检索结果-南通市图书馆

Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection

引用

Signal Transduction and Targeted Therapy 2024年第6期9卷 2791-2803页

作者： Gang Yang Jinpeng Cao Jian Qin Xinyue Mei Shidong Deng Yingjiao xia Jun Zhao Junxiang Wang Tao Luan Daxiang Chen Peiyu Huang Cheng Chen Xi Sun Qi luo Jie Su Yunhui Zhang Nanshan Zhong Zhongfang Wang The Affiliated Hospital of Kunming University of Science and Technology.Department of Respiratory and Critical Care Medicine The First People’s Hospital of Yunnan provinceKunmingYunnanChina Guangzhou National Laboratory BiolandGuangzhouGuangdongChina State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina

The immunoprotective components control COVID-19 disease severity,as well as long-term adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial COVID-19 severity,remain ***,we longitudinally analyzed SARS-CoV-2-specific immune effectors during the acute infection and convalescent phases of 165 patients with COVID-19 categorized by *** found that early and robust SARS-CoV-2-specific CD4^(+)and CD8^(+)T cell responses ameliorate disease progression and shortened hospital stay,while delayed and attenuated virus-specific CD8^(+)T cell responses are prominent severe COVID-19 *** antiviral antibody generation rather than titer level associates with severe ***,initial COVID-19 severity imprints the long-term maintenance of SARS-CoV-2-specific adaptive immunity,demonstrating that severe convalescents exhibited more sustained virus-specific antibodies and memory T cell responses compared to mild/moderate ***,initial COVID-19 severity inversely correlates with SARS-CoV-2 reinfection ***,our study unravels the complicated interaction between temporal characteristics of virus-specific T cell responses and COVID-19 severity to guide future SARS-CoV-2 wave management.

关键词： severity immunity infection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Three-dimensional nanoscale vortex line visualization and chiral nanostructure fabrication of tightly focused multi-vortex beams via direct laser writing

引用

Photonics Research 2024年第1期12卷 70-77页

作者： MENGDI luo JISEN WEN PENGCHENG MA QIUYUAN SUN xiaNMENG xia GANGYAO ZHAN ZHENYAO YANG LIANG XU DAZHAO ZHU CUIFANG KUANG XU LIU Research Center for Intelligent Chips and Devices Zhejiang LabHangzhou 311100China State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311200China

Optical singularity is pivotal in nature and has attracted wide interest from many disciplines nowadays,including optical communication,quantum optics,and biomedical *** vortex lines formed by phase singularities and fabricating chiral nanostructures using the evolution of vortex lines are of great *** this paper,we introduce a promising method based on two-photon polymerization direct laser writing(2PP-DLW)to record the morphology of vortex lines generated by tightly focused multi-vortex beams(MVBs)at the *** to Gouy phase,the singularities of the MVBs rotate around the optical axis and move towards each other when approaching the focal *** propagation dynamics of vortex lines are recorded by 2PP-DLW,which explicitly exhibits the evolution of the phase ***,the MVBs are employed to fabricate stable three-dimensional chiral nanostructures due to the spiral-forward property of the vortex *** of the obvious chiral features of the manufactured nanostructures,a strong vortical dichroism is observed when excited by the light carrying orbital angular momentum.A number of applications can be envisioned with these chiral nanostructures,such as optical sensing,chiral separation,and information storage.

关键词： vortex chiral singularity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhancing solid-state lithium metal battery performance via indium-based modification of electrolytes and lithium metal surfaces: mechanistic insights and optimization

引用

Science China Chemistry 2024年

作者： Zhongkai Wu Chen Liu Ziling Jiang Lin Li Siwu Li Chaochao Wei Qiyue luo xia Chen Long Zhang Shijie Cheng Chuang Yu State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and Technology School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Interdisciplinary Research Center of Smart Sensors Academy of Advanced Interdisciplinary Research Xidian University College of Physics and Energy Fujian Normal University

