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DNA methyltransferases in hematological malignancies

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Journal of Genetics and Genomics 2020年第7期47卷 361-372页

作者： nguyet-Minh Hoang Lixin Rui Department of Medicine University of Wisconsin School of Medicine and Public HealthMadisonWI53792USA Carbone Cancer Center University of Wisconsin School of Medicine and Public HealthMadisonWI53792USA

DNA methyltransferases(DNMTs)are an evolutionarily conserved family of DNA methylases,transferring a methyl group onto the fifth carbon of a cytosine *** mammalian DNMT family includes three major members that have functional methylation activities,termed DNMT1,DNMT3A,and ***3A and DNMT3B are responsible for methylation establishment,whereas DNMT1 maintains methylation during DNA *** evidence demonstrates that regulation of DNAmethylation by DNMTs is critical for normal *** DNA methylation due to DNMT dysregulation and mutations is known as an important molecular event of hematological malignancies,such as DNMT3A mutations in acute myeloid *** this reviewwe first describe the basic methylation mechanisms of DNMTs and their functions in lymphocyte maturation and differentiation,We then discuss the current understanding of DNA methylation heterogeneity in leukemia and lymphoma to highlight the importance of studying DNA methylation *** also discuss DNMT mu-tations and pathogenic roles in human leukemia and *** summarize the recent understanding of how DNMTs interact with transcription factors or cofactors to repress the expression of tumor suppressor *** highlight current clinical studies using DNMT inhibitors for the treatment of these hematological malignancies.

关键词： DNA methyltransferases Leukemia lymphoma Tumor suppressor DNA methylation

Evaluation of Weathering Performance of Rosin-Copper Based Treated Wood

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Journal of Renewable Materials 2022年第11期10卷 2765-2780页

作者： Thi Thanh Hien Nguyen Nho Quyet Tran Thi Minh nguyet Nguyen Hien Mai Trinh Xuan Phuong Le Trong Kien Nguyen College of Wood Industry and Interior Design Vietnam National University of ForestryHa NoiViet Nam College of Economics and Management Northeast Forestry UniversityHarbinChina

This study aimed to evaluate the effect of natural weathering on some surface characteristics and mechanical properties of Styrax wood treated with mixtures of 1.0%,2.0%,or 4.0%rosin sizing agent and 3%copper *** samples after treatment were exposed to outdoor conditions for one year and changes in color,glossiness,weight loss,compression strength parallel to grain(CSPG),modulus of rupture(MOR),and modulus of elasticity(MOE)were investigated after 6 and 12-month of natural *** results showed that rosin-copper treatment could improve color stability and gloss of samples after *** losses of all rosin-copper treated samples after 12 months of exposure were negligible compared with the untreated control *** addition,rosin-copper treatment enhanced the CSPG compared to untreated controls,but slightly decreased the MOR and MOE of Styrax wood before *** weathering factors induced a reduction for all strength properties,however,the decrease rate for strength properties of rosin-copper treated samples was negligible compared with the untreated control samples after 12-month natural weathering *** FTIR and SEM-EDX confirmed that the use of the rosin-copper formulations to impregnate wood could decrease the hazard of the copper preservative leaching into the environment,while also enhancing more resistance against weathering factors and other biotic factors.

关键词： Rosin-copper weathering color stability CSPG MOR MOE

Effects of low energy (160 keV) X-ray on microbial inactivation,sprouting inhibition and genetic variation in potato

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Food Bioscience 2022年第3期47卷 262-270页

作者： Nguyen An Son Nguyen Thi nguyet Ha Nguyen Thi Minh Sang Le Doan Dinh Duc Le Ngoc Trieu Faculty of Physic and Nuclear Engineering Da Lat UniversityViet Nam Dalat Vocational Training College Viet Nam Faculty of Biology Da Lat UniversityViet Nam

The effects of low energy X-ray irradiation on microbial inactivation,sprouting inhibition and genetic variation were *** was an inverse correlation between the exposure dose in range of 0 Gy–5000 Gy and the survival rate of *** dose of 1000 Gy seemed to be suitable for inactivation of microorganisms because the respective survival rate is relatively low (0.59%).Dose rate of 13.87 Gy/min was the most appropriate to inactivate the microorganisms,with the survival rate of 0.37%.Applying the irradiation dose of 1000 Gy and dose rate of 13.87 Gy/min,there was a significant sprouting inhibition of irradiated potatoes compared to the control for six months *** effect of irradiation dose (100–1200 Gy) and dose rate (8.63–19.62 Gy/min) on genetic variation of the irradiated samples was assessed by DNA fingerprints induced from using three molecular techniques including Random Amplified Polymorphic DNA (RAPD),Start Codon Targeted Polymorphism (SCoT) and CAAT box – derived polymorphism (CBDP).At the irradiation dose of 1000 Gy and dose rate of 13.87 Gy/min,the level of genetic variation was relatively low (4.85%).Thus,this treatment is a suitable condition of irradiation for potato treatment with the purpose of preservation.

