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Identification and functional characterization of fish IL‑17 receptors suggest important roles in the response to nodavirus infection

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marine Life Science & Technology 2024年第2期6卷 252-265页

作者： carmen González‑Fernández miguel A.García‑Álvarez Alberto cuesta Department of cell Biology and Histology Faculty of BiologyUniversity of Murcia30100 MurciaSpain Laboratoire d’écotoxicologie Centre de Lyon-VilleurbanneINRAEUR RiverLy69625 VilleurbanneFrance

Th17 is a lymphocyte T helper(Th)subpopulation relevant in the control and regulation of the immune response characterized by the production of interleukin(IL)-*** crucial cytokine family acts through their binding to the IL-17 receptors(IL-17R),having up to six *** the biology of fish Th17 is well-recognized,the molecular and functional characterization of IL-17 and IL-17R has been ***,our aim was to identify and characterize the IL-17R repertory and regulation in the two main mediterranean cultured fish species,the gilthead seabream(Sparus aurata)and the European sea bass(Dicentrarchus labrax).Our in silico results showed the clear identification of six members in each fish species,from IL-17RA to IL-17RE-like,with well-conserved gene structure and protein domains with their human *** of them showed wide and constitutive transcription in naïve tissues but with highest levels in mucosal tissues,namely skin,gill or *** leucocytes,T mitogens showed the strongest up-regulation in most of the il17 receptors though il17ra resulted in inhibition by most ***,in vivo nodavirus infection resulted in alterations on the transcription of il17 *** nodavirus infection led to some increments in the il17ra,il17rb,il17rc and il17rd transcripts in the susceptible European sea bass,many down-regulations were observed in the resistant gilthead *** data identify the presence and conservation of six coding IL-17R in gilthead seabream and European sea bass as well as their differential regulation in vitro and upon nodavirus infection.

关键词： Th17 cells IL-17 receptors Immunity Teleost fish Nodavirus(NNV) Aquaculture

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A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinic.l opportunities

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military medical Research 2024年第2期11卷 228-267页

作者： miguel A.Ortega Oscar Fraile-martinez cielo García-montero Sergio Haro miguel Ángel Álvarez-mon Diego De Leon-Oliva Ana m.Gomez-Lahoz Jorge monserrat mar Atienza-Pérez David Díaz Elisa Lopez-Dolado melchor Álvarez-mon Department of medicine and medical Specialities University of Alcala28801 Alcala de HenaresSpain Ramón y cajal Institute of Sanitary Research(IRYcIS) 28034 MadridSpain Department of Psychiatry and mental Health Hospital Universitario Infanta Leonor28031 MadridSpain Service of Rehabilitation National Hospital for Paraplegic PatientsCarr.de la PeraledaS/N45004 ToledoSpain Immune System Diseases‑Rheumatology Service and Internal medicine University Hospital Príncipe de Asturias(CIBEREHD)28806 Alcala de HenaresSpain

Spinal cord injury(ScI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after ScI,explaining the progression and detrimental consequences related to this ***(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a *** initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and *** the present review,we will explore the most important local and systemic consequences of ScI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are ***,potential clinic.l approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinic.l management of these patients.

关键词： Spinal cord injury(ScI) Psychoneuroimmunoendocrinology(PNIE) Secondary injury Immunoinflammatory dysfunction Gut microbiota Translational opportunities

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Solar-driven cO_(2) conversion to methane and methanol using different nanostructured cu_(2)O-based catalysts modified with Au nanoparticles

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Journal of Energy chemistry 2024年第4期91卷 287-298页

作者： João Angelo Lima Perini Lilian D.moura Torquato Juliana Fde Brito Gustavo A.Andolpho mateus A.Gonçalves Leonardo D.De Angelis Lucas D.Germano Susana I.c.rdoba de Torresi Teodorico c.Ramalho maria V.Boldrin Zanoni São Paulo State University(UNESP) Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil National Institute of Alternative Technologies for Detection Toxicological Evaluation and Removal of Micropollutants and Radioactive Substances(INCT-DATREM)São Paulo State University(UNESP)Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil Laboratory of molecular modelling Department of ChemistryNatural Sciences InstituteFederal University of LavrasLavrasMG 37200-900Brazil Department of chemistry Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Instituto de Química Universidade de São PauloAv.Prof.Lineu Prestes 74805508-080São PauloSPBrazil

