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Animal models used to study direct peripheral nerve repair: a systematic review

neural Regeneration Research 2020年第3期15卷 491-502页

作者： Francisco Javier Vela Guadalupe martínez-Chacón Alberto Ballestín.joséluis Campos Francisco Miguel Sánchez-Margallo Elena Abellán Department of Microsurgery Jesús Usón Minimally Invasive Surgery CentreCáceresSpain Scientific Director Jesús Usón Minimally Invasive Surgery CentreCáceresSpain

Objective:Peripheral nerve repair is required after traumatic *** common condition represents a major public health problem *** after nerve repair depends on several factors,including the severity of the injury,the nerve involved,and the surgeon’s technical *** the precise microsurgical repair of nerve lesions,adequate functional recovery is not always achieved and,therefore,the regeneration process and surgical techniques are still being ***-clinical animal models are essential for this research and,for this reason,the focus of the present systematic review(according to the PRISMA statement)was to analyze the different animal models used in pre-clinical peripheral nerve repair *** sources:Original articles,published in English from 2000 to 2018,were collected using the Web of Science,Scopus,and PubMed *** selection:Only preclinical trials on direct nerve repair were included in this *** articles were evaluated by the first two authors,in accordance with predefined data *** measures:The primary outcomes included functional motor abilities,daily activity and regeneration *** outcomes included coaptation technique and animal ***:This review yielded 267 articles,of which,after completion of the screening,49 studies were *** were 1425 animals in those 49 studies,being rats,mice,guinea pigs,rabbits,cats and dogs the different pre-clinical *** nerves used were classified into three groups:head and neck(11),forelimb(8)and hindlimb(30).The techniques used to perform the coaptation were:microsuture(46),glue(12),laser(8)and mechanical(2).The follow-up examinations were histology(43),electrophysiological analysis(24)and behavioral observation(22).Conclusion:The most widely used animal model in the study of peripheral nerve repair is the *** animal models are also used but the cost-benefit of the rat model provides several strengths over the ***

关键词： nerve microsurgery peripheral nerve regeneration repair reconstruction direct nerve repair animal model coaptation PRISMA systematic review

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Relationships between soil pollution by heavy metals and melanin-dependent coloration of a fossorial amphisbaenian reptile

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Integrative Zoology 2022年第4期17卷 596-607页

作者： josémartÍn Pablo RECIO Gonzalo RODRÍGUEZ-RUIZ Isabel BARJA Eduardo GUTIÉRREZ luis VGARCÍA Departamento de Ecología Evolutiva Museo Nacional de Ciencias NaturalesCSICMadridSpain Departamento de Zoología Facultad de BiologíaUniversidad Autónoma de MadridMadridSpain Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridMadridSpain Departamento de Biogeoquímica Ecología Vegetal y MicrobianaInstituto de Recursos Naturales y Agrobiología de SevillaCSICSevillaSpain

Melanin is the basis of coloration in many animals,and although it is often used in communication,thermoregulation,or camouflage,melanin has many other physiological *** example,in polluted habitats,melanin can have a detoxifying *** coloration would help to sequester in the skin the heavy metal contaminants from inside the body,which will be expelled to the exterior when the skin is ***,animals should have evolved more melanic colorations in more polluted habitats(“industrial melanism”hypothesis).We examined whether the fossorial amphisbaenian reptile,Trogonophis wiegmanni,is able to eliminate heavy metals,derived from soil pollution by seagull depositions,through sloughing its *** results suggest a covariation between levels of soil pollution by heavy metals and the concentration of heavy metals in the sloughed skins of *** suggests that amphisbaenians may expel heavy metals from their bodies when they slough the *** also tested whether amphisbaenians inhabiting soils with higher levels of heavy metal pollution had darker(melanin-dependent)body ***,contrary to predictions from the“industrial melanization”hypothesis,we found a negative relationship between soil pollution and proportions of melanic *** contradictory result could,however,be explained because heavy metals have endocrine disruption effects that increase physiological stress,and higher stress levels could result in decreased *** suggest that although amphisbaenians might have some detoxifying mechanism linked to melanin in the skin,this process might be negatively affected by stress and result ineffective under conditions of high soil pollution.

