检索结果-南通市图书馆

三药固定剂量复方制剂的利福平相对生物利用度

在线全文

学校读者我要写书评

暂无评论

国际结核病与肺部疾病杂志 2011年第2期6卷 85-90页

作者： R.C.milán-Segovia A.m.Domínguez-Ramírez H.jung-Cook m.magaa-Aquino m.C.Romero-méndez S.E.medellín-Garibay m.Vigna-Pérez S.Romano-moreno 金海霞 Universidad Autónoma metropolitana Unidad XochimilcoMexico DF Facultad de Ciencias Químicas Universidad Autónoma de San Luís PotosíSan Luis Potosí Facultad de Química Universidad Nacional Autónoma de MéxicoMexico City Hospital Central 'Dr Ignacio morones Prieto' Secretaría de Salud San Luis PotosíMexico Facultad de Ciencias Químicas Universidad Autónoma de San Luís PotosíSan Luis Potosí

背景:先前的一个利福平(RmP)监测性研究显示,结核病(TB)患者在使用常规的3药固定剂量复方制剂(3FDC)治疗时,RmP浓度很低。因此,我们对该制剂的生物利用度进行研究。目的:利用健康志愿者研究墨西哥卫生保健系统中常规使用的3FDC制剂相对... 详细信息

背景:先前的一个利福平(RmP)监测性研究显示,结核病(TB)患者在使用常规的3药固定剂量复方制剂(3FDC)治疗时,RmP浓度很低。因此,我们对该制剂的生物利用度进行研究。目的:利用健康志愿者研究墨西哥卫生保健系统中常规使用的3FDC制剂相对于参比制剂的RmP相对生物利用度。设计:两周期、两序列的交叉研究。结果:受试制剂和参比制剂的药代动力学参数均值如下:达峰浓度(Cmax)分别为3.13±2.01μg/ml和9.95±2.66μg/ml;对于血药浓度-时间曲线下面积(AUC),零到最后实测浓度的AUC(AUC0-12 h)分别为15.51±9.77μg.h/ml和58.03±16.1μg.h/ml,零到无限大时间的AUC(AUC0-∞)分别为17.92±10.66μg.h/ml和68.43±22.39μg.h/ml。Cmax的受试/参比均值比(90%CI)为25.36%(17.33~37.10);AUC0-12 h为21.25%(14.61~30.89);AUC0-∞为22.08%(15.44~31.56)。这些结果不符合生物等效性标准。结论:受试制剂与参比制剂相比,显示吸收延迟和RmP生物利用度明显偏低...

关键词：相对生物利用度利福平固定剂量复方

modified Fenton Degradation of 2,4-dinitrotoluene in Soil Slurries in the Presence of Lead

在线全文

学校读者我要写书评

暂无评论

Modified Fenton Degradation of 2,4-dinitrotoluene in Soil Sl...

A rapid, simple, and high-throughput UPLC-mS/mS method for simultaneous determination of bioactive constituents in Salvia miltiorrhiza with positive/negative ionization switching.

2012年环境污染与大众健康学术会议

作者： Eun Hea Jho 1 , Jaewoong jung 1 , Kyoungphile Nam 1 1 Department of Civil and Environmental Engineering, Seoul National University, Seoul, South Korea

This study investigates the effects of lead （Pb） on 2,4-dinitrotoluene （2,4-DNT） degradation when modified Fenton reactions are used to remediate soils contaminated with both Pb and 2,4-DNT. At all H 2 O 2 concentrations, the Pb sorption after 24 h reaction was ＞95%;but a significantly greater amount of Pb was sorbed at 0.01 m-0.2 m H 2 O 2 （＞99%） when compared with the Pb sorption at higher H 2 O 2 concentrations. This indicates Pb mobilization due to the Fenton reactions. The 2,4-DNT degradation increased with increasing H 2 O 2 concentrations from 0.01 m to 1 m, but no further increase was observed with further increase in the H 2 O 2 concentration. This could be attributed to the increased 2,4-DNT desorption due to the reductive moieties produced by the Fenton reactions at higher H 2 O 2 concentrations. At 0.01 m and 0.05 m H 2 O 2 , the 2,4-DNT degradation was similar in the presence and the absence of Pb;however, it was lower in the presence of Pb at higher H 2 O 2 concentrations （≥0.2 m）. This can be explained by the stable complex formation between Pb and soil organic matter （SOm）, which could likely reduce the loss of SOm due to Fenton reactions, hence the 2,4-DNT desorption. Thus, Pb removal prior to the application of Fenton reactions is recommended when remediating 2,4-DNT from soils contaminated with both Pb and 2,4-DNT.

