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Extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum

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世界胃肠病学杂志：英文版 2009年第28期15卷 3565-3568页

作者： Fabiana Pirani Carneiro Maria de Nazareth Machado Sobreira Lívia Bravo Maia Alesso Cervantes Sartorelli luiz eduardo de almeida prado franceschi Mauro Brito Brando Bárbara Wosnjuk Calaca Fernando Silva Lustosa Joo Vieira Lopes department of Pathology University Hospital of Brasília department of Radiology University Hospital of Brasília department of Hematology University Hospital of Brasília department of Surgery University Hospital of Brasília

We report a rare case of extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum.A 72-year-old Japanese man was admitted to our hospital presenting with a 3-mo history of epigastric pain, vomiting and weight *** computed tomography(CT) a wall thickening of the fourth part of the duodenum was *** biopsies obtained from the lesion showed inflltration of plasma cells and lymphocytes, but they were not *** patient underwent resection of the lesion and, on histopathological examination, the lesion consisted of a dense and diffuse inflltrate of plasma cells and a few admixed lymphocytes with reactive follicles extending to the muscular *** extensive deposition of amyloid was also *** stains revealed that a few plasmacytoid cells showed λ light chain staining, though most were κ light chain *** cells also were positive for CD138 and CD56 but negative for CD20 and *** flndings were consistent with extramedullary plasmocytomaassociated with a massive deposit of amyloid in duodenum.A subsequent workup for multiple myeloma was completely *** patient showed no signs of local recurrence or dissemination of the disease after 12 mo *** of the association of plasmocytoma and amyloidosis, the patient must be followed up because of the possible systemic involvement of the neoplasm and amyloidosis in future.

关键词：淀粉样蛋白十二指肠浆细胞存款免疫组织化学染色计算机断层扫描组织病理学检查淀粉样变性

ProTSA: A Testing Process for Automotive Software Domain

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Journal of Software Engineering and Applications 2024年第7期17卷 571-615页

作者： Renato Rafael Arcanjo luiz eduardo Galvão Martins Dirceu Lavoiser Fernandes Graci department of Inovation and Science Federal University of Sao Paulo (UNIFESP) Sao Jose dos Campos Brazil department of Automotive Electronics Faculty of Technology of Sao Paulo (Fatec) Santo Andre Brazil

This study evaluates the development of a testing process for the automotive software domain, highlighting challenges stemming from the absence of adequate processes. The research demonstrates the application of design Science Research methodology in developing, an automotive software testing process—ProTSA, using six functional testing modules. Additionally, the study evaluates the benefits of implementing ProTSA in a specific Original Equipment Manufacturer (OEM) using an experimental single-case approach with industry professionals’ participation through a survey. The study concludes that combining testing techniques with effective communication and alignment is crucial for enhancing software quality. Furthermore, survey data indicates that implementing ProTSA leads to productivity gains by initiating tests early, resulting in time savings in the testing program and increased productivity for the testing team. Future work will explore implementing ProTSA in cybersecurity, over-the-air software updates, and autonomous vehicle testing processes. .

关键词： Verification and Validation Automotive Software Automotive Systems

From liver to hormones:The endocrine consequences of cirrhosis

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World Journal of Gastroenterology 2024年第9期30卷 1073-1095页

作者： Juan eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio María del Carmen Durand-Vásquez Luciana del Pilar Rafael-Robles Jhean Gabriel Gonzáles-Yovera María Alejandra Quispe-Flores Luis Alberto Concepción-Urteaga Alejandro Román-González José Paz-Ibarra Marcio José Concepción-Zavaleta Non-communicable Diseases Endocrinology Research LineHospital de Apoyo ChepénChepén 13871Peru department of Endocrinology Hospital Víctor Lazarte EchegarayTrujillo 13006Peru department of Endocrinology Clínica Javier PradoLima 15046Peru department of Gastroenterology Hospital Nacional Guillermo Almenara IrigoyénLima 15018Peru department of Endocrinology Hospital de Emergencias GrauLima 15001Peru Internal Medicine Hospital Regional Docente de TrujilloTrujillo 13011Peru department of Endocrinology Hospital Universitario de San Vicente FundaciónMedellin 050010Colombia Internal Medicine Universidad de AntioquiaMedellín 050010Colombia School of Medicine Universidad Nacional Mayor de San MarcosLima 15081Peru department of Endocrinology Hospital Nacional Edgardo Rebagliati MartinsLima 15072Peru Carrera de Medicina Humana Universidad Científica del SurLima 15067Peru

