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Sonic hedgehog expression in a rat model of chronic pancreatitis

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World Journal of Gastroenterology 2014年第16期20卷 4712-4717页

作者： luo-wei wang Han Lin Yi Lu wei Xia Jun Gao Zhao-Shen Li Department of Gastroenterology Changhai HospitalSecond Military Medical University Department of Respiratory Medicine Shanghai Sixth People’s HospitalShanghai Jiaotong University

AIM: To analyze the activation of sonic hedgehog (SHh) signaling pathways in a rat model of chronic pancreatitis.

关键词： Sonic hedgehog Chronic pancreatitis Pancreatic cancer Ptch1 Smo Gli1

Metformin induces apoptosis of pancreatic cancer cells

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World Journal of Gastroenterology 2008年第47期14卷 7192-7198页

作者： luo-wei wang Zhao-Shen Li Duo-Wu Zou Zhen-Dong Jin Jun Gao Guo-Ming Xu Department of Gastroenterology Changhai Hospital the Second Military Medical UniversityShanghai 200433 China

AIM:To assess the role and mechanism of metformin in inducing apoptosis of pancreatic cancer ***:The human pancreatic cancer cell lines ASPC-1,BxPc-3,PANC-1 and SW1990 were exposed to *** inhibition of cell proliferation and colony formation via apoptosis induction and S phase arrest in pancreatic cancer cell lines of metformin was ***:In each pancreatic cancer cell line tested,metformin inhibited cell proliferation in a dose dependent manner in MTS(3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assays).Flow cytometric analysis showed that metformin reduced the number of cells in G1 and increased the percentage of cells in S phase as well as the apoptotic *** immunosorbent assay(ELISA) showed that metformin induced apoptosis in all pancreatic cancer cell *** Western blot studies,metformin induced poly-ADP-ribose polymerase(PARP) cleavage(an indicator of caspase activation) in all pancreatic cancer cell *** general caspase inhibitor(VAD-fmk) completely abolished metformin-induced PARP cleavage and apoptosis in ASPC-1 BxPc-3 and PANC-1,the caspase-8 specific inhibitor(IETD-fmk) and the caspase-9 specific inhibitor(LEHD-fmk) only partially abrogated metformin-induced apoptosis and PARP cleavage in BxPc-3 and PANC-1 *** also observed that metformin treatment dramatically reduced epidermal growth factor receptor(EGFR) and phosphorylated mitogen activated protein kinase(P-MAPK) in both a time-and dose-dependent manner in all cell lines ***:Metformin significantly inhibits cell proliferation and apoptosis in all pancreatic cell *** the metformin-induced apoptosis is associated with PARP cleavage,activation of caspase-3,-8,and-9 in a time-and dose-dependent ***,both caspase-8 and-9-initiated apoptotic signaling pathways contribute to metformin-induced apoptosis in pancreatic cell lines.

关键词： Metformin Pancreatic cancer Molecular classification Apoptosis

Establishing a model to measure and predict the quality of gastrointestinal endoscopy

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World Journal of Gastroenterology 2019年第8期25卷 1024-1030页

作者： luo-wei wang Han Lin Lei Xin wei Qian Tian-Jiao wang Jian-Zhong Zhang Qian-Qian Meng Bo Tian Xu-Dong Ma Zhao-Shen Li Digestive Endoscopy Center Department of GastroenterologyChanghai HospitalNaval Medical UniversityShanghai 200433China Unimed Scientific Inc. Wuxi 214000Jiangsu ProvinceChina Department of Intensive Care Unit Shanghai East HospitalTongji UniversityShanghai 200120China Department of Medical Quality Medical and Health AdministrationNational Health Commission of ChinaBeijing 100044China

BACKGROUND Tens of millions of gastrointestinal endoscopic procedures are performed every year in China,but the quality varies significantly and related factors are *** endoscopist-and endoscopy division-related factors may be useful to establish a model to measure and predict the quality of *** To establish a model to measure and predict the quality of gastrointestinal endoscopic procedures in China's *** Selected data on endoscopy experience,equipment,facility,qualification of endoscopists,and other relevant variables were collected from the National Database of Digestive Endoscopy of *** multivariable logistic regression analysis was used to identify the potential predictive variables for occurrence of medical malpractice and patient *** and nonlinear regressions were used to establish models to predict incidence of endoscopic *** In 2012,gastroscopy/colonoscopy-related complications in China's Mainland included bleeding in 4,359 cases(0.02%)and perforation in 914(0.003%).Endoscopic-retrograde-cholangiopancreatography-related complications included severe acute pancreatitis in 593 cases(0.3%),bleeding in 2,151(1.10%),perforation in 257(0.13%)and biliary infection in 4,125(2.11%).Moreover,1,313(5.0%)endoscopists encountered with medical malpractice,and 5,243(20.0%)encountered with the disturbance from *** length of endoscopy experience,weekly working hours,weekly night shifts,annual vacation days and job satisfaction were predictors for the occurrence of medical malpractice and patient ***,the length of endoscopy experience and the ratio of endoscopists to nurses were not adequate to establish an effective predictive model for endoscopy *** The workload and job satisfaction of endoscopists are valuable predictors for medical malpractice or patient *** comprehensive data are needed to establish quality-predictive models for endosco

