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Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease

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Genes & Diseases 2024年第1期11卷 67-71页

作者： Souvik Kar Andrea perrelli Kiran Kumar Bali Raffaella Mastrocola Arpita Kar Bushra Khan luis Gand Arnab Nayak Christian Hartmann Wolfram SKunz Amir Samii Helmut Bertalanffy Saverio Francesco Retta International Neuroscience Institute Rudolf-PichlmayrStrasse 4Hannover 30625Germany Department of Clinical and Biological Sciences University of TorinoOrbassano(TO)10043Italy CCM Italia Research Network National Coordination Center at the Department of Clinical and Biological SciencesUniversity of TorinoOrbassano(TO)10043Italy Department of Experimental pain Research Mannheim Center for Translational Neuroscience(MCTN)Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Department of Kidney Liver and Metabolic DiseasesChildren’s HospitalHannover Medical SchoolHannover 30625Germany Ricarda-Huch-Street-10B Hannover 30880Germany Institute of Molecular and Cell physiology Hannover Medical SchoolHannover 30625Germany Department of Neuropathology Institute of PathologyHannover Medical SchoolHannover 30625Germany Institute of Experimental Epileptology and Cognition Research and Department of Epileptology University Hospital BonnVenusberg-Campus 1Bonn 53127Germany epartment of pharmacology and physiology University of Rochester Medical CenterRochesterNY 14642USA

cerebrovascular disease of genetic origin characterized by abnormally dilated capillaries and a wide spectrum of symptoms,including headaches,seizures,neurological deficits,and intracerebral *** unpredictable clinical course and the current lack of therapies make the identification of prognostic and predictive biomarkers an imperative research challenge.1 Herein,we provide evidence that galectin-3(Gal-3),a major tissue and circulating biomarker of oxidative stress and inflammation,is significantly up-regulated both in CCM patients and ***,wholetranscriptome sequencing,qRT-pCR,and Western blotting studies demonstrated a significant up-regulation of Gal-3 expression levels both in surgical CCM specimens and in blood samples of CCM patients.

关键词： inflammation cerebral dilated

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How secure can we expect the surveillance policies to be after the implementation in T1 polyps with carcinoma?

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World Journal of Gastrointestinal Endoscopy 2024年第9期16卷 502-508页

作者： Cristina Mateos Sanchez Elvira Quintanilla Lazaro luis Ramon Rabago Department of Gastroenterological Severo Ochoa HospitalMadridLeganes 28911Spain Department of Gastroenterology San Rafael HospitalMadrid 28016Spain

Approximately 7%of the polyps resected endoscopically have an adenocarcinoma focus,with no previous endoscopic evidence of *** raises the question of whether endoscopic resection has been ***,there is no consensus on what the endoscopic and histological criteria for good prognosis are,the appropriate follow-up strategy and what are the long-term *** aim of the retrospective study by Fábián et al was to evaluate the occurrence of local relapse or distant metastasis in those tumors that were resected endoscopically compared to those that underwent oncologic *** concluded that,regardless of the treatment strategy chosen,there was a higher recurrence rate than described in the literature and that adherence to follow-up was *** management approach for an endoscopically benign polyp histologically confirmed as adenocarcinoma depends on the presence of any of the previously described poor prognostic histological *** none of these factors are present and the polyp has been completely resected en bloc(R0),active surveillance is considered appropriate as endoscopic resection is deemed *** results highlight,once again,the need for further multicentric clinical practice studies to obtain more evidence for the purpose of establishing appropriate treatment and follow-up strategies.

关键词： pT1 adenocarcinoma polyps pT1 follow up management Histological recurrence rate of pT1 adenocarcinoma Endoscopic and histologic poor prognostic criteria

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The new kid on the block in insect pest management:sprayable RNAi goes commercial

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Science China(Life Sciences) 2024年第8期67卷 1766-1768页

作者： Junjie Yan Ralf Nauen Stuart Reitz Andrei Alyokhin Jiang Zhang David Mota-Sanchez Yonggyun Kim Subba Reddy palli Silvia I.Rondon Brian A.Nault Juan luis Jurat-Fuentes Michael S.Crossley William E.Snyder Angharad M.R.Gatehouse Myron p.Zalucki Bruce E.Tabashnik Yulin Gao State Key Laboratory for Biology of plant Disease and Insect pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Bayer AG Crop Science DivisionR&DPest ControlMonheim 40789Germany Department of Crop and Soil Science Oregon State UniversityOntario 97914USA School of Biology and Ecology University of MaineOrono 04469USA Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China Department of Entomology Michigan State UniversityEast Lansing 48864USA Department of plant Medicals Andong National UniversityAndong 36729Republic of Korea Department of Entomology University of KentuckyLexington 40503USA Oregon State University Oregon Integrated Pest Management CenterCorvallis 97838USA Department of Entomology Cornell UniversityCornell AgriTechGeneva 14456USA Department of Entomology and plant pathology University of TennesseeKnoxville 37996USA Department of Entomology and Wildlife Ecology University of DelawareNewark 19716USA Department of Entomology University of GeorgiaAthensGeorgia 30602USA School of Natural and Environmental Sciences Newcastle UniversityNewcastle upon TyneNE17RUUK School of the Environment University of QueenslandBrisbane 4072Australia Shandong Engineering Research Center for Environment-Friendly Agricultural pest Management College of Plant Health and MedicineQingdao Agricultural UniversityQingdao 266109China Department of Entomology University of ArizonaTucson 85721USA National Center of Excellence for Tuber and Root Crop Research Chinese Academy of Agricultural SciencesBeijing 100081China

