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Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease

World Journal of Gastroenterology 2015年第35期21卷 10080-10090页

作者： John J miklavcic Glen K Shoemaker Vera C mazurak m tom clandinin Tasha DL Hart Kareena L Schnabl Gordon m Lees Bodil mK Larsen Oliver F Bathe Alan BR Thomson m tom clandinin Alberta Institute for Human Nutrition University of Alberta Edmonton AB T6G 2R1 Canada Department of Laboratory medicine and Pathology University of Alberta Edmonton AB T6G 2B7 Canada Division of General Surgery University of Alberta Edmonton AB T6G 2B7 Canada Alberta Health Services Edmonton AB T6G 2B7 Canada Alberta Health Services Calgary AB T2N 4N2 Canada Division of Gastroenterology Western University London ON N6A 5A5 Canada Department of medicine University of Alberta Edmonton AB T6G 2B7 Canada

AIm: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. mETHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes Gm1, Gm3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative Gm3 ganglioside content was 2-fold higher(P m patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of Gm3 and ratio of Gm3/GD3 was also higher in IBD intestine than control tissue(P more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold

关键词： Ganglioside Phospholipid Fatty acid Lipid Inflamma

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morphological,kinetic,membrane biochemical and genetic aspects of intestinal enteroplasticity

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World Journal of Gastroenterology 2009年第7期15卷 774-787页

作者： Laurie A Drozdowski m tom clandinin Alan BR Thomson medical Affairs mead Johnson Nutritionals Department of Agriculture Food and Nutritional SciencesUniversity of Alberta Division of Internal medicine Department of MedicineUniversity of Alberta

The process of intestinal adaptation("enteroplasticity") is complex and *** a number of trophic nutrients and non-nutritive factors have been identified in animal studies,successful,reproducible clinical trials in humans are *** mechanisms underlying this adaptive process may direct research toward strategies that maximize intestinal function and impart a true clinical benefit to patients with short bowel syndrome,or to persons in whom nutrient absorption needs to be *** this review,we consider the morphological,kinetic and membrane biochemical aspects of enteroplasticity,focus on the importance of nutritional factors,provide an overview of the many hormones that may alter the adaptive process,and consider some of the possible molecular *** most of the data is derived from rodent studies,wherever possible,the results of human studies of intestinal enteroplasticity are provided.

关键词： Diabetes Diet Hormonal regulation Intestinal resection mechanisms morphology Nutrientabsorption Short bowel syndrome Signals

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Nutritional modulation of the inflammatory response in inflammatory bowel disease-From the molecular to the integrative to the clinical

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World Journal of Gastroenterology 2007年第1期13卷 1-7页

作者： Gary E Wild Laurie Drozdowski Carmela Tartaglia m tom clandinin Alan BR Thomson Department of medicine Division of Gastroen- terology McGill University Montreal Quebec Department of Anatomy and Cell Biology McGill University Montreal Quebec Canada Division of Gastro- enterology University of Alberta Edmonton Alberta Canada Department of Physiology McGill Univer- sity Montreal Quebec Canada Department of Agriculture Foods and Nutri- tion University of Alberta Edmonton Alberta Canada

Nutrient deficiencies are common in patients with inflammatory bowel disease （IBD）. Both total parenteral and enteral nutrition provide important supportive therapy for IBD patients, but in adults these are not useful for primary therapy. Dietary intervention with omega-3 polyunsaturated fatty acids contained in fish oil may be useful for the care of IBD patients, and recent studies have slyessed the role of PPAR on NFKB activity on the potential beneficial effect of dietary lipids on intestinal function.

