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RsERF40 contributes to cold stress tolerance and cell expansion of taproot in radish (Raphanus sativus L.)

Horticulture Research 2023年第3期10卷 223-234页

作者： Cui Li Baozhen mao Kai Wang Liang Xu Lianxue Fan Yan Wang Ying Li Yinbo Ma lun Wang Liwang Liu National Key Laboratory of Crop Genetics&Germplasm Enhancement and utilization Key Laboratory of Horticultural Crop Biology and Genetic Improvement(East China)of MOARCollege of HorticultureNanjing Agricultural UniversityNanjing 210095China College of Horticulture and Landscape Architecture Yangzhou UniversityYangzhou 225009China

The growth and development of taproots are inhibited by cold stress in radish(Raphanus sativus L.).Ethylene-responsive element binding factors(ERF)are key participators in the cold stress response and growth regulation of ***,the function of ERF genes in cold tolerance and root development in radish remains ***,we showed that the secondary growth of radish taproots was inhibited by cold *** transcriptome analysis demonstrated that the RsERF40 gene is an important regulator of the cold stress response and root growth *** cold tolerance of transgenic Arabidopsis plants overexpressing the RsERF40 gene was significantly *** RsERF40 in the cold-sensitive radish genotype and silencing RsERF40 in the cold-tolerant radish genotype indicated that RsERF40 was beneficial for alleviating oxidative damage under cold stress in *** Arabidopsis seedlings showed an increase in the elongation and radial growth of dark-grown ***-qPCR analysis showed that the expression of the cold-related genes(CORs)RsCOR78 and RsCOR413PM1 and the cell wall strengthening-related genes RsCESA6 and RsEXPB3 was upregulated in transgenic Arabidopsis *** one-hybrid(Y1H)and dual-luciferase reporter assays(DLA)revealed that RsERF40 directly regulates RsCOR78,RsCOR413PM1,RsCESA6 and RsEXPB3 expression,illustrating that RsERF40 enhances cold tolerance and taproot growth by modulating osmotic adjustment and cell wall mechanical strength in *** this study,the RsERF40-regulon was firstly found to be a new cold response pathway independent of the CBF-COR pathway conferring cold stress tolerance with increasing radish taproot *** results provided novel insight into the molecular mechanism underlying cold stress response and would facilitate the genetic improvement of cold tolerance in radish and other root vegetable crops.

关键词： stress Raphanus roots

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Structural phase transition,strength,and texture in vanadium at high pressure under nonhydrostatic compression

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Chinese Physics B 2018年第3期27卷 335-341页

作者： lun Xiong Jing Liu School of Intelligent Manufacturing Sichuan University of Arts and ScienceDazhou 635000China DaZhou Industrial Technology Institute of Intelligent Manufacturing Dazhou 635000China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

The structural phase transition,strength,and texture of vanadium have been studied under nonhydrostatic compression up to 70 GPa using an angle-dispersive radial x-ray diffraction technique in a 2-fold paranomic diamond anvil cell and up to 38 GPa using an angle-dispersive x-ray diffraction technique in a modified mao-Bell diamond anvil cell at room *** have confirmed a phase transition from body-centered cubic structure to rhombohedral structure at 27-32 GPa under nonhydrostatic *** radial x-ray diffraction data yields a bulk modulus K_(0)=141(5)GPa and its pressure derivative K_(0)'=5.4(7)for the bcc phase and K_(0)=154(13)GPa with K_(0)′=3.8(3)for the rhombohedral phase atψ=54.7°.The nonhydrostatic x-ray diffraction data of both bcc and rhombohedral phases yields a bulk modulus K_(0)=188(5)GPa with K_(0)′=2.1(3).Combined with the independent constraints on the high-pressure shear modulus,it is found that the vanadium sample can support a differential stress of-1.6 GPa when it starts to yield with plastic deformation at-36 GPa.A maximum differential stress as high as-1.7 GPa can be supported by vanadium at the pressure of-47 *** addition,we have investigated the texture up to 70 GPa using the software package *** is convinced that the body-centered cubic to rhombohedral phase transition and plastic deformation due to stress under high pressures are responsible for the development of texture.

