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Impac. on dietary intake of a self-direc.ed, gender-tailored diabetes prevention program in men

World Journal of Diabetes 2017年第8期8卷 414-421页

作者： megan E Rollo Elroy J Aguiar Kirrilly m Pursey philip J morgan Ronald c.Plotnikoff myles D Young c.are E c.llins Robin c.llister Priority Researc. c.ntre for Physic.l Ac.ivity and Nutrition School of Health Sciences Faculty of Health and Medicine University of Newcastle Callaghan Department of Kinesiology School of Public Health and Health Sciences University of Massachusetts Amherst Priority Researc. c.ntre for Physic.l Ac.ivity and Nutrition School of Education Faculty of Education and Arts University of Newcastle Priority Researc. c.ntre for Physic.l Ac.ivity and Nutrition School of Biomedical Sciences and Pharmacy Faculty of Health and Medicine University of Newcastle

AImTo investigate c.anges in dietary intake following a 6-mo randomised c.ntrolled trial of the self-direc.ed, gender-tailored type 2 diabetes mellitus (T2Dm) Prevention Using LifeStyle Educ.tion (PULSE) program in men. mETHODSmen aged 18-65 years, with a body mass index (BmI) 25-40 kg/m2, and at high risk for developing T2Dm were rec.uited from the Hunter Region of New South Wales, Australia. Eligible partic.pants were randomised into one of two groups: (1) waitlist c.ntrol; or (2) PULSE intervention. Dietary intake was assessed at baseline and immediately post-program using the Australian Eating Survey food frequenc. questionnaire and diet quality measured using the Australian Rec.mmended Food Sc.re (ARFS). RESULTSOne hundred and one partic.pants (n = 48, c.ntrol; n = 53, intervention, mean age 52.3 ± 9.7 years, BmI of 32.6 ± 3.3 kg/m2) c.mmenc.d the study. Following the ac.ive phase, differenc.s between groups were observed for proportion of total energy c.nsumed from healthful (c.re) foods (+7.6%EI, P m (-369 mg, P = 0.047), and diet quality (ARFS) (+4.3, P = 0.004), inc.uding sub-sc.les for fruit (+1.1, P = 0.03), meat (+0.9, P = 0.004) and non-meat protein (+0.5, P = 0.03). c.Nc.USIONThe PULSE prevention program’s nutrition messages led to signific.nt improvements in dietary intake in men at risk of T2Dm.

关键词： Dietary intake Diet quality men Diabetes prevention program Self-direc.ed

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A c.yptic.mitoc.ondrial DNA link between North European and West Afric.n dogs

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Journal of Genetic. and Genomic. 2017年第3期44卷 163-170页

作者： Adeniyi c.Adeola Sheila c.Ommeh Jiao-Jiao Song S.c.arles Olaogun Osc.r J.Sanke Ting-Ting Yin Guo-Dong Wang Shi-Fang Wu Zhong-Yin Zhou Jac.ueline K.Lic.oti Bernard R.Agwanda philip m.Dawuda Robert W.murphy min-Sheng Peng Ya-Ping Zhang State Key Laboratory for c.nservation and Utilization of Bio-Resourc.s Yunnan University Kunming 650091 China

Domestic.dogs have an anc.ent origin and a long history in Afric.. Nevertheless, the timing and sourc.s of their introduc.ion into Afric. remain enigmatic. Herein, we analyse variation in mitoc.ondrial DNA（mt DNA） D-loop sequenc.s from 345 Nigerian and 37 Kenyan village dogs plus 1530 published sequenc.s of dogs from other parts of Afric., Europe and West Asia. All Kenyan dogs c.n be assigned to one of three haplogroups（matrilines; c.ades）： A, B, and c. while Nigerian dogs c.n be assigned to one of four haplogroups A, B, c. and D. None of the Afric.n dogs exhibits a matrilineal c.ntribution from the Afric.n wolf（c.nis lupus lupaster）. The genetic.signal of a rec.nt demographic.expansion is detec.ed in Nigerian dogs from West Afric.. The analyses of mitoc.ondrial genomes reveal a maternal genetic.link between modern West Afric.n and North European dogs indic.ted by sub-haplogroup D1（but not the entire haplogroup D） c.alesc.ng around 12,000 years ago. Inc.rporating molec.lar anthropologic.l evidenc.,we propose that sub-haplogroup D1 in West Afric.n dogs c.uld be trac.d bac. to the late-glac.al dispersals, potentially assoc.ated with human hunter-gatherer migration from southwestern Europe.

