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Liver transplantation as an alternative for the treatment of perihilar cholangiocarcinoma: A critical review

Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 139-145页

作者： Wellington Andraus francisco Tustumi Alexandre Chagas Santana Rafael Soares Nunes Pinheiro Daniel Reis Waisberg Liliana Ducatti Lopes Rubens Macedo Arantes Vinicius Rocha Santos Rodrigo Bronze de Martino luiz Augusto Carneiro D’Albuquerque Department of Gastroenterology Transplantation UnitUniversidade de São PauloSão PauloBrazil

Background:Perihilar cholangiocarcinoma(phCCC)is a dismal *** is no consensus regard-ing the best treatment for patients with unresectable *** present review aimed to gather the current pieces of evidence for liver transplantation and liver resection as a treatment for phCCC and to build better guidance for clinical *** sources:The search was conducted in PubMed,Embase,Cochrane,and *** related references were searched *** criteria were:reports in English or Portuguese literature that a)patients with confirmed diagnosis of phCCC;b)patients treated with a curative intent;c)patients with the outcomes of liver resection and liver *** reports,reviews,letters,editorials,conference abstracts and papers with full-text unavailability were excluded from the ***:Most of the current literature is based on observational retrospective studies with low grades of *** resection has better long-term outcomes than systemic chemotherapy or palliation ther-apy and liver transplantation is a good alternative for selected patients with unresectable *** candidates for resection or transplantation should be medically fit and free of intrahepatic or extrahep-atic *** a general rule,patients presenting with a tumor having a longitudinal size>3 cm or extending below the cystic duct,lymph node disease,confirmed extrahepatic dissemination;intraoper-atively diagnosed metastatic disease;a history of other malignancies within the last five years,and did not complete chemoradiation regimen and were medically unfit should not be considered for *** of these criteria should be individually *** transplantation or resection should only be considered in highly experienced hepatobiliary centers,and any decision-making must be based on a multidisciplinary ***:phCCC is a complex condition with high *** therapies,including hepatec-tomy and liv

关键词： Liver transplantation Cholangiocarcinoma Liver neoplasms

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Comparison of Functional Capability,Flexibility,Strength and Quality of Life in Aged Women Engaged in Resistance Exercise,Weight-Bearing Training or Hydro-Gymnastics

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Journal of Sports Science 2019年第4期7卷 106-114页

作者： Otávio Augusto Soares Machado Waldecir Paula Lima Bruna Vieira de Souza Fábio Gianolla luiz francisco killian Giovanna Athanásio Chaves Machado Renata Gorjao Physiology and Metabolism Research Center YMCA Physical Education FacultySorocaba-SPBrazil Federal Institute of Education Science and TechnologySao Paulo-SPBrazil Postgraduate Program in Interdisciplinary Health Science Cruzeiro do Sul UniversitySao Paulo-SPBrazil

Although any type or amount of physical exercise may reverse the cellular processes that lead to the aging,regular physical exercise can attenuate the decline in physical and functional abilities observed in ***,the most encouraged activities in gyms and clubs are resistance training,functional training,and *** main objective of this study was to compare the effects of the aforementioned exercises regarding muscle strength,flexibility,functional capability and quality of life of elderly *** divided 36 elderly women in four groups:Sedentary(S);Hydro-gymnastics(H);Functional Training(F);or Resistance Training(RT).The results reveal that the groups engaged in physical exercise showed a significant difference(p<0.05)in relation to S in all *** results also show that between the different exercises evaluated,resistance training practitioners have greater strength and better functional capability.

关键词： Aged exercise physical fitness quality of life

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Dipole (hyper)polarizabilities of neutral silver clusters

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Chinese Physics B 2016年第12期25卷 217-222页

作者： francisco E Jorge luiz G M de Macedo Departarnento de Fisica Universidade Fedoral do Espirito Santo 29060-900 Vitoria Brazil Unidade Academica de Fisica Universidade Federal de Campina Grande 58429-900 Campina Grande Brazil Faculdade de Biotecnologia ICB Universidade Federal do Para 66075-110 Belem Brazil