关键词： Fenton reaction 2,4-dinitrotoluene Lead Nitroaromatic compounds Hydrogen peroxide

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

A rapid, simple, and high-throughput UPLC-MS/MS method for s...

钕与旋锻对AZ71镁合金力学性能的影响（英文）

2018年中国质谱学术大会（CmSC2018）

作者： Hung-Yu Lin Ting-Sian Lin Han-Ju Chien Yu-min Juang Chao-jung Chen Chang-Shen Wang Chien-Chen Lai Institute of molecular Biology Chung Hsing University Waters Corporation No.90 Jianguo North RoadZhongshan District Proteomics Core Lab Department of Medical ResearchChinaMedical University Hospital Department of Agronomy Chung Hsing University

The dried root of Danshen(Salvia miltiorrhiza) is a Chinese medicine that has been used in traditional treatments for more than 2000 years in Asia. It has also been used to treat cardiovascular diseases for decades. The goal of this study was to develop a new, fast, and simple ultrahigh-performance liquid chromatography tandem mass spectrometry(UPLC–mS/mS) analytical method for the analysis of phenolic acids and tanshinones in Danshen. The samples were separated on a Kinetex F5 column(2.1?x?100?mm, 1.7?μm, pentafluorophenyl) using 78% acetonitrile with 0.1% formic acid as the mobile phase with isocratic elution while the flow rate was set at 0.45?mL/min. The analysis was performed in a Waters Xevo TQ mass spectrometer via multiple reaction monitoring(mRm) in polarity switching mode. The linearity values of the calibration curves of eight compounds were in the range from 3 to 3200?ng/mL(r2 > 0.99). method validation was performed in terms of linearity, the relative standard deviations(RSDs) of the intra-day and inter-day, and it was found that precisions were within 15% and the accuracy ranged from 93% to 118%. The recovery was more than 87%. The limit of detection(LOD) and limit of quantification(LOQ) values of the eight analytes varied between 0.023 to 0.75?ng/mL and 0.375 to 1.5?ng/mL, respectively. This approach has the shortest analysis time for the separation of phenolic acids and tanshinones in Danshen using a UPLC core-shell column with F5 stationary phase. meanwhile, this robust and high-throughput method not only has a short run time(2?min) but also reduce the consumption of organic solvents.

关键词： Salvia miltiorrhiza Tanshinones Phenolic acids UPLC-mS/mS

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Transactions of Nonferrous metals Society of China 2015年第10期25卷 3223-3231页

作者：陈贞光陈宇辰李宪宗陈锦修张浚荣国立台北科技大学材料科学与工程研究所台北市10608 鸿准精密工业股份有限公司新北市23680

探讨钕的添加对AZ71镁合金的力学性能和塑性加工性能的影响。添加0.5%~2.0%的钕时,AZ71镁合金的晶粒尺寸和脆性β-mg17Al12相的含量均随着钕添加量的增加而降低,并形成纳米级的AlxNdy析出相。经过32%旋锻和退火后,加钕AZ71镁合金的晶粒... 详细信息

探讨钕的添加对AZ71镁合金的力学性能和塑性加工性能的影响。添加0.5%~2.0%的钕时,AZ71镁合金的晶粒尺寸和脆性β-mg17Al12相的含量均随着钕添加量的增加而降低,并形成纳米级的AlxNdy析出相。经过32%旋锻和退火后,加钕AZ71镁合金的晶粒尺寸由350μm减小到30μm以下。当钕的添加量达到1%时,合金的强度与延性可同时获得提升;当钕的添加量超过1%时,组织中杆状Al11Nd3以及块状Al2Nd聚集析出,导致合金的强度与延性降低。因此,1.0%钕添加量为AZ71镁合金的最佳添加量,添加1.0%钕的AZ71镁合金可以获得253mPa的抗拉强度和10.7%的伸长率,在铸态或经旋锻退火后均具有最高的韧性。