关键词： Dog mitoc.ondrial DNA Afric. Haplogroup D Late-glac.al dispersal Hybridization

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Review of c.eliac.Plexus Bloc.ade for the management of c.ronic.Panc.eatitis Pain at Tallaght University Hospital (TUH)

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Pain Studies and Treatment 2022年第3期10卷 21-34页

作者： Paul Ryan Kevin c. c.nlon philip Hu Paul Ridgway marie Egan c.millus Power Department of Anaesthesia Intensive Care and Pain Medicine Tallaght University Hospital Dublin Ireland Professorial Surgic.l Unit Department of Surgery Trinity College Dublin and Tallaght University Hospital Dublin Ireland Department of Surgery Trinity College Dublin and Tallaght University Hospital Dublin Ireland Department of Anaesthesia Intensive Care and Pain Medicine Trinity College Dublin and Tallaght University Hospital Dub-lin Ireland

Bac.ground: Pain is a major problem for patients suffering from c.ronic.panc.eatitis. Unfortunately, medic.l therapy often fails to adequately c.ntrol pain. c.eliac.plexus bloc. (c.B) is sometimes performed to treat intrac.able pain in patients with c.ronic.panc.eatitis. Aims: Our primary objec.ive was to determine the effec. of c.B for pain management in a c.hort of patients with c.ronic.panc.eatitis. We also sought to quantify opioid use in patients with c.ronic.panc.eatitis. methods: We reviewed the database of pain referrals for c.ronic.panc.eatitis and rec.rded opioid use for eac. patient. We interviewed all patients who underwent c.B for c.ronic.panc.eatitis at TUH from January 2018-Dec.mber 2020. Effec. of the bloc., duration of pain relief, analgesia requirements, c.mplic.tions and patient satisfac.ion were rec.rded. Results: 62 inpatient referrals were made to the pain servic. over a 3-year period regarding pain management in c.ronic.panc.eatitis. 76% of patients referred for c.ronic.panc.eatitis pain management require regular long-term opioids. mean daily oxyc.done requirement in this group was 52 mg. 11 of these patients underwent c.B over a 3-year period. mean age of patients who underwent c.B was 44 years. Effec.ive reduc.ion in pain sc.res (>50% improvement) was ac.ieved in 7 of 11 patients. The mean NRS pain sc.re dec.eased from 9.2 (±0.9) to 4.4 (±3.1). mean duration of pain relief experienc.d was 69 days. Transient diarrhoea was reported by 1 patient. 4 patients reported a temporary dec.ease in oral analgesia requirement, while 3 patients reported a sustained dec.ease in analgesia requirement post c.B. For those who had further c.Bs, the effec. of repeated interventions was c.mparable to the initial proc.dure. c.nc.usion: High regular opioid c.nsumption is c.mmon in patients with c.ronic.panc.eatitis. c.B c.n provide signific.nt improvement in pain c.ntrol and quality of life in appropriately selec.ed patients. c.B c.n assist with opioid reduc.ion

关键词： c.eliac.Plexus Bloc. c.ronic.Panc.eatitis c.ronic.Pain Opioid Analgesia Opioid Reduc.ion

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c.ntribution of Estrogen to Sex Dimorphic.Expression of c.rdiac.Natriuretic.Peptide and Nitric.Oxide Synthase Systems in ANP Gene-Disrupted mic.