关键词： Endoscopy Gastroscopy Colonoscopy Endoscopic retrograde cholangiopancreatography Quality control Predictive model Performance predictor

Simultaneous oxidation of NO,SO_2 and Hg^0 from flue gas by pulsed corona discharge

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Journal of Environmental Sciences 2009年第3期21卷 328-332页

作者： XU Fei,luo Zhongyang,CAO wei,wang Peng,wei Bo,GAO Xiang,FANG Mengxiang,CEN Kefa State key Laboratory of Clean Energy Utilization,Zhejiang University,Hangzhou 310027,China. State key Laboratory of Clean Energy Utilization Zhejiang University Hangzhou 310027 China

A process capable of simultaneously oxidizing NO, SO2, and Hg^0 was proposed, using a nigh-voltage and short-duration positive pulsed corona discharge. By focusing on NO, SO2, and Hg^0 oxidation efficiencies, the influences of pulse peak voltage, pulse frequency, initial concentration, electrode number, residence time and water vapor addition were investigated. The results indicate that NO, SO2 and Hg^0 oxidation efficiencies depend primarily on the radicals （OH, HO2, O） and the active species （O3, H2O2, etc.） produced by the pulsed corona discharge. The NO, SO2 and Hg^0 oxidation efficiencies could be improved as pulse peak voltage, pulse frequency, electrode number and residence time increased, but they were reduced with increasing initial concentrations. By adding water vapor, the SO2 oxidation efficiency was improved remarkably, while the NO oxidation efficiency decreased slightly. In our experiments, the simultaneous NO, SO2, and Hg^0 oxidation efficiencies reached to 40%, 98%, and 55% with the initial concentrations 479 mg/m^3, 1040 mg/m^3, and 15.0 μg/m^3, respectively.

关键词： pulsed corona discharge NO SO2 Hg^0 radical active species oxidation efficiency

Application of an artificial intelligence system for endoscopic diagnosis of superficial esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2022年第37期28卷 5483-5493页

作者： Qian-Qian Meng Ye Gao Han Lin Tian-Jiao wang Yan-Rong Zhang Jian Feng Zhao-Shen Li Lei Xin luo-wei wang Department of Gastroenterology Changhai HospitalShanghai 200433China Qingdao Medcare Digital Engineering Co.Ltd. Qingdao Medcare Digital Engineering Co.Ltd.Qingdao 26600Shandong ProvinceChina

BACKGROUND Upper gastrointestinal endoscopy is critical for esophageal squamous cell carcinoma(ESCC)detection;however,endoscopists require long-term training to avoid missing superficial *** To develop a deep learning computer-assisted diagnosis(CAD)system for endoscopic detection of superficial ESCC and investigate its application *** We configured the CAD system for white-light and narrow-band imaging modes based on the YOLO v5 algorithm.A total of 4447 images from 837 patients and 1695 images from 323 patients were included in the training and testing datasets,*** experts and two non-expert endoscopists reviewed the testing dataset independently and with computer *** diagnostic performance was evaluated in terms of the area under the receiver operating characteristic curve,accuracy,sensitivity,and *** The area under the receiver operating characteristics curve,accuracy,sensitivity,and specificity of the CAD system were 0.982[95%confidence interval(CI):0.969-0.994],92.9%(95%CI:89.5%-95.2%),91.9%(95%CI:87.4%-94.9%),and 94.7%(95%CI:89.0%-97.6%),*** accuracy of CAD was significantly higher than that of non-expert endoscopists(78.3%,P<0.001 compared with CAD)and comparable to that of expert endoscopists(91.0%,P=0.129 compared with CAD).After referring to the CAD results,the accuracy of the non-expert endoscopists significantly improved(88.2%vs 78.3%,P<0.001).Lesions with Paris classification type 0-IIb were more likely to be inaccurately identified by the CAD *** The diagnostic performance of the CAD system is promising and may assist in improving detectability,particularly for inexperienced endoscopists.