Argyrodite-based solid-state lithium metal batteries exhibit significant potential as next-generation energy storage ***,their practical applications are constrained by the intrinsic poor stability of argyrodite towards Li metal and exposure to air/***,an indium-involved modification strategy is employed to address these *** optimized doping yields a high Li-ion conductivity of 7.5 mS cm-1for Li5.54In0.02PS4.47O0.03Cl1.5electrolyte,accompanied by enhanced endurance against air/moisture and bare Li *** retains 92.0%of its original conductivity after exposure to air at a low dew point of-60°C in dry ***,a composite layer comprising Li–In alloy and LiF phases is generated on the surface of lithium metal anode via the reaction between In F3and molten *** layer effectively mitigates Li dendrite growth by creating a physical barrier from the robust LiF phase,while the Li–In alloy induces uniform Li-ion deposition and accelerates Li transport dynamics across the interphase between the solid electrolyte/Li ***,the In-doped electrolyte facilitates the in-situ generation of Li–In alloy within its voids,reducing local current density and further inhibiting lithium dendrite ***,the combination of the Li5.54In0.02PS4.47O0.03Cl1.5electrolyte and the InF3@Li anode provides exceptional electrochemical performances in both symmetric cells and solid-state lithium metal batteries across different operating ***,the LiNbO3@LiNi0.7Co0.2Mn0.1O2/Li5.54In0.02PS4.47O0.03Cl1.5/InF3@Li cell delivers a high discharge capacity of 167.8 mAh g-1at 0.5 C under 25°C and retains 80.0%of its initial value after 400 *** work offers a viable strategy for designing functional interfaces with enhanced stability for sulfide-based solid-state lithium batteries.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Protective Effect of Naringenin on Acute Myocardial Ischemia-reperfusion Injury in Rats

引用

Medicinal Plant 2024年第3期15卷 50-52页

作者： xia ZHANG Ping ZHOU Juan LI Zhaojun xiaNG Qianqian luo Qing DENG Department of Neurosurgery Taihe Hospital of Shiyan CityHubei University of MedicineShiyan 442000China Gynecology and Obstetrics Taihe HospitalHubei University of MedicineShiyan 442000China

[Objectives]To investigate the protective mechanism of naringenin on acute myocardial ischemia-reperfusion injury(AMI-RI)in Sprague-Dawley(SD)rats.[Methods]A total of 32 SD rats with AMI-RI model construction were randomly divided into AMI-RI model control group and citrus pigment A/B/C groups(n=8).The naringenin A,B,and C groups were administrated 20,40 and 80 mg/(kg•d)for 10 *** AMI group served as the negative control and was not *** the conclusion of the treatment regimen,a sample of intraventricular blood was collected for the purpose of measuring lactate dehydrogenase(LDH),glutathione peroxidase(GLH-PX),nitric oxide(NO),and superoxide dismutase(SOD)***,myocardial tissue was identified within the ischemic *** content of malondialdehyde(MDA)was determined by inducing nitric oxide synthase(iNOS)and endodermal nitric oxide synthase(eNOS)positive cells in the left anterior descending coronary artery.[Results]Following citrus treatment,the contents of GLH-PX and SOD in ventricular blood of the citrus B group were found to be significantly elevated,while the contents of NO and LDH in myocardial MDA and ventricle were observed to be significantly *** number of eNOS-positive cells was significantly increased,while the number of iNOS-positive cells was significantly *** difference was statistically significant when compared with the AMI-RI group(P<0.05).The changes observed in the above indicators in the citrus C group were more pronounced than those observed in the citrus B *** difference between the citrus C and the B group was statistically significant(P<0.05),indicating that this effect is concentration dependent.[Conclusions]In addition to its ability to inhibit myocardial lipid peroxidation during AMI-RI by increasing SOD activity,naringenin may also affect the synthesis and release of NO by regulating eNOS and iNOS,thereby achieving protection against *** effect is enhanced as the dose of the drug inc

关键词： Rat Naringenin Acute myocardial ischemia-reperfusion Lipid peroxidation Inducible/endothelial nitric oxide synthase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gastrointestinal contrast-enhanced ultrasonography for diagnosis and treatment of peptic ulcer in children