This work describes the use of TiO_(2)nanotubes-based electrodes(TNT)modified with cu_(2)O nanostructures and gold nanoparticles for the photoelectroreduction of cO_(2)to produce value-added compounds.A thin layer of polydopamine was used as both an adherent agent and an electron transfer mediator,due to itsπ-conjugated electron *** highest production yield was achieved using a TNT@PDA/Nc/Au40%electrode,with Faradaic efficiencies of 47.4%(110.5μm cm^(-2))and 27.8%(50.4μm cm^(-2))for methanol and methane,*** performance of the photoelectrodes was shown to be cu_(2)O facet-dependent,with cubic structures leading to greater conversion of cO_(2)to methanol(43%)and methane(27%),compared to the octahedral morphology,while a higher percentage of metallic gold on the nanostructured cu_(2)O surface was mainly important for *** functional theory(DFT)calculations supported these findings,attributing the superior photoelectrocatalytic performance of the TNT@PDA/Nc/Au40%electrode for cH4generation to the formation of an OcH3intermediate bonded to Au *** using isotope-labeling and analysis by gas chromatograph-mass(Gc-mS)demonstrated that13cO_(2)was the source for photoelectrocatalytic generation of13cH3OH and13cH313cH2OH.

关键词： cu_(2)O nanocubes Photoelectrocatalysis Polydopamine cO_(2) photoelectroreduction DFT calculations

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Human Papillomavirus Within Psoriasis Plaques in a Patient With Psoriasis:A case Report

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International Journal of Dermatology and Venereology 2024年第1期7卷 55-57页

作者： Karen P.Lema-matehu Nathalie P.Lascano-Gallegos Santiago A.Palacios-Álvarez School of medicine Eugenio Espejo UTE UniversityQuito 170147Ecuador Department of Dermatology Centro de la PielQuito 170508Ecuador

Introduction:Psoriasis may be triggered by several factors,and its pathophysiology is related to inflammatory cellular *** herein describe a patient with psoriasis who developed warts on multiple psoriasis plaques and was successfully treated with systemic subcutaneous *** presentation:A 67-year-old man who had been diagnosed with psoriasis 14 years previously developed an outbreak of small erythematous desquamative plaques distributed symmetrically on his arms and *** spiny whitish papules had developed over his previously established psoriasis *** appearance of the papules was consistent with viral *** patient was treated with systemic methotrexate injected subcutaneously and oral folic acid,both dosed *** treatment produced good ***:A remarkable feature of this case is that psoriasis was the first diagnosis and that human papillomavirus(HPV)appeared over widespread erythematous squamous *** pathophysiology of psoriasis is related to inflammatory cellular *** authors have reported that HPV proteins may stimulate keratinocyte *** have reported that HPV infection mostly stimulates systemic interleukin 17 production;consequently,HPV infection could provide a better environment for interleukin 17 secretion and facilitate new onset of *** report indicated that methotrexate was discontinued in a patient who presented with both pathologies,although we had very good ***:Psoriasis and HPV may be pathophysiologically *** may stimulate keratinocyte proliferation and systemic interleukin 17 production,resulting in a better environment for *** methotrexate injected subcutaneously resulted in a good outcome in our patient.

关键词： human papillomavirus methotrexate psoriasis case report

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multichannel coupling induced topological insulating phases with full multimerization

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Photonic. Research 2024年第3期12卷 491-498页

作者： JUN LI YAPING YANG c-m.HU mOE Key Laboratory of Advanced micro-Structured materials School of Physics Science and EngineeringTongji UniversityShanghai 200092China Department of Physics and Astronomy University of ManitobaWinnipegManitoba R3T 2N2Canada

We propose and experimentally realize a class of quasi-one-dimensional topological lattices whose unit cells are constructed by coupled multiple identical resonators,with uniform hopping and inversion *** the presence of coupling-path-induced effective zero hopping within the unit cells,the systems are characterized by complete multimerization with degenerate-1 energy edge states for open boundary condition.