关键词： phase transition strength texture vanadium

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Puerarin reduces increased c-fos, c-jun, and type Ⅳ collagen expression caused by high glucose in glomerular mesangial cells

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Acta Pharmacologica Sinica 2005年第8期26卷 982-986页

作者： Cai-ping mao, Zhen-lun GU~1 Department of Pharmacology, Suzhou Institute of Chinese Materia Medica, Medical College of Soochow University Suzhou 215007, China Department of Pharmacology Suzhou Institute of Chinese Materia Medica Medical College of Soochow University Suzhou China

Aim: Increased expression of c-fos, c-jun and type Ⅳ collagen (CoⅣ) in glomerular mesangial cells (GMC) are important characteristics of diabetic nephropathy. Both c-los and c-jun regulate the gene expression of extracellular matrix components, and CoⅣ is the main component of the extracellular matrix. It has been reported that puerarin inhibits aggregation of the extracellular matrix in diabetic rats by an as yet unknown mechanism. The aim of this study is to investigate the effect of puerarin on c-fos, c-jun and CoⅣ expression in GMC cultured in medium containing 5.6 or 27.8 mmol/L glucose. Methods: The expressions of c-fos and c-jun were measured at the protein level using flow cytometry. CoⅣ content was detected using radioimmunoassay. Protein kinase C (PKC) activity was measured using liquid scintillation counting. Results: Puerarin (10-5mmol/L) significantly ameliorated the high-glucose effect on c-fos, c-jun and CoⅣ expression. This effect is accompanied by a reduced PKC activity in these cells. Coclusion: Our results suggest that reduced PKC activity and expression of c-fos and c-jun in GMC might participate in the mechanisms underlying the therapeutic effect of puerarin on diabetic nephropathy.

关键词： puerarin glomerular mesangial cells extracellular matrix diabetic nephropathy

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早中孕期血清学筛查唐氏综合征策略比较

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解放军医学院学报 2017年第4期38卷 313-316页

作者：姜淑芳付玉荣马莹徐虹李江华毛仑汪龙霞高志英卢彦平解放军总医院妇产科北京1008531 解放军总医院超声科北京1008531

目的比较早孕期、中孕期及早中孕期联合血清学筛查唐氏综合征策略,探索更加适用于临床的血清学筛查策略。方法对2014年3月-2015年11月来我院建档产检的110例早孕期孕妇进行胎儿的颈后透明层(nuchal translucency,NT)超声测量、早孕期及... 详细信息

目的比较早孕期、中孕期及早中孕期联合血清学筛查唐氏综合征策略,探索更加适用于临床的血清学筛查策略。方法对2014年3月-2015年11月来我院建档产检的110例早孕期孕妇进行胎儿的颈后透明层(nuchal translucency,NT)超声测量、早孕期及中孕期血清学标记物浓度检测,分别按照早孕一站式、中孕期血清学三联筛查及早中孕期联合筛查的策略进行风险评估。对92例资料完整的病例进行筛查高风险率的一致性检验。结果总的早孕期高风险率为10.9%(12/110);中孕期高风险率为9.8%(9/92);早中孕期联合评估高风险率为5.4%(5/92)。早中孕联合筛查的高风率较低,与早孕期一站式筛查、中孕期血清学三联筛查比较差异有统计学意义(χ~2=29.54,P<0.05;χ~2=20.65,P<0.05)。结论早中孕联合筛查对于降低筛查的高风险率,提高产前筛查的临床效率,减少进一步有创产前诊断的病例数量具有重要意义。

关键词：早孕期中孕期血清学唐氏综合征

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强化抗血小板治疗在缺血性脑卒中复发高危患者二级预防中的临床研究

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中国临床神经科学 2013年第6期21卷 637-641页

作者：郝冬琳吴波娜毛伦林许元丰张金季莉莉王佳佳江苏大学附属武进医院神经内科 213002

目的观察强化抗血小板药物氯吡格雷在缺血性脑卒中复发高危患者二级预防中的长期疗效及安全性。方法采用艾森卒中风险评分(ESRS)量表筛选住院的急性非心源性缺血性脑卒中复发高危患者100例,随机分为氯吡格雷组和阿司匹林组,每组50例。... 详细信息

