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化学与生物工程 1986年第3期 46-48+38页

作者：王纪珂 ,luke r.ocone

农药的使用剂型必须具有生物活性,使用方便和安全的性能。可是,大田使用经验表明,早期的农药剂型并不总是象人们所期望的那样安全可靠。再说,工业和民众所愿意接受的风险在不断地下降,而对于安全方面的要求逐渐提高。

关键词：微胶囊剂经皮毒性微囊剂毒力农药剂型甲基1605 甲基对硫磷微胶囊化活性组分

High-yield and rapid isolation of extracellular vesicles by flocculation via orbital acoustic trapping:FLOAT

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Microsystems & Nanoengineering 2024年第1期10卷 313-323页

作者： Joseph rufo Peiran Zhang Zeyu Wang Yuyang Gu Kaichun Yang Joseph rich Chuyi Chen ruoyu Zhong Ke Jin Ye He Jianping Xia Ke Li Jiarong Wu Yingshi Ouyang Yoel Sadovsky luke P.Lee Tony Jun Huang Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNCUSA Department of Biomedical Engineering Duke UniversityDurhamNCUSA Department of Obstetrics Gynecologyand Reproductive SciencesMagee-Womens Research InstituteUniversity of PittsburghPittsburghPAUSA Department of Microbiology and Molecular Genetics School of MedicineUniversity of PittsburghPittsburghPAUSA renal Division and Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Department of Bioengineering Department of Electrical Engineering and Computer ScienceUniversity of CaliforniaBerkeleyBerkeleyCAUSA Department of Biophysics Institute of Quantum BiophysicsSungkyunkwan UniversitySuwonKorea

Extracellular vesicles(EVs)have been identified as promising biomarkers for the noninvasive diagnosis of various ***,challenges in separating EVs from soluble proteins have resulted in variable EV recovery rates and low ***,we report a high-yield(>90%)and rapid(rbital Acoustic Trapping(FLOAT).The FLOAT approach utilizes an acoustofluidic droplet centrifuge to rotate and controllably heat liquid *** adding a thermoresponsive polymer flocculant,nanoparticles as small as 20 nm can be rapidly and selectively concentrated at the center of the *** demonstrate the ability of FLOAT to separate urinary EVs from the highly abundant Tamm-Horsfall protein,addressing a significant obstacle in the development of EV-based liquid *** to its high-yield nature,FLOAT reduces biofluid starting volume requirements by a factor of 100(from 20 mL to 200µL),demonstrating its promising potential in point-of-care diagnostics.

关键词： trapping utilize separating

On the Existence of robot Zombies and our Ethical Obligations to AI Systems

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Journal of Social Computing 2023年第4期4卷 270-274页

作者： luke r.Hansen the Computer Science Department Stanford UniversityStanfordCA 94305USA

As artificial intelligence algorithms improve,we will interact with programs that seem increasingly *** may never know if these algorithms are sentient,yet this quality is crucial to ethical considerations regarding their moral *** will likely have to make important decisions without a full understanding of the relevant issues and *** this ignorance,we ought to take seriously the prospect that some systems are *** would be a moral catastrophe if we were to treat them as if they were not sentient,but,in reality they are.

关键词： artificial intelligence sentience ethics

Heme oxygenase system in hepatic ischemia-reperfusion injury

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World Journal of Gastroenterology 2010年第48期16卷 6068-6078页

作者： James A richards Stephen J Wigmore luke r Devey Centre for Inflammation research The University of EdinburghThe Queen's Medical Research Institute

Hepatic ischemia-reperfusion injury (IrI) limits access to transplantation. Heme oxygenase-1 (HO-1) is a powerful antioxidant enzyme which degrades free heme into biliverdin,free iron and carbon monoxide. HO-1 and its metabolites have the ability to modulate a wide variety of inflammatory disorders including hepatic IrI. Mechanisms of this protective effect include reduction of oxygen free radicals,alteration of macrophage and T cell phenotype. Further work is required to understand the physiological importance of the many actions of HO-1 identified experimentally,and to harness the protective effect of HO-1 for therapeutic potential.

关键词： Ischemia-reperfusion injury Heme oxygenase Transplantation Ischemic pre-conditioning

Apologos:A Lightweight Design Method for Sociotechnical Inquiry

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Journal of Social Computing 2021年第4期2卷 297-308页

作者： luke Stark the Faculty of Information and Media Studies Western UniversityLondonN6A 0A2Canada

While scholars involved in studying the ethics and politics flowing from digital information and communication systems have sought to impact the design and deployment of digital technologies,the fast pace and iterative tempo of technical development in these contexts,and the lack of structured engagement with sociotechnical questions,have been major barriers to ensuring values are considered explicitly in the r&D *** I introduce Apologos,a lightweight design methodology informed by the author’s experience of the challenges and opportunities of interdisciplinary collaboration between computational and social sciences over a five-year ***,which is inspired by“design apologetics”,is intended as an initial mechanism to introduce technologists to the process of considering how human values impact the digital design process.

