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Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype

Journal of molecular Cell Biology 2020年第7期12卷 499-514页

作者： Eduard Sarró mónica durán Ana Rico Diana Bou-Teen Vanesa Fernández-majada Anthony J.Croatt Karl A.nath maria Teresa Salcedo Justin H.Gundelach Daniel Batlle Richard J.Bram Anna meseguer Renal Physiopathology Group CIBBIM-NanomedicineVall d’Hebron Research Institute08035 BarcelonaSpain Cardiovascular Diseases Group Vall d’Hebron Research Institute08035 BarcelonaSpain Biomimetic Systems for Cell Engineering Laboratory Institute for Bioengineering of Catalonia(IBEC)The Barcelona Institute of Science and Technology(BIST)08028 BarcelonaSpain Division of nephrology and Hypertension and Department of medicine Mayo ClinicRochesterMN 55905USA Department of Pathology Hospital Universitari Vall d’Hebron08035 BarcelonaSpain Department of Pediatric and Adolescent medicine College of MedicineMayo ClinicRochesterMN 55905USA Department of Biochemistry and molecular Biology College of MedicineMayo ClinicRochesterMN 55905USA Division of nephrology and Hypertension Northwestern University Feinberg School of MedicineChicagoIL 60611USA Department of Immunology College of MedicineMayo ClinicRochesterMN 55905USA Departament de Bioquímica i Biologia molecular Unitat de Bioquímica de MedicinaUniversitat Autònoma de Barcelona08193 BellaterraSpain Red de Investigación Renal(REDInREn) Instituto de Salud Carlos III-FEDER28040 MadridSpain

Restoration of kidney tubular epithelium following sublethal injury sequentially involves partial epithelial–mesenchymal transition(pEmT),proliferation,and further redifferentiation into specialized tubule epithelial cells(TECs).Because the immunosuppressant cyclosporine-A produces pEmT in TECs and inhibits the peptidyl-prolyl isomerase(PPIase)activity of cyclophilin(Cyp)proteins,we hypothesized that cyclophilins could regulate TEC *** we demonstrate that in cultured TECs,CypA silencing triggers loss of epithelial features and enhances transforming growth factorβ(TGFβ)-induced EmT in association with upregulation of epithelial repressors Slug and *** pro-epithelial action of CypA relies on its PPIase *** contrast,CypB emerges as an epithelial repressor,because CypB silencing promotes epithelial differentiation,prevents TGFβ-induced EmT,and induces tubular structures in 3D *** addition,in the kidneys of CypB knockout mice subjected to unilateral ureteral obstruction,inflammatory and pro-fibrotic events were *** silencing/knockout leads to Slug,but not Snail,*** support of Slug expression depends on its endoplasmic reticulum location,where it interacts with calreticulin,a calcium-buffering chaperone related to Slug *** CypB silencing reduces ionomycin-induced calcium release and Slug upregulation,we suggest that Slug expression may rely on CypB modulation of calreticulin-dependent calcium *** conclusion,this work uncovers new roles for CypA and CypB in modulating TEC plasticity and identifies CypB as a druggable target potentially relevant in promoting kidney repair.

关键词： cyclophilins epithelial phenotype Slug TGFβ UUO fibrosis

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Ultrasound cyclo plasty for the management of glaucoma secondary to ocular irradiation for choroidal melanoma

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International Journal of Ophthalmology(English edition) 2020年第1期13卷 184-188页

作者： Stefano Sebastiani mónica Asencio-durán Cosme Lavín-Dapena Beatriz manzanomuñoz Oriana D’Anna-mardero Rosa Cordero-Ros marco Pellegrini Federico Bernabei Andrea mercanti Vincenzo Scorcia Giuseppe Giannaccare Ophthalmology Unit S.Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Ophthalmology Unit Infermi HospitalRimini 47838Italy Ophthalmology Department Hospital Universitario La PazMadrid 28046Spain Department of Ophthalmology University of“Magna Graecia”Catanzaro 88100Italy

Dear Editor,In the past, enucleation has been considered the only available option and the standard of care for the management of malignant intraocular tumors. Thanks to the advances in the field of radiotherapy, new therapeutic approaches have been developed in the last decades, such as plaque brachytherapy and proton beam therapy(PBT)^([1]).

