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PACK-CXL *** therapy for bacterial,fungal,and mixed infectious keratitis:a prospective randomized phase 3 trial

Eye and Vision 2024年第1期10卷 10-20页

作者： Farhad Hafezi Mohammed Hosny Rohit Shetty Boris Knyazer Shihao chen Qinmei Wang Hassan Hashemi Emilio A.Torres‑Netto 无 Center for Applied Biotechnology and Molecular Medicine(CABMM) University of ZurichZurichSwitzerland ELZA Institute DietikonSwitzerland. Faculty of Medicine University of GenevaGenevaSwitzerland Department of Ophthalmology Medical University of WenzhouWenzhouChina USC Roski Eye Institute University of Southern California Los AngelesLos AngelesUSA Department of Ophthalmology University of CairoCairoEgypt Narayana Nethralaya Eye Hospital and the Postgraduate Institute of Ophthal‑mology BangaloreIndia Department of Ophthalmology Soroka University Medical CenterBen-Gurion University of the NegevBeershebaIsrael Noor Ophthalmology Research Center Noor Eye HospitalTehranIran University Hospital Zurich ZurichSwitzerland. the PACK-CXL Working Group

Background:Infectious keratitis is a major cause of global *** tested whether standalone photoactivated chromophore corneal cross-linking(PACK-CXL)may be an efective frst-line treatment in early to moderate infectious keratitis,compared with standard antimicrobial ***:This is a randomized,controlled,multinational phase 3 clinical *** in fve centers in Egypt,India,Iran,Israel,and china,aged≥18 years,with infectious keratitis of presumed bacterial,fungal,or mixed origin,were randomly assigned(1:1)to PACK-CXL,or antimicrobial *** measures included healing,defned as time to re-epithelialization of the corneal epithelial defect in the absence of infammatory activity in the anterior chamber and clearance of stromal *** success was defned as the complete resolution of signs of ***:Between July 21,2016,and March 4,2020,participants were randomly assigned to receive PACK-CXL(n=18)or antimicrobial therapy per American Academy of Ophthalmology(AAO)guidelines(n=21).No participants were lost to *** eyes were excluded from the epithelialization time analysis due to treatment failure:two in the antimicrobial therapy group,and two in the PACK-CXL *** rates were 88.9%(16/18 patients)in the PACK-CXL group and 90.5%(19/21 patients)in the medication *** was no signifcant diference in time to complete corneal re-epithelialization(P=0.828)between both treatment ***:PACK-CXL may be an alternative to antimicrobial drugs for frst-line and standalone treatment of early to moderate infectious keratitis of bacterial or fungal origin.

关键词： Photoactivated chromophore Corneal cross-linking Infectious keratitis Corneal melting PACK-CXL

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骨钉骨膜联合髂骨松质骨植骨术修复替牙期唇腭裂牙槽突裂效果评价

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上海口腔医学 2024年第4期33卷 426-431页

作者：唐坤伦何晓玲陈丹电子科技大学医学院附属妇女儿童医院·成都市妇女儿童中心医院口腔科四川成都610091

目的:评价骨钉骨膜联合髂骨松质骨植骨术修复替牙期唇腭裂牙槽突裂的效果。方法:回顾性分析2020年1月—2023年12月收治的62例替牙期唇腭裂牙槽突裂患儿的临床资料,按照术式分为对照组(单纯髂骨松质骨植骨,n=42)和试验组(骨钉骨膜联合髂... 详细信息