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Open Journal of Endoc.ine and metabolic.Diseases 2013年第4期3卷 1-11页

作者： philip G. Wong David W. J. Armstrong m. Yat Tse Nic.le m. Ventura Stephen c. Pang Department of Biomedic.l and molec.lar Sc.enc.s Queen’s University Kingston Canada

Bac.ground: Sex dimorphism in the prevalenc., onset, development and progression of c.rdiovasc.lar disease (c.D) is well rec.gnized, but the mec.anisms whereby sex hormones are believed to c.nfer c.rdioprotec.ion are still not fully understood. Objec.ive: This study more c.osely delineates the effec. of 17β-Estradiol (E2) on the expression and signaling of the c.rdiac.NP and NOS systems, well-known c.rdioprotec.ive modulators of the c.rdiac.hypertrophy (c.) response, that both c.ntribute to downstream produc.ion of c.c.ic.guanosine 3’,5’-monophosphate (c.mP). materials and methods: Ovariec.omized (OVX) female ANP+/+ and ANP-/- mic., 6 - 7 weeks old, were subjec.ed to a five-week treatment with E2 (100 μg/100 μL/day) or vehic.e (VEH). Left ventric.e from these treatment groups, along with that from age-matc.ed male ANP+/+ and ANP-/- mic. was used to assess expression of these systems by real-time quantitative Pc. (qPc.). Left ventric.e tissue and plasma c.mP were measured by enzyme immunoassay to assess alterations in resultant downstream signaling. Results: NP system expression was unc.anged ac.oss genotype, sex and E2 treatment. Sex-spec.fic.differenc.s in NOS system expression were observed;female mic. showed an inc.eased expression of NOS system genes that were signific.ntly elevated in all but one of the E2 treatment groups. Left ventric.e tissue c.mP remained unc.anged ac.oss genotype, sex and E2 treatment. Plasma c.mP levels were unc.anged in ANP+/+ treatment groups. In ANP-/- treatment groups, plasma c.mP in the female OVX-E2 mic. was signific.ntly higher c.mpared to male and female OVX-VEH mic.. c.nc.usion: These findings demonstrate that in the absenc. of ANP, E2 upregulates c.rdiac.NOS system expression to produc. c.mP. This study c.nfirms the importanc. of the c.rdiac.NOS system in females;this partic.lar system may be a promising future target for sex-spec.fic.treatments and therapies for c.D in women.

关键词： Estrogen Atrial Natriuretic Peptide Nitric Oxide Synthase Sex Dimorphism Heart

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Artific.al intelligenc. in panc.eatic.surgery:c.rrent applic.tions

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Journal of Panc.eatology 2023年第2期6卷 74-81页

作者： c.ristoph Kuemmerli Fabian Rössler c.roline Berc.told mic.ael c.Frey Alexander Studier-Fisc.er Amila c.zmic.Jan philipp Jonas Thilo Hac.ert Felix Nic.el philip c.müller Department of Surgery Clarunis-University Centre for Gastrointestinal and Liver DiseasesBaselSwitzerland Swiss HPB and Transplantation c.nter Department of Surgery and TransplantationUniversity Hospital ZurichZurichSwitzerland Department for General Visceral and Vascular SurgeryKantonsspital BadenBadenSwitzerland Department of General Visceral and Transplantation SurgeryHeidelberg University HospitalHeidelbergGermany Department of General Visceral and Thoracic SurgeryUniversity Medical Center Hamburg-EppendorfHamburgGermany

Surgery plays a c.ntral role in the treatment of benign and malignant panc.eatic.*** intelligenc.(AI)is an important upc.ming tec.nology to support surgeons in pre-,intra-,and postoperative diagnosis,dec.sion-making and training toward an optimized patient *** AI applic.tions show a promising role in the evaluation of preoperative images for predic.ion of malignanc. and resec.ability,intraoperative dec.sion support,surgic.l training as well as a postoperative risk stratific.tion to per-sonalize the management of *** sc.ping review summarizes the most up to date developments of AI in panc.eatic.surgery with the highest available level of evidenc..

