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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-jia Chen Xin-Ning Yu Hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

负载骨形态发生蛋白2水凝胶诱导牙髓干细胞的成骨分化

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中国组织工程研究 2025年第16期29卷 3301-3310页

作者：伊斯拉尔古丽·麦麦提贾森刘佳新疆医科大学第一附属医院(附属口腔医院)儿童口腔科-口腔预防科新疆维吾尔自治区乌鲁木齐市830054 西安医学院口腔医学院陕西省西安市710021 新疆维吾尔自治区口腔医学研究所新疆维吾尔自治区乌鲁木齐市830054

背景:前期研究证明,甲基丙烯酸酐改性明胶/经处理牙本质基质复合水凝胶支架可促进人牙髓干细胞的增殖及分化。水凝胶负载骨形态发生蛋白2被认为是骨修复中有前景的材料。目的:观察负载不同质量浓度骨形态发生蛋白2的甲基丙烯酸酐改性明... 详细信息

背景:前期研究证明,甲基丙烯酸酐改性明胶/经处理牙本质基质复合水凝胶支架可促进人牙髓干细胞的增殖及分化。水凝胶负载骨形态发生蛋白2被认为是骨修复中有前景的材料。目的:观察负载不同质量浓度骨形态发生蛋白2的甲基丙烯酸酐改性明胶/经处理牙本质基质复合水凝胶对人牙髓干细胞成骨向分化的诱导作用。方法:制备含0,50,100,200μg/mL骨形态发生蛋白2的甲基丙烯酸酐改性明胶/经处理牙本质基质复合水凝胶,分别记为GelMA/TDM、BMP-2(50 ng/mL)GelMA/TDM、BMP-2(100 ng/mL)GelMA/TDM、BMP-2(200 ng/mL)GelMA/TDM,检测复合水凝胶对骨形态发生蛋白2的体外缓释性能。采用改良组织块酶消化法提取人牙髓干细胞,分别接种于4种水凝胶表面,采用CCK-8法检测细胞增殖,DAPI染色检测细胞黏附;对各组水凝胶表面的人牙髓干细胞进行成骨诱导,进行碱性磷酸酶染色、碱性磷酸酶活性检测与茜素红染色,采用RT-PCR法检测相关成骨基因(Runx2、骨形态发生蛋白2、骨桥蛋白、骨钙素、Ⅰ型胶原)表达。结果与结论:①甲基丙烯酸酐改性明胶/经处理牙本质基质复合水凝胶可持续释放骨形态发生蛋白2长达21 d,在第3-6天释放较快,第6天之后释放趋于平稳;②4种水凝胶均可促进人牙髓干细胞的增殖,其中以BMP-2(100 ng/mL)-GelMA/TDM复合水凝胶的作用最明显;相较于GelMA/TDM复合水凝胶,BMP-2-GelMA/TDM复合水凝胶可促进人牙髓干细胞的黏附,其中以BMP-2(200 ng/mL)-GelMA/TDM复合水凝胶的作用最明显;③相较于GelMA/TDM复合水凝胶,BMP-2-GelMA/TDM复合水凝胶可提升碱性磷酸酶活性、钙结节含量与相关成骨基因表达,综合分析显示BMP-2(100 ng/mL)-GelMA/TDM复合水凝胶的作用更明显;④结果表明,BMP-2(100 ng/mL)-GelMA/TDM复合水凝胶促进牙髓干细胞成骨向分化的能力更明显。

关键词：人牙髓干细胞骨形态形成蛋白2 细胞增殖细胞分化组织工程牙髓-牙本质再生

Heterologous expression of the Haynaldia villosa pattern-recognition receptor CERK1-V in wheat increases resistance to three fungal diseases

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The Crop Journal 2022年第6期10卷 1733-1745页

作者： Anqi Fan luyang Wei Xu Zhang jia Liua Li Sun Jin Xiao Yajia Wang Haiyan Wang jian Hua Ravi P.Singh Zongkuan Wang Xiue Wang State Key Lab of Crop Genetics and Germplasm Enhancement Cytogenetics InstituteNanjing Agricultural University/JCIC-MCPNanjing 210095JiangsuChina Department of Plant Biology Cornell UniversityIthacaNY 14853USA International Maize and Wheat Improvement Center(CIMMYT) El BatanTexcoco 56237Estado de MexicoMexico