Insect pest damage to crops is a threat to global food security(Tilman et al.,2011).Climate change,the evolution of insecticide resistance,and the phasing out of insecticides due to environmental and safety concerns exacerbate this *** urgently need safe and effective crop protection tools to sustainably generate yields that meet ever-increasing global demand.

关键词： crops damage pest

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Slow light bimodal interferometry in onedimensional photonic crystal waveguides

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Light(Science & Applications) 2021年第2期10卷 154-165页

作者： luis Torrijos-Morán Amadeu Griol Jaime García-Rupérez Nanophotonics Technology Center Universitat Politècnica de Valencia46022 ValenciaSpain

Strongly influenced by the advances in the semiconductor industry,the miniaturization and integration of optical circuits into smaller devices has stimulated considerable research efforts in recent *** other structures,integrated interferometers play a prominent role in the development of photonic devices for on-chip applications ranging from optical communication networks to point-of-care analysis ***,it has been a longstanding challenge to design extremely short interferometer schemes,as long interaction lengths are typically required for a complete modulation *** approaches,including novel materials or sophisticated configurations,have been proposed to overcome some of these size limitations but at the expense of increasing fabrication complexity and ***,we demonstrate for the first time slow light bimodal interferometric behaviour in an integrated single-channel one-dimensional photonic *** proposed structure supports two electromagnetic modes of the same polarization that exhibit a large group velocity ***,an over 20-fold reduction in the higher-order-mode group velocity is experimentally shown on a straightforward all-dielectric bimodal structure,leading to a remarkable optical path reduction compared to other conventional ***,we experimentally demonstrate the significant performance improvement provided by the proposed bimodal photonic crystal interferometer in the creation of an ultra-compact optical modulator and a highly sensitive photonic sensor.

关键词： interferometer polarization modulator

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The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction

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Molecular plant 2024年第7期17卷 1129-1150页

作者： paula Berman luis Alejandro de Haro Ana-Rita Cavaco Sayantan panda Younghui Dong Nikolay Kuzmich Gabriel Lichtenstein Yoav peleg Hila Harat Adam Jozwiaki Jianghua Cai Uwe Heinig Sagit Meir Ilana Rogachev Asaph Aharoni Department of plant and Environmental Sciences Weizmann Institute of ScienceRehovot 7610001Israel Life Sciences Core Facilities Weizmann Institute of ScienceRehovot 7610001Israel The Maurice and Vivienne Wohl Institute for Drug Discovery Weizmann Institute of ScienceRehovot 7610001Israel present address:Department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryWeinberg 306120 Halle(Saale)Germany Department of Molecular&Cellular pharmacology University of Miami Miler School of MedicineMiamiFL 33136USA Department of Botany and plant Sciences University of California RiversideRiversideCA 92521USA Laboratory of plant Hormones and Development Regulation of Chongqing School of Life SciencesChongqing UniversityChongqing 401331China

Mescaline,among the earliest identified natural hallucinogens,holds great potential in psychotherapy ***,despite the existence of a postulated biosynthetic pathway for more than half a century,the specific enzymes involved in this process are yet to be *** this study,we investigated the cactus Lophophora williamsii(peyote),the largest known natural producer of the phenethylamine *** employed a multi-faceted approach,combining de novo whole-genome and transcriptome sequencing with comprehensive chemical profiling,enzymatic assays,molecular modeling,and pathway engineering for pathway *** identified four groups of enzymes responsible for the six catalytic steps in the mescaline biosynthetic pathway,and an N-methyltransferase enzyme that N-methylates all phenethylamine intermediates,likely modulating mescaline levels in ***,we reconstructed the mescaline biosynthetic pathway in both Nicotiana benthamiana plants and yeast cells,providing novel insights into several challenges hindering complete heterologous mescaline *** together,our study opens up avenues for exploration of sustainable production approaches and responsible utilization of mescaline,safeguarding this valuable natural resource for future generations.

