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Activity of Recombinant Human Interleukin-15 against Tumor Recurrence and Metastasis in Mice

Cellular & Molecular Immunology 2008年第3期5卷 189-196页

作者： Feng Tang luting zhao Yan Jiang Denian Ba Lianxian Cui Wei He Department of Immunology Institute of Basic Medical Sciences Chinese Academy of Medical Science ＆ School of Basic Medicine Peking Union Medical College Beijing 100005 China Department of Immunology Institute of Basic Medical Sciences Chinese Academy of Medical Science ＆ School of Basic Medicine Peking Union Medical College 5 Dong Dan San Tiao Beijing 100005 China.

Transplantable experimental tumor models were constructed to study the activities of recombinant human interleukin-15 （rhIL-15） against tumor recurrence and metastasis. The results showed that tumor nodule formation was retarded and tumor growth was inhibited in the subcutaneous tumor model of LA795 lung adenocarcinoma after treatment with rhIL-15, and the survival rate of T739 tumor-bearing mice treated with rhIL-15 was much higher than that of mice treated with either saline or with the same dose of rhIL-2. This indicats that rhIL-15 had better antitumor effect than rhIL-2 at the same dose level. In some rhIL-15 treated mice, the tumor cells inoculated subcutaneously were eradicated and there was no tumor formation even 138 days after tumor cell inoculation. The tumor-free mice were rechallenged with live tumor cells and no tumor reoccurred in the following two months in all of these mice, indicating that long-lasting antitumor systemic immunity developed. It was also shown that tumor recurrence and metastasis were inhibited markedly after treatment with rhIL-15, but not with the same dose of rhIL-2, in both subcutaneously and intravenously disseminated tumor models of LA795 lung adenocarcinoma. Simultaneously, the CTL and NK cell activities of the splenocytes obtained from tumor-bearing mice that had been treated with either rhIL-15 or rhIL-2 were both markedly enhanced. However, the enhancement of CTL and NK cell activities was more significant in rhIL-15 treated mice than that in rhIL-2 treated mice. This suggests that the anti-tumor effect of rhIL-15 in vivo was achieved by enhancing the CTL and NK cell activities in tumor immune response.

关键词： rhIL-15 LA795 transplantable experimental tumor model recurrence metastasis

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自体、同种异体纯化富血小板血浆治疗兔膝骨关节炎的差异

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中国组织工程研究 2021年第26期25卷 4123-4129页

作者：赵露婷方其林唐海燕胥方元资阳市第一人民医院四川省资阳市641300 自贡市第一人民医院四川省自贡市643000 西南医科大学附属医院四川省泸州市646000

背景:活化后的纯化富血小板血浆可促进软骨细胞的增殖,调控关节内炎症反应,有效治疗膝骨关节炎。目的:对比自体、同种异体纯化富血小板血浆修复膝骨关节炎的效果。方法:取32只3月龄新西兰大耳兔,采用随机数字表法分4组,每组8只:正常组... 详细信息

背景:活化后的纯化富血小板血浆可促进软骨细胞的增殖,调控关节内炎症反应,有效治疗膝骨关节炎。目的:对比自体、同种异体纯化富血小板血浆修复膝骨关节炎的效果。方法:取32只3月龄新西兰大耳兔,采用随机数字表法分4组,每组8只:正常组不作任何处理;模型组、自体纯化富血小板血浆组、异体纯化富血小板血浆组通过关节内注射木瓜蛋白酶与L-半胱氨酸混合溶液制备膝骨关节炎模型,造模2周后,自体纯化富血小板血浆组、异体纯化富血小板血浆组分别关节内注射自体纯化富血小板血浆与同种异体纯化富血小板血浆,每2周注射1次,共注射3次。末次注射2周后,进行关节软骨大体观察、组织学观察与免疫组化观察。实验经西南医科大学实验动物管理委员会批准。结果与结论:①大体观察:模型组关节软骨表面粗糙,出现软骨缺损、侵蚀、溃疡,关节骨赘形成,有大量的关节腔积液,自体纯化富血小板血浆组关节软骨损伤及骨赘形成轻于模型组,异体纯化富血小板血浆组关节软骨损伤及骨赘形成与模型组相比无明显改善;②组织学观察:与模型组相比,自体纯化富血小板血浆组软骨结构、基质染色、细胞、潮线等各方面均明显改善(P均<0.05),异体纯化富血小板血浆组软骨结构有一定改善(P<0.05),但细胞排列、基质染色、潮线方面改善不明显;③免疫组化观察:自体纯化富血小板血浆组、异体纯化富血小板血浆组骨形态发生蛋白2与Sox9表达量的高于模型组(P<0.05),自体纯化富血小板血浆组骨形态发生蛋白2表达量高于异体纯化富血小板血浆组(P<0.05);④结果表明,自体、同种异体纯化富血小板血浆均能在一定程度上改善膝骨关节炎软骨细胞的增殖能力,促进软骨细胞修复,但自体纯化富血小板血浆的治疗效果更为明显。