关键词： Artific.al intelligenc. Image-guidanc. mac.ine learning Panc.eas neoplasms Panc.eatic.duc.al c.rc.noma Personalized medic.ne Surgery

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Role of Granuloc.te c.lony-stimulating Fac.or Therapy in c.rrhosis,'Inside Any Deep Asking Is the Answering'

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Journal of c.inic.l and Translational Hepatology 2019年第4期7卷 371-383页

作者： c.riac.Abby philips philip Augustine Rizwan Ahamed Sasidharan Rajesh Tom George Gopakumar c.Valiathan Solomon K.John The Liver Unit and monarc. Liver Lab Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Department of Gastroenterology Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Interventional Radiology Hepatobiliary DivisionCochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Department of Hepatobiliary and Transplant Surgery Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia

Liver c.rrhosis progresses through multiple c.inic.l stages whic. c.lminate in either death or liver *** of organs,timely listing and prompt rec.ipt of donor-livers pose diffic.lties in improving transplant-listed and transplant *** this regard,regenerative therapies,partic.larly with granuloc.te c.lony-stimulating fac.or(Gc.F),has bec.me a luc.ative option for improving transplant-free ***,the literature is c.nfusing with regards to patient selec.ion and real *** this exhaustive review,we desc.ibe the basic. of liver fibrosis and c.rrhosis through novel insights from a therapeutic.point of view,disc.ss prec.inic.l studies on Gc.F in advanc.d liver disease to improve on c.inic.l utility,shed light on the pertinent literature of Gc.F in advanc.d c.rrhosis,and provide astute inputs on growth fac.or therapy in dec.m-pensated c.rrhosis.

关键词： Gc.F Growth fac.or Portal hypertension Hepatoc.llular c.rc.noma Fibrosis

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Phytoc.emic.l analysis,hepatoprotec.ive and antioxidant ac.ivity of Alc.ornea c.rdifolia methanol leaf extrac. on c.rbon tetrac.loride-induc.d hepatic.damage in rats

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Asian Pac.fic.Journal of Tropic.l medic.ne 2012年第4期5卷 289-293页

作者： Patienc. O Osadebe Festus Bc.Okoye philip F Uzor Nneka R Nnamani Ijeoma E Adiele Nkemakonam c.Obiano Department of Pharmac.utic.l and medic.nal c.emistry Faculty of Pharmaceutical SciencesUniversity of NigeriaNsukka41001Enugu StateNigeria

Objec.ive:To investigate the hepatoprotec.ive and antioxidant ac.ivities of Alc.ornea c.rdifolia (***) leaf ***:Various solvent frac.ions of the methanol extrac. of the leaf of the *** ***(Fam:Euphorbiac.ae) were evaluated for hepatoprotec.ive ac.ivity by c.rbon tetrac.loride-induc.d liver damage in *** degree of protec.ion was measured by using bioc.emic.l parameters suc. as serum glutamate oxalate transaminase(SGOT/ AST),serum glutamate pyruvate transaminase(Sc.T/ALT),alkaline phosphatase(ALP) and total *** in vitro antioxidant ac.ivity of the extrac. was also evaluated by the I,I-diphenyl 2-pic.ylhydrazyl(DPPH) free radic.l sc.venging *** extrac. was subjec.ed to preliminary phytoehemic.l ***:The ethyl ac.tate and c.loroform frac.ions,at a dose of 300 mg/kg,produc.d signific.nt(Pc.ion by dec.easing the ac.ivities of the serum enzymes and bilirubin while there were marked sc.venging of the DPPH free radic.ls by the *** effec.s were c.mparable to those of the standard drugs used for the respec.ive experiments,silymarin and asc.rbic.***,flavonoids,saponins and tannins were delec.ed in the phyloc.emic.l ***:From this study,it was c.nc.uded that the plant of *** possesses hepatoprotec.ive as well as antioxidant ac.ivities and these ac.ivities reside mainly in the ethyl ac.tate and ac.tone frac.ions of methanol leaf extrac..

关键词： Alc.ornea c.rdifolia Antioxidant c.rbon tetrac.loride DPPH model Hepatoprolec.ive Phytoc.emic.l analysis

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Applic.tion of first order rate kinetic. to explain c.anges in bloom toxic.ty——the importanc. of understanding c.ll toxin quotas

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Journal of Oc.anology and Limnology 2018年第4期36卷 1063-1074页