关键词： mescaline Lophophora williamsi peyote biosynthetic pathway de novo genome sequencing mo-lecular modeling

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Evaluation of p53 codon 72 polymorphism in adenocarcinomas of the colon and rectum in La plata, Argentina

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World Journal of Gastroenterology 2006年第9期12卷 1426-1429页

作者： luis Orlando pérez Martin Carlos Abba Fernando Noel Dulout Carlos Daniel Golijow Centro de Investigaciones en Genética Básica y Aplicada Facultad de Ciencias Veterinarias Universidad Nacional de La PlataCalle 60 y 118 S/NB 1900 AVWLa PlataArgentina

AIM： To evaluate the potential association between p53 codon 72 polymorphism and sporadic colorectal adenocarcinoma development, and human papillornavirus （HpV） infection. METHODS： One-hundred and nine controls and 53 patients with colon cancer from the city of La plata, Argentina were analyzed, p53 codon 72 genotypes and HpV infection were identified using allele-specific polymerase chain reaction and nested polymerase chain reaction, respectively. RESULTS： The differences in the distribution ofp53 codon 72 polymorphisrn between the cases and controls were statistically significant. The arginine allele had a prevalence of 0.65 in controls and 0.77 in cases. The corresponding odds ratio for the homozygous arginine genotype was 2.08 （95% CI, 1.06-4.05; p〈0.05）. Lack of association was found between ,053 polymorphism and HpV infection in the set of adenocarcinomas. CONCLUSION： The findings of the present study indicate that p53 codon 72 arginine homozygous genotype may represent a genetic predisposing factor for colon cancer development. However, further studies are needed in order to elucidate the role of p53 codon 72 polymorphism in colorectal cancer.

关键词： p53 codon 72 polymorphism Human papillomavirus, Colorectal cancer

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Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2233-2240页

作者： Joaquina Martínez-Galán Cristina Jiménez-Luna Isabel Rodriguez Elisabeth Maza Carlos García-Collado Antonio Rodríguez-Fernández Javier luis López-Hidalgo Octavio Caba Department of Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain Instituto de Investigación Biosanitaria Ibs.GranadaGranada 18012Spain Institute of Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain pharmacogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain Department of Medicina Nuclear Virgen de las Nieves University HospitalGranada 18014Spain Department of Anatomía patológica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGROUND Metastatic pancreatic ductal adenocarcinoma(pDAC)is a lethal malignancy with dispiriting survival *** is a promising approach to many cancer types,but achieves poor outcomes in advanced pDAC due to its immunosuppressive tumor *** describe a case of metastatic pDAC effectively treated with *** SUMMARY We report the case of a 67-year-old woman with unresectable locally advanced pDAC,treated with gemcitabine plus nab-paclitaxel followed by radiotherapy plus *** nine months,pancreatic tumor progression was observed at the level of the hepatic hilum with the appearance of a new pulmonary nodule suggestive of a second primary,confirmed by left lung *** immunotherapy was then initiated with pembrolizumab,an immune checkpoint inhibitor targeting programmed cell death protein-1 that covers the two tumor *** patient showed a complete metabolic response that was maintained throughout the *** patient continues to be disease-free at 5.6 years since the start of *** These results suggest that the administration of pembrolizumab after chemoradiotherapy has a beneficial effect in patients with metastatic *** our knowledge,this is the first reported case of a patient with metastatic pDAC and metastatic lung cancer showing such a long-lasting complete response after pembrolizumab treatment without curative *** studies are required to determine biomarkers that identify pDAC patients most likely to benefit from this immunotherapy.

关键词： pancreatic ductal adenocarcinoma Lung cancer Immunotherapy pembrolizumab programmed cell death protein-1 Case report

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Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128

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Neural Regeneration Research 2024年第11期19卷 2532-2542页

作者： Aina Bellver-Sanchis pedro AAvila-López Iva Tic David Valle-García Marta Ribalta-Vilella luis Labrador Deb Ranjan Banerjee Ana Guerrero Gemma Casadesus Coralie poulard Mercè pallàs Christian Grinán-Ferré Department of pharmacology and Therapeutic Chemistry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Institute of Biotechnology National Autonomous University of MexicoCuernavacaMexico Department of pharmacology and Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA Department of Chemistry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Cancer Research Cancer Lyon Universitéde LyonLyonFrance Inserm U1052 Centre de Recherche en Cancérologie de LyonLyonFrance CNRS UMR5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Centro de Investigación en Red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neuroimmunology Department National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