关键词： Dose Dose rate Low energy X-ray Microbial inactivation Potato

SFRP5 inhibits melanin synthesis of melanocytes in vitiligo by suppressing the Wnt/b-catenin signaling

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Genes & Diseases 2021年第5期8卷 677-688页

作者： Daopei Zou Yangmei Chen Lingzhao Zhang Xiaohui Yuan Yujie Zhang Adelina Inggawati Pham Thi Kieu nguyet Tianwen Gao Jin Chen Department of Dermatology The First Affiliated Hospital of Chongqing Medical UniversityChongqing400010PR China Key Laboratory of Clinical Laboratory Diagnostics Ministry of EducationChongqing Medical UniversityChongqing400016PR China Department of Dermatology Xijing HospitalFourth Military Medical UniversityXi’anShanxi Province710032PR China

Secreted frizzled-related protein 5(SFRP5)plays a pivotal role in regulating the development of many tissues and organs,however,as an inhibitor of Wnt signaling,the role of SFRP5 in vitiligo remains ***,we speculated that SFRP5 might be associated with melanogenesis in melanocytes by regulating Wnt signaling in *** this study,we found that SFRP5 was overexpressed in the skin lesions of patients with *** with that in normal epidermal melanocytes(PIG1),the expression of SFRP5 was increased in vitiligo melanocytes(PIG3V).To investigate the effect of SFRP5 on melanin synthesis,PIG1 cells were infected with recombinant SFRP5 adenovirus(AdSFRP5),and PIG3V cells were infected with recombinant siSFRP5 adenovirus(AdsiSFRP5).The results showed that SFRP5 overexpression inhibited melanin synthesis in PIG1 cells through downregulation of microphthalmia-associated transcription factor(MITF)and its target proteins via suppression of the Wnt/b-catenin signaling ***,SFRP5 silencing increased melanin synthesis and activated the Wnt signaling pathway in PIG3V ***,SFRP5 overexpression also downregulated the transcriptional activity of T cell factor/lymphoid enhancer factor(TCF/LEF)in PIG1 ***,this inhibitory effect of SFRP5 on melanin synthesis was reversed by treatment with the b-catenin agonist,*** inhibitory action of SFRP5 in pigmentation was further confirmed in vivo using a nude mouse ***,our results indicate that SFRP5 can inhibit melanogenesis in ***,our findings showed that SFRP5 plays a vital role in the development of vitiligo,and thus may serve as a potential therapeutic target for vitiligo.

关键词： Melanin synthesis Melanocytes MITF SFRP5 Vitiligo Wnt signaling

中国家电企业在越南成立跨国公司的战略选择研究 ——以TCL公司为例

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中国家电企业在越南成立跨国公司的战略选择研究 ——以TCL公司为...

作者： DANG THI nguyet ANH 上海大学

学位级别：硕士

随着经济的发展,中国家电企业不再满足于国内市场,开始寻求海外市场,跨国并购已成为国际投资的一大选择。近年来,越来越多的中国企业开始实施国际战略,在海外开展业务。由于中国经济正处于转型过程中,中国的经济环境不仅复杂多变,而且... 详细信息

随着经济的发展,中国家电企业不再满足于国内市场,开始寻求海外市场,跨国并购已成为国际投资的一大选择。近年来,越来越多的中国企业开始实施国际战略,在海外开展业务。由于中国经济正处于转型过程中,中国的经济环境不仅复杂多变,而且难以预测。这与西方较为稳定的商业环境截然不同。尽管国际化在中国兴起,但作为一个新手,中国企业在实施国际化战略方面将有别于多年来实施国际化战略的其他企业。本文以TCL集团为例,探讨了中国企业的国际化战略。本文基于对管理公司中的TCL公司基本理论分析与控制存在问题的探究,分析其问题出现的原因,并提出了相应的对策和建议。本文的第一部分主要介绍了研究意义以及目的等相关内容,它们是本文的理论基础。本文的第二部分详细阐述了TCL公司概述,重点对内容进行分析和把握。本文的第三部分是TCL公司在发展战略现状,本文的第四部分是TCL在越南战略选择存在的问题,第五部分是对TCL在越南战略选择的改进这都是本文研究的重要内容。根据以上的阐述和分析,本文的第六部分为第六章结论与展望,这也是本文的重点内容。针对现阶段存在的问题,分析研究得出的TCL在越南战略选择的改进,以期对今后的研究实践有一定的借鉴意义。在信息的发展的背景迅速发展之下,世界各国空间距离也不是问题。个人可以反映整个社会,而单个企业又可以代表整个国家的发展。寻找发展与生存是每个企业的目标。中国经济三十多年的改革开放在世界各国不断进行对外投资与贸易越南作为中国企业所瞄准的潜力市场本文对于既有的在越南发展成功的企业进行分析,研究中国企业怎么在越南实行国际化战略的问题,本文基于相关的国际化战略理论,在介绍回顾中国企业在越南经营情况和越南家电行业在这些年来的发展情况的基础上,以TCL为例研究,把握市场进入和市场渗透中的成功经营规律。如今更多研究倾向于企业国际化的进入模式理论研究,而针对发展中国家中某一个中国企业国际化的战略选择问题的研究较少。因此,本文主要通过中国在越南成立跨国公司的具体案例研究,发现其中存在的问题,并针对现实存在的问题提出合适的对策,以更好地帮助中国在越南设立跨国公司并很好地经营下去,同时为中国企业进军东南亚区域的战略选择提供借鉴。