关键词： ocular therapy glaucoma

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Towards defining soil quality of mediterranean calcareous agricultural soils:Reference values and potential core indicator set

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International Soil and Water Conservation Research 2024年第1期12卷 145-155页

作者： Germán A.durán Daniel Sacristán Edelweis Farrús Jaume Vadell Institut de Recerca i FormacióAgrària i Pesquera de les Illes Balears C/Eusebi Estada14507009PalmaSpain Plant Biology Department University of Valencia46100BurjassotValenciaSpain Soil and Environmental Quality Department Centro de Investigaciones sobre Desertificación-CIDE(CSIC-Universitat de València-Generalitat Valenciana)Carretera Moncada-Náquera km 4.546113MoncadaValenciaSpain Universitat de les Illes Balears Cra.De Valldemossakm 7507122PalmaSpain

To avoid soil degradation,adapt to climate change and comply with the Sustainable Development goals 2030(Un General Assembly),establishing the quality/fertility of the agricultural soils of the mediterranean region and evaluate how these evolve with time is *** enables adequate management practices to be *** mediterranean calcareous region has received little attention in this sense,in spite its soil ***,24 different representative calcareous agricultural soils of the mediterranean region,including the main management strategies of agricultural soils(rainfed and irrigated),were sampled from the island of mallorca;and their physical,chemical and biological properties *** values obtained for most of the soil characteristics allowed to establish an initial approach to the reference values for the type of calcareous agricultural soils considered,and to clearly distinguish the effect of rainfed or irrigation management practices on soils properties and *** enzyme activities were not stimulated by the irrigation conditions assayed or they were only in dry conditions,suggesting optimum enzyme activities could be obtained when alternating dry and humid soil *** organic carbon,calcium carbonate and active lime revealed of significant importance in the collection of ***,the results obtained clearly indicate the heterogeneity of the region and its implications on the different soil ***,this study could serve as a starting point to adequately establish the quality(fertility)for mediterranean calcareous agricultural soils and their reference values by conducting further research in this region and including more type of soils.

关键词： Soil fertility mediterranean agricultural soils Calcareous soils Soil enzymes Soil management

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The Ti-TAn plasmid toolbox for TurboID-based proximity labeling assays in nicotiana benthamiana

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Journal of Integrative Plant Biology 2024年第2期66卷 166-168页

作者： Huang Tan Yu Zhou Erik Dinius Rosa Lozano-durán Department of Plant Biochemistry Center for Plant MolecularBiology(ZMBP)Eberhard Karls UniversityTubingenD‐72076Germany

Protein-protein interactions and the formation of protein complexes play a central role in the regulation of virtually all aspects of *** identification and characterization of interactions between proteins is the bas... 详细信息

关键词： proximity complexes enable

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Endoscopic treatment of biliopancreatic pathology in patients with Whipple's pancreaticoduodenectomy surgical variants: Lessons learned from single-balloon enteroscopy-assisted ERCP

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 509-514页

作者： Rodrigo Garcés-durán Laurent monino Pierre H Deprez Hubert Piessevaux Tom G moreels Department of Gastroenterology and Hepatology Universitécatholique de LouvainCliniques Universitaires Saint-LucAvenue Hippocrates 101200 BrusselsBelgium

Background: Endoscopic treatment of biliopancreatic pathology is challenging due to surgically altered anatomy after Whipple's pancreaticoduodenectomy. This study aimed to evaluate the feasibility and safety of single-balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography(SBE-ERCP) to treat biliopancreatic pathology in patients with Whipple's pancreaticoduodenectomy surgical variants. methods: We retrospectively analyzed 106 SBE-ERCP procedures in 46 patients with Whipple's variants. Technical and clinical success rates and adverse events were evaluated. Results: Biliary SBE-ERCP was performed in 34 patients and pancreatic SBE-ERCP in 17, including 5 with both indications. From a total of 106 SBE-ERCP procedures, 76 were biliary indication with technical success rate of 68/76(90%) procedures and clinical success rate of 30/34(88%) patients. mild adverse event rate was 8/76(11%), without serious adverse events. From a total of 106 SBE-ERCP procedures, 30 were pancreatic indication with technical success rate of 24/30(80%) procedures( P = 0.194 vs. biliary SBEERCP) and clinical success rate of 11/17(65%) patients( P = 0.016 vs. biliary SBE-ERCP). mild adverse event rate was 6/30(20%)( P = 0.194 vs. biliary SBE-ERCP), without serious adverse events. After SBE-ERCP failure, endoscopic ultrasound-guided drainage, percutaneous drainage and redo surgery were alternative therapeutic options. Conclusions: Biliopancreatic pathology after Whipple's pancreaticoduodenectomy variants can be treated using SBE-ERCP without serious adverse events. Technical and clinical success rates are high for biliary indications, whereas clinical success rate of pancreatic indications is significantly lower. SBE-ERCP can be considered as first-line treatment option in this patient group with surgically altered anatomy.

关键词： Enteroscopy Endoscopic retrograde cholangiopancreatography Pancreaticoduodenectomy Surgically altered anatomy Whipple’s procedure

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machine learning in liver surgery:Benefits and pitfalls

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World Journal of Clinical Cases 2024年第12期12卷 2134-2137页

作者： Rafael Calleja manuel durán maría Dolores Ayllón Ruben Ciria Javier Briceño Hepatobiliary Surgery and Liver Transplantation Unit Hospital Universitario Reina SofíaMaimonides Biomedical Research Institute of CordobaCórdoba 14004Spain

The application of machine learning(mL)algorithms in various fields of hepatology is an issue of ***,we must be cautious with the *** this letter,based on a published mL prediction model for acute kidney injury after liver surgery,we discuss some limitations of mL models and how they may be addressed in the *** the future faces significant challenges,it also holds a great potential.