关键词：实验动物兔膝骨关节炎纯化富血小板血浆骨形态发生蛋白2 Sox9

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富血小板血浆关节腔注射治疗慢性膝关节骨性关节炎对患者疼痛情况及血清基质金属蛋白酶-3、软骨寡聚基质蛋白水平的影响研究

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陕西医学杂志 2024年第7期53卷 918-921,953页

作者：余小夏何仁健赵露婷杨凌四川大学华西医院资阳医院资阳市中心医院康复科四川资阳641300 自贡市第一人民医院骨科四川自贡643000

目的:探究富血小板血浆(PRP)关节腔注射治疗慢性膝关节骨性关节炎(KOA)对患者疼痛情况及血清基质金属蛋白酶-3(MMP-3)、软骨寡聚基质蛋白(COMP)水平的影响。方法:选取86例慢性KOA患者,按随机信封法分为透明质酸(HA)组和PRP组,每组43例... 详细信息

目的:探究富血小板血浆(PRP)关节腔注射治疗慢性膝关节骨性关节炎(KOA)对患者疼痛情况及血清基质金属蛋白酶-3(MMP-3)、软骨寡聚基质蛋白(COMP)水平的影响。方法:选取86例慢性KOA患者,按随机信封法分为透明质酸(HA)组和PRP组,每组43例。HA组予以关节腔注射HA治疗,每次2 ml, PRP组以相同操作注射PRP,每次3.5 ml,两组均每周1次,连续治疗3周。比较两组治疗前后疼痛评分、症状严重程度、膝关节评分、血清炎症因子水平及不良反应发生情况。结果:治疗后3、6个月PRP组疼痛评分低于HA组(均P0.05)。结论:注射PRP对慢性KOA的远期疗效明显,可减轻其关节疼痛,改善关节功能,减轻膝关节炎症,安全性高。

关键词：富血小板血浆慢性膝关节骨性关节炎基质金属蛋白酶-3 软骨寡聚基质蛋白疼痛视觉模拟评分透明质酸

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Analysis-Aware Modelling of Spacial Curve for Isogeometric Analysis of Timoshenko Beam

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Computer Modeling in Engineering & Sciences 2020年第8期124卷 605-626页

作者： Yang Xia luting Deng Jian zhao School of Automotive Engineering State Key Laboratory of Structural Analysis for Industrial EquipmentDalian University of TechnologyDalian116024China

Geometric fitting based on discrete points to establish curve structures is an important problem in numerical *** purpose of this paper is to investigate the geometric fitting method for curved beam structure from points,and to get high-quality parametric model for isogeometric *** beam element is established for an initially curved spacial beam with arbitrary *** approximation and interpolation methods to get parametric models of curves from given points are examined,and three strategies of parameterization,meaning the equally spaced method,the chord length method and the centripetal method are *** influences of the different geometric approximation algorithms on the precision of isogeometric analysis are *** static analysis and the modal analysis with the established parametric models are carried *** examples with different complexities,the quarter arc curved beam,the Tschirnhausen beam and the Archimedes spiral beam are *** results show that for the geometric approximation the interpolation method performs good and maintains high *** fitting algorithms are able to provide parametric models for isogeometric analysis of spacial beam with Timoshenko *** equally spaced method and centripetal method perform better than the chord length method for the algorithm to carry out the parameterization for the sampling points.

关键词： Analysis-aware modelling curve fitting Timoshenko beam spatial curve isogeometric analysis

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院校合作型教学模式应用于护理人才培养的效果

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中国药业 2022年第S1期31卷 188-190页

作者：郑玉梅刘腊梅赵露婷兰甜杨维四川省资阳市第一人民医院康复科四川资阳641300 四川希望汽车技师学院四川资阳641300

目的探讨一种新型的教学方法,培养理论与实践相结合的高素质护理人才。方法医院与学校签订合作协议,双方在课程教学、临床见习、实习等方面开展深入合作,选择学校康复与养老护理专业2018级专科护生62名为试验组,实施院校合作型教学模式... 详细信息