At the Douglas-Kroll-Hess （DKI4） level, the B3PW91 functional along with the all-eleclron relativistic basis sets of valence triple and quadruple zeta qualities are used to determine the structure, stability, and electronic properties of the small silver clusters （Agn, n ≤ 7）. The results presented in this study are in good agreement with the experimental data and theoretical values obtained at a higher level of theory from the literature. Static polarizability and hyperpolarizability are also reported. It is verified that the mean dipole polarizability per atom exhibits an odd-even oscillation and that the polarizability anisotropy is directly related to the cluster shape. In this article, the first study of hyperpolarizabilities of small silver clusters is presented. Except for the monomer, the second hyperpolarizabilities of the silver clusters are significantly larger than those of the copper clusters.

关键词： B3PW91 functional all-electron basis sets non-relativistic and DKH2 calculations silver clusters,dipole (hyper)polarizabilities

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The assessment of climatic, environmental, and socioeconomic aspects of the Brazilian Cerrado

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Ecological Processes 2023年第2期12卷 59-70页

作者： Washington luiz Félix Correia Filho José francisco de Oliveira-Júnior Dimas de Barros Santiago Hazem Ghassan Abdo Hussein Almohamad Ahmed Abdullah Al Dughairi Carlos Antonio da Silva Junior Postgraduate Program in Environmentrics(PPGAmb) Institute of Mathematics Statistics and Physics(IMEF) Federal University of Rio Grande(FURG) Institute of Atmospheric Sciences(ICAT) Federal University of Alagoas(UFAL) Postgraduate Program in Biosystems Engineering(PGEB) Federal Fluminense University(UFF) Postgraduate Program in Meteorology Unidade Acadêmica de Ciências Atmosféricas(UACA) Federal University of Campina Grande(UFCG) Geography Department Faculty of Arts and Humanities Tartous University Geography Department Faculty of Arts and Humanities Damascus University Geography Department Faculty of Arts and Humanities Tishreen University Department of Geography College of Arabic Language and Social Studies Qassim University Departamento de Geografia State University of Mato Grosso(UNEMAT)

Background The Cerrado is the most biodiverse savanna and maintains other biomes. Aware of its significance, this paper evaluated the Brazilian Cerrado's climatic, environmental, and socioeconomic aspects using remote sensing data and spatial statistics(correlation analysis and principal components analysis—PCA). Following the measures of sample adequacy(MSA) and Kaiser–Meyer–Olkin(KMO) tests, seventeen variables were *** The MSA revealed that the dataset had a good quality(0.76), and nine variables were selected: elevation, evapotranspiration, active fires, Human Development Index(HDI), land use and land cover(LULC; shrubland and cropland/rainfed), rainfall(spring and autumn), and livestock. The correlation matrix indicated a positive(negative) association between HDI and autumn rainfall(HDI and active fires) with a value of 0.77(-0.55). The PCA results determined which three principal components(PC) were adequate for extracting spatial patterns, accounting for 68.02% of the total variance with respective values of 38.59%, 16.89%, and 12.5%. Due to economic development and agribusiness, Cerrado's northern(central, western, and southern) areas had negative(positive) score HDI values, as shown in PC1. Climatic(rainfall—spring and fall) and environmental(cropland/rainfed and shrubland) aspects dominated the PC2, with negative scores in northern and western portions due to the transition zone between Amazon and Cerrado biomes caused by rainfall variability. On the other hand, environmental aspects(LULC-shrubland and elevation) influenced the PC3; areas with high altitudes(> 500 m) received a higher *** Agricultural expansion substantially affected LULC, leading to deforestation-caused suppression of native vegetation.