Wheat production is under continuous threat by various fungal *** of multipledisease resistance genes may lead to effective disease control via the development of cultivars with broad-spectrum *** Lysin-motif(LysM)-type pattern-recognition receptors,which elicit innate immunity by recognizing fungal pathogen associated molecular patterns such as chitin,are potential candidates for such *** this study,we cloned a LysM receptor-like kinase gene,CERK1-V,from the diploid wheat relative Haynaldia ***1-V expression was induced by chitin and Blumeria graminis ***,the causal agent of wheat powdery *** overexpression of CERK1-V in wheat inhibited the development of three fungal pathogens,thereby increased resistance to powdery mildew,yellow rust,and Fusarium head ***1-V physically interacted with the wheat Lys M protein Ta CEBi ***1-V/Ta CEBi Ps interaction promoted chitin recognition and activated chitin signal transduction in *** plants with excessively high CERK1-V expression showed high resistance but abnormal plant growth,whereas plants with moderate expression level showed adequate resistance level with no marked impairment of plant *** transgenic lines,RNA-seq showed that gene expression involved in plant innate immunity was *** of genes involved in photosynthesis,ER stress and multiple phytohormone pathways was also *** expression of CERK1-V in wheat can confer disease resistance without compromising growth or defense fitness.

关键词： Wheat Fungal disease LysM PRR Haynaldia villosa CERK1-V

High-dense nanocrystalline W-based alloy prepared by hot isostatic pressing with uniform microstructure, ultrahigh hardness and good thermal stability

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Tungsten 2025年第1期 120-136页

作者： Zao-Ming Wu Lin He Lin-Sen Ye Xiao-Feng Yang jia-jia Zhang Hong-Bo Lei Institute of Materials China Academy of Engineering Physics

High-density uniform microstructure nanocrystalline W-10wt.% Cr-5wt.% Y（W-10Cr-5Y） alloy with an average grain size of 85 nm and a relative density of 99.8% was successfully prepared.W-Cr-Y alloys with different amounts of second-phase particles were prepared by high-energy ball milling and hot isostatic pressing *** effects of composition design,ball milling parameters,and sintering parameters on the microstructure of W-Cr-Y alloys were studied.A feasible technology for controlling the synthesis of high-density nanocrystalline W-based alloys has been *** microstructure analysis of nanocrystalline W-10Cr-5Y alloy shows that there are two types of doping in the second phase:intergranular doping and intragranular *** "uniform distribution YOx-rich particles" effectively suppresses the grain growth of W and leads to the formation of nanocrystalline W-10Cr-5Y alloy.W-10Cr-5Y has an ultra-high hardness,with a Vickers hardness of 1312±12 kgf·***-temperature annealing treatment shows that W-10Cr-5Y has good thermal stability at 1000 and1100℃,as demonstrated by the comparison of Vickers hardness and grain size between annealed and unannealed alloys.

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基于认知语言学与神经语言视域:孤独症儿童语言康复的困境剖析与策略探赜

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四川文理学院学报 2025年第1期35卷 91-96页

作者：加晓昕四川文理学院学报编辑部四川达州635000

基于认知语言学与神经语言学视阈,剖析当前孤独症儿童语言康复的弊端:即语言康复方法单一机械,主体性未被激发;语言康复内容割裂松散,多元能力未能整合;语言康复起点失实失准,认知基础环节未被重视;语言康复情境失真局限,“语言-认知-... 详细信息

基于认知语言学与神经语言学视阈,剖析当前孤独症儿童语言康复的弊端:即语言康复方法单一机械,主体性未被激发;语言康复内容割裂松散,多元能力未能整合;语言康复起点失实失准,认知基础环节未被重视;语言康复情境失真局限,“语言-认知-社会”三维互动不足;提出针对性的康复策略多样化语言康复方法,激发儿童主体性;多元化语言康复内容,整合儿童语言习得能力;多维化语言理解训练,提升儿童语言理解能力;多维语言情境塑造,增强儿童语言迁移能力。

关键词：认知语言学神经语言学语言康复

Thickness and sp3 bond modulation of（Ti/tetrahedral amorphous carbon）_n multilayer coatings

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Tungsten 2025年第1期 152-160页

作者： Zhi-Jun Xie jia-Lin Li Ling Gong Xiang-Li Zhong Hong-jia Song Jin-Bin Wang National-Provincial Laboratory of Special Function Thin Film Materials School of Materials Science and Engineering Xiangtan University