关键词： symmetry topological coupling

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consumer transparency in the production chain for plant varieties produced using new genomic techniques

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aBIOTEcH 2024年第2期5卷 239-246页

作者： J.m.Lukasiewicz c.c.m.van de Wiel L.A.P.Lotz m.J.m.Smulders Wageningen University&Research P.O.Box 386NL-6700 AJ WageningenThe Netherlands

Plants edited with new genomic techniques(NGTs)currently fall under the Genetically modified Organisms Directive(2001/18/Ec)in the European *** the proposal of the European commission,NGT plants are partially exempted from the regulations of this *** proposal makes a distinction between two categories of NGT plants:NGT-1 and ***-1 category plants are considered equal to plants obtained through conventional breeding *** plants will not be labelled for the consumer,although they will be labelled as ***-2 category plants may be labelled with additional information as a positive *** of seeds of varieties made with gene editing,but not the products,would mean that most steps in the production chain are transparent,but not the last step towards ***“right to know”and increasing knowledge of gene-edited food is a common theme in food labelling towards ***,we describe current labelling regimes and registers and how these may be applied to provide transparency on gene-edited products to ***,we also look into consumer studies,which indicate a greater acceptance of gene-edited food among consumers,especially when additional benefits such as sustainability are mentioned.

关键词： Labelling New genomic techniques consumer transparency Plant products

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mental health in organizations from a healthcare analytics framework:taxonomic model,trends,and impact of cOVID-19

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Journal of management Analytics 2024年第1期11卷 62-86页

作者： Jorge Iván Pérez Rave carlos mario Zapata Jaramillo Gloria Patricia Jaramillo Álvarez IDINNOV research group IDINNOV S.A.SMedellínColombia Department of computing and Decision Sciences Universidad Nacional de ColombiaMedellínColombia

mental disorders negatively affect employee well-being and organizational *** face a challenge in terms of how to manage mental *** paper clarifies three issues(underlying patterns,trends,and impact of cOVID-19)regarding the scientific study of mental health in organizations from a healthcare analytics *** framework comprises eight stages considering a text-driven approach with scientific corpora assisted by linguistic/computational and statistical *** study discovers a new taxonomic model comprising five patterns in the scientific discourse on the *** analyses reveal imbalances and concerns regarding the interests associated with the patterns,which is reinforced by examining patterns“before”and“during”*** paper complements psychological/epidemiological studies on mental health in organizations from a healthcare analytics perspective.

关键词： Healthcare analytics healthcare management analytics mental health scientific discourse text analytics taxonomy cOVID-19 management analytics

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Diplopoda in the world fossil record

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Zoological Systematics 2024年第3期49卷 185-245页

作者： michelle Álvarez-Rodríguez Francisco Riquelme miguel Hernández-Patricio Fabio cupul-magaña Laboratorio de Sistemática molecular Escuela de Estudios Superiores del JicareroUniversidad Autónoma del Estado de MorelosC.P.62909JojutlaMorelosMexico mmRN Centro de Investigaciones BiológicasUniversidad Autónoma del Estado de MorelosC.P.62209CuernavacaMorelosMexico Unafíliate centro Universitario de la costa Universidad de GuadalajaraC.P.48280Puerto VallartaJaliscoMexico

We present a comprehensive catalog with an updated database of the fossil record of Diplopoda in the *** data was collected from descriptions and reports published from 1854 to the *** also include new records from mexican amber(Upper Oligocene-Lower miocene),counting 83 unknown fossil inclusions,with the first records of the orders Polyxenida,Platydesmida,and Julida,as well as the families Sphaeriodesmidae and Trichopolydesmidae within *** to our results,Diplopoda counts 413 records featuring 299 distinct taxa ranging from the middle Silurian to the Upper Pleistocene,representing three subclasses,two subterclasses,six superorders,25 orders,15 superfamilies,55 families,93 genera,and 161 fossil *** date,no fossils of the order Siphonocryptida have been *** fossil record extends over three geological eras:the Paleozoic,with 161 taxa,including 97 species;the mesozoic,with 53 taxa and 22 species;and the cenozoic,with 85 taxa and 42 *** referred material shows different forms of fossil *** comprises 123 impressions,99 compressions,26 ichnites,predominantly from Paleozoic and mesozoic sediments,and 165 amber inclusions from late mesozoic and cenozoic ***,this catalog allows us to estimate the size and taxonomic composition of Diplopoda in the fossil record worldwide.