关键词： Crohn's disease Ulcerative colitis Enteral nutrition Parenteral nutrition Glutamine Fiber Long chain fatty acids

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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep tomàs Víctor Cilleros-mañé Laia Just-Borràs marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal marta tomàs Carolina Silvera-Simón manel m.Santafé maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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Ontogeny,growth and development of the small intestine:Understanding pediatric gastroenterology

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World Journal of Gastroenterology 2010年第7期16卷 787-799页

作者： Laurie A Drozdowski tom clandinin Alan BR Thomson medical Affairs Mead Johnson NutritionalsOttawaOntarioK1S 5N4Canada Department of Agricultural Food and Nutritional ScienceUniversity of AlbertaAlbertaT6G 2B7Canada Division of General Internal medicine Department of MedicineUniversity of AlbertaAlbertaT6G 2B7Canada

Throughout our lifetime,the intestine *** alterations in its form and function may be genetically determined,and some are the result of adaptation to diet,temperature,or *** critical period programming of the intestine can be modified,such as from subtle differences in the types and ratios of n3:m6 fatty acids in the diet of the pregnant mother,or in the diet of the *** early forced adaptation may persist in later life,such as the unwanted increased intestinal absorption of sugars,fatty acids and ***,the ontogeny,early growth and development of the intestine is important for the adult gastroenterologist to appreciate,because of the potential for these early life events to affect the responsiveness of the intestine to physiological or pathological challenges in later life.

关键词： Intestinal development Ontogeny Pediatrics

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Recent advances in small bowel diseases:Part Ⅰ

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World Journal of Gastroenterology 2012年第26期18卷 3336-3352页

作者： Alan BR Thomson Angeli Chopra michael tom clandinin Hugh Freeman Department of medicine University of Western OntarioLondonON N6A 5A5Canada Division of General Internal medicine University of AlbertaEdmontonAB T6G 2X8Canada Department of Agricultural Foodand Nutritional ScienceUniversity of AlbertaEdmontonAB T6G 2R1Canada Division of Gastroenterology University of British ColumbiaVancouverBC V6T 2B5Canada

As is the case in all parts of gastroenterology and hepatology,there have been many advances in our knowledge and understanding of small intestinal *** 1000 publications were reviewed for 2008 and 2009,and the important advances in basic science as well as clinical applications were *** Part Ⅰ of this Editorial Review,seven topics are considered:intestinal development;proliferation and repair;intestinal permeability;microbiotica,infectious diarrhea and probiotics;diarrhea;salt and water absorption;necrotizing enterocolitis;and immunology/*** topics were chosen because of their importance to the practicing physician.

关键词： Diarrhea Infectious diarrhea Intestinal development Intestinal proliferation and repair Intestinalpermeability microbiotica Necrotizing enterocolitis Probiotics

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Recent advances in celiac disease

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World Journal of Gastroenterology 2011年第18期17卷 2259-2272页

作者： Hugh James Freeman Angeli Chopra michael tom clandinin Alan BR Thomson Division of Gastroenterology University of British Columbia Division of General Internal medicine University of Alberta Department of Agricultural Food and Nutritional Science University of Alberta

Celiac disease now affects about one person in a hundred in Europe and North America. In this review, we consider a number of important and exciting recent developments, such as clinical associations, HLA-DQ2 and HLA-DQ8 predispositions, the concept of potential celiac disease, the use of new imaging/endoscopy techniques, and the development of refractory disease. This review will be of use to all internists, pediatricians and gastroenterologists.

关键词： Inflammation Infection malabsorption Pathophysiology Physiology

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Dehydration melting and Proterozoic Granite Petrogenesis in a Collisional Orogen——A Case from the Svecofennian of Southern Finland

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Journal of Earth Science 2021年第6期32卷 1289-1299页

作者： tom Andersen O.Tapani Rämö Department of Geosciences University of OsloN-0316OsloNorway Department of Geosciences and Geography Geology and Geophysics Research ProgramUniversity of Helsinki00014HelsinkiFinland

