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Decreased anaerobic performance and hormone adaptation after expedition to Peak Lenin

Chinese medical Journal 2008年第22期121卷 2229-2233页

作者： CHEN Kung-tung CHEN Yu-yawn WU Huey-june CHANG Chen-kang LEE Wen-tsung LU Yen-yuan LIU Chieh-chung YANG Rong-sen LIN jung-charng College of Humanities Social and Natural Sciences Ming Hsin University of Science and Technology Hsinchu 304 Taiwan China National Taiwan College of Physical Education Taichung Taiwan China Graduate Institute of Sports Coaching Science Chinese Culture University Taipei Taiwan China Department of Laboratory Kuo General Hospital Tainan Taiwan China Department of Cardiovascular medicine Kuo General Hospital Tainan Taiwan China Department of Physical Education Yuanpei University of Science and Technology Hsin ChnTaiwan China Department of Orthopaedics College of Medicine National Taiwan University & Hospital Taiwan China

Background The change of anaerobic exercise abilities during and after a high-altitude expedition or hypoxic exposure is not well studied. To evaluate the effects of an extreme-altitude expedition on anaerobic performance, the lO-second supramaximal test and endocrine hormones were evaluated before and after an expedition to Peak Lenin. methods Four subjects （3 male and 1 female, age （30.5＋16.5） years） were recruited into the study. Three sets of tests were performed, including a basic test at sea level and 20 days before first arrival at the base camp （3600 m）, a middle test done at day after returning from the summit to the base camp and the post test at the lOth day after return to the sea level. Both the supramaximal test, performed by a cycle ergometer, and body composition, performed by bioelectrical impedance analysis, were completed before the basic test and post test. The endocrine hormones including cortisol, growth hormone, testosterone, noradrenaline, adrenaline, dopamine, glucagon and β-endorphin were measured at all tests. Results Comparing the conditions before and after the expedition, the body measurement parameters were decreased alter the expedition, i.e., body weight （-4.22%, P〈O.05）, fat-free mass （-2.09%, P〈O.01） and body fat （-8.95%, P=0.172）. The peak power relative/body weight ratio （PP/BW） was similar （（9.70±1.97） vs （9.11±1.80） W/kg, P=-0.093）, while mean power/body weight ratio （mP/BW） was reduced significantly after the expedition （（9.14±1.77） vs （8.33±1.74） W/kg, P 〈0.05）. Peak power/fat-free mass （PP/FFm）, mean power/fat-free mass （mP/FFm） and fatigue index （FI） were significantly lower after the expedition （PP/FFm：（11.95±1.71） vs （10.99±1.59） W/kg, P 〈0.05; mP/FFm：（11.26±1.50） vs （10.04±1.55） W/kg, P〈O.O05; FI （85.55±4.17）% vs （77.25±4.40）%, P〈O.05）. Hormone assays showed a significant increase of noradrenaline （basic vs middle, P〈O.05） as well as decrease of adrenaline （P〈O.05）. meanwhile, a trend towards an increase in dopamine （b

关键词： anaerobic exercise high-altitude expedition peak power mean power endocrine

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广州西塔结构抗震设计

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建筑结构学报 2010年第1期31卷 47-55页

作者：方小丹韦宏江毅陈福熙曾宪武赖洪涛华南理工大学建筑设计研究院广东广州510641

广州西塔地下4层(局部5层),地面以上103层,主塔楼高432m,采用巨型钢管混凝土柱斜交网格外筒+钢筋混凝土内筒的筒中筒结构。斜交网格筒侧向刚度、抗扭刚度大,以斜柱轴力抵抗水平荷载引起的结构楼层水平剪力和倾覆力矩,充分发挥了高强钢... 详细信息

广州西塔地下4层(局部5层),地面以上103层,主塔楼高432m,采用巨型钢管混凝土柱斜交网格外筒+钢筋混凝土内筒的筒中筒结构。斜交网格筒侧向刚度、抗扭刚度大,以斜柱轴力抵抗水平荷载引起的结构楼层水平剪力和倾覆力矩,充分发挥了高强钢管混凝土柱的优势,是超高层建筑的优良结构形式。介绍西塔结构的抗震设计,以概念设计和简单演算论证了结构的抗震安全性。由于结构构件承载力及刚度需求为风荷载组合所控制,相对于地震作用而言,结构的超强系数大,易于达到比现行建筑结构抗震设计要求更高的抗震性能目标。结合西塔的具体情况,讨论了西塔结构抗震等级的设定问题,指出有必要循R-μ-T关系改进关于结构抗震等级的规定。

关键词：超高层建筑概念设计地震反应超强系数抗震等级

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mutation-Specific Antibodies for the Detection of EGFR mutations in Non-Small-Cell Lung Cancer

Mutation-Specific Antibodies for the Detection of EGFR Mutat...