关键词： TCL公司战略发展选择有效策略

复合酸联合585nm染料激光治疗寻常痤疮的临床疗效观察

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复合酸联合585nm染料激光治疗寻常痤疮的临床疗效观察

作者： Pham Thi Kieu nguyet 重庆医科大学

学位级别：硕士

目的:临床上,寻常痤疮治疗方法众多,各临床医师选择治疗方法差异大,疗效亦千差万别。本研究利用复合酸(10%水杨酸和20%果酸以比例1:1组成的凝胶)联合585nm染料激光治疗寻常痤疮,观察其临床疗效以及可能存在的不良反应,最终为有效服务于... 详细信息

目的:临床上,寻常痤疮治疗方法众多,各临床医师选择治疗方法差异大,疗效亦千差万别。本研究利用复合酸(10%水杨酸和20%果酸以比例1:1组成的凝胶)联合585nm染料激光治疗寻常痤疮,观察其临床疗效以及可能存在的不良反应,最终为有效服务于临床,为寻常痤疮的治疗提供指导作用。方法:本文通过门诊随机抽取56例寻常痤疮患者,其中28例痤疮患者采用复合酸联合585nm染料激光治疗为实验组,28例患者单用585nm染料激光治疗寻常痤疮为对照组。通过统计对比治疗前以及治疗后4、8、12、16、20、24周各类皮损计数包括粉刺、丘疹、脓疱、结节、囊肿的个数得出结论。结果:随访56例痤疮患者,16例未完成试验,其中试验组6例和对照组10例。完成随访的40例寻常痤疮治疗的患者,无一例出现较严重并发症。在治疗前两组患者情况对比:年龄(26.00±6.517VS 26.39±7.461,p=0.861>0.05)、性别(女:男)(16±6VS12±6,p=0.677>0.05)、痤疮的各类皮损计数包括粉刺(P=0.422>0.05)、丘疹(P=0.427>0.05)、脓疱(P=0.892>0.05)、结节(P=0.162>0.05)、囊肿(P=0.067>0.05)均无统计学差异。对治疗前以及治疗后4、8、12、16、20、24周各类皮损计数包括粉刺、丘疹、脓疱、结节、囊肿的对比:1、实验组粉刺、丘疹的数量较对照组少,差异有统计学意义(P0.05,无统计学意义,不同实验组和时间之间无交互效应。3、囊肿不同实验组间(P=0.509>0.05),无统计学意义,故认为实验组对寻常痤疮的治疗效果和对照组间无明显优势。结论:在寻常痤疮的治疗中,实验组复合酸联合585nm染料激光较对照组单用585nm染料激光治疗寻常痤疮总体具有更好的疗效,对寻常痤疮的皮损如粉刺、丘疹、脓疱、结节的治疗均优于对照组。但对囊肿的治疗,实验组较对照组无明显优势。

关键词：痤疮复合酸染料激光

Improving the Dispersion and Integration of Multi-Walled Carbon Nanotubes in PolyvinyI-Alcohol Composite Thin Film through Surface Modification

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Journal of Chemistry and Chemical Engineering 2013年第1期7卷 18-25页

作者： Van Thang LE T. Mirth nguyet NGUYEN Duy Vinh CAO Key Laboratory of Materials Technology Vietnam National University Ho Chi Minh City 70000 Vietnam Faculty of Materials Technology University of Technology Ho Chi Minh City 70000 Vietnam

The article investigated the influence of modification process parameters on dispersity of MWNTs DI （in deionized） water and PVA/MWNT composite＇s electrical conductivity. Experimental results obtained by SEM （scanning electron microscope）, TEM （transmission electron microscope）, transform Fourier infrared spectroscopy, pH meter confirmed the most effective conditions in modifying the MWNT surface at the 1：3 mixture of nitric and sulfuric acid at 60 ℃. The extinction coefficient value of functionalized MWNTs at 500 nm wavelength was determined to be 41.24 cm^2·mg^-1, while their dispersibility in DI water was about 12.85 mg/mL and stable in more than 3 weeks via UV-vis spectroscopy. The other important result is the decrease of volume resistivity from 7.98 × 10^6 MΩ·m ofPVA （polyvinyl alcohol） to 4.15 × 10^4 MΩ·m of PVA/1 wt% modified MWNT thin film.