引用

World Journal of Gastroenterology 2024年第7期30卷 705-713页

作者： Yu-Hua Zhang Zhi-Hua Xu Shuang-Shuang Ni Hong-xia luo Department of Ultrasound The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The detection rate of peptic ulcer in children is improving,with development of diagnostic *** is the gold standard for the diagnosis of peptic ulcer,but it is an invasive *** contrast-enhanced ultrasonography(CEUS)has the advantages of being painless,noninvasive,nonradioactive,easy to use,and *** To investigate the clinical value of CEUS for diagnosis and treatment of peptic ulcer in *** We investigated 43 children with digestive tract symptoms in our hospital from January 2021 to June *** children were examined by routine ultrasound,gastrointestinal CEUS,and *** pathological results of gastroscopy were taken as the gold *** ultrasonography was performed before gastrointestinal *** ultrasound showed the thickness of the gastroduodenal wall,gastric peristalsis,and the adjacent organs and tissues around the abdominal *** CEUS recorded the thickness of the gastroduodenal wall;the size,location and shape of the ulcer;gastric peristalsis;and adjacent organs and tissues around the abdominal *** results of routine ultrasound and gastrointestinal ultrasound were compared with those of gastroscopy to evaluate the diagnostic results and coincidence rate of routine ultrasound and gastrointestinal *** children received informed consent from their guardians for *** study was reviewed and approved by the hospital medical ethics *** Among the 43 children,17(15 male,2 female)were diagnosed with peptic ulcer by *** were 26 children with nonpeptic *** were eight cases of peptic ulcer and 35 of nonpeptic ulcer diagnosed by conventional *** diagnostic coincidence rate of peptic ulcer in children diagnosed by conventional ultrasound was 79.1%(34/43),which was significantly different from that of gastroscopy(P=0.033).It indicates that the coincidence rate of gastrointestinal contrast-enhanc

关键词： Contrast-enhanced ultrasound Peptic ulcer Children Gastrointestinal tract Abdominal pain Acoustic contrast agent

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ARHGAP4 variants are associated with X-linked early-onset temporal lobe epilepsy

引用

World Journal of Pediatrics 2024年第8期20卷 859-867页

作者： Yuan-Yuan Hu Wang Song Zhi-Gang Liu Xing-Guang Ye Hong-Wei Zhang Xin Li Jun-xia luo Peng-Yu Wang Jie Wang xiao-Fei Lin Hong-Li Zhu Wei-Ping Liao Bin Li Xu-Qin Chen Department of Neurology Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of ChinaInstitute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical UniversityChang-gang-dong RoadGuangzhou510260China Epilepsy Center and Neurology Department of Children’s Hospital of Soochow University Suzhou215000JiangsuChina Department of pediatrics Foshan Women and Children HospitalFoshan528000China Children’s Hospital Affiliated to Shandong University Jinan250000ShandongChina Second Hospital of Shandong University Jinan250000China Huai’an Maternity&Child Healthcare Hospital Huai’an223001China Institute of Neuroscience of Guangzhou Medical University and Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Chang-gang-dong Road 250Guangzhou510260GuangdongChina

The ARHGAP4 gene(OMIM*300,023),also known as Rho GTPase activating protein 4,encodes a protein that has an essential role in the regulation of small ***4 message RNA(mRNA)is highly expressed during the developing and adult nervous *** the protein level,ARHGAP4 is exclusively present in certain brain regions,such as the mesial temporal lobe,specifically the stratum lucidum of the CA3 region[1].ARHGAP4 enhances the GTPase activity of Rho proteins,which modulate morphological alterations in neuron development and synaptic plasticity by interacting with the actin cytoskeleton[2].

