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Ident.ficat.on of new genet.c risk fact.rs for prost.t. cancer

Asian Journal of Andrology 2009年第1期11卷 49-55页

作者： Michelle Guy Zsofia Kot.-Jarai Graham G. Giles Ali Amin Al olama Sarah K. Jugurnaut. Shani Mulholland Daniel A. Leongamomlert.St.phen M. Edwards Jonat.an Morrison Helen I. Field Melissa C. Sout.ey Gianluca Severi Jenny L. Donovan Freddie C. Hamdy David R Dearnaley Kennet. R. Muir Charmaine Smit. Melisa Bagnat. Audrey t. Ardern-Jones Amanda L. Hall lynne t. o＇brien Beat.ice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah Lewis Paul M. Brown Sameer G. Jhavar Malgorzat. t.mrakiewicz Art.t.ya Lophat.nanon Sarah L. Bryant.t.e UK Genet.c Prost.t. Cancer St.dy Collaborat.rs Brit.sh Associat.on of Urological Surgeons＇ Sect.on of oncology and t.e UK Prot.ct.St.dy Collaborat.rs Alan Horwich Robert.A. Huddart.Vincent.S. Khoo Christ.pher C. Parker Christ.pher J. Woodhouse Alan t.ompson t.m Christ.as Chris ogden Cyril Fisher Charles Jameson Colin S. Cooper Dallas R. English John L. Hopper David E. Neal Douglas E East.n Rosalind A. Eeles Sect.on of Cancer Genet.cs The Institute of Cancer Research Sutton Surrey SM2 5NG UK Cancer Epidemiology Cent.e The Cancer Council Victoria Carlton VIC 3053 Australia Cent.e for Molecular Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia Cancer Research UK Genet.c Epidemiology Unit University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Depart.ent.of oncology University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Genet.c Epidemiology Laborat.ry Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Depart.ent.of Social Medicine University of Bristol Bristol BS8 2PR UK Academic Urology Unit University of Sheffield Sheffield SIO 2JF UK t.e Royal Marsden NHS Foundat.on t.ust Sutton Surrey SM2 5PT and London SW3 6JJ UK Universit. of Not.ingham Medical School Queens Medical Centre Nottingham NG7 2UH UK Inst.t.t. for Cancer St.dies University of Sheffield Sheffield SIO 2RX UK Surgical oncology （Uro-oncology S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK A full list.of aut.ors is provided in t.e Supplement.ry Not. online Ka Shing Centre Cambridge CB2 ORE UK Cancer Research UK Cambridge Research Inst.t.t. Li Ka Shing Centre Cambridge CB2 ORE UK.

t.ere is evidence t.at.a subst.nt.al part.of genet.c predisposit.on t. prost.t. cancer （PCa） may be due t. lower penet.ance genes which are found by genome-wide associat.on st.dies. We have recent.y conduct.d such a st.dy and seven new regions of t.e genome linked t. PCa risk have been ident.fied. t.ree of t.ese loci cont.in candidat. suscept.bilit. genes： MSMB, LMt.2 and KLK2/3. t.e MSMB and KLK2/3 genes may be useful for PCa screening, and t.e LMt.2 gene might.provide a pot.nt.al t.erapeut.c t.rget. t.get.er wit. result. from ot.er groups, t.ere are now 23 germline genet.c variant. which have been report.d. t.ese result. have t.e pot.nt.al t. be developed int. a genet.c t.st. However, we consider t.at.market.ng of t.st. t. t.e public is premat.re, as PCa risk can not.be evaluat.d fully at.t.is st.ge and t.e appropriat. screening prot.cols need t. be developed. Follow-up validat.on st.dies, as well as st.dies t. explore t.e psychological implicat.ons of genet.c profile t.st.ng, will be vit.l prior t. roll out.int. healt.care.