关键词： AZ71镁合金钕旋锻力学性能再结晶

光学相干断层成像评价植入不同药物洗脱支架后的血管愈合情况

在线全文

学校读者我要写书评

暂无评论

中国介入心脏病学杂志 2011年第1期19卷 33-37页

作者：范春雨 Kim jung-Sun Kim Tae-Hoon 吕吉元山西医科大学第一医院心内科太原030001 韩国延世大学severance医院心血管中心

目的应用光学相干断层成像(OCT)比较急性心肌梗死(AmI)患者植入不同药物洗脱支架(DES)后的新生内膜覆盖和支架贴壁情况以评估血管愈合。方法 49例AmI患者植入不同DES后9个月时进行OCT检查。其中20个雷帕霉素药物洗脱支架(SES,Cypher),1... 详细信息

目的应用光学相干断层成像(OCT)比较急性心肌梗死(AmI)患者植入不同药物洗脱支架(DES)后的新生内膜覆盖和支架贴壁情况以评估血管愈合。方法 49例AmI患者植入不同DES后9个月时进行OCT检查。其中20个雷帕霉素药物洗脱支架(SES,Cypher),12个紫杉醇药物洗脱支架(PES,Taxus)和17个雷帕霉素衍生物药物洗脱支架(ZES,Endeavor)。每隔1mm评估OCT横断面影像每个支架柱的新生内膜覆盖和贴壁情况,同时观察每个支架内的血栓发生情况。结果总计对12378个支架柱进行了分析。SES的新生内膜增生最少,新生内膜厚度:SES(77±60)μm、PES(153±82)μm、ZES(265±130)μm,且新生内膜增生面积百分比最低,SES(10±8)%、PES(19±8)%、ZES(28±9)%,但SES和PES有更多未被新生内膜覆盖的支架柱,SES(15.1±16)%、PES(7.1±10)%、ZES(0.6±1.5)%,且贴壁不良支架柱的发生率也高于ZES,SES(3.8±7.2)%、PES(2.1±4.4)%、ZES(0±0)%,而有完全新生内膜覆盖的支架比例以ZES为高,SES5%、PES33.3%、ZES82.4%。血栓的发生率SES和PES高于ZES,SES34%、PES33%、ZES6%。结论 AmI患者植入不同类型DES后,其支架的新生内膜覆盖程度和贴壁不良的发生率是显著不同的,因此DES的类型可能影响了AmI血栓性病变的血管愈合过程。

关键词：心肌梗死体层摄影术,光学相干药物洗脱支架

Thermodynamics of the Second Stage Dissociation Step (pK<sub>2</sub>) of Buffer monosodium 1,4-Piperazinediethanesulfonate from (278.15 to 328.15) K

在线全文

学校读者我要写书评

暂无评论

Journal of Biophysical Chemistry 2014年第3期5卷 91-98页

作者： Rabindra N. Roy Lakshmi N. Roy John J. Dinga matthew R. medcalf katherine E. Hundley Eric B. Hines Ryan R. Parmar Jamie A. Veliz Clark B. Summers Lucas S. Tebbe Hoffman Department of Chemistry Drury University Springfield USA

