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Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions

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World Journal of Clinical Oncology 2014年第3期5卷 440-454页

作者： Gonzalo Recondo Jr Enrique Dìaz Canton màximo de la vega martin Greco Gonzalo Recondo Sr matias E Valsecchi Centro de Educación médica e Investigaciones Clínicas (CEmIC) 4102 Buenos AiresArgentina Fundaleu Fundación para Combatir la LeucemiaServicio de Oncología Clínica4102 Buenos AiresArgentina medical Oncology HIMGHuntingtonWV 25705United States

During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available.

关键词： Breast cancer Human epidermal growth factor receptor-2 Trastuzumab Pertuzumab Adotrastuzumab lapatinib

How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1405-1406页

作者： Livia la Barbera Paraskevi Krashia Annalisa Nobili department of medicine and Surgery UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly department of Experimental Neurosciences IRCCS Santa Lucia FoundationVia del Fosso di FioranoRomeItaly department of Science and Technology for Sustainable development and One Health UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly

despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc *** is cha racterized by featured histological alterations including amyloid-beta (AB) plaque deposition,accumulation of neurofibrillary to ngles of hyperphosphorylated-tau,and neuronal loss,accompanied by progressive cognitive decline and behavioral changes.

关键词： Alzheimer alterations dopamine

Concentrations and sources of an emerging pollutant, decabromodiphenylethane (DBDPE), in sewage sludge for land application

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Journal of Environmental Sciences 2012年第3期24卷 558-563页

作者： de la Torre A Concejero m A martínez m A Persistent Organic Pollutant Group Environment Department CIEMAT Avd. Complutense 22 Madrid 28040 Spain

The presence of an emerging brominated flame retardant, decabromodiphenylethane （DBDPE）, has been confirmed in Spanish sewage sludge. Thirty one samples from different urban wastewater treatment plants （WWTPs） were analyzed for this brominated flame retardant. DBDPE was positively identified and quantified in all samples at lower concentrations （47.0 ± 29.7 ng/g dry weight （dw）; mean ± SD） than those obtained for decabromodiphenyl ether （Bde-209）（290 ± 236 ng/g dw; mean ± SD） in a previous study. Influence of the WWTP characteristics in the pollutant levels was evaluated. No significant correlations were obtained between DBDPE concentrations and the population or sewage sludge production rate associated with the plants, neither wastewater treatment method. Sources of DBDPE in the sludge were also evaluated. Data indicate a common origin for DBDPE and Bde-209, which may be related to leaching processes during the use and disposal of consumer products containing these chemicals. Nevertheless, DBDPE contents are not influenced by industrial activities, which suggests that the infusion of DBDPE commercial mixture is not a source of this chemical into the environment, and indicates that the use of DBDPE in the Spanish industry is still low compared to deca-Bde.

关键词： decabromodiphenylethane polybrominated diphenyl ethers wastewater treatment plants sewage sludge

Resting metabolic rates increase with elevation in a mountain-dwelling lizard

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Integrative Zoology 2020年第5期15卷 363-374页

作者： melissa PlaSmAN Amando BAUTISTA marshall D.mcCUE Aníbal H.DÍAZ de la vega-PÉREZ Centro Tlaxcala de Biología de la Conducta Universidad Autónoma de TlaxcalaTlaxcalaMéxico Sable Systems International Las VegasNevadaUSA Consejo Nacional de Ciencia y Tecnología–Centro Tlaxcala de Biología de la Conducta Universidad Autónoma de TlaxcalaTlaxcalaMéxico

ndividuals that inhabit broad elevational ranges may experience unique environmental *** temperature decreases with increased elevation,the ectotherms living at high elevations have to manage limited activity time and high thermoregulatory *** resting metabolic rate(RmR)of a postabsorptive animal is related to its total energy requirements as well as many other fitness *** lizards(Sceloporus grammicus)living on la malinche Volcano,mexico,inhabit a wide elevational range with some populations apparently thriving above the tree *** measured the RmR of lizards from different elevations(i.e.,2,600,3,200,and 4,100 m)at four ecologically relevant temperatures(i.e.,15,25,30,and 35°C)and found that RmR of mesquite lizards increased with temperature and body *** importantly,lizards from the high-elevation population had mass specific RmR that was higher at all *** the higher RmRs of high-elevation populations imply higher metabolic costs at a given temperature these lizards were also *** of these traits may allow these high elevation populations to thrive in the face of the thermal challenges imposed by their environment.

关键词： altitudinal gradient energetics reptile Sceloporus temperature

A Note on Tropical Triangles in the Plane

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Acta mathematica Sinica,English Series 2009年第11期25卷 1775-1786页

作者： m.ANSOla m.J.de la PUENTE departamento de Algebra Facultad de matemáticas Universidad Complutense

We define transversal tropical triangles （affine and projective） and characterize them via six inequalities to be satisfied by the coordinates of the vertices. We prove that the vertices of a transversal tropical triangle are tropically independent and they tropically span a classical hexagon whose sides have slopes ∞, 0, 1. Using this classical hexagon, we determine a parameter space for transversal tropical triangles. The coordinates of the vertices of a transversal tropical triangle determine a tropically regular matrix. Triangulations of the tropical plane are obtained.