关键词： prost.t. cancer genet.cs suscept.bilit. loci SNPs relat.ve risks

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Macular carot.noid supplement.t.on improves disabilit. glare performance and dynamics of phot.st.ess recovery

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Eye and Vision 2016年第1期3卷 231-238页

作者： James M.St.ingham Kevin J.o’brien Nicole t.St.ingham Nut.it.onal Neuroscience Laborat.ry Department of Physiology and PharmacologyUniversity of GeorgiaAthensGA 30602USA Vision Sciences Laborat.ry Department of PsychologyUniversity of GeorgiaAthensGA 30602USA Int.rdisciplinary Neuroscience Program Biomedical Health Sciences InstituteUniversity of GeorgiaAthensGA 30602USA

Background:t.e so-called macular carot.noids(MC)lut.in(L),zeaxant.in(Z),and meso-zeaxant.in(MZ)comprise t.e diet.derived macular pigment.MP).t.e purpose of t.is st.dy was t. det.rmine effect. of MC supplement.t.on on t.e opt.cal densit. of MP(MPoD),repeat.d-exposure phot.st.ess recovery(PSR),and disabilit. glare(DG)***:t.is was a double-blind,placebo-cont.olled ***-nine young(mean age=21.7),healt.y volunt.ers part.cipat.d in t.is *** supplement.d t.eir daily diet.wit. eit.er 10 mg L+2 mg t.t.l Z(1 mg Z+1 mg MZ;n=24),20 mg L+4 mg t.t.l Z(2 mg Z+2 mg MZ;n=25),or placebo(n=10)for 12 *** primary out.ome was a composit. measure of visual performance in glare,defined by change in DG and *** out.omes included MPoD and visual *** primary endpoint.for out.omes was 12 *** was assessed wit. cust.mized het.rochromat.c flicker *** t.mes for an 8 cycle/degree,15%cont.ast.Gabor pat.h t.rget.were det.rmined aft.r each of five successive exposures t. int.nse LED *** t.reshold was defined as t.e int.nsit. of a ring of light. t.rough which subject. were able t. maint.in visibilit. of t.e aforement.oned *** of all paramet.rs were conduct.d at.baseline,6 mont.s,and 12 ***-measures ANoVA,and Pearson product.moment.correlat.ons were used t. det.rmine st.t.st.cally significant.correlat.ons,and changes wit.in and bet.een ***:MPoD for subject. in bot. supplement.t.on groups increased significant.y versus placebo at.bot. 6-and 12-mont. visit.(por all).Addit.onally,PSR t.mes and DG t.resholds improved significant.y from baseline compared t. placebo at.6-and 12-mont. visit.(por all).At.baseline,MPoD was significant.y relat.d t. bot. DG t.resholds(r=0.444;p=0.0021)and PSR t.mes(r=-0.56;pt.on of MPoD,t.e repeat.d-exposure PSR curves became more asympt.t.c,as opposed t. *** change in subject.’DG t.resholds were significant.y relat.d t. chang

关键词： Lut.in Zeaxant.in Mesozeaxant.in Visual performance Phot.st.ess recovery Disabilit. glare Macular pigment Visual cycle

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cardiGAN:A generat.ve adversarial net.ork model for design and discovery of mult. principal element.alloys

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Journal of Mat.rials Science & t.chnology 2022年第30期125卷 81-96页

作者： Z.Li W.t.Nash S.P.o’brien Y.Qiu R.K.Gupt. N.Birbilis College of Engineering and Comput.r Science The Australian National UniversityA.C.T.Acton 2601Australia Depart.ent.of Mat.rials Science and Engineering Monash UniversityClaytonVictoria 3800Australia Depart.ent.of Mat.rials Science and Engineering North Carolina State UniversityRaleighNC 27695USA

Mult.-principal element.alloys(MPEAs),inclusive of high ent.opy alloys(HEAs),cont.nue t. at.ract.significant.research at.ent.on owing t. t.eir pot.nt.ally desirable *** MPEAs remain under ext.nsive research,t.adit.onal(***)alloy product.on and t.st.ng are bot. cost.y and t.meconsuming,part.y due t. t.e inefficiency of t.e early discovery process which involves experiment. on a large number of alloy *** is int.it.ve t. apply machine learning in t.e discovery of t.is novel class of mat.rials,of which only a small number of pot.nt.al alloys have been probed t. *** t.is work,a proof-of-concept.is proposed,combining generat.ve adversarial net.orks(GANs)wit. discriminat.ve neural net.orks(NNs),t. accelerat. t.e explorat.on of novel *** applying t.e GAN model herein,it.was possible t. direct.y generat. novel composit.ons for MPEAs,and t. predict.t.eir *** verify t.e predict.bilit. of t.e model,alloys designed by t.e model are present.d and a candidat. produced-as *** suggest. t.at.t.e model herein offers an approach t.at.can significant.y enhance t.e capacit. and efficiency of development.of novel MPEAs.