目的观察强化抗血小板药物氯吡格雷在缺血性脑卒中复发高危患者二级预防中的长期疗效及安全性。方法采用艾森卒中风险评分(ESRS)量表筛选住院的急性非心源性缺血性脑卒中复发高危患者100例,随机分为氯吡格雷组和阿司匹林组,每组50例。两组均给予脑卒中常规治疗,氯吡格雷组予氯吡格雷75 mg及阿司匹林100 mg口服,1周后仅予氯吡格雷75 mg,口服。阿司匹林组予阿司匹林200 mg,口服,1周后改为100 mg,口服。随访3个月和1年,观察两组缺血性脑卒中复发率及药物不良反应发生率。结果随访3个月时,脑卒中复发率:阿司匹林组为6.3%,氯吡格雷组为2.0%,差异无统计学意义(P>0.05);药物不良反应发生率:阿司匹林组为14%,氯吡格雷组为2%,差异有统计学意义(P<0.05)。随访1年时,脑卒中复发率:阿司匹林组为13%,氯吡格雷组为2%,差异有统计学意义(P<0.05);药物不良反应发生率:阿司匹林组为38%,氯吡格雷组为6%,差异有统计学意义(P<0.01)。结论缺血性脑卒中复发高危患者二级预防中强化抗血小板治疗可降低脑卒中复发风险,长期应用获益较高,安全性好。

关键词：艾森卒中风险评分量表脑卒中高危二级预防强化抗血小板治疗

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Combination Therapy of Acitretin Capsule and Chinese Herbs for Patients with Lichen Planus Pigmentosus-Inversus

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Chinese Journal of Integrative Medicine 2019年第12期25卷 922-925页

作者： CHEN Yu XUE Liang GUO Dong-jie mao Jing-yi WU Min-feng XU Rong LI Xin LI Bin LI Fu-lun Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineAffiliated to Shanghai University of Traditional Chinese MedicineShanghai(200437)China Department of Burn and Plastic Surgery the Seventh People's Hospital of Integrated Traditional Chinese and Western MedicineAffiliated to Shanghai University of Traditional Chinese MedicineShanghai(200137)China

Lichen planus pigmentosus-inversus(LPPI)is a relatively uncommon variant of lichen planus(LP),characterized by mottled pigmentation of bluish,black or grey color on the flexural folds with or without *** was first described by Pock,et al(1)in *** present,there are only 27 cases of the disease reported from 13 reports internationally.(2)As very few cases about LPPI are reported,the diagnosis and selection of therapeutic scheme are fairly difficult for ***,we report 3 cases who presented with LPPI,obtaining good results after Chinese medicine(CM)*** cases have typical clinical and histological ***,a case of melanosis is reported,which has similar clinic manifestation and is differentiated by pathological *** report was authorized by all patients.

关键词： diagnosis Therapy Patients

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Establishment and application of experimental model of human fetal hepatocytes: protective effects of silybin and polyporus umbellalus polysaccharides on human fetal hepatocytes

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World Journal of Gastroenterology 1997年第4期3卷 30-32页

作者： WANG maoRong, LE MeiZhao, XU JiaZhang and HE Changlun

IM To establish a new experimental model system with human fetal hepatocytes to study the mechanisms of protective effect of silybin and polyporus umbellalus polysaccharides (PSP) on the ultrastructure of human fetal hepatocytes.METHODS The hepatocytes were obtained from the liver of human fetus from induced labor with written consent. The primarily cultured hepatocytes were pretreated with silybin and PSP and exposed to CCl4 for 4 hours. The ultrastructural changes of hepatocytes were observed under scanning electronmicroscopy (SEM) and transmission electronmicroscope (TEM). Transaminase and SOD were also assayed at the end of culture.RESULT The levels of ALT and AST were significantly decreased and the SOD level elevated in two pretreated groups as compared with that in the control group. The cellular integrity and ultrastructure of hepatocytes were well preserved in the two drugs pretreated groups while they were seriously damaged in the control group.CONCLUSION The experimental model system with human fetal hepatocytes pretreated with CCl4 could act as an effective method for studying the protective effect of drugs on human hepatocytes, and could be used for screening the medicines for treatment of hepatitis.

