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国家组织药品集中带量采购政策对某院门诊药房降压药物使用的影响分析

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中国药业 2024年第5期33卷 14-18页

作者：王茂郑明琳何璐璐王世燕高洋洋樊萍四川大学华西医院四川成都610041

目的探讨国家组织药品集中带量采购(简称国家集采)政策对某院门诊患者降压药物使用情况的影响。方法以医院门诊药房国家集采政策实施前(2018年1月至12月)及实施后(2020年1月至12月)23种降压药物为目标药品,共涉及10种中选品种;利用医院... 详细信息

目的探讨国家组织药品集中带量采购(简称国家集采)政策对某院门诊患者降压药物使用情况的影响。方法以医院门诊药房国家集采政策实施前(2018年1月至12月)及实施后(2020年1月至12月)23种降压药物为目标药品,共涉及10种中选品种;利用医院信息系统收集目标药品的价格、销售数量和金额,比较用药频度(DDDs)、限定日费用(DDC)。结果国家集采政策实施后,其中11种降压药物的价格降幅为5.86%~89.70%,23种降压药物的销售金额累计减少2705.60万元。DDDs排名前3的目标药品未发生变化,为苯磺酸氨氯地平片(商品名洛活喜)、富马酸比索洛尔片(商品名康忻)、坎地沙坦酯片(商品名维尔亚);10种中选品种的DDDs排名均居前列。DDC排名前4的目标药品未发生变化,为厄贝沙坦氢氯噻嗪片(商品名安博诺)、厄贝沙坦片(商品名安博维)、缬沙坦胶囊(商品名代文)、氯沙坦钾片;10种中选品种的DDC相对较低,且非中选品种的DDC均降低。结论国家集采政策的实施促使药品价格趋于合理,减轻了患者用药的经济负担,优化了医保资金的使用,提高了医疗保障水平。

关键词：国家组织药品集中带量采购门诊药房降压药物用药频度限定日费用

Kinematic-mapping-model-guided analysis and optimization of 2-PSS&1-RR circular-rail parallel mechanism for fully steerable phased array antennas

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Defence Technology 2024年第8期38卷 136-154页

作者： Guodong Tan Xiangfei Meng Xuechao Duan lulu Cheng Dingchao Niu Shuai he Dan Zhang Laboratory of Electromechanical Coupling in Electronic Equipment Xidian University Department of Mechanical Engineering The Hong Kong Polytechnic University

This paper presents a systematic methodology for analyzing and optimizing an innovative antenna mount designed for phased array antennas, implemented through a novel 2-PSS&1-RR circular-rail parallel mechanism. Initially, a comparative motion analysis between the 3D model of the mount and its full-scale prototype is conducted to validate effectiveness. Given the inherent complexity, a kinematic mapping model is established between the mount and the crank-slider linkage, providing a guiding framework for subsequent analysis and optimization. Guided by this model, feasible inverse and forward solutions are derived, enabling precise identification of stiffness singularities. The concept of singularity distance is thus introduced to reflect the structural stiffness of the mount. Subsequently, also guided by the mapping model, a heuristic algorithm incorporating two backtracking procedures is developed to reduce the mount's mass. Additionally, a parametric finite-element model is employed to explore the relation between singularity distance and structural stiffness. The results indicate a significant reduction(about 16%) in the antenna mount's mass through the developed algorithm, while highlighting the singularity distance as an effective stiffness indicator for this type of antenna mount.

关键词： Backtracking Circular rail Crank-slider linkage Innovative antenna mount Kinematic mapping model Stiffness singularity

LPS-induced mitochondrial DNA synthesis and release facilitate RAD50-dependent acute lung injury

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1104-1106页

作者： Xueqin Zhan Rui Cui Xinwei Geng Jiaqian Li Yunlian Zhou lulu he Chao Cao Chao Zhang Zhimin Chen Songmin Ying Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children's Regional Medical CenterHangzhouZhejiangChina International Institutes of Medicine the Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwuChina Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital Zhejiang University School of MedicineKey Laboratory of Respiratory Disease of Zhejiang ProvinceHangzhouZhejiangChina

Dear Editor,ATP-binding cassette(ABC)-ATPase(RAD50),together with meiotic recombination 11 homolog 1(MRE11)subunits,to form MRE11-RAD50 complex,plays important roles in recognition of double-stranded DNA(dsDNA)and initiation of consequent inflammatory *** lung injury(ALI)and acute respiratory destress syndrome(ARDS)are systemic uncontrolled inflammation and ***,the function of the DNA sensor in ALI/ARDS remains poorly *** we investigated functions of RAD50 using mouse primary macrophages and conditionally RAD50 knockout mice in vitro and in a lipopolysaccharide(LPS)-induced lung injury model.