目的:评价骨钉骨膜联合髂骨松质骨植骨术修复替牙期唇腭裂牙槽突裂的效果。方法:回顾性分析2020年1月—2023年12月收治的62例替牙期唇腭裂牙槽突裂患儿的临床资料,按照术式分为对照组(单纯髂骨松质骨植骨,n=42)和试验组(骨钉骨膜联合髂骨松质骨植骨,n=40)。比较2组植骨区存活骨量体积、移植骨整体和不同植骨区吸收率、植骨成功率、植骨成活率及并发症发生情况。采用SPSS 25.0软件包对数据进行统计学分析。结果:试验组术后3、9个月植骨区存活骨量体积显著大于对照组(P0.05)。试验组术后3、9个月及3~9个月的移植骨吸收率显著小于对照组(P0.05)。试验组术后3、9个月鼻腔侧1/2区、牙槽嵴侧1/2区、唇侧1/2区和腭侧1/2区移植骨吸收率显著低于对照组,且2组牙槽嵴侧1/2区移植骨吸收率显著高于鼻腔侧1/2区,腭侧1/2区显著高于唇侧1/2区(P<0.05)。试验组植骨成功率、植骨成活率显著高于对照组(P<0.05),并发症发生率显著低于对照组(P<0.05)。结论:骨钉骨膜联合髂骨松质骨植骨术可有效修复替牙期唇腭裂牙槽突裂,降低骨吸收率和并发症,提高成骨效果。术后骨量吸收主要发生于术后3个月内,且主要发生于牙槽嵴顶区、腭侧区。

关键词：骨钉骨膜髂骨松质骨植骨术唇腭裂牙槽突裂

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Nonlinear Time Series Prediction Using LS-SVM with Chaotic Mutation Evolutionary Programming for Parameter Optimization

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Communications in Theoretical Physics 2006年第4期45卷 641-646页

作者： XU Rui-Rui chen Tian-lun GAO cheng-Feng Department of Physics Nankai University Tianjin 300071 China

Nonlinear time series prediction is studied by using an improved least squares support vector machine （LSSVM） regression based on chaotic mutation evolutionary programming （CMEP） approach for parameter optimization. We analyze how the prediction error varies with different parameters （σ, γ） in LS-SVM. In order to select appropriate parameters for the prediction model, we employ CMEP algorithm. Finally, Nasdaq stock data are predicted by using this LS-SVM regression based on CMEP, and satisfactory results are obtained.

关键词： nonlinear time series prediction least squares support vector machine chaotic mutation evolu tionary programming

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Geology and genesis of the Aqishan Pb-Zn deposit,NW china:Insights from mineralogy,geochemistry,and in situ U-Pb geochronology

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Geoscience Frontiers 2024年第5期15卷 489-514页

作者： Kang Wang Yinhong Wang Jun Deng Jiajun Liu Fangfang Zhang Wei Zhang Hui Zhang Wenxin Gu Hong chen State Key Laboratory of Geological Processes and Mineral Resources and School of Earth Sciences and ResourcesChina University of GeosciencesBeijing 100083China

The unique ore-forming processes and the key factors responsible for formation of skarn deposits are still obscure,and challenges exist in the determination of timing of Pb-Zn skarns owing to lacking suitable mineral *** we present detailed paragenesis,bulk geochemistry,in situ U-Pb dating of zircon and garnet,and garnet oxygen isotopes together with in situ zircon Hf-O isotopes from the newly discovered Aqishan Pb-Zn deposit in the southern Central Asian Orogenic Belt(CAOB),northwest *** comprehensive data set revealed a Late Carboniferous subduction-related distal Pb-Zn skarn system associated with the granitic ***-ore stage garnets are generally subhedral to euhedral with oscillatory zoning and show slightly fractionated rare earth element patterns with positive Eu anomalies that point to an infiltration metasomatism origin under high water/rock *** syn-ore stage sphalerite is typically enriched in Mn and Cd and has moderate Zn/Cd ratios(337–482),with a formation temperature of 265℃to 383℃,which indicate magmatic-hydrothermal *** isocons defined by P_(2)O_(5)decipher that the principal factors for skarn formation were elevated activities of Fe,Ca,and Si species,where remobilization of Pb metals,meanwhile,contributed to ore-forming budgets to mineralizing *** U-Pb dating of zircons from granite porphyry that occurs distal to the skarns and Pb-Zn orebodies shows that these intrusions emplaced at ca.311.3–310.6 Ma,recording the subduction of the Paleo-Tianshan oceanic *** garnets in close textural association with Pb-Zn sulfides yield indistinguishable in situ LA-ICP-MS U-Pb ages of 310.5±4.1 ***-rock geochemistry and in situ zircon Hf-O isotopes(δ^(18)O=4.6‰–6.0‰)indicate that the granite porphyry was derived from partial melting of juvenile crust and influenced by subducted oceanic *** isotope compositions of garnets(δ^(18)O=8.0‰–9.0‰)demonstrate that the equilibrated ore fluids