关键词： Alloy design Machine learning Generat.ve adversarial net.ork Neural net.ork Mult.-principal element.alloy High ent.opy alloys

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Will oscillat.ng wave surge convert.rs survive t.unamis?

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t.eoret.cal & Applied Mechanics Let.ers 2015年第4期5卷 160-166页

作者： L.o'brien P.Christ.doulides E.Renzi t.St.fanakis F.Dias School of Mat.emat.cal Sciences Monash University Facult. of Engineering and t.chnology Cyprus University of Technology School of Mat.emat.cal Sciences University College Dublin Depart.ent.of Mat.emat.cal Sciences Loughborough University Cent.e de Mat.émat.ques et.de Leurs Applicat.ons (CMLA) Ecole Normale Supérieure de Cachan

Wit. an increasing emphasis on renewable energy resources, wave power t.chnology is becoming one of t.e realist.c solut.ons. However, t.e 2011 t.unami in Japan was a harsh reminder of t.e ferocit. of t.e ocean. It.is known t.at.t.unamis are nearly undet.ct.ble in t.e open ocean but.as t.e wave approaches t.e shore it. energy is compressed, creat.ng large dest.uct.ve waves. t.e quest.on posed here is whet.er an oscillat.ng wave surge convert.r （oWSC） could wit.st.nd t.e force of an incoming t.unami. Several t.ols are used t. provide an answer： an analyt.cal 3D model developed wit.in t.e framework of linear t.eory, a numerical model based on t.e non-linear shallow wat.r equat.ons and empirical formulas. Numerical result. show t.at.run-up and draw-down can be amplified under some circumst.nces, leading t. an oWSC lying on dry ground t

关键词： t.unami Wave energy convert.r Wave loading oscillat.ng wave surge convert.r Wave-st.uct.re int.ract.on

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Novel t.chnique of Mult.slice Ct.Angiography for Diagnosis of Port.syst.mic Shunt. in Sedat.d Dogs

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open Journal of Vet.rinary Medicine 2013年第2期3卷 115-120页

作者： Merja R. Lait.nen Jodi S. Mat.eson Robert.t. o’brien Depart.ent.of Equine and Small Animal Medicine University of Helsinki Helsinki Finland

Diagnosing port.syst.mic shunt. (PSS) can be challenging in vet.rinary pat.ent.. Mult.ple imaging t.chniques have been described t. diagnose PSS. t.e aim of t.e st.dy was t. invest.gat. whet.er a novel mult.-slice comput.d t.mography (Ct. angiographic prot.col could be used for diagnosis of PSS in dogs ut.lizing only pat.ent.sedat.on and wit.out.t.e need of t.st.inject.on. Independent. blinded reviewers evaluat.d Ct.st.dies in a randomized order for st.dy qualit., shunt.presence, number, and locat.on of shunt.origin and t.rminat.on. t.ent. t.o confirmed dogs were included in t.e st.dy including 16 dogs wit. single ext.ahepat.c congenit.l PSS, one dog wit. single int.ahepat.c congenit.l PSS, and t.o dogs wit. mult.ple acquired PSS. t.ree of t.e dogs (3/22) were surgically and hist.logically confirmed free of shunt.. Final diagnosis was confirmed by surgery or necropsy. t.e new Ct.angiography prot.col was shown t. be diagnost.c in dogs wit. PSS wit. no need for general anest.esia, t.st.inject.ons, delay t.mes or t.ming det.rminat.ons. Specificit. and sensit.vit. were good (100%). t.e qualit. of t.e st.dies was considered good in t.e majorit. of cases (20/22). t.e amount.of mot.on art.fact.in t.e Ct.scans was minimal, and had no effect.on t.e diagnost.c qualit.. t.e Ct.prot.col was found t. be a useful, fast. and accurat. t.ol for diagnosing port.syst.mic shunt. wit. a 16-slice syst.m.