关键词： RAD50 acute lung

Catalyst design and structure control for photocatalytic refineries of cellulosic biomass to fuels and chemicals

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Journal of Energy Chemistry 2024年第7期94卷 102-127页

作者： lulu Sun Nengchao Luo State Key Laboratory of Catalysis Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Lignocellulosic biomass is the largest renewable hydrocarbon resource on *** cellulose,one of the major components of lignocellulose,powered by solar energy is a promising way of providing lowcarbon-footprint energy chemicals such as H_(2),HCOOH,CO,and transportation ***-of-the-art biorefineries target the full use of biomass feedstocks as they have a maximum collection radius of 75-100 km,requesting efficient and selective photocatalysts that significantly influence the outcome of photocatalytic ***-performed photocatalysts can harvest a broad solar spectrum and are active in breaking the chemical bonds of cellulose,decreasing the capital investments of ***,photocatalysts should control the selectivity of cellulose conversion,originating target products to level down separation *** separation in photocatalysts and interfacial charge transfer between photocatalysts and cellulose affect the activity and selectivity of cellulose refineries to H2 and carbonaceous *** account for the challenges above,this review summarizes photocatalysts for the refineries of cellulose and downstream platform molecules based on the types of products,with the structure features of different types of photocatalysts discussed in relation to the targets of either improving the activity or product *** addition,this review also sheds light on the methods for designing and regulating photocatalyst structures to facilitate photocatalytic refineries of cellulose and platform molecules,meanwhile summarizing proposed future research challenges and opportunities for designing efficient photocatalysts.

关键词： Photocatalysts Biorefineries Cellulose Fuels Hydrogen

Equivalent linear model for seismic damage evaluation of single-degree-of-freedom systems representing reinforced concrete structures considering cyclic degradation behavior

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 637-648页

作者： lulu Yan Ding-Hao Yu Research Center for Geotechnical and Structural Engineering Technology of Liaoning Province Dalian UniversityDalian116622China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

In this study,a novel equivalent damping ratio model that is suitable for reinforced concrete(RC)structures considering cyclic degradation behavior is developed,and a new equivalent linearization analysis method for implementing the proposed equivalent damping ratio model for use in seismic damage evaluation is *** this end,Ibarra’s peak-oriented model,which incorporates an energy-based degradation rule,is selected for representing hysteretic behavior of RC structure,and the optimized equivalent damping for predicting the maximum displacement response is presented by using the empirical method,in which the effect of cyclic degradation is ***,the relationship between the hysteretic energy dissipation of the inelastic system and the elastic strain energy of the equivalent linear system is established so that the proposed equivalent linear system can be directly integrated with the Park-Ang seismic model to implement seismic damage *** to the simplicity of the equivalent linearization method,the proposed method provides an efficient and reliable way of obtaining comprehensive insight into the seismic performance of RC *** verification demonstrates the validity of the proposed method.

关键词： degrading system equivalent linear system equivalent damping seismic damage RC structures

某三级甲等综合医院门诊药房中成药药品说明书信息标注情况分析

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中国药业 2024年第10期33卷 16-20页

作者：杜雅丽胡晨吉何璐璐郭毅高洋洋王世燕樊萍四川大学华西医院临床药学部四川成都610041

目的完善医院门诊药房中成药药品说明书的信息标注,促进临床合理用药。方法通过医院信息系统收集某三级甲等(简称三甲)综合医院门诊药房83种中成药的药品说明书,参照相关法规、指南等分析各项目信息标注情况。结果83份药品说明书中,非... 详细信息

目的完善医院门诊药房中成药药品说明书的信息标注,促进临床合理用药。方法通过医院信息系统收集某三级甲等(简称三甲)综合医院门诊药房83种中成药的药品说明书,参照相关法规、指南等分析各项目信息标注情况。结果83份药品说明书中,非处方药中除11份未标注警示语外,其余各项目均标注完整;处方药药品说明书【药品名称】【成分】【性状】【功能主治】【规格】等17项内容均标注完整,【药代动力学】【老年患者用药】【儿童用药】【孕妇及哺乳期妇女用药】【药物相互作用】等7项有缺项。结论该院门诊药房使用的中成药药品说明书信息标注存在缺项严重、表述模糊、界定不清的情况,建议相关部门加强对中成药药品说明书的管理,督促药品上市许可持有人进行修改和完善,以保障临床用药安全。

关键词：三级甲等综合医院门诊药房中成药药品说明书信息标注用药安全合理用药

Protecting Important Agricultural heritage Systems(IAHS)by Industrial Integration Development(IID):Practices from China

