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Research on object-oriented SOC design methodology

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High Technology Letters 2005年第3期11卷 235-239页

作者： luo juan（罗娟） Cao Yang School of Electronec Information Wuhan University Wuhan 430072 P.R.China

The growing complexity of System on Chip （SOC） requres a system level specicanon and design approach. High-level languages such as C＋＋/SystemC can play multiple roles in system design as target languages. There are many practical problems in the application of object-oriented methods for this goal. Based on the analysis of traditional and system-level design methodology, a new object-oriented SOC design methodology with object-oriented design patterns is proposed, which emphasizes high-level design and verification. Aiming at the final goal of developing design patterns specific to SOC design, the reuse of design patterns in SOC systems and the capability of new SOC design patterns are discussed. With the illustration of some concrete examples of SOC design patterns, the application of object-oriented design methodology in the SOC design process is presented.

关键词： object-oriented (OO) System on Chip (SOC) design pattern transaction level SystemC

Heat Treatment of Cold-Rolled Low-Carbon Si-Mn Dual Phase Steels

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Journal of Iron and Steel Research International 2010年第1期17卷 54-58页

作者： luo juan-juan SHI Wen HUANG Qun-fei LI Lin Material Science and Engineering College Shanghai University Shanghai 200072 China

The effects of overageing （OA） and vanadium addition on microstructure and properties of cold-rolled lowcarbon Si-Mn dual phase （DP） steel sheets are studied. The results show that the microstructure and mechanical properties of DP steels are greatly affected by OA temperature. When OA is done at low temperatures （473 -- 573 K）, the elongation rate increases sharply while both the yield strength and tensile strength decrease significantly, When OA is done at high temperatures （〉573 K）, the elongation does not further increase, but the yield strength increases and tensile strength decreases, which deteriorates the mechanical properties of the steel. The results also show that both the strength and the tempering stability can be significantly improved by vanadium microalloying. Finally, the optimum OA temperature for the traditional steel appears to be around 523 K, while it is around 573 K for the V-containing steel, resulting in the best overall mechanical properties.

关键词： dual phase steel overageing microstructure mechanical property vanadium

Effect of recombinant human platelet-derived growth factor B on cat corneal endothelial cell viability mediated by adeno-associated virus

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 419-423页

作者： Wen-juan luo, Hui Li Department of Ophthalmology the Affiliated Hospital of Medical College Qingdao University Qingdao 266003 Shandong Province China Department of Pathology the Affiliated Hospital of Medical College Qingdao University Qingdao 266003 Shandong Province China Central Laboratory of the Affiliated Hospital of Medical College Qingdao University Qingdao 266003 Shandong Province China

AIM: To transduce recombinant human platelet-derived growth factor B (PDGF-B) gene adeno-associated virus(AAV) to in vitro cultured cat corneal endothelial cell (CEC) and observe the effect of the expressed PDGF-BB protein on the viability of cat CEC. METHODS: Cat cornea endothelium was torn under microscope and rapidly cultivated in DMEM to form single layer CEC and the passage 2 endothelial cells were used in this study. The recombinant human PDGF-B gene AAV was constructed and transduced into cat CEC directly. Three groups were as following: blank control group, AAV control group and recombinant AAV group. At 24 hours, 48 hours, and 5 days after transduction, total RNA was extracted from the CEC by Trizol and the expression of PDGF-B gene was detected by fluorescence quantitative polymerase chain reaction. Viability of the transduced CEC was detected at 48 hours after transduction by MTT assay. Cell morphology was observed under inverted phase contrast microscope. RESULTS: With the torn endothelium culture technique, we rapidly got single layer cat CEC. At 24 hours, 48 hours and 5 days after transduction, fluorescence quantitative polymerase chain reaction showed there was no significant difference of the expressed PDGF-B gene mRNA between blank control group and AAV control group (P>0.05). In contrast, there were significant differences between two control groups and recombinant AAV group (P<0.05). MTT assay showed that in recombinant AAV group, the expressed PDGF-BB protein could promote the viability of cat CEC. Morphology observation showed at 48 hours after transduction, cells in CEC-AAV-PDGF-B group proliferated into bigger scales in regular triangle to hexagon shape with distinct boundary, while the number of cells was significantly less in the two control groups. CONCLUSION: The recombinant AAV-PDGF-B expresses biological active PDGF-BB protein in cat CEC, which promotes the viability and proliferation of cells.

关键词： platelet-derived growth factor corneal endothelial cell transduction viability proliferation

OPTIMAL CONTROL FOR A NONLINEAR n-DIMENSIONAL COMPETING SYSTEM WITH AGE-STRUCTURE

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International Journal of Biomathematics 2012年第3期5卷 133-144页

作者： ZHI-XUE luo JIAN-YU YANG YA-juan luo Department of Mathematics Lanzhou Jiaotong University Lanzhou 730070 P. R. China Department of AuditLanzhou Jiaotong UniversityLanzhou 730070 P. R. China School of Automation & Electrical Engineering Lanzhou Jiaotong University Lanzhou 730070 P. R. China

This paper is concerned with optimal harvesting control of a first order partial differential equation system representing a nonlinear n-dimensional competitive population model with age-structure. By the Ekeland＇s variational principle, the existence and unique char- acterization of the optimal control strategy are established. The optimality conditions for the control problem are obtained by the concept of the normal cone.

关键词： Optimal control age-dependence competition the maximum principle.

The relationship of blood cell-associated inflammatory indices and diabetic retinopathy: a Meta-analysis and systematic review

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International Journal of Ophthalmology(English edition) 2019年第2期12卷 312-323页

作者： Wen-juan luo Wen-Fang Zhang Department of Ophthalmology Lanzhou University Second Hospital

AIM: To explore the correlation between several blood cell-associated inflammatory indices including mean platelet volume(MPV), platelet distribution width(PDW), neutrophil to lymphocyte ratio(NLR) and platelet-lymphocyte ratio(PLR), and the presence and severity of diabetic retinopathy(DR). METHODS: We searched for eligible studies from PubMed, EMBASE, Web of Science and CNKI up to December 13, 2017. Standardized mean difference(SMD) calculated with confidence interval(CI) of 95% was used to estimate the values of those indices. RESULTS: A total of 31 studies were included in the present Meta-analysis. As compared with type 2 diabetes mellitus(T2 DM) patients without DR, the values of MPV, PDW, NLR, and PLR were higher in patients with DR(SMD=0.67; 95%CI: 0.36 to 0.98; SMD=0.51; 95%CI: 0.27 to 0.75; SMD=0.77; 95%CI: 0.49 to 1.05 and SMD=1.18; 95%CI: 0.07 to 2.28). Additionally, it was also observed that MPV was closely correlated with the severity of DR. CONCLUSION: MPV, PDW, NLR, and PLR could be recommended as diagnostic biomarkers for DR, and MPV could be applied to assess the severity of DR.

关键词： mean platelet volume platelet distribution width neutrophil to lymphocyte ratio platelet-lymphocyte ratio diabetic retinopathy

Biomineralization Precursor Carrier System Based on Carboxyl- Functionalized Large Pore Mesoporous Silica Nanoparticles

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Current Medical Science 2020年第1期40卷 155-167页

作者： Sheng WEI Hua WU Xiao-juan luo Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Stomatology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Bone and teeth are derived from intrafibrillarly mineralized collagen fibrils as the second level of *** to polymer-induced liquid-precursor process,using amorphous calcium phosphate precursor(ACP)is able to achieve intrafibrillar mineralization in the case of bone biomineral in ***,ACP precursors might be blended with any osteoconductive scaffold as a promising bone formation supplement for in-situ remineralization of collagens in *** this study,mesoporous silica nanoparticles with carboxyl-functionalized groups and ultra large-pores have been synthesized and used for the delivery of liquid like biomimetic precursors(ACP).The precursor delivery capacity of the nanoparticles was verified by the precursor release profile and successful mineralization of 2D and 3D collagen *** nanoparticles could be completely degraded in 60 days and exhibited good biocompatibility as *** successful translational strategy for biomineralization precursors showed that biomineralization precursor laden ultra large pore mesoporous silica possessed the potential as a versatile supplement in demineralized bone formation through the induction of intrafibrillar collagen mineralization.

关键词： biomineralization mesoporous silica amorphous calcium phosphate biocompatibility biodegradability carboxyl functionalization

The study of human PDGF-B gene transferred to cat corneal endothelial cells

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International Journal of Ophthalmology(English edition) 2012年第1期5卷 18-22页

作者： Wen-juan luo, Chuan-Fu Wang Department of Ophthalmology the Affiliated Hospital of Medical College Qingdao University Qingdao 266003 Shandong Province China School of Pharmacy Jiangxi Science and Technology Normal University Nan Chang 330013 Jiangxi Province China Department of Pathology the Affiliated Hospital of Medical College Qingdao University Qingdao 266003 Shandong Province China

AIM: To demonstrate that human platelet-derived growth factor-B (PDGF-B) cDNA could be Expressed in primary cultured cat corneal endothelia cells by using gene transfer techniques; to explore a useful tool for the further studies of the molecular mechanisms of corneal endothelium failure and provide a potential effective genetic therapy for the blind patients. ' METHODS: Human PDGF-B cDNA was isolated from human placent by RT-PCR and inserted into pcDNA(4) vector to construct recombinant eukaryotic expression plasmid pcDNA(4)-PDGF-B. The full length was confirmed by the DNA sequencing analysis. By tearing endothelium technique we obtained pure single layer of cat corneal endothelial cells. The pcDNA(4)-PDGF-B eukaryotic Expression vector was transferred into cat corneal endothelial cells by Effectene (TM) lipofectine. The transfection efficiency of Effectene (TM) lipofectine in pcDNA(4)-B was detected with pcDNA(4)-GFP. 5 days later, RT-PCR was used to check the PDGF-B expression. Cell viability was tested by modified tertrozalium salt (MU) method. Cell morphology was observed under inverted phase contrast microscope. RESULTS: The human PDGF-B cDNA was isolated successfully from healthy parturien placent tissue and the sequence was confirmed by computer automatic sequence and PCR analysis. Pure single layer cat corneal endothelial cells were successfully cultured by tearing endothelium technique. Effectene (TM) lipofectine transfection technique could be effectively used to transfer pcDNA(4)-PDGF-B into cat corneal endothelial cells in vitro, the transfection efficiency was 30%. RT-PCR result showed that human PDGF-B gene was highly expressed in transfected cat corneal endothelial cells. The expressed PDGF-BB protein promoted the viability of cat corneal endothelial cells. CONCLUSION: Human platelet-derived growth factor-B (PDGF-B) cDNA could be highly Expressed in cultured cat corneal endothelial cells by gene transfection techniques. Expressed PDGF-BB protein sign

关键词： platelet-derived growth factor corneal endothelial cell viability gene transfection.

Decision guidance framework to support operations and analysis of a hybrid renewable energy system

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Journal of Management Analytics 2016年第4期3卷 285-304页

作者： Roberto Levy Alexander Brodsky juan luo Computer Science Department George Mason UniversityFairfaxVA22030USA Information Technology Services George Mason UniversityFairfaxVA22030USA

In this paper we develop a framework to support the introduction of renewable energy generation and carbon emission constraints into a defined electric power network,and the key operational decisions regarding its *** describe and model the major components of a hybrid renewable energy system(HRES),including renewable energy sources(solar and wind),fossil fuel generators,transmission/distribution,power storage,energy markets,and end-customer *** methodology involves a conceptual diagram notation for power network topology,combined with a formal mathematical model that describes the HRES optimization *** introduce environmental goals as constraints to the model,based on emissions restrictions dictated by a policy-maker extraneous to the *** then proceed to implement the HRES optimization problem solution through a mixed-integer linear programming(MILP)model by leveraging IBM Optimization Programming Language(OPL)CPLEX ***,we develop a proof-of-concept to demonstrate the feasibility of the model.

关键词： renewable energy decision guidance conflicting objectives optimization electric network modelling

Anaplastic lymphoma kinase-negative anaplastic large cell lymphoma masquerading as Behcet’s disease: A case report and review of literature

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World Journal of Clinical Cases 2019年第20期7卷 3377-3383页

作者： juan luo Ying-Han Jiang Zi Lei Ying-Lei Miao Department of Gastroenterology the First Affiliated Hospital of Kunming Medical UniversityInstitute of Digestive DiseaseKunming 650000Yunnan ProvinceChina Department of Pathology the First People’s Hospital of Yunnan ProvinceKunming 650000Yunnan ProvinceChina Department of Pathology the First Affiliated Hospital of Kunming Medical UniversityKunming 650000Yunnan ProvinceChina

BACKGROUND Anaplastic large cell lymphoma(ALCL)is a CD30-positive T cell lymphoma,a rare type of non-Hodgkin *** current World Health Organization classification system divides ALCLs into anaplastic lymphoma kinase(ALK)-positive and ALK-negative *** rarely presents in the gastrointestinal *** SUMMARY A 54-year-old male was admitted to the department of gastroenterology for abdominal *** presented with lower abdominal pain,diarrhea and recurrent oral and penile *** was misdiagnosed with Behcet's disease and treated with *** after one month,he was hospitalized in another hospital for *** time,the lesion on the penis was biopsied for histological *** final pathological diagnosis was ALCL,*** patient was treated with cyclophosphamide,doxorubicin,vincristine,prednisolone ***,he died within one *** Gastrointestinal ALCL needs to be considered in the differential diagnosis to avoid delaying *** biopsy is the most important for early diagnosis and treatment.

关键词： Anaplastic large cell lymphoma Anaplastic lymphoma kinase Behcet's disease Colon ulcer Penis ulcer Case report