关键词： Dog Port.syst.mic Shunt Comput.d t.mography Angiography

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t.e role of soluble sugars during drought.in t.opical t.ee seedlings wit. cont.ast.ng t.lerances

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Journal of Plant.Ecology 2020年第4期13卷 389-397页

作者： Michael J.o’brien Annabelle Valt.t.Samuel Abiven Mirjam S.St.der Robert.ong Bernhard Schmid Área de Biodiversidad y Conservación Universidad Rey Juan Carlosc/Tulipán s/n.E-28933 MóstolesMadridSpain Sout.east.Asia Rainforest.Research Part.ership The Peak VistaLorang Punjak 1Tanjung LipatKota KinabaluSabah 88400Malaysia Depart.ent.of Evolut.onary Biology and Environment.l St.dies University of ZurichWinterthurerstrasse 1908057 ZurichSwitzerland Depart.ent.of Geography University of ZurichWinterthurerstrasse 1908057 ZurichSwitzerland Laborat.ire de Géologie UMR 8538Ecole Normale SupérieurePSL Research UniversityCNRSParisFrance Cent.e de recherche enécologie expériment.le et.prédict.ve(CEREEP-Ecot.on IleDeFrance) Département de biologieEcole normale supérieureCNRSPSL University77140St-Pierre-les-NemoursFrance Forest.Research Cent.e Sepilok90715 SandakanSabahMalaysia

Aims Non-st.uct.ral carbohydrat.s(NSCs)are plant.st.rage compounds used for met.bolism,t.ansport.osmoregulat.on and regrowt. following t.e loss of plant.*** in condit.ons suit.ble for opt.mal growt.,plant. cont.nue t. st.re *** st.rage may be due t. passive accumulat.on from sink-inhibit.d growt. or act.ve reserves t.at.come at.t.e expense of *** former pat.way implies t.at.NSCs may be a by-product.of sink limit.t.on,while t.e lat.er suggest. a funct.onal role of NSCs for use during poor *** Using 13C pulse labelling,we t.aced t.e source of soluble sugars in st.m and root.organs during drought.and everwet.condit.ons for seedlings of t.o t.opical t.ee species t.at.differ in drought.t.lerance t. est.mat. t.e relat.ve allocat.on of NSCs st.red prior t. drought.versus NSCs assimilat.d during *** monit.red growt.,st.mat.l conduct.nce,st.m wat.r pot.nt.al and NSC st.rage t. assess a broad carbon response t. *** Findings We found t.at.t.e drought.sensit.ve species had reduced growt.,conserved NSC concent.at.ons in leaf,st.m and root.organs and had a larger proport.on of soluble sugars in st.m and root.organs t.at.originat.d from pre-drought.st.rage relat.ve t. seedlings in cont.ol *** cont.ast.t.e drought.t.lerant.species maint.ined growt. and st.m and root.NSC concent.at.ons but.had reduced leaf NSCs concent.at.ons wit. a larger proport.on of st.m and root.soluble sugars originat.d from freshly assimilat.d phot.synt.at.s relat.ve t. cont.ol *** result. suggest.t.e drought.sensit.ve species passively accumulat.d NSCs during wat.r deficit.due t. growt. inhibit.on,while t.e drought.t.lerant.species act.vely responded t. wat.r deficit.by allocat.ng NSCs t. st.m and root.*** st.at.gies seem correlat.d wit. baseline maximum growt. rat.s,which support. previous research suggest.ng a t.ade-off bet.een growt. and drought.t.lerance while providing new evidence for t.e import.nce of plast.cit. in

关键词： ^(13)C labelling carbohydrat. st.rage drought.t.lerance hydraulic funct.on Shorea parvifolia Shorea beccariana source–sink allocat.on

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Using High-t.roughput.Phenot.ping t. Explore Growt. Responses t. Mycorrhizal Fungi and Zinc in t.ree Plant.Species

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Plant.Phenomics 2019年第1期1卷 121-132页

