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Interrelationship between physical activity and depression in nonalcoholic fatty liver disease

World Journal of hepatology 2022年第3期14卷 612-622页

作者： Ali A Weinstein Leyla De Avila Saisruthi Kannan James M Paik Pegah Golabi lynn h gerber Zobair M Younossi Betty and Guy Beatty Center for Integrated Research Inova Health SystemFalls ChurchVA 22042United States Global and Community health George Mason UniversityFairfaxVA 22030United States Center for Liver Disease Department of MedicineInova Fairfax Medical CampusFalls ChurchVA 22042United States Inova Medicine Inova Health SystemFalls ChurchVA 22042United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is associated with a sedentary lifestyle and depressive symptoms.It is also well established that physical inactivity and depressive symptoms are related.however,an investigation of the interaction between all of these factors in NAFLD has not been previously conducted.AIM To investigate the interrelationship between physical inactivity and depressive symptoms in individuals with NAFLD.METhODS Data from the Rancho Bernardo Study of healthy Aging were utilized.589 individuals were included in the analyses(43.1%male;95.8%non-hispanic white;aged 60.0±7.0 years).NAFLD was defined by using the hepatic steatosis index,depression using the Beck Depression Inventory,and physical activity by selfreport of number of times per week of strenuous activity.Multivariable generalized linear regression models with Gamma distribution were performed to investigate the proposed relationship.RESULTS About 40%of the sample had evidence of NAFLD,9.3%had evidence of depression,and 29%were physically inactive.Individuals with NAFLD and depression were more likely to be physically inactive(60.7%)compared to individuals with neither NAFLD nor depression(22.9%),individuals with depression without NAFLD(37.0%),and individuals with NAFLD without depression(33.3%).After accounting for various comorbidities(i.e.,age,sex,diabetes,hypertension,obesity),individuals with NAFLD and higher levels of physical activity were at a decreased odds of having depressive symptoms[16.1%reduction(95%confidence interval:-25.6 to-5.4%),P=0.004],which was not observed in those without NAFLD.CONCLUSION Individuals with NAFLD have high levels of physical inactivity,particularly those with depressive symptoms.Because this group is at high risk for poor outcomes,practitioners should screen for the coexistence of depressive symptoms and NAFLD.This group should receive appropriate interventions aimed at increasing both participation and levels of intensity of physical activity.

关键词： Liver disease Outcomes research Psychiatric disorders Exercise

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Importance of fatigue and its measurement in chronic liver disease

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World Journal of Gastroenterology 2019年第28期25卷 3669-3683页

作者： lynn h gerber Ali A Weinstein Rohini Mehta Zobair M Younossi Department of Medicine Beatty Center for Liver and Obesity Research Inova Health System Falls Church VA 22042 United States Center for the Study of Chronic Illness and Disability George Mason University Fairfax VA 22030 United States Beatty Center for Liver and Obesity Research Inova Health System Falls Church VA 22042 United States

The mechanisms of fatigue in the group of people with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are protean. The liver is central in the pathogenesis of fatigue because it uniquely regulates much of the storage, release and production of substrate for energy generation. It is exquisitely sensitive to the feedback controlling the uptake and release of these energy generation substrates. Metabolic contributors to fatigue, beginning with the uptake of substrate from the gut, the passage through the portal system to hepatic storage and release of energy to target organs (muscle and brain) are central to understanding fatigue in patients with chronic liver disease. Inflammation either causing or resulting from chronic liver disease contributes to fatigue, although inflammation has not been demonstrated to be causal. It is this unique combination of factors, the nexus of metabolic abnormality and the inflammatory burden of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis that creates pathways to different types of fatigue. Many use the terms central and peripheral fatigue. Central fatigue is characterized by a lack of self-motivation and can manifest both in physical and mental activities. Peripheral fatigue is classically manifested by neuromuscular dysfunction and muscle weakness. Therefore, the distinction is often seen as a difference between intention (central fatigue) versus ability (peripheral fatigue). New approaches to measuring fatigue include the use of objective measures as well as patient reported outcomes. These measures have improved the precision with which we are able to describe fatigue. The measures of fatigue severity and its impact on usual daily routines in this population have also been improved, and they are more generally accepted as reliable and sensitive. Several approaches to evaluating fatigue and developing endpoints for treatment have relied of biosignatures associated with fatigue. These have been used singly or in combination and include: phy

关键词： Fatigue Chronic liver disease Non-alcoholic fatty liver diseases Nonalcoholic steatohepatitis Measurement Patient-reported outcomes

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MUON DECAY PARAMETERS

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Chinese Physics C 2016年第10期40卷 638-640页