关键词： values in design values sensitive design(VSD) artificial intelligence Values@Play design methods sociotechnical ethics values

revealing a Transformation-Induced Plasticity(TrIP)Phenomenon in a Medium-Entropy Alloy

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Acta Metallurgica Sinica(English Letters) 2020年第8期33卷 1159-1165页

作者： Ibrahim Ondicho Bernard Alunda Dicken Owino luke Otieno Melody Chepkoech Department of Mechanical Engineering Dedan Kimathi University of TechnologyPrivate Bag-10143NyeriKenya Materials Design and Manufacturing(MADEMA)GroupDedan Kimathi University of TechnologyPrivate Bag-10143Dedan KimathiNyeriKenya Department of Advanced root Industry Engineering Yuengnam UniversityGyeongsanSouth Korea Department of Mining and Minerals Processing Engineering Taita Taveta UniversityP.O.Box 635-80300VoiKenya Department of Mechanical Engineering Inha UniversityIncheonSouth Korea School of Mechanical Engineering Kyungpook National UniversityDaeguSouth Korea Department of Mechanical Engineering Howard UniversityWashingtonDCUSA

A transformation-induced plasticity phenomenon in Fe65(CoCrMnNi)35 medium-entropy alloy was *** to the X-ray diffraction patterns,the as-cast specimen contains a single-phase face-centered cubic(fcc),while low-temperature annealing at 500℃and 600℃leads to the introduction of a body-centered cubic(bcc)phase as a secondary *** increment of the annealing temperature to above 700℃eliminates the bcc phase,and the microstructure was found to contain a single-phase *** 20%true strain,an fcc-to-bcc phase transformation is observed;whereas,at 28%true strain,an fccto-hcp phase transformation takes place as an additional deformation *** strain-induced phase transformation phenomenon leads to improved tensile properties of this alloy.

关键词： Phase transformation X-ray diffraction Mechanical behavior Microstructure evolution Multicomponent alloys

Intensification of Ethylene Production from Naphtha via a redox Oxy-Cracking Scheme： Process Simulations and Analysis

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Engineering 2018年第5期4卷 714-721页

作者： Vasudev Pralhad Haribal Yun Chen luke Neal Fanxing Li Department of Chemical and Biomolecular Engineering North Carolina State University Raleigh NC 27695-7905 USA School of Chemistry and Chemical Engineering South China University of Technology Guangzhou 510640 China

Ethylene production by the thermal cracking of naphtha is an energy-intensive process （up to 40 GJ heat per tonne ethylene）, leading to significant formation of coke and nitrogen oxide （NOx）, along with 1,8- 2 kg of carbon dioxide （CO2） emission per kilogram of ethylene produced, We propose an alternative pro- cess for the redox oxy-cracking （rOC） of naphtha, In this two-step process, hydrogen （H2） from naphtha cracking is selectively comhusted by a redox catalyst with its lattice oxygen first, The redox catalyst is subsequently re-oxidized by air and releases heat, which is used to satisfy the heat requirement for the cracking reactions, This intensified process reduces parasitic energy consumption and CO2 and NOx emissions, Moreover, the formation of ethylene and propylene can he enhanced due to the selective com-bustion of H2, In this study, the rOC process is simulated with ASPEN Plus^r based on experimental data from recently developed redox catalysts, Compared with traditional naphtha cracking, the rOC process can provide up to 52% reduction in energy consumption and CO2 emissions, The upstream section of the process consumes approximately 67% less energy while producing 28% more ethylene and propylene for every kilogram of naphtha feedstock,

关键词： Ethylene Naphtha cracking Process intensification Chemical looping Process simulations

Functional genomics studies on the innate immunity of disease vectors

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Insect Science 2008年第1期15卷 15-27页

作者： luke A. Baton Lindsey Garver Zhiyong Xi George Dimopoulos W. Harry Feinstone Department of Molecular Microbiology and Immunology Malaria Research Institute Bloomberg School of Pubfic Health Johns Hopkins University Baltimore Maryland USA