关键词： amphisbaenians coloration fossorial reptiles heavy metals melanin soil pollution

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Towards Innovative Research Approaches to Investigating the Role of Emotional Variables in Promoting Language Teachers’ and Learners’ Mental Health

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International Journal of Mental Health Promotion 2023年第7期25卷 823-832页

作者： Ali Derakhshan Yongliang Wang Yongxiang Wang josé luis Ortega-martín Department of English Language and Literature Faculty of Humanities and Social SciencesGolestan UniversityGorgan15759-49138Iran School of Foreign Languages and Cultures Nanjing Normal UniversityNanjing210023China Department of Didactics of Language and Literature Faculty of EducationUniversity of GranadaGranada18071Spain

The adequacy of language education largely depends on the favorable and unfavorable emotions that teachers and students experience throughout the education *** said,emotional factors play a key role in improving the quality of language teaching and ***,these emotional factors also promote the well-being of language teachers and learners and place them in a suitable mental *** view of the favorable impact of emotional factors on the mental health of language teachers and learners,many educational scholars around the world have studied these factors,their background,and their pedagogical ***,the majority of previous studies have employed traditional research methods in assessing these variables and their inﬂuences on language teachers’and learners’mental *** of the complex and dynamic quality of emotional factors,traditional research approaches often fail to evaluate these factors and their dynamic,non-linear connections with teachers’and learners’mental health and ***,some novel research approaches are required to measure the dynamicity and complexity of emotional factors in language education *** address this call,the current state-of-the-art conceptual article seeks to provide new insights for investigating emotional factors and their potential impact on language teachers’and learners’mental *** study also intends to offer a comprehensive list of emerging methods that take into account the complex and dynamic nature of emotional ***,the study outlines the potential implications of this review for educational researchers.

关键词： Complexity dynamicity emotional factors mental health well-being innovative research approaches second and foreign language education

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nickel-based cerium zirconate inorganic complex structures for CO_(2)valorisation via dry reforming of methane

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Journal of Environmental Sciences 2024年第6期140卷 12-23页

作者： Juan luis martín-Espejo Loukia-Pantzechroula Merkouri Jesús Gándara-Loe josé Antonio Odriozola Tomas Ramirez Reina Laura Pastor-Pérez Department of Inorganic Chemistry and Material Sciences Institute of Seville University of Seville-CSICSeville 41092Spain Department of Chemical and Process Engineering University of SurreyGuildford GU27XHUnited Kingdom

The increasing anthropogenic emissions of greenhouse gases(GHG)is encouraging extensive research in CO_(2)*** reforming of methane(DRM)depicts a viable strategy to convert both CO_(2)and CH4into syngas,a worthwhile chemical *** the different active phases for DRM,the use of nickel as catalyst is economically favourable,but typically deactivates due to sintering and carbon *** stabilisation of ni at different loadings in cerium zirconate inorganic complex structures is investigated in this work as strategy to develop robust ni-based DRM *** and TPR-H2analyses confirmed the existence of different phases according to the ni loading in these ***,superficial ni is observed as well as the existence of a CeniO_(3)perovskite *** catalytic activity was tested,proving that 10 wt.%ni loading is the optimum which maximises *** catalyst was also tested in long-term stability experiments at 600and 800℃in order to study the potential deactivation issues at two different *** 600℃,carbon formation is the main cause of catalytic deactivation,whereas a robust stability is shown at 800℃,observing no sintering of the active phase evidencing the success of this strategy rendering a new family of economically appealing CO_(2)and biogas mixtures upgrading catalysts.

关键词： CO_(2)conversion Dry reforming of methane nickel catalysts Pyrochlore Cerium zirconate

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Re-folded structure of syn-orogenic granitoids(Padrón dome, nW Iberia):Assessing rheological evolution of cooling continental crust in a collisional setting

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Geoscience Frontiers 2019年第2期10卷 651-669页

作者： Rubén Díez Fernández Francisco J.Rubio Pascual luis Miguel martín Parra Departamento de Geodinámica Estratigrafía y PaleontologíaFacultad de Ciencias GeológicasUniversidad Complutense de Madrid Instituto Geológico y Minero de Espana

This contribution discusses about the rheological, kinematic and dynamic frameworks necessary to produce recumbent and upright folds from syn-orogenic granitic massifs that were formed during an early stage of magma genesis related to the onset of a migmatitic dome. Syn-kinematic granitoids occurring within the high-grade infrastructure of the Padron migmatitic dome(nW Iberia) are deformed into largescale recumbent folds(D_2) that are later affected by upright folds(D_3). Petrostructural analysis of a selected area of this dome reveals that after a period of crustal thickening(D_1), nnW-directed extensional flow gave way to recumbent folds and penetrative axial plane foliation(S_2). Superimposed subhorizontal compression resulted in upright folds(D_3). A closer view into the dynamics of the dome allows exploring the factors that may condition the nucleation of folds with contrasting geometries during progressive deformation of molten continental crust. The formation of folds affecting syn-kinematic granitoids suggests a cooling metamorphic path in migmatitic domes. Active and passive folding mechanisms require a crystallizing(cooling) magma to nucleate folds. A more competent metamorphic host inhibits fold nucleation from much less competent magmas. As it crystallizes, magma becomes more rigid(competent),and approaches viscosity values of its host. Passive folding is favored when no significant competence contrast exists between magma and host, so this folding mechanism is more likely shortly after magma genesis and emplacement. In such conditions, and under dominant subhorizontal flow accompanied by flattening(D_2),passive folding would produce isoclinal recumbent geometries. Further magma cooling introduces a shift into the rheological behavior of partially molten crust. Thereon, crystallizing magma bodies would represent significant competence contrasts relative to their host. At this point, buckling is a more likely folding mechanism, and more regular, buckle fo

