Role of Granulocyte Colony-stimulating Factor Therapy in Cirrhosis,'Inside Any Deep Asking Is the Answering'

作     者：Cyriac Abby Philips Philip Augustine Rizwan Ahamed Sasidharan Rajesh Tom George Gopakumar C.Valiathan Solomon K.John 

作者机构：The Liver Unit and Monarch Liver LabCochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Department of GastroenterologyCochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Interventional RadiologyHepatobiliary DivisionCochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Department of Hepatobiliary and Transplant SurgeryCochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2019年第7卷第4期

页      面：371-383页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：GCSF Growth factor Portal hypertension Hepatocellular carcinoma Fibrosis 

摘      要：Liver cirrhosis progresses through multiple clinical stages which culminate in either death or liver *** of organs,timely listing and prompt receipt of donor-livers pose difficulties in improving transplant-listed and transplant *** this regard,regenerative therapies,particularly with granulocyte colony-stimulating factor(GCSF),has become a lucrative option for improving transplant-free ***,the literature is confusing with regards to patient selection and real *** this exhaustive review,we describe the basics of liver fibrosis and cirrhosis through novel insights from a therapeutic point of view,discuss preclinical studies on GCSF in advanced liver disease to improve on clinical utility,shed light on the pertinent literature of GCSF in advanced cirrhosis,and provide astute inputs on growth factor therapy in decom-pensated cirrhosis.