目的探讨一种新型的教学方法,培养理论与实践相结合的高素质护理人才。方法医院与学校签订合作协议,双方在课程教学、临床见习、实习等方面开展深入合作,选择学校康复与养老护理专业2018级专科护生62名为试验组,实施院校合作型教学模式教学;选择同期护生61名为对照组。通过理论考核、操作考核、学生评价、带教科室评价、行业评价等方法评价两组护理人才培养的效果。结果试验组的护生理论知识考核及操作考核成绩均显著优于对照组(P0.05)。结论院校合作型教学模式能显著提高护生的护理综合能力,提高护生与兼职教师双方的教学满意度,值得推广。

关键词：院校合作教学模式双向合作护理人才

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高速收费站广场设计及收费亭分布优化

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重庆科技学院学报（自然科学版） 2018年第4期20卷 110-112页

作者：姚兴贵赵陆挺徐正阳张超薛良松安徽农业大学工学院合肥230036

分析某收费站广场的结构和交通流量,确定优化目标的影响因素。选择收费通道的数量、出入口的长度以及排队面积和出入口角为决策变量,建立了工程造价、事故率、吞吐量与决策变量之间的函数关系,确定了入口处和出口区的长度以及排队区的... 详细信息

分析某收费站广场的结构和交通流量,确定优化目标的影响因素。选择收费通道的数量、出入口的长度以及排队面积和出入口角为决策变量,建立了工程造价、事故率、吞吐量与决策变量之间的函数关系,确定了入口处和出口区的长度以及排队区的排队长度。建立数学规划模型,得到高速收费站广场设计及收费亭分布最优设计方案。

关键词：收费站广场工程造价吞吐量排队模型规划模型

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Bioactive chemical constituents from the marine-derived fungus Cladosporium ***-5

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Journal of Oceanology and Limnology 2024年第3期42卷 905-914页

作者： luting DAI Qingyi XIE Jiaocen GUO Qingyun MA Li YANG Jingzhe YUAN Haofu DAI Zhifang YU Youxing zhao College of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095China Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural Sciences&Hainan Academy of Tropical Agricultural ResourceHaikou 571101China

A new isochromanone,cladosporinisochromanone(1),accompanied by 15 known compounds(2–16)were obtained from secondary metabolites produced by marine-derived fungus Cladosporium *** and HRESIMS spectra elucidation determined the planar structure of *** electronic circular dichroism(ECD)experiment assigned the absolute configuration of *** 1,2,4–6,and 10 displayed different degrees of neuroprotective activities on human neuroblastoma cells *** compounds(1,3–5,and 13)emerged resistance to protein tyrosine phosphatase 1B(PTP1B),further kinetic analysis and molecular docking study indicated that the most potent compound 13(IC50value of 10.74±0.61μmol/L)was found as a noncompetitive inhibitor for *** plasmon resonance(SPR)and molecular docking studies also demonstrated the interaction between compound 12 and Niemann-Pick C1 Like 1(NPC1L1),which has been identified as significant therapeutic target for *** addition,compounds 3,6,and 14 showed attractive inhibitory activity against the phytopathogenic fungi:Colletotrichum ***,library of Cladosporium metabolites is enriched and new active uses of known compounds are explored.

关键词： Cladosporium sp. marine-derived fungus neuroprotective effects protein tyrosine phosphatase 1B(PTP1B) Niemann-Pick C1 Like 1(NPC1L1) antifungal activity

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肌电生物反馈对偏瘫患者上肢运动功能的影响

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西南军医 2018年第2期20卷 115-118页

作者：赵露婷张驰王剑雄唐海燕陈汝艳虞记华刘亚辉方其林胥方元西南医科大学附属医院康复医学科四川泸州646000

目的探讨表面肌电生物反馈作用于肩外展肌群对脑卒中患者上肢运动功能、日常生活能力的影响。方法将33例脑卒中患者随机分为观察组(n=17)、对照组(n=16),两组患者均接受常规康复治疗,观察组在常规康复治疗基础上给予表面肌电生物反馈治... 详细信息

目的探讨表面肌电生物反馈作用于肩外展肌群对脑卒中患者上肢运动功能、日常生活能力的影响。方法将33例脑卒中患者随机分为观察组(n=17)、对照组(n=16),两组患者均接受常规康复治疗,观察组在常规康复治疗基础上给予表面肌电生物反馈治疗肩外展肌群,每天1次,每周5次;两组疗程均为6周。治疗前及治疗6周后测定上肢肩外展肌(冈上肌、三角肌中束)表面肌电信号均值、肩外展活动度,并进行FuglMeyer上肢运动功能评分、改良Barthel指数评分。结果治疗6周后,两组患者肌肉表面肌电信号均值、肩外展活动度、Fugl-Meyer上肢运动功能评分、日常生活能力较治疗前均改善(P<0.05),且观察组各项评定指标优于对照组(P<0.05)。结论表面肌电生物反馈能使脑卒中患者肩关节外展功能恢复,改善卒中后患者上肢运动功能,提高其日常生活能力。