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第六届全国免疫学学术大会

作者： Susan Kane Elisa Benedettini Cynthia Reeves Gregory Innocenti Randy Wetzel katherine Crosby Alison Becker michelle Ferrante Gabriel Cheung Lucian R.Chirieac Lynette m.Sholl Herbert Haack Bradley Smith Roberto D.Polakiewicz massimo Loda michael J.Comb Cell Signaling Technology Inc.3 Trask LaneDanversMA 01923 Department of medical Oncology and Center for molecular Oncologic Pathology Dana-Farber Cancer InstituteBrigham & Women’s HospitalBostonMassachusetts 02115USA

Activating mutations within the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) are found in approximately 10-20% of non-small cell lung cancer (NSCLC) patients and are associated with response t...

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A Study on Welding Defect of Welded Tube by Using CO2 Laser

A Study on Welding Defect of Welded Tube by Using CO2 Laser

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第二十三届中国控制会议

作者： Jeong Suh Jae-Hoon Lee Hie-Sin Kang Kyoung-Taik Park moon-Yong Lee Byung-Hun jung Korea Institute of machinery & materials Technical Institute of Sungwoo Hitech Co. LTD

To minimize the weld defect in manufacturing the welded tube by using CO2 laser, the monitoring of the welding quality and the seam tracking along the butt-joint lengthwise to the tube axis are studied. The tube, 60kgf/mm2grade steel sheet, is formed by 2 roll bending machine. The tube has the thickness 1.5mm, diameter 105.4mm and length 2000mm. The longitudinal butt-joint of the tube is welded by the CO2 laser welding system equipped with the seam tracker and plasma *** precise positioning (m) of the laser beam on the butt-joint to be assembled is obtained by the seam tracker with mVS-5 sensor (combination of laser emitter and CCD camera). The artificial defects (mm) in the butt-joint are well observed by the signal of plasma intensity measured by the plasma sensor of UV wavelength range (m). The developed CO2 laser tube welding system has the function of the precision seam tracking and the real-time monitoring of the welding quality. Finally, the laser welded tube can be used for manufacturing of automobile chassis and components after tubular hydro-forming.

关键词： CO2 Laser welded tube seam tracking plasma intensity weld quality monitoring.

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Inhibitory Effect of Hesperetin,a Bioflavonoid,on Rabbit Platelet Aggregation

Inhibitory Effect of Hesperetin,a Bioflavonoid,on Rabbit Pla...

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第十五届国际药理学大会

作者： jung-Jin Lee mukhtsetseg Tudev Hyeong-Jun Han Tack-Joong Kim Hwa-Sup Shin Yeo-Pyo Yun College of Pharmacy. Research Center for Bioresource and Health. Chungbuk National University Cheongju 361-763 Korea College of Pharmacy. Research Center for Bioresource and Health. Chungbuk National University Cheongju 361-763 Korea College of Pharmacy. Research Center for Bioresource and Health. Chungbuk National University Cheongju 361-763 Korea College of Pharmacy. Research Center for Bioresource and Health. Chungbuk National University Cheongju 361-763 Korea Division of Life Science College of Natural Sciences Konkuk University Chungju 380-701 Korea College of Pharmacy. Research Center for Bioresource and Health Chungbuk National University Cheongju 361-763 Korea

＜正＞ In the present study, the antiplatelet activity of hesperetin was investigated in vitro and ex vivo. Hesperetin concentration-dependently inhibited washed rabbit platelet aggregation induced by collagen and arachidonic acid （AA）. with IC50 of 20.5 ±3.5 and 69.2±5.1 μm. respectively, while has little effect U46619- or thrombin-mediated platelet aggregation, suggesting that hesperetin may selectively inhibited collagen-mediated signal transduction. Accordingly, hesperetin revealed blocking of the collagen-mediated PLC-γ2 activation, and caused a concentration-dependent decrease of arachidonic acid liberation, cytosolic calcium mobilization and serotonin release. It was also supported by the ex vivo platelet aggregation study that administration of hesperetin （100 mg/kg） potently inhibited collagen-induced platelet aggregation in rats. Furthermore, hesperetin inhibited AA-mediated platelet aggregation by interfering with COX activity as established by mea- suring the productions of TXA2 and PGD2 when arachidonic acid was added. Taken together, the present results provide a molecular basis for the antiplatelet activity of hesperetin. through inhibition of PLC-72 phosphorylation and COX activity.

