Structure-function Relationships in Human Hypoxanthine-guanine Phosphoribosyltransferase(HGPRT) by Random Mutagenesis

作     者：Luke Guddat Anthony Farlow John de Jersey 

作者机构：Department of Biochemistry and Molecular Biology University of Queensland St Lucia Queensland 4072 Australia 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2006年第22卷第2期

页      面：251-252页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

主　　题：Hypoxanthine-guanine phosphoribosyltransferase Random mutagenesis Structure-function relationship 

摘      要：Hypoxanthine-guanine phosphoribosyltransferase （ HGPRT, EC 2.***.2.8） is a key enzyme of the purine salvage pathway, which allows recycling of purine bases into DNA and RNA. It is widely distributed in nature and has been studied both in prokaryotes and eukaryotes. In humans, a complete lack of HGPRT activity causes the Lesch-Nyhan syndrome, which is characterized by hyperuricaemia and neural disorders,