关键词： epilepsy alterations stratum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Physical exercise reverses immuno-cold tumor microenvironment via inhibiting SQLE in non-small cell lung cancer

引用

Military Medical Research 2024年第4期11卷 616-619页

作者： Zhi-Wen luo Ya-Ying Sun Wei xia Jun-Ying Xu Dong-Jing Xie Chun-Meng Jiao Ji-Ze Dong Hui Chen Ren-Wen Wan Shi-Yi Chen Jie Mei Wen-Jun Mao Department of Sports Medicine Huashan Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Sports Medicine Shanghai General HospitalShanghai 200080China Department of Critical Care Medicine the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina Department of Oncology the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina Guangdong Pharmaceutical University Guangzhou 510006China Institute of Acupuncture Research Institutes of Integrative MedicineFudan UniversityShanghai 200433China Department of Cardiothoracic Surgery the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina

Dear Editor,Physical exercise has been shown to be associated with reduced cancer incidence and cancer-associated mortality[1,2],but the underlying mechanisms are *** regulation has emerged as one of the most prominent mechanisms explaining the effects of exercise on cancer[1,2].Physical exercise primarily lowers blood cholesterol and triglycerides,and protects against cardiovascular diseases[3].However,whether physical exercise can modulate cholesterol metabolism in tumor cells is currently unknown.

关键词： Physical exercise Non-small cell lung cancer(NSCLC) Squalene epoxidase(SQLE) Tumor immune microenvironment(TIME)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

贵州高原典型喀斯特县域生境质量时空演变及定量归因

引用

环境科学 2024年第5期45卷 2793-2805页

作者：李月冯霞吴路华罗光杰罗红芬贵州财经大学公共管理学院贵阳550025 铜仁学院经济管理学院铜仁554300 贵州师范学院贵州省流域地理国情监测重点实验室贵阳550018

揭示贵州高原喀斯特县域生境质量时空演变规律及其驱动因素,为平衡喀斯特区域生态保护和可持续发展提供科学依据.利用1989年、2003年、2010年和2020年4期土地利用数据、DEM数据、气象数据和社会经济数据,采用InVEST模型阐明普定县近30... 详细信息

揭示贵州高原喀斯特县域生境质量时空演变规律及其驱动因素,为平衡喀斯特区域生态保护和可持续发展提供科学依据.利用1989年、2003年、2010年和2020年4期土地利用数据、DEM数据、气象数据和社会经济数据,采用InVEST模型阐明普定县近30年生境质量时空分布格局及演变特征,并对其空间分异的驱动力进行了定量探测.结果表明:①耕地和林地是普定县的主要土地利用类型,构成了地表覆盖景观基质.2003~2010年土地利用变化最显著,其中林地的增幅最大,达86.42%,耕地是流失最严重的土地利用类型,面积减少157.57 km^(2),主要流向林地和建设用地;②1989~2020年普定县生境质量指数平均值由0.60上升至0.73,空间上由东北部向西南部大体呈现出“高-低-高”的分布格局,生境质量高值区主要分布在东北部林地和草地区,低值区集中在中部和南部的建设用地,生境质量等级上升的区域主要集中在东部及西北部的大部分地区;③土地利用类型是影响生境质量时空分布的首要因素,解释程度为91.00%.在交互作用探测中,任意两种影响因素的交互作用大于单个因素的单独作用,土地利用类型和年均降水量的交互作用最强,达到96.00%,其与岩性因子的交互作用达到94.00%,自然与人文因素共同主导生境质量的时空变化.1989~2020年普定县生境质量总体较好,土地利用类型变化与生境质量关系密切,优化土地利用结构、减小人类活动的影响对提高普定县生境质量具有重要意义.