Hepatocrinology explores the intricate relationship between liver function and the endocrine *** liver diseases such as liver cirrhosis can cause endocrine disorders due to toxin accumulation and protein synthesis *** its importance,assessing endocrine issues in cirrhotic patients is frequently *** article provides a comprehensive review of the epidemiology,pathophysiology,diagnosis,and treatment of endocrine disturbances in liver *** review was conducted using the PubMed/Medline,EMBASE,and Scielo databases,encompassing 172 *** cirrhosis is associated with endocrine disturbances,including diabetes,hypoglycemia,sarcopenia,thyroid dysfunction,hypogonadotropic hypogonadism,bone disease,adrenal insufficiency,growth hormone dysfunction,and secondary *** optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and continuous glucose monitoring system,*** can be assessed through imaging and functional tests,while other endocrine disorders are evaluated using hormonal assays and imaging *** options include metformin,glucagon-like peptide-1 analogs,sodium-glucose co-transporter-2 inhibitors,and insulin,which are effective and safe for diabetes *** standards are followed for managing hypoglycemia,and hormone replacement therapy is often necessary for other endocrine *** transplantation can address some of these problems.

关键词： Diabetes mellitus Hypoglycemia Thyroid diseases Hypogonadism Metabolic bone diseases Liver cirrhosis

Recycling process and proto-kimberlite melt metasomatism in the lithosphere-asthenosphere boundary beneath the Amazonian Craton recorded by garnet xenocrysts and mantle xenoliths from the Carolina kimberlite

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Geoscience Frontiers 2022年第5期13卷 89-105页

作者： Fernanda Gervasoni Tiago Jalowitzki Marcelo Peres Rocha Ricardo Kalikowski Weska eduardo Novais-Rodrigues Rodrigo Antonio de Freitas Rodrigues Yannick Bussweiler Elisa Soares Rocha Barbosa Jasper Berndt Elton luiz Dantas Valmir da Silva Souza Stephan Klemme Centro de Engenharias Universidade Federal de Pelotas(UFPel)PelotasBrazil Programa de Pós-graduação em Geociências Universidade Federal do Rio Grande do SulPorto AlegreBrazil Programa de Pós-graduação em Geologia Instituto de GeociênciasUniversidade de Brasília(UnB)BrasíliaBrazil Faculdade de Geociências Universidade Federal do Mato Grosso(UFMT)CuiabáBrazil Institut für Geologie und Mineralogie Universität zu KölnGermany Faculdade de Ciências e Tecnologia Universidade Federal de Goiás(UFG)Aparecida de GoiâniaBrazil Institut für Mineralogie Universität MünsterMünsterGermany

Here we present new data on the major and trace element compositions of silicate and oxide minerals from mantle xenoliths brought to the surface by the Carolina kimberlite,Pimenta Bueno Kimberlitic Field,which is located on the southwestern border of the Amazonian *** also present Sr-Nd isotopic data of garnet xenocrysts and whole-rocks from the Carolina *** xenoliths are mainly clinopyroxenites and *** of the clinopyroxenites were classified as GPP–PP–PKP(garnet-phlogopite peridotite,phlogopite-peridotite,phlogopite-K-richterite peridotite)suites,and two clinopyroxenites(eclogites)and two garnetites are relicts of an ancient subducted *** and pressure estimates yield 855–1102℃ and 3.6–7.0 GPa,*** are enriched in light rare earth elements(LREE)(La_(N)/Yb_(N)=5–62;Ce_(N)/Sm_(N)=1–3;where N=primitive mantle normalized values),they have high Ca/Al ratios(10–410),low to medium Ti/Eu ratios(742–2840),and low Zr/Hf ratios(13–26),which suggest they were formed by metasomatic reactions with CO_(2)-rich silicate *** with high TiO_(2)(>2.0 wt.%),Al_(2)O_(3)(>12.0 wt.%),and FeOt(5.0–13.0 wt.%)resemble those found in the groundmass of kimberlites,lamproites and ***,phlogopite with low TiO_(2)(de)and PIC(phlogopite-ilmenite-clinopyorxene)*** GPP-PP-PKP suite of xenoliths,together with the clinopyroxene and phlogopite major and trace element signatures suggests that an intense proto-kimberlite melt metasomatism occurred in the deep cratonic lithosphere beneath the Amazonian *** Sr-Nd isotopic ratios of pyrope xenocrysts(G3,G9 and G11)from the Carolina kimberlite are characterized by high ^(143)Nd/^(144)Nd(0.51287–0.51371)and eNd(+4.55 to+20.85)accompanied with enriched ^(87)Sr/^(86)Sr(0.70405–0.71098).These results suggest intera

关键词： Carolina kimberlite K-rich mantle xenoliths Ancient subducted slab Proto-kimberlite melt metasomatism

Biochar and sugar cane filter cake interaction on physical and hydrological soil properties under tropical field conditions