Dysregulation of G9a,a histone-lysine N-methyltransferase,has been observed in Alzheimer’s disease and has been correlated with increased levels of chronic inflammation and oxidative ***,microRNAs are involved in many biological processes and diseases playing a key role in pathogenesis,especially in multifactorial diseases such as Alzheimer’s ***,our aim has been to provide partial insights into the interconnection between G9a,microRNAs,oxidative stress,and *** better understand the biology of G9a,we compared the global microRNA expression between senescence-accelerated mouse-prone 8(SAMp8)control mice and SAMp8 treated with G9a inhibitor *** found a downregulation of miR-128 after a G9a inhibition treatment,which interestingly binds to the 3′untranslated region(3′-UTR)of peroxisome-proliferator activator receptor γ(ppARG)***,pparg gene expression levels were higher in the SAMp8 group treated with G9a inhibitor than in the SAMp8 control *** also observed modulation of oxidative stress responses might be mainly driven pparg after G9a *** confirm these antioxidant effects,we treated primary neuron cell cultures with hydrogen peroxide as an oxidative *** this setting,treatment with G9a inhibitor increases both cell survival and antioxidant ***,up-regulation of ppARγby G9a inhibitor could also increase the expression of genes involved in DNA damage responses and *** addition,we also described that the ppARγ/AMpK axis partially explains the regulation of autophagy markers ***,ppARγ/GADD45αpotentially contributes to enhancing synaptic plasticity and neurogenesis after G9a ***,we propose that pharmacological inhibition of G9a leads to a neuroprotective effect that could be due,at least in part,by the modulation of ppARγ-dependent pathways by miR-128.

关键词： aging cognitive decline epigenetics G9a inhibition microRNAs miR-128 peroxisome-proliferator activator receptorγ(ppARγ) ppARG SAMp8

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Urbanization has opposite effects on the territory size of two passerine birds

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Avian Research 2020年第2期11卷 191-199页

作者： Roselvy Juárez Eduardo Chacón‑Madrigal luis Sandoval Escuela de Biología Universidad de Costa RicaCP:11501‑2060San PedroMontes de OcaSan JoséCosta Rica Ambientey Desarrollo Universidad ZamoranoCarretera a Danlíkm 30Francisco MorazánHonduras.

Background:Urban expansion has been identified as one of the leading drivers of biodiversity change or *** birds,urbanization is specifically related to survival,breeding success,and territory *** how different birds adjust territory size in response to urbanization is essential for their conservation in urban environments and to better understand why some species are lost and others persist under this *** evaluated the effect of urbanization on the territory size of an urban avoider species,White-eared Ground-Sparrow(Melozone leucotis),and an urban adapter species,House Wren(Troglodytes aedon),at five Costa Rican ***:We measured the size of 30 ground-sparrow and 28 wren territories using a total of 296 h of *** followed each individual for at least 1 h per day for at least 2 days of two consecutive years,and geo-referenced their *** size was estimated using the minimum convex polygon *** measured the urban surfaces(roads,buildings,any other paved area,soccer fields,lawns,and gardens with short grass)within ***:Ground-sparrow territories were larger at the highly urbanized site than at the non-urbanized *** territories were larger at the low urbanized site than at the highly urbanized *** found a positive relationship between urban surface and territory size for the ground-sparrow,but not for the ***:Our results showed that not all birds adjust territory size in the same way in response to *** showed that urban avoiders probably need to defend larger territories in urban environments to find all the resources required to survive because urban environments may provide insufficient resources such as food or *** adapters on the other hand defend smaller territories in urban environments because even small territories may provide sufficient *** results suggest specific behavioral adaptations developed by Neotropical birds inha

关键词： House Wren Melozone leucotis Troglodytes aedon Urban adapter Urban avoider Urban-rural gradient Territory size White‑eared Ground‑Sparrow

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Catalytic feasibility of Ce-doped LaCoO_(3) systems for chlorobenzene oxidation:An analysis of synthesis method

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Journal of Rare Earths 2022年第6期40卷 897-905,I0002页

作者： Héctor Acosta pérez Carlos A.López luis E.Cadús Fabiola N.Agüero Chemical Technology Research Institute(INTEQUI) UNSL-CONICETFaculty of Biochemical Chemistry and Pharmacy(UNSL)Almirante Brown 14555700San LuisArgentina

A family of Ce-doped LaCoO_(3) perovskites are presented as possible catalysts for Cl-VOCs *** materials with different contents of Ce were obtained through the citrate and the reactive grinding *** insertion of Ce in the original perovskite structure favours the presence of Co^(2+)/Co^(3+) and Ce^(3+)/Ce^(4+) redox pairs and a higher content of oxygen vacancies that enhances the catalytic performance in chlorobenzene combustion based on differential kinetics *** family obtained by the grinding method presents a performance as high as that synthesized by citrate ***,the reactive grinding is a feasible green chemistry alternative to obtain a catalyst with the same performance as that obtained from traditional ***,the stability of samples was evaluated under total combustion reaction conditions showing an excellent activity during 45 h time on stream.

关键词： Cl-VOCs perovskites Chlorobenzene Cerium Cobalt Rare earths

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