Values of the second thermodynamic dissociation constant pK2 of the protonated form of monosodium 1,4-piperazinediethanesulfonate (PIPES) have been determined at twelve different temperatures in the temperature range from (278.15 to 328.15) K including the body temperature 310.15 K by measurement of the electromotive-force for cells without liquid junction of the type: Pt (s), H2 (g), 101.325 kPa|Na-PIPES (m1) + Na 2-PIPES (m2) + NaCl (m3)|AgCl (s), Ag (s), where m1, m2 and m3 indicate the molalities of the corresponding species at 1 atm = 101.325 kPa in SI units. The pK2 values for the dissociation of Na-PIPES are represented by the equation: pK2 = -1303.76/T + 48.369 - 6.46889 lnT with an uncertainty of ± 0.001. The values of pK2 for Na-PIPES were found to be 7.1399 ± 0.0004 at 298.15 K and 7.0512 ± 0.0004 at 310.15 K, respectively, and indicate that this buffer would be useful as pH standard in the range of physiological application. Standard thermodynamic quantities for the acidic dissociation process of Na-PIPES have been derived from the temperature coefficients of the pK2. These values are compared with those of structurally related N-substituted PIPERAZINE and TAURINE at 298.15 K.

关键词： Dissociation Constant Zwitterion Ionic Strength pK2 Buffer Compound e.m.f Thermodynamic Quantities

Bedouin farms in the Saint katherine mountainous area(South Sinai,Egypt)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of mountain Science 2019年第10期16卷 2232-2242页

作者： Kamal H.SHALTOUT Khaled H.EL-HAmDI Safaa A.EL-mASRY Ebrahem m.EID Botany Department Faculty of ScienceTanta UniversityTanta31527Egypt Soil Department Faculty of AgricultureMansoura UniversityMansoura35516Egypt Biology Department College of ScienceKing Khalid UniversityAbha61321P.O.Box9004Saudi Arabia Botany Department Faculty of ScienceKafr El-Sheikh UniversityKafr El-Sheikh33516Egypt

This study aims to assess the natural and cultivated plant species in 26 Bedouin farms in Saint katherine Protectorate(SKP),identify their soil and water characteristics,and assess the suitability of these farms for the cultivation of some wild medicinal *** farms were selected to represent wide wadis with deep sand and clay deposits,gorge-like wadis covered with rock fragments of different sizes,spot-like oases,and the Al Q’aa *** TWINSPAN(two-way indicator species analysis)and DCA(detrended correspondence analysis)techniques,the 26 farms were classified into 5 groups(Ⅰ-Ⅴ)based on their floristic composition of wild *** groups reflect an elevation gradient among the farms above sea level from a mean of 119 m to a mean of1,865m.A total of 73 wild species were recorded,with47 in groupⅡ(500-1,000 m)and 25 in group V(>1,700 m).The common target species were Artemisia judaica,Acacia tortilis ***,Origanum syriacum *** and Varthemia montana(34.6%-26.9%).The cultivated speciesnumbered 25,with 17 in groupⅡ(500-1,000 m) andⅡin groupⅣ(1,500-1,700 m).The common fruit trees were olive,grape,fig,apple,palm,almond,apricot and pomegranate(73.0%-42.3%).Based on the soil characteristics,13 farms belong to soil class 2that describes good soils with moderate limitations,and 12 belong to soil class 3 that describes moderately good soils,which can be used regularly for crops after proper treatment.

关键词： Agroforestry Saint katherine Protectorate Wild medicinal plants Elevation gradient multivariate analysis Wadi Feiran

A solution scan of societal options to reduce transmission and spread of respiratory viruses:SARS-CoV-2 as a case study