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Biochar 2020年第2期2卷 195-210页

作者： Sara de Jesus Duarte Bruno Glaser Blanca Lucia prado Pano Carlos eduardo Pellegrino Cerri Soil and Plant Nutrition Luiz de Queiroz College of AgricultureUniversity of São PauloAvenida Pádua Dias11-AgronomiaPiracicabaSP 13418-900Brazil Soil Biogeochemistry Martin Luther University Halle-WittenbergVon-Seckendorff-Platz 306120 HalleGermany Instituto de Geología Universidad Nacional Autónoma de MéxicoMéxicoD.F.Mexico

Biochar is known for its effects on carbon sequestration and soil ***,there is a lack of information about its effects on soil physical and hydraulic properties for tropical *** assessed the effects of biochar(BC)plus sugar cane filter cake(FC)rate,and time of interaction on soil physical and hydraulic properties under humid tropical *** this purpose,a field experiment was installed at a loamy sandy soil with five treatments and four replicates:control(only soil),25 Mg ha^(−1) sugar cane filter cake,and 25 Mg ha^(−1) sugar cane filter cake plus 6.25,12.5,and 25 Mg ha^(−1) Miscanthus biochar,respectively,two soil depths(0-10 and 10-20 cm)and two times of interaction(9 and 18 months).Physical prop-erties(aggregate stability,bulk density,total porosity,pores size distribution)and hydraulic properties(soil water holding capacity,hydraulic conductivity,plant-available water holding capacity)were measured after nine and eighteen *** bulk density decreased slightly,and the porosity increased after nine months,for the biochar plus sugar cane filter cake(both 25 Mg ha^(−1)).After 18 months,biochar plus filter cake interaction increase micropores,aggregate stability,and plant-available water *** hydraulic conductivity was not influenced by sugar cane filter ***,biochar significantly reduced saturated hydraulic conductivity when combined with sugar cane filter cake after 18 *** concluded that sugar cane filter cake in combination with biochar modified the pore size distribution,slightly increased plant-available water holding capacity,and significantly decreased saturated hydraulic conductivity.

关键词： Water retention Hydraulic conductivity Miscanthus biochar Soil physics

Physical activity and emotions in a period of social distancing due to the COVID-19 pandemic

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Sports Medicine and Health Science 2022年第3期4卷 172-176页

作者： Raphaela Espanha Corrêa Paulo eduardo Neves Ferreira Velho Rafael do prado Calazans Calvino Camargo Rute Estanislava Tolocka Postgraduate Program in Clinical Medicine Faculty of Medical SciencesUniversidade Estadual de Campinas-UNICAMPCampinasSP13083-887Brazil department of dermatology Faculty of Medical SciencesUniversidade Estadual de Campinas-UNICAMPCampinasSP13083-887Brazil Postgraduate Program in Human Movement Sciences Universidade Metodista de Piracicaba-UNIMEPPiracicabaSP13390-000Brazil Health Science Graduate Program Universidade Federal de Roraima-UFRRBoa VistaRR69310-000Brazil

Social distancing(SD)to prevent SARS-CoV-2(COVID-19)transmission reduced practices of physical activities(PA)and changed emotional conditions,but the relationship between PA and the emotions has to be further *** study aimed to analyze PA and the intensity of basic emotions during a period of social distancing in the State of S~ao Paulo,*** collection was performed using the snowball system and an online survey with questions about the minimum weekly frequency of 30-min moderate and/or vigorous activities(MVPA),intensity of basic emotions,and sociodemographic profile.A total of 704 volunteers participated;mean age 38.113.4 years,67.9%female,82.0%insufficiently practiced MVPA,and 37.9%of the group reported no weekly ***/fear was the emotion with the highest intensity in the study period.A significant association was observed between PA and intensity of happiness(rho=0.125;p<0.01)and a negative association between PA practice and intensity of anxiety/fear(rho=-0.090;p<0.05),sadness(rho=-0.134;p<0.01),and anger(rho?0.109;p<0.01).Also,an association was observed between anxiety/fear and social isolation(rho=0.082;p<0.05).These results suggest that public policies offering PA programs and psychological care are required to improve the quality of life of the population.

关键词： Emotions expressed Physical activity Quarantine COVID-19

Papillary fistulotomy vs conventional cannulation for endoscopic biliary access:A prospective randomized trial

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World Journal of Gastroenterology 2018年第16期24卷 1803-1811页

作者： Carlos Kiyoshi Furuya Paulo Sakai Fabio Ramalho Tavares Marinho Jose Pinhata Otoch Spencer Cheng Lívia Lemes Prudencio eduardo Guimaraes Hourneaux de Moura Everson luiz de almeida Artifon department of Gastrointestinal Endoscopy Unit University of Sao PauloSao Paulo 05409001Brazil department of Surgery University of Sao PauloSao Paulo 05403000Brazil department of Gastroenterology and Radiology University of Sao PauloSao Paulo 04107-030Brazil