关键词：脑卒中肌电生物反馈肩关节外展上肢运动功能

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白鲜皮化学成分分离与鉴定

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化工时刊 2018年第1期32卷 28-30页

作者：谢飞翔赵璐婷张树东崔涛刘春峰丛欢李红梅王晓丽蕫巍郭丽娜齐齐哈尔医学院黑龙江齐齐哈尔161006 齐齐哈尔市食品药品检验检测中心黑龙江齐齐哈尔161006

白鲜皮乙醇提取物乙酸乙酯萃取层采用反复硅胶柱色谱、凝胶柱色谱、制备HPLC分离得到单体化合物,通过光谱方法对其化学成分进行结构鉴定。从白鲜皮乙醇提取物的乙酸乙酯萃取层中分离得到6个化合物,分别鉴定为3-醛基吲哚(1),5-羟基-2-羟... 详细信息

白鲜皮乙醇提取物乙酸乙酯萃取层采用反复硅胶柱色谱、凝胶柱色谱、制备HPLC分离得到单体化合物,通过光谱方法对其化学成分进行结构鉴定。从白鲜皮乙醇提取物的乙酸乙酯萃取层中分离得到6个化合物,分别鉴定为3-醛基吲哚(1),5-羟基-2-羟甲基吡啶(2),白鲜碱(3),大叶桉亭(4)邻苯二甲酸二丁酯(5),β-谷甾醇(6)。其中化合物1及化合物2为白鲜皮种内首次分离。

关键词：白鲜皮 3-醛基吲哚 5-羟基-2-羟甲基吡啶

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The effect of urbanization and exposure to multiple environmental factors on life-history traits and breeding success of Barn Swallows(Hirundo rustica)across China

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Avian Research 2022年第3期13卷 301-310页

作者： Yanyan zhao Emilio Pagani-Nú~nez Yu Liu Xiaoying Xing Zhiqiang Zhang Guangji Pan luting Song Xiang Li Zhuoya Zhou Yanqiu Chen Donglai Li Yang Liu Rebecca J.Safran State Key Laboratory of Biocontrol School of EcologySun Yat-sen UniversityGuangzhou510006China Institute of Eco-Environmental Research Guangxi Academy of SciencesNanning530007China Department of Health and Environmental Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou215028China Key Laboratory for Biodiversity Science and Ecological Engineering Ministry of EducationCollege of Life SciencesBeijing Normal UniversityBeijing100091China College of Wildlife and Protected Area Northeast Forestry UniversityHarbin150006China Institute of Wildlife Conservation Central South University of Forestry and TechnologyChangsha410004China College of Life Science Liaoning UniversityShenyang110036China Department of Ecology and Evolutionary Biology University of ColoradoBoulderUSA

In addition to landscape changes,urbanization also brings about changes in environmental factors that can affect *** the common referral in the published literature to multiple environmental factors such as light and noise pollution,there is a gap in knowledge about their combined *** developed a multidimensional environmental framework to assess the effect of urbanization and multiple environmental factors(light,noise,and temperature)on life-history traits and breeding success of Barn Swallows(Hirundo rustica)across rural to urban gradients in four locations spanning over 2500 km from North to South *** a single breeding season,we measured these environmental factors nearby nests and quantified landscape urbanization over a 1km~*** then analysed the relationships between these multiple environmental factors through a principal component analysis and conducted spatially explicit linear-mixed effects models to assess their effect on lifehistory traits and breeding *** were particularly interested in understanding whether and how Barn Swallows were able to adapt to such environmental conditions associated with *** results show that there is significant variation in the exposure to environmental conditions experienced by Barn Swallows breeding across urbanization gradients in *** changes and their effects are complex due to the behavioural responses ameliorating potential negative effects by selecting nesting sites that minimize exposure to environmental ***,significant relationships between landscape urbanization,exposure to environmental factors,and life-history traits such as laying date and clutch size were ***,the impact on breeding success was,at least in our sample,negligible,suggesting that Barn Swallows are extremely adaptable to a wide range of environmental features.

关键词： Fitness Heat-island effect Latitude Light pollution Noise pollution Parental investment

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