作者： S.J.Wat.s-Williams N.Jewell C.brien B.Berger t.Garnet. t.R.Cavagnaro t.e School of Agricult.re Food and Wineand The Waite Research InstituteThe University of AdelaidePMB 1Glen OsmondSA 5064Australia Aust.alian Research Council Cent.e of Excellence in Plant.Energy Biology The University of AdelaideGlen OsmondSAAustralia Aust.alian Plant.Phenomics Facilit. The Plant AcceleratorThe University of AdelaidePMB1Glen OsmondSA 5064Australia

t.ere are many report.d benefit. t. plant. of arbuscular mycorrhizal fungi(AMF),including posit.ve plant.biomass responses;however,AMF can also induce biomass depressions in plant.,and t.is response receives lit.le at.ent.on in t.e *** phenot.ping(Ht.)t.chnology permit. repeat.dmeasures of an individual plant.s aboveground *** examined t.e effect.on AMF inoculat.on on t.e shoot.biomass of t.ree cont.ast.ng plant.species:a veget.ble crop(t.mat.),a cereal crop(barley),and a past.re legume(Medicago).We also considered t.e int.ract.on ofmycorrhizal growt. responseswit. plant.available soil zinc(Zn)and phosphorus(P)*** appearance of a depression in shoot.biomass due t. inoculat.on wit. AMF occurred at.different.t.mes for each plant.species;depressions appeared earliest.in t.mat.,t.en Medicago,and t.en *** usually posit.ve-responding Medicago plant. were not.responsive at.t.e high level of soil available P *** growt. responsiveness in all t.ree species was also highly int.ract.ve wit. soil Zn supply;t.mat. growt. responded negat.vely t. AMF inoculat.on in all soil Zn t.eat.ent. except.t.e t.xic soil Zn t.eat.ent.where it.responded *** result. illust.at. how cont.xt.dependent.ycorrhizal growt. responses are and t.e value of Ht. approaches t. exploring t.e complexit. of mycorrhizal responses.

关键词： Species Fungi soil

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Biologic Augment.d Microdrilling Surgery for Mult.ple and Large Full-t.ickness Cart.lage Lesions in t.e Knee: Early Clinical and Radiological Result.

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Surgical Science 2017年第2期8卷 102-117页

作者： Joseph E. Broyles M. Adaire o’brien St.phanie t. Broyles M. Pat.ick St.gg Bone and Joint.Clinic of Bat.n Rouge Baton Rouge Louisiana USA Penningt.n Biomedical Research Cent.r Baton Rouge Louisiana USA Medical oncology oLoL Physician Group Baton Rouge Louisiana USA

Background: Various biologic t.eat.ent. are available for art.cular cart.lage lesions in t.e knee, but.no one exist. t.at.is applicable t. t.e full range of chondral disease and t.at.is compliant.wit. Unit.d St.t.s Food and Drug Administ.at.on regulat.ons. t.e aim of t.is st.dy was t. evaluat. out.omes following microdrilling surgery augment.d wit. post.perat.ve inject.ons of bone marrow aspirat. concent.at. (BMAC), plat.let.rich plasma (PRP) and hyaluronic acid (HA). Met.ods: Eight.en pat.ent. wit. at.least.one sympt.mat.c, full-t.ickness chondral lesion underwent.art.roscopic microdrilling surgery. Immediat.ly following surgery, pat.ent. received an int.a-art.cular inject.on of fresh BMAC, PRP, and HA. t.is inject.on was repeat.d once per week for 5 consecut.ve weeks. At.4 and 12 mont.s post.perat.vely, pat.ent. received 3 addit.onal weekly inject.ons for a t.t.l of 12 inject.ons. out.ome Measures: IKDC (Int.rnat.onal Knee Document.t.on Commit.ee) scores, KS (Knee Societ.) scores and plain radiographs. Result.: t.e mean t.eat.d area was 6.2 ± 4.5 (range, 0.6 - 14.7) cm2. t.e mean preoperat.ve IKDC and KS scores (±SE) were 43.0 ± 3.2 and 68.3 ± 3.6 respect.vely. At.24 mont.s post.perat.vely, IKDC and KS scores improved t. 85.3 ± 4.2 and 94.7 ± 4.4, respect.vely;bot. changes from baseline were significant.(p p = 0.05). t.is change was great.r in pat.ent. wit. preoperat.ve JS p for t.e difference bet.een groups = 0.1). Conclusions: Microdrilling of cart.lage lesions augment.d wit. BMAC, PRP, and HA may be a viable t.eat.ent.for a range of chondral disease wit. good early clinical and radiological result..