作者： W. Fetscher h.-J. gerber ETh Zurich

Introduction： All measurements in direct muon decay, μ- → e- ＋ 2 neutrals, and its inverse, vμ ＋ e-^-→ μ-＋ neutral, are successfully described by the ＂V-A interaction,＂ which is a particular case of a local, derivative-free, lepton-number- conserving, four-fermion interaction [1]. As shown below, within this framework, the Standard Model assumptions,

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Effectiveness of exercise in hepatic fat mobilization in nonalcoholic fatty liver disease: Systematic review

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World Journal of Gastroenterology 2016年第27期22卷 6318-6327页

作者： Pegah Golabi Cameron T Locklear Patrick Austin Sophie Afdhal Melinda Byrns lynn gerber Zobair M Younossi Betty and Guy Beatty Center for Integrated Research Inova Health System Department of Medicine Center for Liver Disease Inova Fairfax Hospital health Sciences Library Inova Fairfax Hospital

AIM: To investigate the efficacy of exercise interventions on hepatic fat mobilization in non-alcoholic fatty liver disease(NAFLD) patients.METhODS: Ovid-Medline, Pub Med, EMBASE and Cochrane database were searched for randomized trials and prospective cohort studies in adults aged ≥ 18 which investigated the effects of at least 8 wk of exercise only or combination with diet on NAFLD from 2010 to 2016. The search terms used to identify articles, in which exercise was clearly described by type, duration, intensity and frequency were: "NASh", "NAFLD", "nonalcoholic steatohepatitis", "non-alcoholic fatty liver disease", "fat", "steatosis", "diet", "exercise", "MR spectroscopy" and "liver biopsy". NAFLD diagnosis, as well as the outcome measures, was confirmed by either hydrogen-magnetic resonance spectroscopy(h-MRS) or biopsy. Trials that included dietary interventions along with exercise were accepted if they met all criteria. RESULTS: Eight studies met selection criteria(6 with exercise only, 2 with diet and exercise with a total of 433 adult participants). Training interventions ranged between 8 and 48 wk in duration with a prescribed exercise frequency of 3 to 7 d per week, at intensities between 45% and 75% of VO2 peak. The most commonly used imaging modality was h-MRS and one study utilized biopsy. The effect of intervention on fat mobilization was 30.2% in the exercise only group and 49.8% in diet and exercise group. There was no difference between aerobic and resistance exercise intervention, although only one study compared thetwo interventions. The beneficial effects of exercise on intrahepatic triglyceride(IhTG) were seen even in the absence of significant weight loss. Although combining an exercise program with dietary interventions augmented the reduction in IhTG, as well as improved measures of glucose control and/or insulin sensitivity, exercise only significantly decreased hepatic lipid contents.CONCLUSION: Prescribed exercise in subjects with NAFLD reduces IhTG independent of dietary intervention. D

关键词： Non-alcoholic fatty liver disease Exercise Diet Fat mobilization Lifestyle modification

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Identification of Lignin and Polysaccharide Modifications in Populus Wood by Chemometric Analysis of 2D NMR Spectra from Dissolved Cell Walls

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Molecular Plant 2009年第5期2卷 933-942页

作者： Mattias hedenstrom Susanne Wiklund-Lindstrom Tommy Oman Fachuang Lu Lorenz gerber Paul Schatz Bjorn Sundberg John Ralph Department of Chemistry Umea University SE-90187 Umea Sweden Department of Biochemistry and Great Lakes Bioenergy Research Center University of Wisconsin Madison WI 53706 USA Umea Plant Science Centre Department of Forest Genetics and Plant Physiology Swedish University of Agricultural Sciences SE-90183 Umea Sweden US Dairy Forage Research Center USDA-Agricultural Research Service Madison WI 53706 USA

2D ^13C-^1h hSQC NMR spectroscopy of acetylated cell walls in solution gives a detailed fingerprint that can be used to assess the chemical composition of the complete wall without extensive degradation. We demonstrate how multivariate analysis of such spectra can be used to visualize cell wall changes between sample types as high-resolution 2D NMR loading spectra. Changes in composition and structure for both lignin and polysaccharides can subsequently be interpreted on a molecular level. The multivariate approach alleviates problems associated with peak picking of overlapping peaks, and it allows the deduction of the relative importance of each peak for sample discrimination. As a first proof of concept, we compare Populus tension wood to normal wood. All well established differences in cellulose, hemicellulose, and lignin compositions between these wood types were readily detected, confirming the reliability of the multivariate approach, In a second example, wood from transgenic Populus modified in their degree of pectin methylesterification was compared to that of wild-type trees. We show that differences in both lignin and polysaccharide composition that are difficult to detect with traditional spectral analysis and that could not be a priori predicted were revealed by the multivariate approach. 2D NMR of dissolved cell wall samples combined with multivariate analysis constitutes a novel approach in cell wall analysis and provides a new tool that will benefit cell wall research.