关键词： machine learning Liver surgery Artificial intelligence Random forest Prediction model

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球虫和其他原虫(续)

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国外畜牧学（猪与禽） 2014年第4期34卷 31-32页

作者：肖昌 David S. Lindsay Jitender P. Dubey mónica Santín-durán Ronald Fayer 西南大学生物技术学院

1.7治疗和控制1.7.1抗球虫药母猪似乎并不是哺乳仔猪球虫病的主要感染源(Stuart和Lindsay,1986);因此,在母猪的日粮中添加抗球虫药来控制新生仔猪的球虫病价值很小。早期的研究报道称通过治疗母猪来控制新生仔猪球虫病很可能会取得成功... 详细信息

1.7治疗和控制1.7.1抗球虫药母猪似乎并不是哺乳仔猪球虫病的主要感染源(Stuart和Lindsay,1986);因此,在母猪的日粮中添加抗球虫药来控制新生仔猪的球虫病价值很小。早期的研究报道称通过治疗母猪来控制新生仔猪球虫病很可能会取得成功,因为一旦养猪生产者意识到他们的猪有球虫病。

关键词：仔猪球虫病抗球虫药养猪生产者弓形体病弓浆虫感染亚临床症状等孢球虫病母源抗体癸氧喹酯

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球虫和其他原虫(续完)

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国外畜牧学（猪与禽） 2014年第6期34卷 31-33页

作者：肖昌何闪 David S.Lindsay Jitender P.Dubey mónica Santín-durán Ronald Fayer 西南大学生物技术学院

5重要性较小或有可能传播给人类的其他原虫5.1贾第鞭毛虫蓝氏贾第鞭毛虫(Giardia duodenalis),也叫做蓝伯氏贾第虫(Giardia lamblia)和肠贾第虫(Giardia intestinalis),可能是世界各地最常见的人和家畜的肠道寄生虫。它是一个物种群,根... 详细信息

5重要性较小或有可能传播给人类的其他原虫5.1贾第鞭毛虫蓝氏贾第鞭毛虫(Giardia duodenalis),也叫做蓝伯氏贾第虫(Giardia lamblia)和肠贾第虫(Giardia intestinalis),可能是世界各地最常见的人和家畜的肠道寄生虫。它是一个物种群,根据基因分析有7个基因集合体,它们的成员在形态学上不能区别,集合体A和B可感染人和多种哺乳动物;其他的主要是感染动物的特定群,如集合体C和D可感染犬科动物。

关键词：蓝氏贾第鞭毛虫贾第虫病犬科动物肠道寄生虫肠贾第虫微孢子虫基因分析滋养体孢原质经产母

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球虫和其他原虫(续)

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国外畜牧学（猪与禽） 2014年第2期34卷 34-35页

作者：肖昌何闪 David S.Lindsay Jitender P.Dubey mónica Santín-durán Ronald Fayer 西南大学生物技术学院

若7～14日龄的仔猪出现腹泻且抗生素治疗无效，则暗示有猪等孢球虫感染。鉴别诊断时应考虑其他致病因子，如肠致病性大肠杆菌、传染性胃肠炎（TGE）病毒、轮状病毒、C型产气荚膜梭状芽孢杆菌和蓝氏类圆线虫（Strongyloidesransomi）等。

关键词：球虫感染产气荚膜梭状芽孢杆菌致病性大肠杆菌原虫传染性胃肠炎轮状病毒致病因子鉴别诊断

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球虫和其他原虫(续)

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国外畜牧学（猪与禽） 2014年第5期34卷 34-36页

作者：肖昌何闪 David S. Lindsay Jitender P.Dubey mónica Santín-durán Ronald Fayer 西南大学生物技术学院

3住肉孢子虫住肉孢子虫属是一种球虫性寄生虫,其生活史中有两个宿主。其中三个种以猪作为中间宿主,并在猪的肌肉组织中形成组织孢囊(孢子虫)。猪住肉孢子虫(Sarcocystis miescheriana)具有一个由猪到狗的生活史(图6),是在美国发现的仅... 详细信息

3住肉孢子虫住肉孢子虫属是一种球虫性寄生虫,其生活史中有两个宿主。其中三个种以猪作为中间宿主,并在猪的肌肉组织中形成组织孢囊(孢子虫)。猪住肉孢子虫(Sarcocystis miescheriana)具有一个由猪到狗的生活史(图6),是在美国发现的仅有的一个种。狗通过粪便排出处于感染性阶段的虫体(孢囊)。其他的种是猪-人住肉孢子虫(Sarcocystis suihominis)。

关键词：肉孢子虫孢囊生活史临床症状虫体等孢球虫猪场环境致病性终末宿主形成组织

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