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Assessing the corrosion protection property of coatings loaded with corrosion inhibitors using the real-time atmospheric corrosion monitoring technique

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 119-126页

作者： Xiaoxue Wang lulu jin jinke Wang Rongqiao Wang Xiuchun Liu Kai Gao jingli Sun Yong Yuan Lingwei Ma Hongchang Qian Dawei Zhang School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Institute of Space Long March Vehicle Beijing 100076China National Materials Corrosion and Protection Data Center University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal ***,limited studies have applied ACM to the corrosion protection properties of organic *** study compared a bare epoxy coating with one containing zinc phosphate corrosion inhibitors,both applied on ACM sensors,to observe their corrosion protection properties over *** with artificial damage via scratches were exposed to immersion and alternating dry and wet environments,which allowed for monitoring galvanic corrosion currents in *** the corrosion tests,the ACM currents of the zinc phosphate/epoxy coating were considerably lower than those of the blank epoxy *** trend in ACM current variations closely matched the results obtained from regular electrochemical tests and surface *** alignment highlights the potential of the ACM technique in evaluating the corrosion protection capabilities of organic *** with the blank epoxy coating,the zinc phosphate/epoxy coating showed much-decreased ACM current values that confirmed the effective inhibition of zinc phosphate against steel corrosion beneath the damaged coating.

关键词： atmospheric corrosion monitoring technology corrosion inhibitor coating carbon steel corrosion protection

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ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation

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Bioactive Materials 2023年第1期19卷 38-49页

作者： lulu jin Zhixin Zhu Liangjie Hong Zhefeng Qian Fang Wang Zhengwei Mao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China b The MOE Frontier Science Center for Brain Research and Brain-Machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou310058China

Ischemic stroke is an acute and serious cerebral vascular disease,which greatly affects people’s health and brings huge economic burden to ***,as important innate immune components in central nervous system(CNS),are double-edged swords in the battle of nerve injury,considering their polarization between pro-inflammatory M1 or anti-inflammatory M2 *** mobility group box 1(HMGB1)is one of the potent pro-inflammatory mediators that promotes the M1 polarization of microglia.18β-glycyrrhetinic acid(GA)is an effective intracellular inhibitor of HMGB1,but of poor water solubility and dose-dependent *** overcome the shortcomings of GA delivery and to improve the efficacy of cerebral ischemia therapy,herein,we designed reactive oxygen species(ROS)responsive polymer-drug conjugate nanoparticles(DGA)to manipulate microglia polarization by suppressing the translocation of nuclear *** presented excellent therapeutic efficacy in stroke mice,as evidenced by the reduction of infarct volume,recovery of motor function,suppressed of M1 microglia activation and enhanced M2 activation,and induction of ***,our work demonstrates a close association between HMGB1 and microglia polarization,suggesting potential strategies for coping with inflammatory microglia-related diseases.

关键词： HMGB1 Microglia M1/M2 phenotype Polymer-drug conjugates Drug delivery Ischemic stroke

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Study on the adsorption kinetics of orthophosphate anions on layer double hydroxide

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Chinese Journal Of Geochemistry 2009年第2期28卷 184-187页

作者： PENG Shuchuan lulu WANG jin HAN Lu CHEN Tianhu JIANG Shaotong School of Resources and Environment Hefei University of Technology Hefei 230009 China

A kinetic study was conducted on the adsorption of orthophosphate anions on layer double hydroxide (LDH). The adsorption has proved itself to be a spontaneous endothermic process and is large in capacity and rate. The adsorption isotherm correlates well with the Freundlich model, and a rise in temperature will lead to an increase in adsorption efficiency. Additionally, the results suggested that the adsorption is an entropy-increasing process and is in good agreement with the pseudo-second order kinetics. The free energy (ΔG) of adsorption of orthophosphate onto LDH varies within the range of -1.75--3.34 kJ/mol, the enthalpy (ΔH) varies by 7.96 kJ/mol and the entropy (ΔS) by 33.59 kJ/mol. The adsorption activation energy is 8.3 kJ/mol, showing that the adsorption of orthophosphate onto LDH is determined to be a physical adsorption.