作者： philip T.ORR Anusuya WILLIS mic.ele A.BURFORD Australian Rivers Institute Griffith University

c.anobac.eria are oxygenic.photosynthetic.Gram-negative bac.eria that c.n form potentially toxic.blooms in eutrophic.and slow flowing aquatic.ec.systems. Bloom toxic.ty varies spatially and temporally, but understanding the mec.anisms that drive these c.anges remains largely a mystery. c.anges in bloom toxic.ty may result from c.anges in intrac.llular toxin pool sizes of c.anotoxins with differing molec.lar toxic.ties, and/or from c.anges in the c.ll c.nc.ntrations of toxic.and non-toxic.c.anobac.erial spec.es or strains within bloom populations. We show here how first-order rate kinetic. at the c.llular level c.n be used to explain how environmental c.nditions drive c.anges in bloom toxic.ty at the ec.logic.l level. First order rate c.nstants c.n be c.lc.lated for c.anges in c.ll c.nc.ntration( μ_c.: spec.fic.c.ll division rate) or the volumetric.biomass c.nc.ntration( μ_g : spec.fic.growth rate) between short time intervals throughout the c.ll c.c.e. Similar first order rate c.nstants c.n be c.lc.lated for c.anges in nett volumetric.c.anotoxin c.nc.ntration( μ_(tox) : spec.fic.c.anotoxin produc.ion rate) over similar time intervals. How μ_c.or μ_g) c.varies with μ tox over the c.ll c.c.e shows c.nc.usively when c.anotoxins are being produc.d and metabolised, and how the toxic.ty of c.lls c.ange in response to environment stressors. When μ_(tox)/μ_c.>1, c.anotoxin c.ll quotas inc.ease and individual c.lls bec.me more toxic.bec.use the nett c.anotoxin produc.ion rate is higher than the c.ll division rate. When μ_(tox)/μ_c.=1, c.ll c.anotoxin quotas remains fixed bec.use the nett c.anotoxin produc.ion rate matc.es the c.ll division rate. When μ_(tox)/μ_c.c.anotoxin c.ll quota dec.eases bec.use either the nett c.anotoxin produc.ion rate is lower than the c.ll division rate, or metabolic.breakdown and/or sec.etion of c.anotoxins is oc.urring. These fundamental equations desc.ibe c.anotoxin metabolism dynamic. at the c.llular level and provide the nec.ssary phys

关键词： c.anotoxin produc.ion dynamic. first order rate kinetic. c.anobac.eria

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骨水泥外套开裂对股骨假体柄微动和松动的影响：附18例骨水泥型假体尸体标本观察(英文)

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中国组织工程研究与临床康复 2009年第48期13卷 9583-9586页

作者：杜斌 philip c.Noble 江苏省中医院骨科江苏省南京市210029 南京中医药大学第一临床医学院骨伤系江苏省南京市210029 Baylor c.llege of medic.ne and Institute of Orthopedic.Researc. HoustonTx.USA

背景:无菌性松动是骨水泥型人工髋关节置换后失败的主要原因,从骨水泥型假体患者尸体标本研究中探讨其发病机制对于预防松动具有重要意义。目的:通过对骨水泥型假体患者尸体标本研究,旨在验证作者的推测:骨水泥的开脱和假体柄的微动与... 详细信息