关键词： Hesperetin platelet aggregation phospholipase C gamma2 cyclooxygenase

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熔融结晶器保护渣喂入技术对TWIP钢连铸坯可浇性能及其表面质量的改进

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钢铁译文集 2018年第1期 47-56页

作者： jung-Wook CHO 韦菁(译) 郭俊波(校对) 韩国浦项工科大学不详

为了提高连铸生产效率，改善铸坯的表面质量，韩国浦项钢铁公司基于熔融保护渣的喂入技术，开发了一种全新的连铸工艺-PCAST工艺，熔融结晶器保护渣该工艺中，熔融结晶器保护渣用喂线的方式喂入结晶器中，从而提高了弯月面的保温性，由... 详细信息

为了提高连铸生产效率，改善铸坯的表面质量，韩国浦项钢铁公司基于熔融保护渣的喂入技术，开发了一种全新的连铸工艺-PCAST工艺，熔融结晶器保护渣该工艺中，熔融结晶器保护渣用喂线的方式喂入结晶器中，从而提高了弯月面的保温性，由此改善了凝固坯壳与铜结晶器之间的润滑性。先进高Al高强度钢（AHSS）板坯的可浇性与表面质量同时提高是该工艺应用于工业化连铸工艺后的最重要优点之一。在10t试验连铸机和100t、250t工业连铸机上进行TWIP钢的试生产试验。新工艺中的熔融保护渣消耗量超过了0．2kg／m2，远远高于传统工艺的消耗量。在试验连铸机与工厂连铸机的TWIP试浇铸中，结晶器性能（如结晶器传热）均很稳定。另外，连铸板坯显现出周期性／完整的振痕，但几乎没有缺陷。TWIP钢的成功浇铸得益于POCAST的以下特性：熔渣池深度的增加稀释了反应物；渣圈的去除扩大了弯月面处的渣膜的渗透渣道；提高保护渣的温度降低了弯月面处结晶器渣的黏度。

关键词：韩国浦项钢铁公司结晶器保护渣表面质量连铸坯熔融喂入性能技术

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稳定表达LamR的RK13细胞系的建立及RHDV吸附能力的初步研究

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畜牧与兽医 2018年第8期50卷 44-48页

作者：黄萍宋艳华胡波魏后军范志宇仇汝龙陈萌萌薛家宾王芳 jung Yong-Sam 南京农业大学动物医学院/教育部动物健康与食品安全国际合作联合实验室江苏南京210095 江苏省农业科学院兽医研究所/农业部动物疫病诊断与免疫重点开放实验室江苏南京210014

为建立稳定表达层黏连蛋白受体（LamR）RK13细胞系（RK13-LamR）,并研究LamR蛋白在兔出血症病毒（RHDV）与宿主细胞结合中的作用,将完整的LamR序列通过同源重组克隆入慢病毒表达载体pLVX-m Cherry,并将该重组质粒pLVX-m Cherry-LamR与... 详细信息

为建立稳定表达层黏连蛋白受体（LamR）RK13细胞系（RK13-LamR）,并研究LamR蛋白在兔出血症病毒（RHDV）与宿主细胞结合中的作用,将完整的LamR序列通过同源重组克隆入慢病毒表达载体pLVX-m Cherry,并将该重组质粒pLVX-m Cherry-LamR与慢病毒包装质粒pLP1、pLP2、pLP/VSVG共转染293T细胞,在293T细胞中包装成含目的基因的重组慢病毒。将收获的重组病毒感染RK13细胞,经过嘌呤霉素筛选和细胞有限稀释法,筛选出表达LamR蛋白的RK13细胞。通过间接免疫荧光试验（IFA）和Western blotting证明所获细胞株能够稳定表达LamR蛋白,将细胞株命名为RK13-LamR。以纯化的RHDV接种RK13-LamR细胞,IFA检测结果显示,LamR蛋白能促进RHDV对RK13细胞的吸附。本研究建立了RHDV相对敏感的细胞株,证实在RHDV吸附宿主细胞的过程中,LamR蛋白起到一定的作用。

关键词：慢病毒载体 Lam R RK13细胞兔出血症病毒

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农林生物质提取物水溶性木聚糖的静电纺丝研究

农林生物质提取物水溶性木聚糖的静电纺丝研究

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中国化学会第一届农业化学学术讨论会

作者：段久芳 muzaffer A.Karaaslan mi jung Cho 刘黎阳 Amanda m.Johnson Scott Renneckar 北京林业大学材料科学与技术学院不列颠哥伦比亚大学木材科学系

＜正＞能源环境问题日趋严峻,基于生物质来源的高性能材料由于其环境友好、可再生和可持续发展等特点,正逐渐发展成为未来结构和功能应用的理想材料。在这方面,从农业废弃物中提取的木聚糖是丰富的可再生资源,有望取代一些化石燃料衍生...