关键词：吸附动力学金属氢氧化物正磷酸盐 Freundlich模型子层吸附等温线吸热过程吸附效率

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C176-loaded and phosphatidylserine-modified nanoparticles treat retinal neovascularization by promoting M2 macrophage polarization

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Bioactive Materials 2024年第9期39卷 392-405页

作者： An Shao lulu jin Yanni Ge Ziqiang Ye Mingyu Xu Yifan Zhou Yingyu Li Linyan Wang Pinglong Xu Kai jin Zhengwei Mao Juan Ye Eye Center The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310009China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China MOE Key Laboratory of Biosystems Homeostasis&Protection and Zhejiang Provincial Key Laboratory of Cancer Molecular Cell Biology Life Sciences InstituteZhejiang UniversityHangzhou310030China

Retinal neovascularization(RNV),a typical pathological manifestation involved in most neovascular diseases,causes retinal detachment,vision loss,and ultimately irreversible *** intravitreal injections of anti-VEGF drugs were developed against RNV,with limitations of incomplete responses and adverse ***,a new treatment with a better curative effect and more prolonged dosage is ***,we induced macrophage polarization to anti-inflammatory M2 phenotype by inhibiting cGAS-STING signaling with an antagonist C176,appreciating the role of cGAS-STING signaling in the retina in pro-inflammatory M1 polarization.C176-loaded and phosphatidylserine-modified dendritic mesoporous silica nanoparticles were constructed and examined by a single intravitreal *** biosafe nanoparticles were phagocytosed by retinal macrophages through a phosphatidylserine-mediated“eat me”signal,which persistently release C176 to suppress STING signaling and thereby promote macrophage M2 polarization specifically.A single dosage can effectively alleviate pathological angiogenesis phenotypes in murine oxygen-induced retinopathy *** conclusion,these C176-loaded nanoparticles with enhanced cell uptake and long-lasting STING inhibition effects might serve as a promising way for treating RNV.

关键词： Retinal neovascularization Macrophage polarization cGAS-STING pathway Nanocarrier

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Adaptable hydrogel with reversible linkages for regenerative medicine:Dynamic mechanical microenvironment for cells

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Bioactive Materials 2021年第5期6卷 1375-1387页

作者： Zongrui Tong lulu jin Joaquim Miguel Oliveira Rui LReis Qi Zhong Zhengwei Mao Changyou Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China 3B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkZona Industrial da Gandra4805-017Barco GMRPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal The Discoveries Centre for Regenerative and Precision Medicine Headquarters at University of MinhoAvepark4805-017BarcoGuimarãesPortugal Key Laboratory of Advanced Textile Materials&Manufacturing Technology Ministry of EducationNational Base for International Science and Technology Cooperation in Textiles and Consumer-Goods ChemistryZhejiang Sci-Tech University310018HangzhouChina

Hydrogels are three-dimensional platforms that serve as substitutes for native extracellular *** materials are starting to play important roles in regenerative medicine because of their similarities to native matrix in water content and *** would be very advantagoues for researchers to be able to regulate cell behavior and fate with specific hydrogels that have tunable mechanical properties as biophysical *** developments in dynamic chemistry have yielded designs of adaptable hydrogels that mimic dynamic nature of extracellular *** current review provides a comprehensive overview for adaptable hydrogel in regenerative medicine as ***,we outline strategies to design adaptable hydrogel network with reversible linkages according to previous findings in supramolecular chemistry and dynamic covalent ***,we describe the mechanism of dynamic mechanical microenvironment influence cell behaviors and fate,including how stress relaxation influences on cell behavior and how mechanosignals regulate matrix ***,we highlight techniques such as bioprinting which utilize adaptable hydrogel in regenerative *** conclude by discussing the limitations and challenges for adaptable hydrogel,and we present perspectives for future studies.