关键词： Computer-aided diagnosis Artificial intelligence Deep learning Esophageal squamous cell carcinoma Early detection of cancer Upper gastrointestinal endoscopy

Photodynamic therapy of cancer-Challenges of multidrug resistance

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Journal of Innovative Optical Health Sciences 2015年第1期8卷 14-26页

作者： Zheng Huang Yih-Chih Hsu Li-Bo Li luo-wei wang Xiao-Dong Song Christine M.N.Yow Xia Lei Ali I.Musani Rong-Cheng luo Brian J.Day MOE Key Laboratory of OptoElectronic Science and Technology for Medicine Fujian Normal University FuzhouP.R.China College of Engineering and Applied Science University of Colorado Denver COUSA Department of Medicine National Jewish Health COUSA Department of Bioscience Technology Center for Nanotechnology and Institute of Biomedical Technology Chung Yuan Christian University TaoyuanTaiwan TCM-Integrated Cancer Center Southern Medical University GuangzhouP.R.China Department of Gastroenterology&Endoscopy Changhai Hospital Second Military Medical University ShanghaiP.R.China Department of Urologic Surgery Tongji Medical College of Huazhong University of Science&TechnologyWuhanP.R.China Department of Health Technology Informatics Hong Kong Polytechnic University Hong Kong SARP.R.China Department of Dermatology Daping Hospital Third Military Medical UniversityChongqingP.R.China

Photodynamic therapy(PDT)of cancer is a two-step drug device combination modality,which involves the topical or systemie administration of a photosensitizer followed by light ilumnination of cancer *** the presence of oxygen molecules,the light illmnination of photosensitizer(PS)can lead to the generation of cytotoxic reactive oxygen species(ROS)and consequently destroy *** to many other anticancer therapies,PDT is also subject to intrinsic cancer resistance mediated by mutidrug resistance(MDR)*** paper will review the recent progress in understanding the interaction between MDR transporters and PS *** strategies that can be used in a clinical setting to owercome or bypass MDR will also be discussed.

关键词： Photodynamic therapy photosensitizer multidrug resistance cancer

Geo-Agents: Design and Implement

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Wuhan University Journal of Natural Sciences 2001年第Z1期6卷 451-459页

作者： Ding Li, Qu Lei, Zhang Ying, luo Ying wei, wang Xiao lin, Xu Zhuo qun Department of Computer Science & Technology,Peking University, Beijing 100871, China Department of Computer Science & Technology Peking University Beijing China

Geo Agents, a multi agent system that processes distributed geospatial information and geospatial service was presented. Firstly, the requirement for distributed geographical information process was discussed, and the architecture of Geo Agents was introduced. Then in depth discussions were raised on agent system implementation, such as the basic agent, agent advertising, message passing, and collaborating. An example was also given to explain the problem solving process.

关键词： geographical information system (GIS) multi agent system (MAS) Geo Ggents communication collaboration

Characteristics and efficacy of modified adenomyomectomy in the treatment of uterine adenomyoma

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Chinese Medical Journal 2011年第9期124卷 1322-1326页

作者： SUN Ai-jun luo Min wang wei CHEN Rong LANG Jing-he Department of Obstetrics and Gynecology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China

Background Adenomyoma is a very serious disease which influence the quality of life and leads to the infertility, and hysterectomy at the end. Unfortunetly, we still have no effective way to treat this kind of diseases. This study was aimed to evaluate the efficacy and surgical characteristics of modified adenomyomectomy. Methods This is a retrospective study and the subjects were collected in the past 5 years. We divided the subjects by the two different surgical procedures. Cases of adenomyoma patients who underwent conservative surgery, modified adenomyomectomy or wedge resection of the adenomyoma lesion were distributed to two groups retrospectively. Surgical characteristics, symptom relief, and recurrence were analysed in each group. Results General characteristics, including operation time, blood loss, and postoperative complication were similar in both groups. In the modified adenomyometomy group, the median follow-up time was 27.6 months and the rate of relief of dysmenorrhea and menorrhagia symptoms were 91.2% and 40.0%, respectively. In the wedge resection group, the rate of reliefe of dysmenorrhea and menorrhagia symptoms were 88.9% and 50.0%, respectively. Patients in both groups had statistically significant symptom relief, but there was no statistical difference between them. During the following time, ultrasonography relapse rate in modified modified adenomyomectomy group is significantly lower than the wedge resection group 15.0% vs. 69.2% （P 〈0.001）. The relapse rate, in terms of symptoms, was 5.0% in the modified adenomyomectomy group, which was similar to the relapse rate in the wedge resection group. In terms of reproductive outcome, 33.3% of the patients with infertility complications in the modified adenomyomectomy group became pregnant. Among them, the rate of pregnancy by assisted reproductive techniques was 45.5%, which was significantly higher than the rate of natural pregnancy, 23.1% （P =0.039）. Conclusion Modified adenomyomectomy appears

关键词： adenomyomectomy wedge resection adenomyoma lesion efficacy pregnancy relapse

Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

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Nano-Micro Letters 2025年第1期17卷 281-292页

作者： Xing wang wei Pi Sheng Hu Haifeng Bao Na Yao wei luo State Key Laboratory of New Textile Materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer