Biomineralization Precursor Carrier System Based on Carboxyl- Functionalized Large Pore Mesoporous Silica Nanoparticles

作     者：Sheng WEI Hua WU Xiao-juan LUO Sheng WEI;Hua WU;Xiao-juan LUO

作者机构：Department of OrthopedicsTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of StomatologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China 

出 版 物：《Current Medical Science》 (当代医学科学（英文）)

年 卷 期：2020年第40卷第1期

页      面：155-167页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 070301[理学-无机化学] 

基　　金：the National Natural Science Foundation of China(No.81600911) 

主　　题：biomineralization mesoporous silica amorphous calcium phosphate biocompatibility biodegradability carboxyl functionalization 

摘      要：Bone and teeth are derived from intrafibrillarly mineralized collagen fibrils as the second level of *** to polymer-induced liquid-precursor process,using amorphous calcium phosphate precursor(ACP)is able to achieve intrafibrillar mineralization in the case of bone biomineral in ***,ACP precursors might be blended with any osteoconductive scaffold as a promising bone formation supplement for in-situ remineralization of collagens in *** this study,mesoporous silica nanoparticles with carboxyl-functionalized groups and ultra large-pores have been synthesized and used for the delivery of liquid like biomimetic precursors(ACP).The precursor delivery capacity of the nanoparticles was verified by the precursor release profile and successful mineralization of 2D and 3D collagen *** nanoparticles could be completely degraded in 60 days and exhibited good biocompatibility as *** successful translational strategy for biomineralization precursors showed that biomineralization precursor laden ultra large pore mesoporous silica possessed the potential as a versatile supplement in demineralized bone formation through the induction of intrafibrillar collagen mineralization.