作者： Annika Jacobsen Ricardo de miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet melanie Courtot merce Crosas michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara magagna PetermcQuilton Natalie meyers Annalisa montesanti mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn mark Thompson Andra Waagmeester Tobias Weigel mark D.Wilkinson Egon L.Willighagen Peter Wittenburg marco Roos Barend mons Erik Schultes Leiden University medical Center Leiden2333 ZAThe Netherlands Institute of Data Science Maastricht UniversityUniversiteitssingel 60Maastricht 6229 ERThe Netherlands Department of Computer Science The University of ManchesterOxford RoadManchester M139PLUK Oxford e-Research Centre Department of Engineering SciencesUniversity of OxfordOxford OX13PJUK School of Chemistry Faculty of Engineering and Physical SciencesUniversity of SouthamptonSO171BJUK Amsterdam UmC University of AmsterdamAmsterdam 1000 GGThe Netherlands European Bioinformatics Institute(EmBL-EBI) HinxtonCambridgeCB101SDUK Harvard University CambridgeMassachusetts 02138USA Department of Bioinformatics–BiGCaT NUTRIMMaastricht UniversityMaastricht 6229 ERThe Netherlands Conceptual and Cognitive modeling Research Group(CORE) Free University of Bozen-BolzanoBolzano 39100Italy Aalborg University Aalborg DK-9220Denmark Insight Centre for Data Analytics National University of Ireland GalwayH91 TK33Ireland Centre for Digital Scholarship Leiden University LibrariesLeiden2333 ZAThe Netherlands Department of Computer Science Vrije Universiteit AmsterdamDe Boelelaan 11051081 HV AmsterdamThe Netherlands Dutch Techcentre for Life Sciences(DTL) UtrechtThe Netherlands SURF Utrecht 3511 EPThe Netherlands Keith G Jeffery Consultants FaringdonUK Castor EDC Paasheuvelweg 25Wing 5D1105 BPAmsterdamThe Netherlands San Diego Supercomputer Center University of California San DiegoLa JollaCalifornia 92093USA Learning and Research Resources Centre(CRAI) Universitat de Barcelona08007 BarcelonaSpain Environment Agency Austria A-1090 ViennaAustria University of Notre Dame 75004 ParisFrance Health Research Board(HRB) Dublin 2DO2 H638Ireland Liacs Institute of Advanced Computer Science Leiden University2311 GJ LeidenThe Netherlands Czech Technical University in Prague Faculty of Information Technology(FIT CTU)16000 Prague 6Czech Republic GO FAIR International Support&Coordination Office(GFISCO) LeidenThe Netherlands Harvard Catalys

The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in *** intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital *** has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR ***,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible ***,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-*** introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR *** self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the ***,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle.

关键词： FAIR guiding principles FAIR implementation FAIR convergence FAIR communities choices and challenges

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血浆置换治疗儿童溶血尿毒综合征多中心流行病学调查

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中华实用儿科临床杂志 2018年第13期33卷 1022-1027页

作者：中国医师协会儿科医师分会血液净化专家委员会郑悦徐可雷晔飞冯仕品王墨郝志宏高岩李宇红周萍肖政辉赵凯妹夏正坤栾春丽刘雪梅赵丽君陆国平张育才陈朝英栾江威张建江刘翠华陈丽植赵成广吴玉斌姚勇曲强谢敏刘喜万俊丽焦佳石咏琪杨琴于力张瑶李颖杰许自川蒋新辉邵晓珊张思佳卢秀兰张岩马青山何旭史卓李倩孙书珍张洪霞潘艳艳仇三玲蔡小狄徐虹朱艳史婧奕耿海云祝高红戚畅贾莉敏刘俊梅厉洪江李广波蒋小云不详中国医科大学附属盛京医院小儿肾脏风湿免疫科沈阳110004 北京大学第一医院儿科 100034 郴州市第一人民医院儿科湖南郴州423000 成都市妇女儿童中心医院肾内科 610091 重庆医科大学附属儿童医院肾脏免疫科 400014 广州市第一人民医院儿科 510180 广州市妇女儿童医疗中心肾内科 510120 贵阳市儿童医院肾脏风湿科 550003 哈尔滨医科大学附属第二医院儿科 150086 湖南省儿童医院急救中心长沙410007 吉林大学白求恩第一医院儿童肾病科吉林130021 南京军区南京总医院儿科 210002 山东大学附属省立医院儿科肾脏风湿免疫科济南250021 山东大学齐鲁儿童医院肾内科济南250022 山西省儿童医院肾内科太原030013 复旦大学附属儿科医院重症医学科上海201102 上海市儿童医院重症医学科 200042 首都儿科研究所附属儿童医院肾内科 100020 武汉儿童医院肾内科 430016 郑州大学第一附属医院儿内科 450052 郑州大学附属儿童医院肾脏风湿科 450018 中山大学附属第一医院儿科广州510080

目的了解全国儿科血浆置换治疗溶血尿毒综合征（HUS）的现状，为进一步规范诊疗共识提供参考依据。方法中国医师协会儿科医师分会血液净化专家委员会讨论并制定调查表，以问卷调查的形式，收集22家单位2012年1月至2017年12月住院的146... 详细信息

目的了解全国儿科血浆置换治疗溶血尿毒综合征（HUS）的现状，为进一步规范诊疗共识提供参考依据。方法中国医师协会儿科医师分会血液净化专家委员会讨论并制定调查表，以问卷调查的形式，收集22家单位2012年1月至2017年12月住院的146例行血浆置换的HUS患儿的病历资料进行统计学分析。结果1．共收集数据146例，其中男91例，女55例；平均年龄5.68岁（2个月～18岁）；病因主要为感染（60例，41.1%），其次为补体缺陷（18例，12.3%）、药物（15例，10.3%）、风湿性疾病（9例，6.2%）及遗传代谢病（6例，4.1%）等。2.血液置换前患儿主要表现为少尿或无尿（101例），其次为意识障碍（45例）、高血压（58例）、消化道出血（42例）等症状，置换后明显缓解。3.血浆置换前实验室指标主要表现为血红蛋白[（68.26±18.17） g/L]、红细胞计数[（2.43±0.70） ×10^9/L]、血小板计数[（77.49±72.93） ×10^9/L]、补体C3[（0.70±0.26） g/L]、肾小球滤过率（GFR） [（26.98±17.16） mL/1.73 m2]下降，总胆红素[（44.33±42.07） μmol/L]、非结合胆红素[（30.78±26.68） μmol/L]、纤维蛋白降解产物（FDP）[（12.52±14.97） mg/L]、D-二聚体[（2 306.20±2 354.97） μg/L]、肌酐[（305.45±290.19） μmol/L]、24 h尿蛋白[（2.17±2.55） g/d]升高，置换后以上指标均显著好转[分别为（85.08±18.98） g/L、（2.80±0.98）×10^9/L、（183.80±131.95）×10^9/L、（0.85±0.25） g/L、（98.58±66.02） mL/1.73 m2、（19.71±33.24） μmol/L、（9.60±10.00） μmol/L、（7.33±9.81） mg/L、（1 322.05±1 595.23） μg/L、（139.28±163.75） μmol/L、（1.46±2.03） g/d]，差异均有统计学意义（均P〈0.05）。4.出现并发症5例，2例低血压休克，管路堵塞、血小板减少、贫血加重各1例。5.经治疗后好转130例（89%），死亡16例（11%）。结论血浆置换治疗儿童HUS在国内已较广泛开展，有效性和安全性已得到证实，其治疗时机有待循证医学进一步证实。

关键词：溶血尿毒综合征血浆置换儿童流行病学

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