关键词： Cart.lage Microdrilling St.m Cells Joint Space

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Connexins in neurons and glia: t.rget. for int.rvent.on in disease and injury

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Neural Regenerat.on Research 2015年第7期10卷 1013-1017页

作者： Keit. B.Moore John o'brien Richard S.Ruiz M.D.Department of Ophthalmology & Visual Science The University of Texas Health Science Center at Houston t.e Universit. of t.xas Graduat. School of Biomedical Sciences

Bot. neurons and glia t.roughout.t.e cent.al nervous syst.m are organized int. net.orks by gap junct.ons. Among glia, gap junct.ons facilit.t. met.bolic homeost.sis and int.rcellular communicat.on. Among neurons, gap junct.ons form elect.ical synapses t.at.funct.on primarily for communicat.on. However, in neurodegenerat.ve st.t.s due t. disease or injury gap junct.ons may be det.iment.l t. survival. Elect.ical synapses may facilit.t. hyperact.vit. and byst.nder killing among neurons, while gap junct.on hemichannels in glia may facilit.t. inflammat.ry signaling and scar format.on. Advances in underst.nding mechanisms of plast.cit. of elect.ical synapses and development.of molecular t.erapeut.cs t. t.rget.glial gap junct.ons and hemichannels offer new hope t. pharmacologically limit.neuronal degenerat.on and enhance recovery.

关键词： ischemia ret.nal degenerat.on amacrine cells ast.ocyt.s dopamine recept.rs adenosine recept.rs NMDA recept.rs connexin mimet.c pept.des

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Neurological het.rot.pic ossificat.on:novel mechanisms,prognost.c biomarkers and prophylact.c t.erapies

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Bone Research 2020年第4期8卷 379-392页

作者： Ker Rui Wong Richelle Mychasiuk t.rence J.o’brien Sandy R.Shult. St.art.J.McDonald Rhys D.Brady Depart.ent.of Neuroscience Central Clinical SchoolMonash UniversityMelbourneVICAustralia Depart.ent.of Medicine Royal Melbourne HospitalThe University of MelbourneParkvilleVICAustralia Depart.ent.of Physiology Anatomy and MicrobiologySchool of Life SciencesLa Trobe UniversityBundooraVICAustralia

Neurological het.rot.pic ossificat.on(NHo)is a debilit.t.ng condit.on where bone forms in soft.t.ssue,such as muscle surrounding t.e hip and knee,following an injury t. t.e brain or spinal *** abnormal format.on of bone can result.in nerve impingement.pain,cont.act.res and impaired *** are oft.n diagnosed wit. NHo aft.r t.e bone t.ssue has complet.ly mineralised,leaving invasive surgical resect.on t.e only remaining t.eat.ent.*** resect.on of NHo creat.s pot.nt.al for added complicat.ons,part.cularly in pat.ent. wit. concomit.nt.injury t. t.e cent.al nervous syst.m(CNS).Alt.ough recent.work has begun t. shed light.on t.e physiological mechanisms involved in NHo,t.ere remains a significant.knowledge gap relat.d t. t.e prognost.c biomarkers and prophylact.c t.eat.ent. which are necessary t. prevent.NHo and opt.mise pat.ent.*** art.cle reviews t.e current.underst.nding pert.ining t. NHo epidemiology,pat.obiology,biomarkers and t.eat.ent.*** part.cular,we focus on how concomit.nt.CNS injury may drive ect.pic bone format.on and discuss considerat.ons for t.eat.ng polyt.auma pat.ent. wit. *** conclude t.at.underst.nding of t.e pat.ogenesis of NHo is rapidly advancing,and as such,t.ere is t.e st.ong pot.nt.al for fut.re research t. uneart. met.ods capable of ident.fying pat.ent. likely t. develop NHo,and t.rget.d t.eat.ent. t. prevent.it. manifest.t.on.

关键词： such has likely

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