关键词： MWNT modification composite

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汉-越校园内社交称谓语对比研究

汉-越校园内社交称谓语对比研究

作者：陶明月（DAO MINH nguyet）华中师范大学

学位级别：硕士

语言与人类有着紧密的联系。语言本身是非常丰富和多样的,而且非常复杂。语言是许多科学领域,包括语言学,文学,心理学等的研究对象。为了能够顺利地使用语言进行沟通,我们必须遵循语言的语法规则。语言规则与形式常常内化于人们的意识中... 详细信息

语言与人类有着紧密的联系。语言本身是非常丰富和多样的,而且非常复杂。语言是许多科学领域,包括语言学,文学,心理学等的研究对象。为了能够顺利地使用语言进行沟通,我们必须遵循语言的语法规则。语言规则与形式常常内化于人们的意识中,但仍可从语言内容中得以体现。问候与称谓是大多数语言交际的开端。在汉语和越南语中,社交称谓是一个相当完整和复杂的称谓系统。称谓是一种人类用来自称或称谓别人的一种语言形式。只要通过各种各样的称谓形式,我们可以知道自称人和被称人之间的关系。此外,我们可以知道他们的地位,性别或年龄。怎么用正确的称谓语来称被称人是交流中最重要的问题之一。学校环境就像一个微型社会。在这里,我们发现各种关系也非常丰富和复杂,并且在这种环境中都存在社交称谓。通过老师和学生的关系、同学之间的关系或同事之间关系,我们将会了解在校园内的交流丰富多彩的图画。每个国家都是独特无异所以学校环境都不尽相同,因此称谓方式也有所不同。因此,研究和比较两国校园内的社会称谓体系非常必要,也对外语学习者也有很大帮助。在这里,我将深入分析两国在校园内的称谓用语方面的差异。第一部分为第一章绪论部分。这部分明确研究对象,说明选题理由和意义。介绍了国外内相关研究综述,说明采用的研究方法和语料来源,最后介绍社交称谓的概述。社交称谓语包括:人称代词称谓,姓名称谓,社交通用称谓,职业称谓,拟亲属称谓和零称谓。第二部分包括本文的第二章至第四章,是本文的主体部分。第二章主要介绍汉-越语的校园内称谓,专门分析校园内的结构形式和语用。在分析结构形式部分本文深入分析老师和老师、学生和学生、学生和工作人员使用的称谓语。汉-越称谓语之间同中有异,异中有同所以通过分析才更明显看出它们的异同。第三章是调查越南留学生的使用称谓语情况。调查问卷发出去已经收回有效的,调查对象是华中师范大学的越南留学生,针对他们的使用汉语称谓语情况进行调查分析。为了获得最佳的结果,调查问卷还指出所有调查仅与个人研究有关,而其他措施则无关。通过这份调查指出留学生常见的偏误以及教学建议。第四章是校园称谓语的文化内涵。第一部分介绍文化和称谓的内容,具体是师生关系的称谓。此外谈起称谓的礼性。因为在所有环境下,礼性始终是最重要的特别是是在师范环境中。第三部分是结语部分,对全文观点进行归纳总结。

关键词：汉语越南语社交称谓语校园称谓对比分析

Visualization Techniques in Smart Grid

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Smart Grid and Renewable Energy 2012年第3期3卷 175-185页

作者： Dao Viet Nga Ong Hang See Do nguyet Quang Chee Yung Xuen Lai Lee Chee Department of Electronics and Communication Engineering Universiti Tenaga Nasional Kejang Malaysia.

Visualization is an established methodology in scientific computing. It has been used in many fields because of its strong capability in large data management and information display. However, its applications in power systems, especially in Smart Grid are still in infancy stage. Besides, while there were a lot of researches working on visualizing data in transmission power system, the study on displaying distribution power system data was limited. Therefore, in this paper, author proposed some techniques to visualize the Smart Grid data at distribution. They are classified in three categories, which are low dimensional techniques, multivariate high dimensional techniques and Geographical Information System (GIS) techniques.

关键词： Smart Grid Visualization Techniques Google Earth GIS QGIS AMI SCADA Spatial Temporal Animation