关键词： Aspen biostatistics cell walls multivariate data analysis NMR spectroscopy tension wood

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一种测量液态含水量的新方法

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气象科技 1993年第1期21卷 89-93页

作者： h.gerber 孙阳

1 引言目前,有两种较为流行的测量云和雾中液态含水量的方法。第一种方法使用热线探针,如Johnson-Williams探针(Gayett,1986),或King探针(King和Turvey,1986;Biter等,1987)。第二种方法使用粒子谱分析仪测量滴谱分布。

关键词：液态含水量测量光学技术

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配合物(BenzMeIm)_2[PtCl_4]的合成与表征（英文）

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无机化学学报 2018年第4期34卷 728-732页

作者： Mohamad Ali hikmat Mahmoud Jamal Azheen gerber Thomas hosten Eric Department of Chemistry College of EducationUniversity of SalahaddinErbilIraq Department of Chemistry Nelson Mandela Metropolitan UniversityPort ElizabethSouth Africa

通过离子液体氯化1-苄基-3-甲基咪唑(BenzMeIm-Cl)与PtCl_2的反应,合成了配合物(BenzMeIm)_2[PtCl_4],并用元素分析、红外光谱、紫外-可见光谱、1h NMR、13C NMR和单晶X射线衍射对其进行了表征。单晶X射线分析表明,配合物结构属于P21/c... 详细信息

通过离子液体氯化1-苄基-3-甲基咪唑(BenzMeIm-Cl)与PtCl_2的反应,合成了配合物(BenzMeIm)_2[PtCl_4],并用元素分析、红外光谱、紫外-可见光谱、1h NMR、13C NMR和单晶X射线衍射对其进行了表征。单晶X射线分析表明,配合物结构属于P21/c空间群,晶胞参数和结构解析参数为:a=0.981 80(5)nm,b=0.861 47(3)nm,c=0.144 332(7)nm,β=92.480(2)°,V=121.96(1)nm3,R1=0.014 4,w R2=0.038 8。

关键词：氯化1-苄基-3-甲基咪唑铂配合物晶体结构

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Production of Lipase Using Cassava Peel and Sunflower Oil in Solid-State Fermentation： Preliminary Study

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Journal of Agricultural Science and Technology(A) 2013年第12期3卷 948-954页

作者： Caroline Branco gerber Francieli Kaufmann Gabrieli Nicoletti Marilia Dalla Costa Aniela PintoKempka Volunteer Scholarship holder of the Scientific Initiation Food Engineering Department State University of Santa CatarinaPinhalzinho 89870-000 Santa Catarina Brazil Food Engineering Department State University of Santa Catarina Pinhalzinho 89870-000 Santa Catarina Brazil

Full use of residues from industrial processes is a fundamental necessity of contemporary society, since it avoids impacts to the environment by using residues as inputs for other products of high economic and social importance. In this study, lipase production of the crude enzymatic extracts obtained by Aspergillus niger using cassava peel as substrate and sunflower oil as an inductor was investigated. The optimized cultivation temperature and concentration of inductor were determined using the response surface methodology. The two variables studied exercised influence in the production of lipase in the 95% level of confidence. The response surface obtained indicated that the conditions that maximize lipase activity production were 30.5 °C and initial concentration of sunflower oil was 2.5% (w/w). Through this analysis, it is evident that extremes in temperature and concentration of inductor tend to decrease lipase production, since low temperatures decrease metabolism and high temperatures may inactivate the lipase. Optimum lipase yield was 59.8 U/g of dry peel which was fermented for 60 h. Lipase production presents a peak of 61.3 U/g, at 72 h of fermentation. however, this value is statistically equal (p > 0.05) of the value of lipase activity obtained for 60 h and 84 h of fermentation.