关键词： fetal hepatocytes experimental model silybin polyporus umbellalus polysaccharides

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Beneficial effects of a decreased meal frequency on nutrient utilization,secretion of luteinizing hormones and ovarian follicular development in gilts

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Journal of Animal Science and Biotechnology 2021年第3期12卷 1098-1111页

作者： lun Hua Lianpeng Zhao Zhengyu mao Wentao Li Jing Li Xuemei Jiang Lianqiang Che Shengyu Xu Yan Lin Zhengfeng Fang Bin Feng De Wu Yong Zhuo Animal Nutrition Institute Sichuan Agricultural UniversityChengdu 611130People’s Republic of China Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China Sichuan Agricultural UniversityChengdu 611130People’s Republic of China Key Laboratory of Animal Disease-Resistant Nutrition of Sichuan Province Sichuan Agricultural University211 Huimin RoadWenjiang DistrictChengdu 611130People’s Republic of China

Background:Replacement gilts are typically fed ad libitum,whereas emerging evidence from human and rodent studies has revealed that time-restricted access to food has health *** objective of this study was to investigate the effect of meal frequency on the metabolic status and ovarian follicular development in ***:A total of 36 gilts(Landrace×Yorkshire)with an age of 150±3 d and a body weight of 77.6±3.8 kg were randomly allocated into one of three groups(n=12 in each group),and based on the group allocation,the gilts were fed at a frequency of one meal(T1),two meals(T2),or six meals per day(T6)for 14 consecutive *** effects of the meal frequency on growth preference,nutrient utilization,short-chain fatty acid production by gut microbial,the post-meal dynamics in the metabolic status,reproductive hormone secretions,and ovarian follicular development in the gilts were ***:The gilts in the T1 group presented a higher average daily gain(+48 g/d,P<0.05)and a higher body weight(+4.9 kg,P<0.05)than those in the T6 *** meal frequency had no effect on the apparent digestibility of dry matter,crude protein,ether extract,ash,and gross energy,with the exception that the T1 gilts exhibited a greater NDF digestibility than the T6 gilts(P<0.05).The nitrogen balance analysis revealed that the T1 gilts presented decreased urine excretion of nitrogen(−8.17 g/d,P<0.05)and higher nitrogen retention(+9.81 g/d,P<0.05),and thus exhibited higher nitrogen utilization than the T6 *** time-course dynamics of glucose,α-amino nitrogen,urea,lactate,and insulin levels in serum revealed that the T1 group exhibited higher utilization of nutrients after a meal than the T2 or T6 *** T1 gilts also had a higher acetate content and SCFAs in feces than the T6 gilts(P<0.05).The age,body weight and backfat thickness of the gilts at first estrous expression were not affected by the meal frequency,but the gilts in the T1 group had higher levels of seru

关键词： Gilts Luteinizing hormone Meal frequency Nutrient utilization Ovarian follicular development

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大云室组动量选择器

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高能物理与核物理 1979年第2期 210-215页

作者：赵经伦毛素银马纪虎韩中来顾逸东代义方董玉琚中国科学院沈阳自动化研究所中国科学院高能物理研究所

采用“预选—寄存—运算再选”的方案,设计并完成了云南站大云室组的宇宙线事例选择系统.其中动量选择器应用了数字在线计算技术.设计了小型专用计算单元,根据荷电粒子在磁场中的偏转角与动量的对应关系,对寄存下来的描迹信号进行快速... 详细信息

采用“预选—寄存—运算再选”的方案,设计并完成了云南站大云室组的宇宙线事例选择系统.其中动量选择器应用了数字在线计算技术.设计了小型专用计算单元,根据荷电粒子在磁场中的偏转角与动量的对应关系,对寄存下来的描迹信号进行快速运算和逻辑判断,从而实现单个荷电粒子的动量选择.

关键词：宇宙线云南计数管荷电粒子云室选择器

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Cerebral infarction after drug-eluting bead bronchial arterial chemoembolization due to the mechanical force-mediated opening of an errant passage

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Chinese Medical Journal 2021年第8期134卷 989-990页

作者： Wei Luo mao-Gang Wei Hai-Long Wei Ya-lun Li Departm ent of Respiratory and Critical Care Medicine The People's Hospital of LeshanLeshanSichuan 614000China Department of Respiratory and Critical Care Medicine West China Hospital of Sichuan UniversityChengduSichuan 610041China.

To the Editor:Drug-eluting bead bronchial arterial chemoembolization(DEB-BACE)has been proven to be a feasible and well-tolerated treatment option for patients with non-small cell lung cancer(NSCLC)who are ineligible for or refuse to receive standard chemotherapy.[1]Here,we report a rare complication of multiple cerebral embolic infarcts,mainly in the posterior cerebral circulation,in a patient with squamous cell lung cancer who was performed with *** our knowledge,this complication has rarely been reported in patients with NSCLC undergoing *** was obtained from our Institutional Review Board and patient for the publication of this case report.

关键词： arterial cerebral NSCLC chemotherapy

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