关键词： Adaptable hydrogel Dynamic mechanical microenvironment Supramolecular chemistry Dynamic covalent chemistry Yes-associated protein

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C-176 loaded Ce DNase nanoparticles synergistically inhibit the cGAS-STING pathway for ischemic stroke treatment

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Bioactive Materials 2023年第11期29卷 230-240页

作者： Zhixin Zhu Haipeng Lu lulu jin Yong Gao Zhefeng Qian Pan Lu Weijun Tong Pik Kwan Lo Zhengwei Mao Haifei Shi Department of Orthopedics 1st Affiliated Hospital of Zhejiang University School of MedicineQingchun Road 79Hangzhou31000China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Department of Chemistry and State Key Laboratory of Marine Pollution City University of Hong KongTat Chee AvenueKowloonHong Kong

The neuroinflammatory responses following ischemic stroke cause irreversible nerve cell *** free-double strand DNA(dsDNA)segments from ischemic tissue debris are engulfed by microglia and sensed by their cyclic GMP-AMP synthase(cGAS),which triggers robust activation of the innate immune stimulator of interferon genes(STING)pathway and initiate the chronic inflammatory *** decomposition of immunogenic dsDNA and inhibition of the innate immune STING are synergistic immunologic targets for ameliorating *** combine the anti-inflammatory strategies of STING inhibition and dsDNA elimination,we constructed a DNase-mimetic artificial enzyme loaded with *** are self-assembled by amphiphilic copolymers(P[CL35-b-(OEGMA20.7-co-NTAMA14.3)]),C-176,and Ce^(4+)which is coordinated with nitrilotriacetic acid(NTA)group to form corresponding catalytic *** work developed a new nano-drug that balances the cGAS-STING axis to enhance the therapeutic impact of stroke by combining the DNase-memetic Ce^(4+)enzyme and STING inhibitor *** conclusion,it is a novel approach to modulating central nervus system(CNS)inflammatory signaling pathways and improving stroke prognosis.

关键词： Ischemic stroke Ce-based nano-nuclease The cGAS-STING signaling pathway Anti-inflammation

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Synergistically targeting synovium STING pathway for rheumatoid arthritis treatment

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Bioactive Materials 2023年第6期24卷 37-53页

作者： Haotian Shen lulu jin Qiangqiang Zheng Ziqiang Ye Linxiang Cheng Yuxu Wu Honghao Wu Tae Gyong Jon Wenduo Liu Zongyou Pan Zhengwei Mao Yue Wang Department of Orthopedic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou310003China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine Zhejiang University School of MedicineHangzhou310000China International Institutes of Medicine The Fourth Affiliated HospitalZhejiang University School of MedicineN1 Shangchen RoadYiwuZhejiang322000China

Rheumatoid arthritis(RA)is a common autoimmune disease leading to pain,disability,and even *** studies have revealed that aberrant activation of STING was implicated in various autoimmune diseases,the role of STING in RA remains *** the current study,we demonstrated that STING activation was pivotal in RA *** the accumulation of dsDNA,a specific stimulus for STING,is a feature of RA,we developed a spherical polyethyleneimine-coated mesoporous polydopamine nanoparticles loaded with STING antagonist C-176(PEI-PDA@C-176 NPs)for treating *** fabricated NPs with biocompatibility had high DNA adsorption ability and could effectively inhibit the STING pathway and inflammation in ***-articular administration of PEI-PDA@C-176 NPs could effectively reduce joint damage in mice models of dsDNA-induced arthritis and collagen-induced arthritis by inhibiting STING *** concluded that materials with synergistic effects of STING inhibition might be an efficacious strategy to treat RA.