关键词：工业生产过程脂肪酶活性固态发酵向日葵油木薯去皮初始浓度社会意义

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Conception Rate Using the Select-Synch Protocol in Combination with a Lower Dose Progesterone-Releasing Intravaginal Insert (1.38 g) in Swiss Dairy Cows

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Open Journal of Veterinary Medicine 2013年第1期3卷 6-10页

作者： F. Beuchat P. Berthold L. gerber R. M. Bruckmaier A. Steiner J. hüsler Gaby hirsbrunner Clinic for Ruminants Vetsuisse Faculty University of Berne Berne Switzerland

Background: Synchronization programs have become standard in the dairy industry. In Switzerland, these programs are used but newly. The objective of this study was A) to estimate the pregnancy rate after a Select-Synch protocol including a low dosage of progesterone in CIDR (1.38 g). As a second step B) this pregnancy rate should be compared to cows from another Swiss study that used a Select-Synch protocol with the 1.9 g insert ADDIN EN.CITE ADDIN EN.CITE.DATA (Rudolph et al., 2011). Methods: A) 196 cows were included in the study. Cows received a CIDR 1.38 g and 2.5 ml of buserelin i.m. on d 0. On d 7, the CIDR insert was removed and 5 ml of dinoprost was administered i.m. On d 0 a milk sample for progesterone analysis was taken. Pregnancy was determined at or more than 35 days after artificial insemination. B) The 1.38 g group and the 1.9 g group were compared as to cow and farm factors, number of preceding AI’s, gynecological and uterine pretreatment and treatment itself. A forward selection procedure was used (test result considered significant if p-value 0.05). Results: A) The pregnancy rate, using the Select-Synch protocol with the CIDR 1.38 g was 44.4%. B) The CIDR 1.9 g Select-Synch group revealed a pregnancy rate of 50.4% ADDIN EN.CITE ADDIN EN.CITE.DATA (Rudolph et al., 2011). Significant differences between the groups were not found. Conclusion: The 1.38 g CIDR-Select-Synch protocol may be recommended for multiparous dairy cows. The pregnancy rate compared to the 1.9 g CIDR-Select-Synch protocol was 8% lower, but this difference was not significant.

关键词： Cattle Synchronization CIDR 1.38 g Dairy Swiss

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源于体外培养胰岛中表达Ngn3的细胞是胰腺内分泌前体细胞的新证据

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中华外科杂志 2005年第1期43卷 42-45页

作者：宋陆军秦新裕牛伟新沈坤堂刘凤林 K.A.Andreoni D.A.gerber J.h.Fair L.Rice A.Pleasant J.Wang 复旦大学附属中山医院普外科上海200032 Transplantation and Stem Cell Lab Department of SurgeryUniversity of North Carolina at Chape lHillUSA Jian Wang

目的　评估表达Ngn3的细胞对成体胰岛维护和更新的作用及其意义。方法　用 6～ 8周龄的C5 7BL/ 6小鼠分离胰岛。胆总管内插管成功后 ,切除胰腺组织并用浓度为 2 5mg/ml胶原蛋白酶V灌注消化。手工拣取胰岛后 ,置于 6 0mm培养皿内 ,每个... 详细信息

目的　评估表达Ngn3的细胞对成体胰岛维护和更新的作用及其意义。方法　用 6～ 8周龄的C5 7BL/ 6小鼠分离胰岛。胆总管内插管成功后 ,切除胰腺组织并用浓度为 2 5mg/ml胶原蛋白酶V灌注消化。手工拣取胰岛后 ,置于 6 0mm培养皿内 ,每个培养皿内含 10～ 12个胰岛 ,用RPMI 16 4 0 (12 5mmol/LhEPES ,5 2mmol/L葡萄糖和 2 %胎牛血清 )培养液培养。用A6抗体 ,胰岛素抗体 ,胰高血糖素抗体 ,Nestin抗体 ,Ngn3抗体和 5′ 溴 2 脱氧尿嘧啶 (5 bromo 2′ deoxy uridine,BrdU)抗体进行胰岛细胞免疫荧光染色。结果　在增殖的胰岛细胞中 ,只有不到 15 %的细胞表达Ngn3,其中约有 30 %以上的细胞同时表达A6。在培养的胰岛细胞中存在表达Ngn3的细胞 ,这一结果与其他在胚胎发育和成体胰岛中的研究结果一致。本研究发现培养的胰岛细胞中存在同时表达A6和Ngn3的细胞。A6被认为是可分化为胆管上皮细胞的肝脏前体细胞的标记物。胰岛内表达A6的细胞可能来源于成体胰管 ,并迁移至胰岛内。细胞表达A6的同时表达Ngn3,表明这些细胞在胰岛内可分化为内分泌细胞。结论　培养的胰岛细胞中发现共同表达Ngn3和A6的细胞 ,表明胰岛内的 4种内分泌细胞可能来源于成体胰岛中的同一内分泌细胞系。

关键词：胰岛细胞细胞表达抗体前体细胞胰腺标记物治疗成体干细胞培养皿内分泌细胞

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