关键词： In situ U-Pb dating Garnet O isotopes Aqishan Pb-Zn deposit Skarn mineralization Southern CAOB

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Effects of Aging and Self-organized Criticality in a Pulse-Coupled Integrate-and-Fire Neuron Model Based on Small World Networks

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Communications in Theoretical Physics 2007年第5期47卷 869-874页

作者： ZHANG Gui-Qing ZHANG Ying-Yue chen Tian-lun Department of Physics Nankai University Tianjin 300071 China

Effects of aging and self-organized criticality in a pulse-coupled integrate-and-fire neuron model based on small world networks have been studied. We give the degree distribution of aging network, average shortest path length, the diameter of our network, and the clustering coefficient, and find that our neuron model displays the power-law behavior, and with the number of added links increasing, the effects of aging become smaller and smaller. This shows that if the brain works at the self-organized criticality state, it can relieve some effects caused by aging.

关键词： aging self-organized criticality small world networks

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Surgical resection of isolated pancreatic metastatic malignant melanoma

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 908-912页

作者： Xihao Zhong Yiming chen Zhaohong Wang Jisheng Wang Bin Zhou Binglong Bai Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouChina

Pancreatic metastasis from a nonpancreatic primary tumor is rare(<2%)(1,2)and has a potentially poor prognosis(3).Melanoma is an aggressive skin malignancy that commonly exhibits distant metastasis and poor overall prognosis(4).Isolated pancreatic metastasis from melanoma is even less common and poses significant diagnostic and therapeutic challenges.A retrospective study demonstrated that surgical resection increased the survival of patients with abdominal visceral melanoma metastases(5).However,pancreatic resection of metastatic melanoma is potentially associated with high mortality as experience with this type of surgery is limited(6).Here,we describe a rare case of isolated pancreatic metastatic melanoma treated with pancreatic resection at our hospital,including clinical features,treatment,and follow-up.A review of the related literature is also provided.

关键词： Pancreatic metastasis malignant melanoma surgical resection

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Gingipain from Porphyromonas gingivalis causes insulin resistance by degrading insulin receptors through direct proteolytic effects

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International Journal of Oral Science 2024年第3期16卷 539-552页

作者： Fen Liu Bofeng Zhu Ying An Zhifei Zhou Peiying Xiong Xuan Li Yang Mi Tongqiang He Faming chen Buling Wu Shenzhen Stomatology Hospital(Pingshan) Southern Medical UniversityShenzhenChina Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research Laboratory Center of StomatologyDepartment of Paediatric DentistryCollege of StomatologyXi’an Jiaotong UniversityXi’anChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi International Joint Research Center for Oral DiseasesDepartment of PeriodontologySchool of StomatologyThe Fourth Military Medical UniversityXi’anChina Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification School of Forensic MedicineSouthern Medical UniversityGuangzhouChina Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhouChina Department of Stomatology General Hospital of Tibetan Military CommandLhasaChina Department of Stomatology Center Shenzhen HospitalSouthern Medical UniversityShenzhenChina Department of Obstetrics Northwest Women’s and Children’s HospitalXi’anChina

Periodontitis is a critical risk factor for the occurrence and development of *** gingivalis may participate in insulin resistance(IR)caused by periodontal inflammation,but the functional role and specific mechanisms of *** in IR remain *** the present study,clinical samples were analysed to determine the statistical correlation between *** and IR *** culturing of hepatocytes,myocytes,and adipocytes,and feeding mice *** orally,the functional correlation between *** and IR occurrence was further studied both in vitro and in *** data suggested that the amount of *** isolated was correlated with the Homeostatic Model Assessment for IR *** vitro studies suggested that coculture with *** decreased glucose uptake and insulin receptor(INSR)protein expression in hepatocytes,myocytes,and *** fed *** tended to undergo *** was detectable in the liver,skeletal muscle,and adipose tissue of experimental *** distribution sites of gingipain coincided with the downregulation of *** proteolysed the functional insulin-binding region of *** with *** significantly decreased the INSR–insulin binding *** out gingipain from *** alleviated the negative effects of *** on IR in *** together,these findings indicate that distantly migrated *** may directly proteolytically degrade INSR through gingipain,thereby leading to *** results provide a new strategy for preventing diabetes by targeting periodontal pathogens and provide new ideas for exploring novel mechanisms by which periodontal inflammation affects the systemic metabolic state.