关键词： Environment Agribusiness Active fire Human Development Index Land use and land cover

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Out of Sight, Out of Mind, Right? Not in COVID-19 Shock or Anaerobic and Exhaustive Shock versus Septic Shock Dilemma That Means to Live or Die. Emergency Attention and a Necessity of Trials

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Open Journal of Emergency Medicine 2022年第1期10卷 19-47页

作者： luiz Gonzaga francisco de Assis Barros D’Elia Zanella Infectious Diseases Department (MI-HSPE) Hospital do Servidor Público do Estado de S&#227 o Paulo S&#227 o Paulo Brazil PhD Program in Allergy and Immunopathology School of Medicine University of S&#227 o Paulo S&#227 o Paulo Brazil Emergency and Urgency Department University Hospital of University of S&#227 o Paulo Butant&#227 S&#227 o Paulo Brazil

Background: COVID-19 brought challenges that did not end after a two-year pandemic. From more straightforward changes in habits to studying to understand the enigmatic parasite-host relationship, we can better manage the patient infected with SARS-CoV-2 even with a vaccine full of doubts and antivirals that do not correctly cover the viral period. SARS-CoV-2 brought the chronic inflammation now called “The Long COVID-19 Syndrome” (LCS), something still little talked about, but we already see deaths due to non-identification of this inflammatory syndrome that can lead to shock. Theory: LCS Shock is due to a long period of metabolic stress, reflecting the shift from inflammation to oxidative stress and innate immunity, and does not respond to antimicrobials, as its main component is inflammatory, although there may be conjoined bacterial translocation. Thus, we are losing patients to a new syndrome confused with sepsis and septic shock. While septic shock (SS) responds to antimicrobials, Inflammatory Shock (ISc) does not respond to antimicrobials alone, requiring high doses of corticosteroids. Review: This study shows that we need to differentiate SS and ISC, as the treatment is different. The review shows that Lactate, LDH and the presence of new/recent cardiac changes and bradycardia in the face of a status where there should be tachycardia as the usual response can differ ISC from SS. Maybe the main responsible for high LDH is Warburg Effect. Conclusion: We have a dilemma that requires clinical studies that routinely match high doses of corticosteroids (until there is something better to be done) and bring laboratory and imaging differences to diagnose SS vs ISc better.

关键词： Acute Respiratory Distress Syndrome Cardiovascular System Critical Care COVID-19 Lactate

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The assessment of climatic, environmental,and socioeconomic aspects of the Brazilian Cerrado

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Ecological Processes 2023年 274-285页

作者： Washington luiz Félix Correia Filho José francisco de Oliveira-Júnior Dimas de Barros Santiago Hazem Ghassan Abdo Hussein Almohamad Ahmed Abdullah Al Dughairi Carlos Antonio da Silva Junior Postgraduate Program in Environmentrics (PPGAmb) Institute of Mathematics Statistics and Physics (IMEF) Federal University of Rio Grande (FURG) Institute of Atmospheric Sciences (ICAT ) Federal University of Alagoas (UFAL) Postgraduate Program in Biosystems Engineering (PGEB) Federal Fluminense University (UFF) Postgraduate Program in Meteorology Unidade Acadêmica de Ciências Atmosféricas (UACA) Federal University of Campina Grande (UFCG) Geography Department Faculty of Arts and Humanities Tartous University Geography Department Faculty of Arts and Humanities Damascus University Geography Department Faculty of Arts and Humanities Tishreen University Department of Geography College of Arabic Language and Social Studies Qassim University Departamento de Geografia State University of Mato Grosso (UNEMAT)

Background The Cerrado is the most biodiverse savanna and maintains other biomes. Aware of its significance, this paper evaluated the Brazilian Cerrado's climatic, environmental, and socioeconomic aspects using remote sensing data and spatial statistics(correlation analysis and principal components analysis—PCA). Following the measures of sample adequacy(MSA) and Kaiser–Meyer–Olkin(KMO) tests, seventeen variables were *** The MSA revealed that the dataset had a good quality(0.76), and nine variables were selected: elevation,evapotranspiration, active fires, Human Development Index(HDI), land use and land cover(LULC; shrubland and cropland/rainfed), rainfall(spring and autumn), and livestock. The correlation matrix indicated a positive(negative)association between HDI and autumn rainfall(HDI and active fires) with a value of 0.77(-0.55). The PCA results determined which three principal components(PC) were adequate for extracting spatial patterns, accounting for 68.02% of the total variance with respective values of 38.59%, 16.89%, and 12.5%. Due to economic development and agribusiness, Cerrado's northern(central, western, and southern) areas had negative(positive) score HDI values, as shown in PC1. Climatic(rainfall—spring and fall) and environmental(cropland/rainfed and shrubland) aspects dominated the PC2, with negative scores in northern and western portions due to the transition zone between Amazon and Cerrado biomes caused by rainfall variability. On the other hand, environmental aspects(LULC-shrubland and elevation)influenced the PC3; areas with high altitudes(> 500 m) received a higher *** Agricultural expansion substantially affected LULC, leading to deforestation-caused suppression of native vegetation.