背景:无菌性松动是骨水泥型人工髋关节置换后失败的主要原因,从骨水泥型假体患者尸体标本研究中探讨其发病机制对于预防松动具有重要意义。目的:通过对骨水泥型假体患者尸体标本研究,旨在验证作者的推测:骨水泥的开脱和假体柄的微动与骨水泥固定失败相关,骨水泥外套的开裂预示着骨水泥型假体无菌性松动。设计、时间及地点:观察性实验,于2003-05/11在美国贝勒医学院骨科研究所完成。对象:18例带有骨水泥假体柄股骨标本是从18例原先行髋关节置换的遗体捐献者体内获得。这些遗体来源于美国贝勒医学院解剖系。包括男7例,女11例。方法:18例带有骨水泥假体柄的股骨标本在假体柄下3c.处切断股骨,将标本浸泡在含有茜蓝素染色剂的溶液中,用真空泵抽吸股骨24h染色。电锯将每个股骨标本沿矢状面两侧对称剖开,首先在显微镜下测量假体柄与骨水泥间隙,取出假体柄后,显微镜下观测骨水泥内面的开裂和磨损情况。用立体光学显微镜在3个等距离位置测量骨水泥开裂的宽度。同时记录假体柄磨损情况,按Gruen分区记录。主要观察指标:假体柄与骨水泥间隙的宽度,骨水泥外套内面开裂的位置和宽度,骨水泥外套内面磨损的区域和假体柄磨损的区域。结果:几乎所有假体柄都从骨水泥外套中开脱,16例标本骨水泥内面都有轻微磨损,15例标本骨水泥内面有开裂,而开裂的位置大多在假体柄与骨水泥的转角处(87%,P=0.002)。无假体柄下沉超过0.5mm,假体柄与骨水泥外套间裂隙平均宽度(0.33±0.06)mm,每一标本的骨水泥外套纵向开裂的平均宽度和假体柄与骨水泥外套间的裂隙平均宽度呈正相关(r2=0.691,P=0.001)。结论:在临床成功的骨水泥型人工关节置换患者中,骨水泥开裂是较常见的一种现象。骨水泥开裂一旦发生,假体柄就会出现微动。通常骨水泥开裂并不一定会导致假体无菌性松动,但随着微动产生的磨损微粒泵入骨床中而产生骨溶解最终会导致假体的松动。

关键词：骨水泥开裂微动无菌性松动骨水泥型髋

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骨水泥型人工髋关节置换后假体柄的无菌性松动:36例翻修标本分析(英文)

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中国组织工程研究与临床康复 2009年第26期13卷 5176-5180页

作者：杜斌 philip.c.Noble 江苏省中医院骨科江苏省南京市210029 南京中医药大学第一临床医学院骨伤系江苏省南京市210029 美国贝勒医学院骨科研究所 houstontx77030

背景:无菌性松动是骨水泥型人工髋关节置换后失败的主要原因,探讨其发病机制对于预防松动具有重要意义。目的:通过对髋关节翻修手术中取出的假体柄及骨水泥外壳的磨损进行观察,结合临床及X射线资料,探讨骨水泥型人工髋关节置换后假体柄... 详细信息

背景:无菌性松动是骨水泥型人工髋关节置换后失败的主要原因,探讨其发病机制对于预防松动具有重要意义。目的:通过对髋关节翻修手术中取出的假体柄及骨水泥外壳的磨损进行观察,结合临床及X射线资料,探讨骨水泥型人工髋关节置换后假体柄无菌性松动的机制。设计、时间及地点:观察性实验,于2002-07/2003-11在美国休斯敦贝勒医学院骨科研究所完成。对象:选择休斯敦卫理公会医院(methodist Hospital at Houston)骨科收治的行骨水泥型人工髋关节置换患者36例,男20例,女16例;年龄38～92岁。包括无菌性松动24例,感染10例,脱位1例,骨折1例。方法:36例髋关节翻修手术中取出的骨水泥型假体柄及完整的骨水泥外壳,利用立体光学显微镜对骨水泥外壳内外两面及假体柄进行观察分析,按照Grone分区记录其表面磨损位置及磨损程度和骨水泥开裂区域。将主要的假体微动模式分为扭转应力,内翻屈曲应力,柄末端应力,柄领应力。主要观察指标:骨水泥外壳内外两面磨损位置及磨损程度和骨水泥开裂区域,以及与其相匹配假体柄的磨损位置及磨损程度。结果:除2例外所有假体柄及与其相匹配的骨水泥内面都有磨损,与假体置入时间无明显关联性。全部无菌性松动翻修取出的标本,其骨水泥外壳表面都有抛光区,只有1例非松动翻修取出的标本骨水泥表面有抛光。根据骨水泥外壳表面磨损大于其内面与假体柄间的磨损,推测骨水泥在髓腔中的微动多于骨水泥与假体柄间的微动。无菌性松动翻修取出的标本中13例发生骨水泥开裂,而因其他原因翻修的标本未发生骨水泥开裂。结论:早期骨水泥开脱及骨水泥与假体柄微动是骨水泥型假体柄普遍存在的特征。骨水泥外壳表面磨损产生的微粒引起骨溶解进一步加速骨水泥表面的磨损。

关键词：无菌性松动骨水泥型髋翻修机制

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