在线全文

学校读者我要写书评

暂无评论

Journal of Biosafety and Biosecurity 2021年第2期3卷 84-90页

作者： William J.Sutherland Nigel G.Taylor David C.Aldridge Philip martin Catherine Rhodes Gorm Shackelford Simon Beard Haydn Belfield Andrew J.Bladon Cameron Brick Alec P.Christie Andrew P.Dobson Harriet Downey Amelia S.C.Hood Fangyuan Hua Alice C.Hughes Rebecca m.Jarvis Douglas macFarlane William H.morgan Anne-Christinemupepele Stefan J.marciniak Cassidy Nelson SeánÓhÉigeartaigh Clarissa Rios Rojas katherine A.Sainsbury Rebecca K.Smith Lalitha S.Sundaram Ann Thornton John Watkins Thomas B.White Kate Willott Silviu O.Petrovan BioRISC(Biosecurity Research Initiative at St Catharine’s) St Catharine’s CollegeCambridge CB21RLUK Department of Zoology University of CambridgeThe David Attenborough BuildingPembroke StreetCambridge CB23QZUK Tour du Valat Research Institute for the Conservation of Mediterranean Wetlands13200 ArlesFrance Centre for the Study of Existential Risk University of CambridgeCB21SBUK Department of Social Psychology University of AmsterdamNieuwe Achtergracht 129 B1018 WT AmsterdamNetherlands Department of Ecology and Evolutionary Biology 117 Eno HallPrinceton UniversityNJ 08544USA Institute of Ecology College of Urban and Environmental SciencesPeking UniversityBeijing 100871PR China Centre for Integrative Conservation Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesXishuangbannaYunnan 666303PR China Te Kura Putaiao-School of Science Auckland University of TechnologyAucklandNew Zealand School of Psychological Sciences University of Western AustraliaPerth35 Stirling HwyCrawley WA 6009Australia Nature Conservation and Landscape Ecology Biometry and Environmental System AnalysisUniversity of FreiburgGermany Cambridge Institute for medical Research University of CambridgeCambridge Biomedical CampusThe Keith Peters BuildingHills RoadCambridge CB20XYUK Future of Humanity Institute University of OxfordOxford OX11PTUK Faculty of Kinesiology Sportand RecreationUniversity of Alberta2-130V Van Vliet 21 Complex(University Hall)EdmontonAlberta T6G 2H9Canada Division of Population medicine School of MedicineCardiff UniversityCardiff CF144YSUK

Societal biosecurity–measures built into everyday society to minimize risks from pests and diseases–is an important aspect of managing epidemics and *** aimed to identify societal options for reducing the transmission and spread of respiratory *** used SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)as a case study to meet the immediate need to manage the COVID-19 pandemic and eventually transition to more normal societal conditions,and to catalog options for managing similar pandemics in the *** used a‘solution scanning’*** read the literature;consulted psychology,public health,medical,and solution scanning experts;crowd-sourced options using social media;and collated comments on a ***,we present a list of 519 possible measures to reduce SARS-CoV-2 transmission and *** provide a long list of options for policymakers and businesses to consider when designing biosecurity plans to combat SARS-CoV-2 and similar pathogens in the *** also developed an online application to help with this *** encourage testing of actions,documentation of outcomes,revisions to the current list,and the addition of further options.

关键词： Biosecurity Coronavirus COVID-19 Disease control New normal Public health

Spectral tomographic imaging with aplanatic metalens

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2019年第1期8卷 258-265页

作者： Chen Chen Wange Song Jia-Wern Chen jung-Hsi Wang Yu Han Chen Beibei Xu mu-Ku Chen Hanmeng Li Bin Fang Ji Chen Hsin Yu Kuo Shuming Wang Din Ping Tsai Shining Zhu Tao Li National Laboratory of Solid State microstructures Key Laboratory of Intelligent Optical Sensing and IntegrationJiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210093China Collaborative Innovation Center of Advanced microstructures NanjingChina Research Center for Applied Sciences Taipei11529 TaiwanChina Department of Physics Taiwan UniversityTaipei10617 TaiwanChina Graduate Institute of Electronics Engineering Taiwan UniversityTaipei10617 TaiwanChina

Tomography is an informative imaging modality that is usually implemented by mechanical scanning,owing to the limited depth-of-field(DOF)in conventional ***,recent imaging systems are working towards more compact and stable architectures;therefore,developing nonmotion tomography is highly ***,we propose a metalens-based spectral imaging system with an aplanatic GaN metalens(NA=0.78),in which large chromatic dispersion is used to access spectral focus tuning and optical zooming in the visible *** the function of wavelength-switched tomography was confirmed on cascaded samples,this aplanatic metalens is utilized to image microscopic frog egg cells and shows excellent tomographic images with distinct DOF features of the cell membrane and *** approach makes good use of the large diffractive dispersion of the metalens and develops a new imaging technique that advances recent informative optical devices.

关键词： tuning switched dispersion