The increasing availability of genome sequences and the development of highthroughput techniques for gene expression profiling and functional characterization are transforming the study of innate immunity and other areas of insect biology. Already, functional genomic approaches have enabled a quantum advance in the characterization of mosquito immune responses to malaria parasite infection, and similar high-throughput functional genomic studies of other vector-pathogen interactions can be expected in the near future. The application of microarray-based and other expression analyses provide genomewide transcriptional profiles that can be used to identify insect immune system components that are differentially regulated upon exposure to various classes of pathogens, including many important etiologic agents of human and animal diseases. The role of infection-responsive or other candidate immune genes identified through comparative genomic approaches can then be functionally characterized, either in vivo, for instance in adult mosquitoes, or in vitro using cell lines. In most insect vectors of human pathogens, germ-line transgenesis is still technically difficult and maintenance of multiple transgenic lines logistically demanding. Consequently, transient rNA interference （rNAi）-mediated gene-silencing has rapidly become the method of choice for functional characterization of candidate innate immune genes. The powerful combination of transcriptional profiling in conjunction with assays using rNAi to determine gene function, and identify regulatory pathways, together with downstream cell biological approaches to determine protein localization and interactions, will continue to provide novel insights into the role of insect innate immunity in a variety of vector-pathogen interactions. Here we review advances in functional genomics studies of innate immunity in the insect disease vectors, over the past decade, with a particular focus on the Anopheles mosquito and its respo

关键词： Anopheles genomics innate immunity insect mosquito malaria microarray,parasite Plasmodium rNA interference transcriptomics transgenesis vector

Structure-function relationships in Human Hypoxanthine-guanine Phosphoribosyltransferase(HGPrT) by random Mutagenesis

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Chemical research in Chinese Universities 2006年第2期22卷 251-252页

作者： luke Guddat Anthony Farlow John de Jersey Department of Biochemistry and Molecular Biology University of Queensland St Lucia Queensland 4072 Australia

Hypoxanthine-guanine phosphoribosyltransferase （ HGPrT, EC 2.***.2.8） is a key enzyme of the purine salvage pathway, which allows recycling of purine bases into DNA and rNA. It is widely distributed in nature and has been studied both in prokaryotes and eukaryotes. In humans, a complete lack of HGPrT activity causes the Lesch-Nyhan syndrome, which is characterized by hyperuricaemia and neural disorders,

关键词： Hypoxanthine-guanine phosphoribosyltransferase random mutagenesis Structure-function relationship

Phylogeny,molecular evolution,and dating of divergences in Lagerstroemia using plastome sequences

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Horticultural Plant Journal 2023年第2期9卷 345-355页

作者： Jie Wang Wenchuang He Xuezhu Liao Jin Ma Wei Gao Haoqi Wang Dili Wu luke r.Tembrock Zhiqiang Wu Cuihua Gu Zhejiang Provincial Key Laboratory of Germplasm Innovation and Utilization for Garden Plants Key Laboratory of National Forestry and Grassland Administration on Germplasm Innovation and Utilization for Southern Garden PlantsCollege of Landscape and ArchitectureZhejiang A&F UniversityHangzhouZhejiang 311300China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenShenzhenGuangdong 518120China Shenzhen Middle School ShenzhenGuangdong 518000China Department of Agricultural Biology Colorado State UniversityFort CollinsCO80523USA Kunpeng Institute of Modern Agriculture at Foshan FoshanGuangdong 528200China

Lagerstroemia L.(Lythraceae)is a widely distributed genus of trees and shrubs native to tropical and subtropical environments from Southeast Asia to Australia,with numerous species highly valued as *** the plastomes of many species in this genus have been sequenced,the rates of functional gene evolution and their effect on phylogenetic analyses have not been thoroughly *** compared three plastome sequence matrices to elucidate how differences in these datasets affected phylogenetic *** phylogenetic relationships for Lagerstroemia species were reconstructed based on different plastome sequence partitions and multiple phylogenetic *** of single-nucleotide variants within different genes also provides basic data on the patterns of functional gene evolution in Lagerstroemia and may provide insights into how those mutations affect protein structure and potentially drive divergence via cytonuclear *** results as well as analyses of non-synonymous and synonymous mutations,indicate that heterotachic modes of evolution are present in functional plastome genes and should be accounted for in the analyses of molecular *** addition,divergence events within the Lagerstroemia were dated for the first *** of the divergence estimates corresponded to well-known Earth history events,such as the reduction in global temperatures at the Eocene/Oligocene *** analyses conducted in Lagerstroemia here dissects the various patterns in the divergence of Lagerstroemia and may provide a useful guide to help plant breeders,as well as the necessity of using plastomic data and as possible as to combine evidence from morphological characteristics to investigate the complicated interspecies relationship and the evolutionary dynamics of species.

关键词： Lagerstroemia L Evolutionary rate Single-nucleotide variants Molecular dating Chloroplast Codon Covarion