关键词： gingivalis inflammation resistance

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Osteoarthritis versus psoriasis arthritis: Physiopathology, cellular signaling, and therapeutic strategies

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Genes & Diseases 2024年第3期11卷 232-247页

作者： Salma Nassor Juma Junguang Liao Yuping Huang Rexhina Vlashi Qingwan Wang Bocong Wu Dan Wang Mengrui Wu Guiqian chen College of Life Science and Medicine Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and BiomedicineZhejiang Sci-Tech UniversityHangzhouZhejiang 310018China Department of Cell and Developmental Biology College of Life SciencesZhejiang UniversityHangzhouZhejiang 310058China

Osteoarthritis and psoriasis arthritis are two degenerative forms of arthritis that share similar yet also different manifestations at the histological,cellular,and clinical *** have marked them as two entirely distinct *** recent dis-coveries in disease initiation and progression,potential mechanisms,cellular signaling path-ways,and ongoing clinical therapeutics,there are now more opportunities for discovering osteoarthritis *** review summarized the osteoarthritis and psoriasis arthritis signaling pathways,crosstalk between BMP,WNT,TGF-β,VEGF,TLR,and FGF signaling pathways,bio-markers,and anatomical *** bench research,we demonstrated that regen-erative medicine is a promising alternative for treating osteoarthritis by highlighting significant scientific discoveries on entheses,multiple signaling blockers,and novel molecules such as immunoglobulin new antigen receptors targeted for potential drug ***,we offered valuable therapeutic approaches with a multidisciplinary strategy to treat patients with osteoarthritis or psoriasis arthritis in the coming future in the clinic.

关键词： Newantigen receptor Osteoarthritis Physiopathology Psoriasisarthritis Signaling pathway

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Electrochemical Reduction of Benzo[b]thiophene 1,1-Dioxides with HFIP as Hydrogen Donor

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chinese Journal of Chemistry 2024年第6期42卷 585-591页

作者： Ming-Zhong Guo Mei-Jin Mou Zhuo chen Shao-Fei Ni Ming Li Li-Rong Wen Lin-Bao Zhang State Key Laboratory Base of Eco-Chemical Engineering College of Chemistry and Molecular EngineeringQingdao University of Science & TechnologyQingdaoShandong266042 China Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou UniversityShantouGuangdong515063 China

A straightforward electrochemical reduction of benzo[b]thiophene 1,1-dioxides with HFIP as the hydrogen donor has been reported in an undivided cell under metal-free ***,the tolerance of various functional groups and ... 详细信息

关键词： Electrochemistry Reduction Benzo[b]thiophene 1,1-dioxides Deuterium Hydrogen source

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Dynamic analysis of two-degree-of-freedom airfoil with freeplay and cubic nonlinearities in supersonic flow

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Applied Mathematics and Mechanics(English Edition) 2012年第1期33卷 1-14页

作者： Hu-lun GUO Yu-shu chen School of Astronautics Harbin Institute of TechnologyHarbin 150001P.R.China

The nonlinear aeroelastic response of a two-degree-of-freedom airfoil with freeplay and cubic nonlinearities in supersonic flows is investigated. The second-order piston theory is used to analyze a double-wedge airfoil. Then, the fold bifurcation and the amplitude jump phenomenon are detected by the averaging method and the multi-variable Floquet theory. The analyticall results are further verified by numerical simulations. Finally, the influence of the freeplay parameters on the aeroelastic response is analyzed in detail.

关键词： freeplay cubic nonlinearity averaging method limit cycle oscillation amplitude jump phenomenon

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