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Effect of Molasses Addition at Ensiling on Ruminal In Situ Dry Matter and Nutrient Degradation of Whole-Plant Soybean Silage Harvested at Different Phenological Stages

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Agricultural Sciences 2022年第2期13卷 268-281页

作者： Lucas Ghedin Ghizzi Matheus Rebouças Pupo Celso Heinzen Jr. Tiago Antônio Del Valle francisco Palma Rennó luiz Felipe Ferraretto Department of Animal Nutrition and Animal Production University of Sao Paulo Pirassununga Brazil Department of Animal and Dairy Sciences University of Wisconsin Madison USA Federal University of Santa Maria Santa Maria Brazil

Whole-plant soybean ensiling has limitations and challenges that affect silage fermentation patterns and reduce ruminal nutrient degradation. Perhaps either the addition of molasses at ensiling or harvesting at different phenological stages has the potential to enhance whole-plant soybean silage (WSS) ruminal degradation. This experiment was a completely randomized design with a 3 × 2 factorial arrangement of treatments evaluating the effects of molasses (0 and 40 g/kg fresh forage) and phenological stage (R5: beginning seed, R6: full seed, and R7: beginning maturity) on ruminal in situ degradation. Molasses increased effective ruminal degradability (ERD) of dry matter (DM) regardless of the phenological stage and increased ERD of crude protein at R5 and R6. The addition of molasses at later phenological stages increased ERD of neutral detergent fiber (NDF). There was a molasses × phenological stage interaction effect with greater fractions A and B of NDF at R7 and R5, respectively, but lower undegraded NDF at R5 and R6 with molasses addition. Although the benefits of adding molasses were more pronounced in R5 and R6, adding molasses to whole-plant soybean at ensiling is recommended regardless of phenological stage. Increasing the proportion of digestible nutrients at harvesting either by harvesting at later phenological stages or the addition of molasses is a powerful strategy to manage ruminal degradation of DM and nutrients in WSS.

关键词： Additive In Situ Degradation Ruminal Degradation Parameters Legume Ensiling

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Assessment of Genetic Stability Among In Vitro Plants of Arachis retusa Using RAPD and AFLP Markers for Germplasm Preservation

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Journal of Integrative Plant Biology 2007年第3期49卷 307-312页

作者： Rachel Fatima Gagliardi luiz Ricardo Hanai Georgia Pacheco Carlos Alberto Oliveira Leonardo Alves Carneiro José francisco Montenegro Valls Elisabeth Mansur Maria Lucia Carneiro Vieira Laboratório de Micropropagacao e Transformacao de Plantas Universidade do Estado do Rio de Janeiro postal code 20550-013 Maracana Rio de Janeiro Brazil Departamento de Genética - Escola Superior de Agricultura luiz de Queiroz Universidade de Sao Paulo postal code 13418-900 Piracicaba Brazil Embrapa Recursos Genéticos e Biotecnologia postal code 70770-901 Brasilia Brazil

Arachis retusa Krapov. et W. C. Gregory et Valls is endemic in the West-central region of Brazil, occurring In areas endangered by human actions. The establishment of in vitro preservation methods for wild species of Arachis is an alternative to seed banks for germplasm storage, multiplication and distribution. The risk of genetic changes Induced by tissue culture and the monitoring of the genetic stability of the biological material before, during and after storage must be considered In the context of conservation. Random amplified polymorphlc ONA （RAPO） and amplified fragment length polymorphism （AFLP） fingerprinting were used to evaluate the genetic stability of in vitro plants originated from cotyledons and embryo axes of A. retusa. Cotyledons originated shoots through direct organogenesls and embryo axes displayed muItishoot formation Induced by 110 mmol/L and 8.8 mmol/L BAP, respectively. Ninety genomlc regions （loci） generated from RAPO and 372 from AFLP analyses were evaluated. All amplified fragments detected by both techniques in plants derived from the two explant types were monomorphic. The results Indicate that the recovered shoots are genetically stable at the assessed genomic regions.