关键词： tropical triangles tropical triangulation linear inequalities convexity tropical semi-field

Radiomics in pancreatic cancer for oncologist:Present and future

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 356-361页

作者： Carolina de la Pinta Radiation Oncology department Ramón y Cajal University HospitalIRYCISAlcaláUniversity28034 MadridSpain

Radiomics is changing the world of medicine and more specifically the world of *** diagnosis and treatment improve the prognosis of patients with *** treatment,the evaluation of the response will determine future *** oncology,every change in treatment means a loss of therapeutic options and this is key in pancreatic *** has been developed in oncology in the early diagnosis and differential diagnosis of benign and malignant lesions,in the evaluation of response,in the prediction of possible side effects,marking the risk of recurrence,survival and prognosis of the *** studies have validated its use to differentiate normal tissues from tumor tissues with high sensitivity and specificity,and to differentiate cystic lesions and pancreatic neuroendocrine tumor grades with texture *** addition,these parameters have been related to survival in patients with pancreatic cancer and to response to radiotherapy and *** review aimed to establish the current status of the use of radiomics in pancreatic cancer and future perspectives.

关键词： Pancreatic cancer Radiomics Radiogenomics

Stereotactic body radiotherapy in pancreatic adenocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 14-19页

作者： Carolina de la Pinta Radiation Oncology department Ramón y Cajal University HospitalIRYCISAlcaláUniversity28034 MadridSpain

Background:Stereotactic body radiotherapy(SBRT)in pancreatic cancer allows high delivery of radiation doses on tumors without affecting surrounding *** review aimed at the SBRT application in the treatment of pancreatic *** sources:We retrieved articles published in mEDLINE/Pubmed from January 2017 to december *** used in the search included:“pancreatic adenocarcinoma”OR“pancreatic cancer”AND“stereotactic ablative radiotherapy(SABR)”OR“stereotactic body radiotherapy(SBRT)”OR“chemoradiotherapy(CRT)”.English language articles with information on technical characteristics,doses and fractionation,indications,recurrence patterns,local control and toxicities of SBRT in pancreatic tumors were *** articles were assessed for validity and relevant ***:Optimal doses and fractionation have not yet been ***,SBRT could be the standard treatment in patients with pancreatic adenocarcinoma in addition to ***,the combination of SBRT with chemotherapy may have additive or synergic effect on pancreatic ***:SBRT is an effective modality for patients with pancreatic cancer,supported by clinical practice guidelines as it has demonstrated good tolerance and good disease *** opens a possibility of improving outcomes for these patients,both in neoadjuvant treatment and with radical intent.

关键词： Chemoradiotherapy Pancreatic adenocarcinoma Radiotherapy Stereotactic body radiotherapy Stereotactic ablative radiotherapy

Study of the structural,ferroelectric,dielectric,and pyroelectric properties of the K0.5Na0.5NbO3 system doped with Li+,la3+,and Ti4+

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Journal of Advanced Ceramics 2020年第3期9卷 329-338页

作者： C.mONTERO-TAVERA m.D.DURRUTHY-RODRiGUEZ F.D.CORTES-vega J.m.YANEZ-LImON Center for Research and Advanced Studies of IPN Campus QueretaroMexico National Evangelical University Paseo de los Periodistas#54Ensanche MirafloresSanto DomingoDistrito NacionalRepiblica Dominicana

Pure *** sNbO3(KNN)and KNN doped with Lit(6%mole),lat(1.66%,5%,6%mole),and Ti+t(10%mole)were prepared by mixture of oxides using high-energy milling and conventional solid-state *** effects of the dopant on the physical properties of pure KNN have been evaluated based on the structural,ferroelectric,pyroelectric,and dielectric *** XRD measurements show that KNN pure sample contains a mixture of monoclinic and orthorhombic crystalline phases,with a slightly higher concentration of monoclinic *** contrast,all doped samples show a higher concentration of the orthorhombic phase,as well as the presence of a secondary phase(K6Nb10.8O3o),also detected by Raman *** samples with a higher concentration of this secondary phase,also present greater dielectric losses and lower values of remnant *** dielectric measurements allowed us to detect temperatures of structural transitions(orthorhombic-tetragonal,O-T)previous to the ferroelectric paraelectric transition(tetragonal-cubic,T-C),and also in this set of samples,a direct correlation was found between the values of remnant polarization and the corresponding pyroelectric signal response.

关键词： K0.5Na0.5NbO3(KNN) lead-free solid-state reaction structural properties pyroelectric properties dielectric properties Li,la,Ti doping elements

Observations of defect propagation in [100]-oriented opal-type photonic crystals

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Chinese Physics B 2008年第4期17卷 1298-1304页

作者：金崇君 Richard m.de la Rue Nigel P.Johnson department of Electronics & Electrical Engineering University of Glasgow School of Physics and Engineering Laboratory of Optoelectronic Materials and TechnologiesSun Yat-Sen University

Charged colloidal suspensions have been used as experimental models for the study of crystal nucleation. Here we propose that the technique of template-assisted colloidal self-assembly can be used to visualize the effects of defect propagation in atomic crystal films produced using epitaxial growth. Templates with periodic line defects were used to grow [100]-oriented three-dimensional photonic crystals by means of the template-assisted colloidal self-assembly method, aided by capillary and gravitational forces. The defect propagation in the [100]-oriented photonic crystal was observed using scanning electron microscopy, both at the surface of the crystal and on cleaved facets. This method is useful in the understanding of defect propagation in the growth of colloidal films on templates - and the same approach may also prove useful for the understanding of atomic crystal growth on substrates with defects. Additionally, the deliberate incorporation of line defects may prove valuable as a way of introducing waveguide channels into three-dimensional photonic crystals.

关键词： photonic crystal colloidal crystal self-assembly