关键词： millipedes Paleozoic mesozoic cenozoic new records catalog

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Performance of evolutionary optimized machine learning for modeling total organic.carbon in core samples of shale gas fields

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Petroleum 2024年第1期10卷 150-164页

作者： Leonardo Goliatt c.m.Saporetti L.c.Oliveira E.Pereira Department of computational and Applied mechanic. Federal University of Juiz de Fora Department of computational modeling Polytechnic Institute Rio de Janeiro State University Petrobras Department of Stratigraphy and Paleontology Rio de Janeiro State University

Rock samples' TOc content is the best indicator of the organic.matter in source rocks. The origin rock samples' analysis is used to calculate it manually by specialists. This method requires time and resources because it relies on samples from many well intervals in source rocks. Therefore, research has been done to aid this effort. machine learning algorithms can estimate total organic.carbon instead of well logs and stratigraphic studies. In light of these efforts, the current work present a study on automating the total organic.carbon estimation using machine learning approaches improved by an evolutionary methodology to give the model flexibility and precision. Genetic algorithms, differential evolution, particle swarm optimization, grey wolf optimization, artificial bee colony, and evolution strategies were used to improve machine learning models to predict TOc. The six metaheuristics were integrated into four machine learning methods: extreme learning machine, elastic net linear model, linear support vector regression, and multivariate adaptive regression splines. core samples from the YuDong-Nan shale gas field, located in the Sichuan basin, were used to evaluate the hybrid strategy. The findings show that combining machine learning models with an evolutionary algorithms in a hybrid fashion produce flexible models that accurately predict TOc. The results show that, independent of the metaheuristic used to guide the model selection, optimized extreme learning machines attained the best performance scores according to six metrics. Such hybrid models can be used in exploratory geological research,particularly for unconventional oil and gas resources.

关键词： Total organic.carbon Hybrid models Automated machine learning Evolutionary algorithms Geology

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The challenging management of malignant ureteral obstruction:Analysis of a series of 188 cases

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current Urology 2024年第1期18卷 34-42页

作者： Alberto Artiles medina Inés Laso García Fernando González Tello Sara Álvarez Rodríguez manuel Hevia Palacios marina mata Alcaraz césar mínguez Ojeda Fernando Arias Funez Victoria Gómez Dos Santos Francisco Javier Burgos Revilla Department of Urology Hospital Universitario Ramón y CajalMadridSpain Department of Radiology Hospital Universitario Ramón y CajalMadridSpain

Background:malignant ureteral obstruction(mUO)is a common condition that complicates the course of advanced *** aims of this study are to analyze the causes,management,and survival of patients with obstructive nephropathy due to malignant ureteric obstruction and to determine prognostic ***,we studied the complications and outcomes in patients who underwent urinary *** and methods:A retrospective study was conducted on patients with computed tomography-confirmed mUO between January 2016 and November ***,clinic.l,radiological,laboratory,and management data were *** curves were estimated using the Kaplan-meier method,and univariate and multivariate cox proportional hazards models were used to test the association between parameters and ***:A total of 188 patients were *** mean age was 69.01 years(SD,14.95 years),and the majority(54.8%)were *** most common mechanism leading to mUO was compression by a pelvic mass(36.9%),and the 3 most frequent tumors causing mUO were prostate(17.6%),bladder(16.5%),and rectal cancer(11.7%).Forty-seven patients(25%)underwent urinary diversion:23(48.9%)underwent double-J stenting and 21(44.7%)underwent percutaneous *** most common reason for urinary diversion was acute kidney injury(53.3%).Recovery of renal function was observed in 55.8%of the patients after urinary *** most frequently identified complications after urinary diversion were urinary tract infection(24.4%),hematuria(17.0%),and urinary sepsis(14.9%).The median survival after hydronephrosis diagnosis was 6.43 months(interquartile range,1.91-14.81 months).In patients who underwent urinary decompression,the median survival after urinary diversion was 8.67 months(interquartile range,2.99-17.28 months).In the multivariate analysis,a lower grade of hydronephrosis and cancer cachexia negatively impacted ***:cancer patients with mUO have a poor pro

关键词： Hydronephrosis Ureteral obstruction Neoplasms Urinary diversion Survival Prognosis

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