关键词： amplified fragment length polymorphism Arachis retusa in vitro preservation micropropagation random amplifiedpolymorphic DNA somaclonal variation

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ASYMPTOTIC HOMOGENIZATION IN A PARABOLIC SEMILINEAR PROBLEM WITH PERIODIC COEFFICIENTS AND INTEGRABLE INITIAL DATA

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Acta Mathematica Scientia 2013年第5期33卷 1275-1292页

作者： Rogerio luiz Quintino de OLIVEIRA JUNIOR Instituto de Matema'tica e Estat' stica Universidade do Estado do R.de Janeiro Rua S ao Francisco Xavier524 - Pavilha o Reitor Joa o Lyra Filho 6oandar bl.B 20559-900 Rio de Janeiro R.J. Brazil

In this paper, we study the large time behavior of solutions of the parabolic semilinear equation δtu-div（a（x）△↓u） = -｜u｜^αu in （0,∞） × R^N, where α 〉 0 is constant and a∈ Cb^1（R^N） is a symmetric periodic matrix satisfying some ellipticity *** an integrable initial data u0 and α ∈ （2/N, 3/N）, we prove that the large time behavior of solutions is given by the solution U（t, x） of the homogenized linear problem δtU-div（a^h△↓U）=0,U（0） = C, where a^h is the homogenized matrix of a（x）, C is a positive constant and δ is the Dirac measure at 0.

关键词： homogenization similinear parabolic equation integrable initial data matrix with periodic coefficient large time behavior

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Characterization of Cnidoscolus quercifolius Pohl bark root extract and evaluation of cytotoxic effect on human tumor cell lines

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Asian Pacific Journal of Tropical Biomedicine 2018年第7期8卷 345-351页

作者： Paulo Fernando Machado Paredes Selene Maia de Morais Fernando Cesar Rodrigues Brito luiz francisco Wemmenson Goncalves Moura Patricia de Araujo Rodrigues Stephen Rathinaraj Benjamin francisco Ernani Alves Magalhaes Eridan Orlando Pereira Tramontina Florean Maria Izabel Florindo Guedes Northeast Biotechnology Network Graduate Program of Biotechnology State University of Ceara Itaperi campus Department of Chemistry State University of Ceara Itaperi campus Laboratory of Bioprospecting of Natural Products and Biotechnology State University of CearaCECITEC

Objective: To evaluate the chemical components of active extract from Cnidoscolus quercifolius root bark and its cytotoxic potential against several tumor strains. Methods: The high-performance liquid chromatography with diode-array detection and ~1H and ^(13)C nuclear magnetic resonance spectroscopy of the extract were used to distinguish the existence of possible functional groups in the root bark extract. The in vitro cytotoxic activity of methanol extract on human colon cancer cell lines was evaluated using OVCAR-8, SF-295, HCT-116, HL-60 strains and the samples were assessed by 3-(4,5-dimethylthiazol2-yl)-2,5-diphenyltetrazolium bromide method. Results: The analysis of nuclear magnetic spectra of the active chloroform fraction revealed the presence of absorptions bands correspondent to a mixture of favelines such as neofavelanone, deoxofaveline or methyl-faveline, which structures were confirmed by ultraviolet spectra upon high-performance liquid chromatography with diode-array detection analysis. The active fraction showed cytotoxic effects in the tested strains, HCT-116, SF-295, OVCAR-8 and HL-60 cells with IC_(50) of 72 hours ranging from 4.95 to 15.23 μg/mL. Conclusions: The results suggest that the substances present in faveleira(Cnidoscolus quercifolius) root bark extract have a cytotoxic potential against several tumor lines, showing a broader antitumour potential, and in addition no adverse to healthy cells. Therefore, the root bark extract of Cnidoscolus quercifolius has a possibility of use for anticarcinogenic therapies.

关键词： Cnidoscolus quercifolius Pohl. methyl-faveline Deoxofaveline Neofavelanone Faveline Cytotoxicity

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