关键词： Recumbent folds Migmatitic domes Partial melting Crustal-derived granitoids Orogenic collapse Variscan orogen

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Visual perception alterations in COVID-19:a preliminary study

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 1-9页

作者： María Begoña Coco-martín luis Leal-Vega Irene Alcoceba-Herrero Ainhoa molin.-martín Dolores de-Fez María joséLuque Carlos Dueñas-Gutiérrez Juan Francisco Arenillas-Lara David PPiñero Group of Applied Clinical neurosciences and Advanced Data Analysis Department of MedicineDermatology and ToxicologyUniversity of ValladolidValladolid 47005Spain Group of Optics and Visual Perception Department of OpticsPharmacology and AnatomyUniversity of AlicanteAlicante 03690Spain Department of Optics and Optometry and Vision SciencesUniversity of ValenciaValencia 46100Spain COVID-19 Unit Department of Internal MedicineUniversity Clinical Hospital of ValladolidValladolid 47003Spain Stroke Unit Department of NeurologyUniversity Clinical Hospital of ValladolidValladolid 47003Spain Clinical Optometry Unit Department of OphthalmologyVithas Medimar International HospitalAlicante 03016Spain

AIM:To compare the visual perception(color and chromatic-achromatic contrast vision)of a small cohort of COVID-19 patients at the time of infection and after 6mo with that of a healthy population matched for sex and ***:A total of 25 patients(9 females,16 males,mean age:54±10y)with COVID-19 hospitalized in the COVID-19 Unit of the University Clinical Hospital of Valladolid were recruited for this preliminary *** perception,as determined by monocular measurement of contrast sensitivity function(CSF)and color vision was assessed in each patient using the Optopad *** results obtained were then compared with those of a sample of 16 age-and sex-matched healthy controls(5 females,11 males,mean age:50±6y)in which the same measurement procedure was *** significant differences between groups were assessed using the Mann-Whitney U *** were repeated after a minimum follow-up period of 6mo and statistically significant differences between the two time points in each group were assessed using the Wilcoxon signed rank ***:Discrimination thresholds(color and chromatic-achromatic contrast vision)and their corresponding sensitivity,calculated as the inverse of the discrimination threshold,were *** of the data revealed higher contrast threshold results(i.e.,worse contrast sensitivity)in the COVID-19 group than in the control group for all spatial frequencies studied in the Optopad-CSF achromatic test and most of the spatial frequencies studied in the Optopad-CSF chromatic test for the red-green and blue-yellow *** addition,color threshold results in the COVID-19 group were also significantly higher(i.e.,worse color sensitivity)for almost all color mechanisms studied in the Optopad-Color *** 6mo,most of the differences found between the groups were maintained despite COVID-19 ***:The present results provide preliminary evidence that visual perception may be impaired in COVID-19

关键词： SARS-CoV-2 COVID-19 visual perception contrast sensitivity function color vision

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Inverted Meckel’s diverticulum diagnosed using capsule endoscopy: A case report

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World Journal of Gastroenterology 2021年第36期27卷 6154-6160页

作者： Ismael El Hajra martínez marta Calvo joséluis martínez-Porras Lucia Gomez-Pimpollo Garcia jose L Rodriguez Carmen Leon.joséluis Calleja Panero Department of Gastroenterology Hospital Universitario Puerta de HierroMadrid 28222Spain Department of Radiology Hospital Universitario Puerta de HierroMadrid 28222Spain Department of Diagnostic Pathology Hospital Universitario Puerta de HierroMadrid 28222Spain Department of Surgery Hospital Universitario Puerta de HierroMadrid 28222Spain

BACKGROUnD Meckel’s diverticulum is a common asymptomatic congenital gastrointestinal ***,its presentation as an inverted Meckel's diverticulum is a rare complication,of which few cases have been reported in the *** SUMMARY Here,we report the case of a 33-year-old man with iron deficiency anemia without manifestation of gastrointestinal *** upper gastrointestinal endoscopy and total colonoscopy were performed,but no abnormalities were found within the observed ***,a capsule endoscopy was performed and offered us a clue to subsequently confirm the diagnosis of inverted Meckel's diverticulum via computed tomography *** intestinal resection surgery was *** final pathology report described a Meckel’s *** Since inverted Meckel's diverticulum is an uncommon disease and its clinical presentation is not specific,it may go undetected by capsule *** diagnosis and treatment of this disease requires a high index of clinical suspicion.