The durability of wear-resistant tetrahedral amorphous carbon（ta-C） coatings is intimately linked to their thickness and the concentration of *** enhance the lifespan of the coatings,we have prepared a multilayer coating consisting of alternating layers of Ti and ta-C,denoted as（Ti/ta-C）_n,using arc ion plating.A multi-layer structure in conjunction with stage cooling is employed to enhance the thickness and promote *** results indicate that the ID/IGvalue,representing the ratio of the intensity of the D peak to that of the G peak in Raman spectroscopy,decreases from 0.85 when no stage cooling is applied to 0.35 when stage cooling is employed,suggesting an enhancement in the fraction of sp3bonds within the *** obtained（Ti/ta-C）_n multilayer coating without peeling off has a maximum thickness of 1.14 μm,which is almost double that of the ta-C coating single layer *** the same time,the coating has a low coefficient of friction,down to 0.069,and maintains excellent friction properties with a wear rate of 3.4×10-6mm3·N-1·*** results conclusively show that the preparation technology can enhance both thickness and sp3bonding in ta-C coatings,significantly expanding their utility across tools,molds,and precision engineering components.

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中华优秀传统文化融入语言课程教学策略研究——以“京剧”融入汉语国际教育课程为例

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职业技术 2025年第1期24卷 19-24页

作者：李佳浙江水利水电学院人文与外国语学院杭州310000

探究语言课程与中华优秀传统文化的融合方式,为学生提供更加全面的语言学习体验,培养学生的综合素质和文化意识。通过分析中华优秀传统文化对语言类课程教学的启示,从语言类课程教学设计入手,提出语言类课程教学策略,以提高语言类课程... 详细信息

探究语言课程与中华优秀传统文化的融合方式,为学生提供更加全面的语言学习体验,培养学生的综合素质和文化意识。通过分析中华优秀传统文化对语言类课程教学的启示,从语言类课程教学设计入手,提出语言类课程教学策略,以提高语言类课程的教学质量和效果。

关键词：中华优秀传统文化语言类课程教学方法课程设计

基于超声反冲洗过滤器过滤含油污水的试验研究

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煤炭技术 2025年第1期44卷 269-272页

作者：贾利军刘佳新疆天业汇合新材料有限公司新疆石河子832000 宁波安泰环境化工工程设计有限公司浙江宁波315048

针对含油污水处理,进行了基于超声波辅助反冲洗过滤的试验研究,试验考察了滤芯初试压差、无超声/超声反冲洗时间对滤芯压差的影响、超声功率密度对滤芯反冲洗压差的影响、不同反冲流量下,超声反冲时间对反冲过滤液中含油量的影响、滤料... 详细信息

针对含油污水处理,进行了基于超声波辅助反冲洗过滤的试验研究,试验考察了滤芯初试压差、无超声/超声反冲洗时间对滤芯压差的影响、超声功率密度对滤芯反冲洗压差的影响、不同反冲流量下,超声反冲时间对反冲过滤液中含油量的影响、滤料超声反冲洗再生能力、无超声/超声过滤滤芯反冲洗含油量对比等因素。通过该实验研究结果表明,超声辅助反冲洗过滤含油和聚合物污水效果良好,在反冲洗流量为65 L/min、反冲洗超声功率密度为1.7 W/cm^(2)、反冲时间17 min时,超声辅助反冲洗滤芯过滤效率较无超声作用滤芯过滤效率高,其滤芯过滤效率分别为93.81%、43.50%。

关键词：含油污水超声波反冲洗过滤器

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绿色金融、碳排放约束与能源技术创新

生态经济 2025年第1期41卷 99-105,122页

作者：肖黎明贾均焱山西师范大学经济与管理学院山西太原030031

能源技术创新是实现全球长期可持续发展以及“双碳”目标的重要途径。基于2010—2019年全国30个省份的面板数据,构建固定效应模型与调节效应模型实证分析绿色金融对能源技术创新的影响与作用机制,结果表明:(1)绿色金融能够显著促进能源... 详细信息

能源技术创新是实现全球长期可持续发展以及“双碳”目标的重要途径。基于2010—2019年全国30个省份的面板数据,构建固定效应模型与调节效应模型实证分析绿色金融对能源技术创新的影响与作用机制,结果表明:(1)绿色金融能够显著促进能源领域的技术创新,并且绿色金融与碳排放约束之间的协同互补效应也对能源技术创新具有正向影响,经过一系列稳健性检验后结论依然成立。(2)机制分析表明,资本深化在绿色金融影响能源技术创新的过程中发挥负向调节作用,即资本深化削弱了绿色金融对于能源技术创新的积极作用。(3)异质性分析结果显示,绿色金融对能源技术创新的作用存在显著的区域差异,其中绿色金融在中西部地区的促进效果明显优于东部地区。该研究为完善绿色金融对能源技术创新的影响提供了理论依据与经验证据,从而为绿色金融更好服务于能源领域的转型发展提供有益启示。

关键词：绿色金融碳排放约束资本深化能源技术创新

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