Dehydration melting of metasupracrustal rocks at mid-to deep-crustal levels can generate water undersaturated granitic *** this study,we evaluate the potential of~1.89–1.88 Ga metasupracrustal rocks of the Precambrian of southern Finland as source rocks for the 1.86–1.79 Ga late-orogenic leucogranites in the region,using the Rhyolite-mELTS *** close in composition to leucogranite is produced over a range of realistic pressures(5 to 8 kbar)and temperatures(800 to 850℃),at 20%–30%of partial melting,allowing separation of melt from unmelted *** solid residue is a dry,enderbitic to charnoenderbitic ganulite depleted in incompatible components,and will only yield further melt above 1000–1050℃,when rapidly increasing fractions of increasingly calcic(granodioritic to tonalitic)melts are *** solid residue after melt extraction is incapable of producing syenogranitic magmas similar to the mid-Proterozoic,A-type rapakivi granites on further *** granitic fraction of the syenogranitic rapakivi complexes must thus have been formed by a different chain of processes,involving mantle-derived mafic melts and melts from crustal rock types not conditioned by the preceding late-orogenic Svecofennian anatexis.

关键词： leucogranite rapakivi granite anatexis restite depleted granulite Finland

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Biometric Finger Vein Recognition Using Evolutionary Algorithm with Deep Learning

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Computers, materials & Continua 2023年第6期75卷 5659-5674页

作者： mohammad Yamin tom Gedeon Saleh Bajaba mona m.Abusurrah Department of management Information Systems Faculty of Economics and AdministrationKing Abdulaziz UniversityJeddah21589Saudi Arabia Optus Centre for AI Curtin UniversityPerth6102Australia Department of Business Administration Faculty of Economics and AdministrationKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of management Information Systems College of Business AdministrationTaibah UniversityAl-Madinah42353Saudi Arabia

In recent years,the demand for biometric-based human recog-nition methods has drastically increased to meet the privacy and security *** prints,palm veins,finger veins,fingerprints,hand veins and other anatomic and behavioral features are utilized in the development of different biometric recognition *** the available biometric recognition techniques,Finger Vein Recognition(FVR)is a general technique that analyzes the patterns of finger veins to authenticate the *** Learning(DL)-based techniques have gained immense attention in the recent years,since it accomplishes excellent outcomes in various challenging domains such as computer vision,speech detection and Natural Language Processing(NLP).This technique is a natural fit to overcome the ever-increasing biomet-ric detection problems and cell phone authentication issues in airport security *** current study presents an Automated Biometric Finger Vein Recognition using Evolutionary Algorithm with Deep Learning(ABFVR-EADL)*** presented ABFVR-EADL model aims to accomplish bio-metric recognition using the patterns of the finger ***,the presented ABFVR-EADL model employs the histogram equalization technique to pre-process the input *** feature extraction,the Salp Swarm Algorithm(SSA)with Densely-connected Networks(DenseNet-201)model is exploited,showing the proposed method’s ***,the Deep-Stacked Denoising Autoencoder(DSAE)is utilized for biometric *** proposed ABFVR-EADL method was experimentally validated using the benchmark databases,and the outcomes confirmed the productive performance of the proposed ABFVR-EADL model over other DL models.

关键词： Biometric authentication finger vein recognition deep learning evolutionary algorithm security privacy

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Application of electrical capacitance tomography for imaging industrial processes

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2005年第12期6卷 1374-1378页

作者： DYAKOWSKI tom School of Chemical Engineering and Analytical Science The University of Manchester Manchester M60 1QD UK

Electrical tomography is, in certain cases, the most attractive method for real imaging of industrial processes, because of its inherent simplicity, rugged construction of the tomographer and high-speed capability. This paper presents examples illus- trating applications of electrical tomography for imaging fluidized beds, bubble columns and pneumatic conveyors. Electrical tomography opens up new ways for processing, imaging and modelling multi-phase flows as shown by 2D and 3D images illus- trating the various types of flow morphology.

关键词： Process imaging Fluid mixing Stired vessel

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