关键词： Inverted Meckel’s diverticulum Capsule endoscopy Anemia study Small bowel tumor Case report

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A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells

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Cellular & Molecular Immunology 2023年第12期20卷 1499-1512页

作者： Leticia martín-Cruz Marcos Viñuela Ioanna Kalograiaki Alba Angelina Paola Oquist-Phillips Irene Real-Arévalo Francisco Javier Cañada joséIgnacio Tudela luis Moltó Jesús Moreno-Sierra joséluis Subiza Oscar Palomares Department of Biochemistry and Molecular Biology School of ChemistryComplutense University of MadridMadridSpain Inmunotek Alcaláde HenaresMadridSpain Fundación Investigación Hospital Clínico San Carlos Martin Lagos s/n28040MadridSpain Centro de Investigaciones Biológicas Margarita Salas CSICRamiro de Maetzu 928040MadridSpain CIBER de Enfermedades Respiratorias(CIBERES)Avda Monforte de Lemos3-528029MadridSpain Servicio de Urología Hospital Clínico San CarlosUniversidad Complutense de MadridMartín Lagos s/n28040MadridSpain

Functional Tregs play a key role in tumor development and progression,representing a major barrier to anticancer *** mechanisms by which Tregs are generated in cancer and the influence of the tumor microenvironment on these processes remain incompletely ***,by using nMR,chemoenzymatic structural assays and a plethora of in vitro and in vivo functional analyses,we demonstrate that the tumoral carbohydrate A10(Ca10),a cell-surface carbohydrate derived from Ehrlich’s tumor(ET)cells,is a heparan sulfate-related proteoglycan that enhances glycolysis and promotes the development of tolerogenic features in human ***10-stimulated human DCs generate highly suppressive Tregs by mechanisms partially dependent on metabolic reprogramming,PD-L1,IL-10,and ***10 also reprograms the differentiation of human monocytes into DCs with tolerogenic *** solid ET-bearing mice,we found positive correlations between Ca10 serum levels,tumor size and splenic Treg *** of isolated Ca10 also increases the proportion of splenic Tregs in tumor-free ***,we provide evidence supporting the presence of a circulating human Ca10 counterpart(Ca10H)and show,for the first time,that serum levels of Ca10H are increased in patients suffering from different cancer types compared to healthy *** note,these levels are higher in prostate cancer patients with bone metastases than in prostate cancer patients without ***,we reveal novel molecular mechanisms by which heparan sulfate-related structures associated with tumor cells promote the generation of functional Tregs in *** discovery of this novel structural-functional relationship may open new avenues of research with important clinical implications in cancer treatment.

关键词： Tumoral carbohydrate A10 Heparan sulfate-related proteoglycan Cancer immunology Dendritic cell Regulatory T cell

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Heparan sulfate proteoglycans as possible diagnostic molecular tools with therapeutic potential in Alzheimer′s disease

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neural Regeneration Research 2021年第7期16卷 1404-1405页

作者： Iván Fernández-Vega Laura Lorente-Gea Carla martín luis M.Quirós Department of Pathology Hospital Universitario Central de Asturias/Biobank of Principality of AsturiasHealth Research Institute of the Principality of AsturiasOviedoSpain Department of Pathology Hospital Universitario de Araba-Txagorritxu/Biobanco Vasco para la Investigación(O+eHun)Brain BankHospital UniversitarioVitoriaSpain Instituto Universitario Fernández-Vega OviedoSpain Department of Functional Biology University of OviedoSpain

Importance of dementia and Alzheimer's disease(AD): On Earth, there is a "country" that we call Dementia with around 50 million inhabitants and an estimated global economic cost of US $1 trillion(Wimo et al., 2017).AD may contribute to 60–70% of cases, with other major forms of dementia being vascular dementia, dementia with Lewy bodies and a group of diseases that contribute to frontotemporal ***, the boundaries between different forms of dementia are indistinct and mixed forms often co-exist, which are only confirmed after postmortem neuropathological studies(Fernandez-Vega et al., 2015).

关键词： al. diseases Alzheimer

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3-Point Bending of Bars and Rods Made of Materials Obeying a Ramberg-Osgood Criterion

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World Journal of Mechanics 2011年第3期1卷 71-77页

作者： josé luis Lanzagorta Antonio martín-Meizoso 不详

Equations are derived for the non-linear bending of cantilever and 3-point bending of beams (with a non uniform moment distribution along its length) made of materials described according to Ramberg-Osgood behaviour (... 详细信息

关键词： Bending non-Linear Ramberg-Oswood

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