AIM To compare the cannulation success, biochemical profile, and complications of the papillary fistulotomy technique vs catheter and guidewire standard *** From July 2010 to May 2017, patients were prospectively randomized into two groups: Cannulation with a catheter and guidewire(Group Ⅰ) and papillary fistulotomy(Group Ⅱ). Amylase, lipase and C-reactive protein at T0, as well as 12 h and 24 h after endoscopic retrograde cholangiopancreatography, and complications(pancreatitis, bleeding, perforation) were *** We included 102 patients(66 females and 36 males, mean age 59.11 ± 18.7 years). Group Ⅰ and Group Ⅱ had 51 patients each. The successful cannulation rates were 76.5% and 100%, respectively(P = 0.0002). Twelve patients(23.5%) in Group Ⅰ had a difficult cannulation and underwent fistulotomy, which led to successful secondary biliary access(Failure Group). The complication rate was 13.7%(2 perforations and 5 mild pancreatitis) vs 2.0%(1 patient with perforation and pancreatitis) in Groups Ⅰ and Ⅱ, respectively(P = 0.0597). CONCLUSION Papillary fistulotomy was more effective than guidewire cannulation, and it was associated with a lower profile of amylase and lipase. Complications were similar in both groups.

关键词： Catheterization Complications Endoscopic retrograde cholangiopancreatography Therapeutic use Common bile duct

Co-Simulation of an SRG Wind Turbine Control and GPRS/EGPRS Wireless Standards in Smart Grids

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IEEE/CAA Journal of Automatica Sinica 2021年第3期8卷 656-663页

作者： Andre luiz de Oliveira Carlos eduardo Capovilla Ivan Roberto Santana Casella JoséLuis Azcue-Puma Alfeu J.Sguarezi Filho University of Sao Paulo Sao Paulo 05508-010Brazil Federal University of ABC Santo Andre 09210-580Brazil

Wind energy can be considered a push-driver factor in the integration of renewable energy sources within the concept of smart *** its full deployment,it requires a modern telecommunication infrastructure for transmitting control signals around the distributed generation,in which,the wireless communication standards stand out for employing modern digital modulation and coding schemes for error correction,in order to guarantee the power plant *** some developing countries,such as Brazil,the high penetration of commercial mobile wireless standards GPRS and EGPRS(based on GSM technology)have captivated the interests of the energy sector,and they now seek to perform remote monitoring and control *** this context,this article presents a comparative performance analysis of a wireless control system for a wind SRG,when a GPRS or EGPRS data service is *** system performance is analyzed by co-simulations,including the wind generator dynamics and the wireless channel *** satisfactory results endorse the viability and robustness of the proposed system.

关键词： General packet radio service(GPRS)/enhanced GPRS(EGPRS) smart grids switched reluctance generator(SRG) wind energy wireless communications

dendritic Growth, Eutectic Features and Their Effects on Hardness of a Ternary Sn–Zn–Cu Solder Alloy

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Acta Metallurgica Sinica(English Letters) 2017年第6期30卷 528-540页

作者： Bismarck luiz Silva Rodrigo Valenzuela Reyes Amauri Garcia Joséeduardo Spinelli department of Materials Engineering Federal University of Rio Grande do Norte-UFRNNatalRN 59078-970Brazil department of Materials Engineering Federal University of Sao Carlos-UFSCarSao CarlosSP 13565-905Brazil department of Manufacturing and Materials Engineering University of CampinasUNICAMPCampinasSP 13083-860Brazil

The present investigation is based on the results of a directionally solidified （DS） Sn-9 wt%Zn-2 wt%Cu alloy, including primary/secondary/tertiary dendrite arm spacings of the Sn-rich matrix, the morphologies of the eutectic mixture and the corresponding interphase spacing, the nature and proportion of the Cu-Zn intermetallic compound （IMC）. The main purpose is to establish interrelations of these microstructure features with experimental solidification thermal parameters, such as cooling rates and growth rates （v）, macrosegregation and hardness. Such interrelations are interesting for both industry and academy since they represent a tool permitting the preprogramming of final properties based on the design of the microstructure. In the case of Sn-Zn-Cu alloys, hardly anything is known about the combined effects of the length scale of the microstructure and fraction and distribution of the primary IMC on hardness. The alloy microstructure is composed of a β-Sn dendritic region, surrounded by a eutectic mixture of α-Zn and β-Sn phases and the γ-Cu5Zn8 IMC. The eutectic interphase spacing varies in the range 1.2-3.6 μm, with the α-Zn phase having a globular morphology for ν 〉 0.5 mm/s and a needle-like morphology for ν 〈 0.3 mm/s. A modified Hall-Petch-type experimental expression relating hardness to the interphase spacing is proposed.

关键词： Sn-Zn-Cu solder alloy Solidification Microstructure Eutectic morphology Hardness