关键词：贵州喀斯特 InVEST模型生境质量地理探测器驱动因子

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

爆破地震作用下的老旧砌体结构动力特性分析

引用

爆破 2024年第2期41卷 185-193,202页

作者：黄俊夏界宁罗松湖北省地震局地震预警湖北省重点实验室武汉430071 武汉地震科学仪器研究院有限公司武汉430071

城市内老旧砌体结构多但抗震性能较差,在爆破作用下可能产生破坏。为研究爆破作用下老旧砌体的动力特性,在爆破现场附近的老旧砌体结构上布设强震仪,以观测爆破地震波对结构的瞬时作用以及长期爆破作用下的累积损伤效应。通过对爆破加... 详细信息

城市内老旧砌体结构多但抗震性能较差,在爆破作用下可能产生破坏。为研究爆破作用下老旧砌体的动力特性,在爆破现场附近的老旧砌体结构上布设强震仪,以观测爆破地震波对结构的瞬时作用以及长期爆破作用下的累积损伤效应。通过对爆破加速度和速度记录进行时域和频域分析比较,认为爆破速度记录相比爆破加速度记录可以更好地识别出砌体结构的动力特性,且爆破地震速度对砌体结构横向的共振影响最大。采用对比分析法,分别用爆破地震速度和地脉动加速度记录识别老旧砌体结构的动力特性,发现两种方法都能近似地识别出砌体结构的低阶平动和扭转频率,但采用爆破速度计算的自振频率比地脉动法要小1.8%~3.4%,这主要是因为爆破振动更能反映在较大振动作用下结构的响应,频繁的爆破可能导致老旧砌体结构出现非线性反应。通过监测结构自振频率在长期爆破作用下的变化,发现虽然单个爆破振动能满足《爆破安全规程》的安全要求,但在长期爆破作用下,结构1阶扭转频率、2阶横向和纵向频率随爆破次数的增加分别减少了4%、3.6%和5.2%,因此在爆破安全监测中应考虑长期爆破作用对老旧砌体结构等抗震能力较差建筑的累积损伤效应。

关键词：爆破地震波老旧砌体结构自振频率累积损伤效应爆破安全评估

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Jianqu,a traditional Chinese medicine,alleviates functional dyspepsia in high-calorie and high-protein diet mice

引用

Traditional Medicine Research 2024年第6期9卷 42-54页

作者： Jing-Yan Yang xiao-Xing Li Juan Chen Yan-Jun Liu Yue-Hong Wu Ning-Yu luo Cai-xia Yang Yang Li Si-Jing Liu Jin-Lin Guo College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 611137China Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine Chengdu 611137China Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China College of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China

Background:Jianqu has been used to alleviate symptoms in patients with functional dyspepsia,but its specific anti-functional dyspepsia effect is still ***,our study aimed to investigate the impact of Jianqu on functional dyspepsia in ***:The phytochemical profile of Jianqu was analyzed by ***,Kunming mice were fed a high-calorie or high-protein diet(HCHP)for 7 days,and then orally treated with vehicle or Jianqu(1.62 g/kg body weight(b.w.)and 3.25 g/kg b.w.)for 10 days.A carbon powder solution was used to detect the gastric emptying and intestinal transit *** pathological changes in stomach and duodenum were evaluated by hematoxylin-eosin *** occludin,claudin-1,ZO-1 and CD45 expression was measured by immunocytochemical ***,the serum gastrointestinal hormones were detected by *** addition,the gut microbiota composition was determined using 16S rRNA gene *** cecal short chain fatty acids were assessed by gas ***:In general,17 phytochemical compounds were identified from Jianqu,which significantly improved the gastric emptying rate and intestinal transit rate(p<0.01),increased the body weight and food intake(p<0.0001)in HCHP mice as *** HCHP did not cause significant pathological lesions in the gastrointestinal tract,increased the expression of CD45 in the duodenum(p<0.05)was ***,Jianqu attenuated this abnormal expression of CD45(p<0.05).The levels of serum gastrointestinal hormones were significantly normalized by Jianqu intervention(p<0.05).Moreover,Jianqu increased the relative abundance of Roseburia as well as short chain fatty acids levels in cecum(p<0.05).Conclusion:The present results showed that Jianqu alleviated dyspeptic symptoms in HCHP mice possibly through reducing the duodenal leukocyte infiltration,and regulating the expression of gastrointestinal *** effects may be partly related to the increasing cecal short ch

关键词： herbal formula dyspepsia gastrointestinal hormones gastric emptying intestinal transit

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：