关键词： Mesoporous nanoparticles STING Inflammation Drug delivery Rheumatoid arthritis

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基于预处理的IFOA-ELM煤与瓦斯突出预测模型

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中国安全科学学报 2020年第1期30卷 35-41页

作者：温廷新靳露露辽宁工程技术大学系统工程研究所辽宁葫芦岛125105

为快速准确地预测煤与瓦斯突出危险性,提出一种基于预处理的改进果蝇优化算法(IFOA)-极限学习机(ELM)的预测模型。首先预处理平顶山八矿的部分实测数据,采用灰色关联分析(GRA)法与熵权法(EWM)结合的灰色关联熵分析(GREA)法剔除影响程度... 详细信息

为快速准确地预测煤与瓦斯突出危险性,提出一种基于预处理的改进果蝇优化算法(IFOA)-极限学习机(ELM)的预测模型。首先预处理平顶山八矿的部分实测数据,采用灰色关联分析(GRA)法与熵权法(EWM)结合的灰色关联熵分析(GREA)法剔除影响程度较小的因素,应用主成分分析法(PCA)进一步约简因素;构建煤与瓦斯突出危险性预测模型,基于果蝇优化算法(FOA),引入自适应步长更新策略及群体适应度方差策略设计IFOA;利用IFOA优选ELM输入层权值及隐含层阈值,对预处理样本数据进行训练、预测并对比其他模型预测效果。结果表明:基于预处理的IFOA-ELM模型预测结果与实际结果完全拟合,预测效果显著优于未预处理的模型;基于预处理的IFOA-ELM模型的分类准确率和召回率均为100%,显著高于其他对比模型。

关键词：煤与瓦斯突出预测灰色关联熵分析(GREA) 主成分分析(PCA) 极限学习机(ELM) 改进的果蝇优化算法(IFOA)

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论班彪与两汉之际文学新变

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江苏大学学报（社会科学版） 2019年第6期21卷 85-92页

作者：金璐璐商丘师范学院人文学院

受两汉之际社会变迁和政治文化转型的影响,班彪创作较西汉文学发生了新变。在内容上,变超越现实的夸张想象、一味对统治者歌功颂瑞为对国家前途命运的积极思索和对大一统的维护;文学书写的笔触从上层社会拓展到社会生活的广阔领域;变独... 详细信息

受两汉之际社会变迁和政治文化转型的影响,班彪创作较西汉文学发生了新变。在内容上,变超越现实的夸张想象、一味对统治者歌功颂瑞为对国家前途命运的积极思索和对大一统的维护;文学书写的笔触从上层社会拓展到社会生活的广阔领域;变独尊儒术为兼综儒道。在艺术上,骚散结合的文章体式、多样化的文学表现手法、典雅庄重的语言以及对六言诗的有益尝试,开启了东汉文学的新变,并对后世文学产生了深远影响。

关键词：两汉之际社会变迁班彪文学创作新变

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大庆原油降凝降黏剂合成及性能评价

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精细石油化工 2020年第5期37卷 31-34页

作者：靳璐璐龙小柱沈阳化工大学化学工程学院辽宁沈阳110000

以甲基丙烯酸(MA)、十四醇、二十二醇、苯乙烯(ST)、富马酸(FA)为原料制备了具有降凝降黏作用的三元共聚物。最佳酯化工艺条件为:甲基丙烯酸与混合醇[n(C14醇)∶n(C22醇)=3∶1]摩尔比为1∶1.4,携水剂用量为40%,催化剂质量分数为0.5%;最... 详细信息

以甲基丙烯酸(MA)、十四醇、二十二醇、苯乙烯(ST)、富马酸(FA)为原料制备了具有降凝降黏作用的三元共聚物。最佳酯化工艺条件为:甲基丙烯酸与混合醇[n(C14醇)∶n(C22醇)=3∶1]摩尔比为1∶1.4,携水剂用量为40%,催化剂质量分数为0.5%;最佳聚合工艺条件为:甲基丙烯酸混合醇酯/苯乙烯/富马酸(摩尔比)为6∶2∶2,引发剂的量为0.8%,聚合反应温度为80℃,聚合反应时间为3.5 h。加剂量为0.4%时,大庆原油凝固点可降低14℃,降黏率可达66.02%。

关键词：降凝降黏三元共聚物大庆原油降黏率

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