＜正＞能源环境问题日趋严峻,基于生物质来源的高性能材料由于其环境友好、可再生和可持续发展等特点,正逐渐发展成为未来结构和功能应用的理想材料。在这方面,从农业废弃物中提取的木聚糖是丰富的可再生资源,有望取代一些化石燃料衍生的化学品和材料,本研究从麦秸中提取具有广泛应用前景的木聚糖,采用高分子量聚乙二醇为载体,以水为纺丝溶剂,提出了一种制备木聚糖基纳米纤维的新方法。本研究采用高分子量载体聚合物-聚乙二醇（PEO）将水溶性木聚糖电纺成纳米纤维。制备了直径为167～634nm的均匀纳米纤维,PEO含量最低可为木聚糖干重的4%。木聚糖与聚乙二醇的配比、电压、纺丝溶液的流变性等影响纳米纤维性能。通过傅立叶变换红外光谱和差示扫描量热法,发现木聚糖和聚氧化乙烯之间存在着强烈的分子间相互作用。

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Effects of traditional Chinese herbal medicine San-HuangXie-Xin-Tang on gastrointestinal motility in mice

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World Journal of Gastroenterology 2015年第4期21卷 1117-1124页

作者： min Woo Hwang Tae Seok Ahn Noo Ri Hong Han-Sol Jeong myeong Ho jung Ki-Tae Ha Byung Joo Kim Department of Sasang Constitutional medicine College of Korean MedicineKyung Hee UniversitySeoul 130-701South Korea School of Korean medicine Pusan National UniversityYangsan 626-870South Korea

AIm: To investigate the effects of San-Huang-Xie-XinTang(SHXXT), a herbal product used in traditional Chinese medicine, on gastrointestinal(GI) motility in ***: The in vivo effects of SHXXT on GI motility were investigated by measuring the intestinal transit rates(ITRs) using Evans blue in normal mice and in mice with experimentally induced GI motility dysfunction(GmD).RESULTS: In normal ICR mice, ITRs were significantly and dose-dependently increased by SHXXT(0.1-1 g/kg). GmD was induced by injecting acetic acid or streptozotocin intraperitoneally. The ITRs of GmD mice were significantly reduced compared to normal mice, and these reductions were significantly and dose-dependently inhibited by SHXXT(0.1-1 g/kg).CONCLUSION: These results suggest that SHXXT is a novel candidate for the development of a prokinetic agent that may prevent or alleviate GmD.

关键词： Gastrointestinal disorders San-Huang-XieXin-Tang m

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Clonal Dissemination of Genetically Diverse Fluoroquinolone-Resistant Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli ST131 in a Veterans Hospital in Southern Taiwan

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Advances in microbiology 2016年第9期6卷 590-601页

作者： Wen-Chung Chang Chung-jung Wu Chuan-Shee Liu Yilin Tsai Jen-Jain Lee Yuting Hsiao Shu-Ling Chou Chih-Hao Sun Chishih Chu Dentistry Division Chiayi Branch Taichung Veterans General Hospital Taiwan Internal medicine Department Chiayi Branch Taichung Veterans General Hospital Taiwan medical Laboratory Division Chiayi Branch Taichung Veterans General Hospital Taiwan Department of microbiology Immunology and Biopharmaceutics National Chiayi University Taiwan

Uropathogenic Escherichia coli is the common pathogen to cause urinary tract infections (UTIs) and have become multidrug-resistant (mDR) extended-spectrum β-lactamase (ESBL) producers. The differences in the antimicrobial susceptibility, 5 bla genes, 12 virulence genes of 87 clinical ESBL-producing E. coli isolates and genomic variations and sequence types of 18 recurrent and repeated isolates from 9 patients were investigated. The 87 mDR-ESBL isolates collected mainly from indwelling urinary catheters (IUCs) and UTIs were highly resistant to fluoroquinolones, with over 50% of the isolates being resistant to cefepime and piperacillin/tazobactam and a few being resistant to carbapenem. These isolates carried at least two of the five bla genes examined, with the highest prevalence (87.4%) found for blaCTX-m (blaCTX-m3-like and blaCTX-m14-like), followed by blaCmY-2 (80.5%) and blaSHV (56.3%). The predominant virulence genes were the fimbriae gene fimH and the toxin genes cnf1 and hlyA in blood isolates and the capsule gene kpsmTII in UTI and blood isolates. Over 80% of the isolates carried yersiniabactin and aerobactin of siderophores. In 18 isolates, the fluoroquinolone-resistant ST131 isolate of pulsotypes I and II with blaCTX-m-15 was clonally disseminated in the hospital. The genomic plasticity of these ST131 occurred mainly through the conjugative plasmids with differences in replicon types A/C, I1, FIA, FIB and Y, size and number. In conclusion, mDR ESBL-producing E. coli isolates differed in virulence genes of UPEC and antibiotic resistance associated with the sources. Plasmid acquisition and chromosomal variations increase the spread of fluoroquinolone-resistant UPEC ST131 worldwide.

关键词： E. coli ESBL Virulence Genes Antimicrobial Resistance mLST

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