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Journal of Resources and Ecology 2021年第4期12卷 555-566页

作者： ZHANG Yongxun he lulu Institute of Agricultural Economics and Development Chinese Academy of Agricultural SciencesBeijing 100081China College of Humanities and Development China Agricultural UniversityBeijing 100094China

With Globally Important Agricultural heritage Systems(GIAHS)increasing in number around the world,their conservation has become a new international research *** the perspective of combining theoretical analyses and practical case applications,this study examines the Important Agricultural heritage Systems(IAHS)conservation pathways and operation mechanisms through industrial integration development(IID).First,the theoretical framework of IID in IAHS sites was constructed according to the requirements of IAHS conservation,which include analyses of the connotation and basic principles of IID,the necessity of IID for IAHS sites,the resource conditions,and the IID *** then based on the theoretical framework,the IID of Longji Terraces in Guangxi,Honghe Hani Rice Terraces System in Yunnan(HHRTS),Aohan Dryland Farming System in Inner Mongolia(ADFS),and Huzhou Mulberry-dyke&Fish-pond System(HMFS)in Zhejiang are analyzed *** main finding is that IID is an effective pathway for IAHS ***,the IID in IAHS sites must stress the ecological and cultural values of the resources;IID should be based on local resource advantages;and IID should attach importance to the combination of different policies and coordination between different stakeholders.

关键词： Important Agricultural heritage Systems(IAHS) integrated development of industries(IID) heritage conservation Multi-function values China

Ground Passive Microwave Remote Sensing of Atmospheric Profiles Using WRF Simulations and Machine Learning Techniques

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Journal of Meteorological Research 2024年第4期38卷 680-692页

作者： lulu ZHANG Meijing LIU Wenying he Xiangao XIA Haonan YU Shuangxu LI Jing LI Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871 Key Laboratory of Middle Atmosphere and Global Environment Observation(LAGEO) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029 University of Chinese Academy of Sciences Beijing 101408

Microwave radiometer(MWR) demonstrates exceptional efficacy in monitoring the atmospheric temperature and humidity profiles.A typical inversion algorithm for MWR involves the use of radiosonde measurements as the training ***,this is challenging due to limitations in the temporal and spatial resolution of available sounding data,which often results in a lack of coincident data with MWR deployment *** study proposes an alternative approach to overcome these limitations by harnessing the Weather Research and Forecasting(WRF) model's renowned simulation capabilities,which offer high temporal and spatial *** using WRF simulations that collocate with the MWR deployment location as a substitute for radiosonde measurements or reanalysis data,our study effectively mitigates the limitations associated with mismatching of MWR measurements and the sites,which enables reliable MWR retrieval in diverse geographical *** machine learning(ML) algorithms including extreme gradient boosting(XGBoost),random forest(RF),light gradient boosting machine(LightGBM),extra trees(ET),and backpropagation neural network(BPNN) are tested by using WRF simulations,among which BPNN appears as the most superior,achieving an accuracy with a root-mean-square error(RMSE) of 2.05 K for temperature,0.67 g m~(-3) for water vapor density(WVD),and 13.98% for relative humidity(RH).Comparisons of temperature,RH,and WVD retrievals between our algorithm and the sounding-trained(RAD) algorithm indicate that our algorithm remarkably outperforms the *** study verifies the feasibility of utilizing WRF simulations for developing MWR inversion algorithms,thus opening up new possibilities for MWR deployment and airborne observations in global locations.

关键词： microwave radiometer(MWR) Weather Research and Forecasting(WRF)model extreme gradient boosting(XGBoost) random forest(RF) light gradient boosting machine(LightGBM) extra trees(ET) backpropagation neural network(BPNN) monochromatic radiative transfer model(MonoRTM)

Value Iteration-Based Cooperative Adaptive Optimal Control for Multi-Player Differential Games With Incomplete Information

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 690-697页

作者： Yun Zhang lulu Zhang Yunze Cai the Department of Automation Shanghai Jiao Tong UniversityShanghai 200240 the Key Laboratory of System Control and Information Processing Ministry of Education of ChinaShanghai 200240China

This paper presents a novel cooperative value iteration(VI)-based adaptive dynamic programming method for multi-player differential game models with a convergence *** players are divided into two groups in the learning process and adapt their policies *** method removes the dependence of admissible initial policies,which is one of the main drawbacks of the PI-based ***,this algorithm enables the players to adapt their control policies without full knowledge of others’ system parameters or control *** efficacy of our method is illustrated by three examples.

关键词： Adaptive dynamic programming incomplete information multi-player differential game value iteration