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e.olution of se.ual size.dimorphism and its re.ationship with se. ratio in carabid be.tle. of Ge.us Ce.oglossus Solie.

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Curre.t Zoology 2013年第6期59卷 769-777页

作者： Hugo A. Be.ITe. Jorge.AVARIA-LLAUTURe. Cristian B.CANALe.-AGUIRRe.Viviane.Je.e. luis e. parra Cristifin e.He.NANDe. Faculty of Life.Scie.ce. University of Manchester Michael Smith Building Oxford Road Manchester M13 9PT UK Instituto de.Alta Inve.tigaci6n Universidad de Tarapaca Casilla 7-D Arica Chile De.artame.to de.Zoologia Facultad de Ciencias Naturales y Oceanograficas Universidad de Concepcion Casilla 160-C Concepcion Chile De.artame.to de.Oce.nografia Facultad de Ciencias Naturales y Oceanograficas Universidad de Concepci6n Casilla 160-C Concepcion Chile

Although the.de.re. of mate.compe.ition, give. e.tre.e.diffe.e.ce. in se. ratio, e.plains much of the.patte.n of male.biase. size.dimorphism among dive.se.taxa, it fails for some.spe.ie. which have.pote.tial for inte.se.male.compe.ition for mate. and ye. e.hibit little.or no se.ual size.dimorphism (SSD). This fact sugge.t that spe.ie. with low SSD should be.e.pre.s the.e.fe.t of e.olutionary pre.sure.in non-obvious ge.me.rical shape.promote. by se. ratio in an e.olutionary time.scale. To e.aluate.this hypothe.is we.use. phyloge.e.ic comparative.me.hod in a Baye.ian frame.ork to inve.tigate.the.e.olution of SSD and the.role.of se. ratio at inte.-spe.ific le.e. in the.spe.ie. ofCe.oglossus(Cole.pte.a: Carabidae.. In our re.ults the.proportion farthe.t from 1:1 is associate. with more.disparate.body shape. e.e. though the.e.tire.group has minimum variation in se. ratio, which is an intrinsic life.history characte. of this group conside.ing its phyloge.e.ic conse.vatism or phyloge.e.ic signal. We.sugge.t that the.se. ratio has de.e.mine. the.dimorphism de.re. during e.olution of this group, since.both traits have.incre.se. or de.re.se. toge.he. during the.spe.ie. dive.ge.ce.(i.e. positive.phyloge.e.ic corre.ation: r2≈0.85). We.sugge.t that morphological studie. of SSD will be.e.it from using comparative.me.hod with Baye.ian approache. to asse.s the.e.fe.t of phyloge.e.ic history and its unce.tainty. Finally, this will be.allow to re.e.rche.s to quantify the.unce.tainty of spe.ific e.olutionary hypothe.e. accounting for obse.ve. se.ual dimorphism patte.ns.

关键词：进化保守性性别比例两性异形步甲科贝叶斯方法物种分化系统发育不确定性

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Ca-base. mate.ials de.ive. from calcine. cigare.te.butts for CO_(2)capture.and the.moche.ical e.e.gy storage

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Journal of e.vironme.tal Scie.ce. 2024年第6期140卷 230-241页

作者： Nabil Amghar Virginia More.o Pe.ro e.Sánche.-Jiméne. Antonio Pe.e.ón luis A.Pére.-Maque.a Instituto de.Cie.cia de.Mate.iale. de.Se.illa C.S.I.C.-Universidad de SevillaC.Américo Vespucio4941092 SevillaSpain Instituto de.Te.nología de.Mate.iale.(ITM) Universitat Politècnica de València(UPV)Plaza Ferrándiz y Carbonell 1AlcoyAlicante 03801Spain De.artame.to de.Química Inorgánica Facultad de QuímicaUniversidad de Sevilla41012 SevillaSpain

Cigare.te.butts(CBs)are.one.of the.most common type. of litte. in the.*** to the.toxic substance. the. contain,the.waste.ge.e.ate. pose. a harmful risk to the.e.vironme.t,and the.e.ore.the.e.is an urge.t ne.d for alte.native.solutions to landfill ***,this work pre.e.ts a possible.re.alorization of this waste.mate.ial,which implie. inte.e.ting e.vironme.tal *** we.e.use. as sacrificial te.plate. for the.pre.aration of CaO-base. mate.ials by impre.nation with calcium and magne.ium nitrate. followe. by flaming *** mate.ials pre.e.te. e.hance. porosity for the.r use.in the.Calcium Looping proce.s applie. e.the. to the.moche.ical e.e.gy storage.or CO_(2)capture.*** influe.ce.of the.conce.tration of Ca and Mg in the.impre.nating solutions on the.multicycle.re.ctivity of the.sample. was *** improve. multicycle.pe.formance.was obtaine. in te.ms of conve.sion for both applications.

关键词： Cigare.te.butts Calcium-Looping CO_(2)Capture The.moche.ical e.e.gy storage

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Optical magne.ic fie.d e.hance.e.t using ultrafast azimuthally polarize. lase. be.ms and tailore. me.allic nanoante.nas

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Photonics Re.e.rch 2024年第5期12卷 1078-1092页

作者： RODRIGO MARTIN-He.NANDe. LORe.Z GRUNe.ALD luis SANCHe.-Te.e.INA luis PLAJA e.RIQUe.ONe.e.O JARQUe.CARLOS He.NANDe.-GARCIA Se.ASTIAN MAI Grupo de.Inve.tigacion e. Aplicacione. de. Lase. y Fotonica Departamento de Fisica AplicadaUniversidad de SalamancaE-37008 SalamancaSpain Unidad de.e.ce.e.cia e. Luz y Mate.ia e.tructuradas(LUMe.) Universidad de SalamancaE-37008 SalamancaSpain Institute.of The.re.ical Che.istry Faculty of ChemistryUniversity of Vienna1090 ViennaAustria Vie.na Doctoral School in Che.istry(DoSChe.) Faculty of ChemistryUniversity of Vienna1090 ViennaAustria De.artame.to de.e.e.tricidad y e.e.trónica Universidad de Valladolid47011 ValladolidSpain

*** *** thank Vale.tina Shumakova,e.izave.a Gangrskaia,Ale.sandra Be.lissimo,Audrius Pugzlys,and Andrius Baltu?ka for fruitful discussions and computational support by the.Vie.na Scie.tific Cluste.(VSC 4).The.authors thankfully acknowle.ge.the.compute. re.ource. at Mare.ostrum and SCAYLe.and the.te.hnical support provide. by Barce.ona Supe.computing Ce.te.(Re.-FI-2022-3-0041).R.M.-H.,L.S.-T.,L.P.,e.C.J.,and C.H.-*** funding from the.e.rope.n Re.e.rch Council(e.C)unde. the.e.rope.n Union’s Horizon 2020 re.e.rch and innovation program(Grant Agre.me.t No.851201)and support from Ministe.io de.Cie.cia e.Innovación(PID2022-142340NB-I00,PID2019-106910GB-I00).This re.e.rch was funde. in whole.or in part by the.Austrian Scie.ce.Fund(FWF)(10.55776/ZK91).For ope. acce.s purpose.,the.author has applie. a CC BY public copyright lice.se.to any author acce.te. manuscript ve.sion arising from this submission.

关键词： me.allic polarize. discussions

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Bre.king paradigms: Long non-coding RNAs forming ge.e.fusions with pote.tial implications in cance.

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Ge.e. & Dise.se. 2024年第3期11卷 311-323页

作者： David Sanche.-Marin Macrina Be.triz Silva-Cazare. Fany Iris Porras-Re.e. Re.e.a Garcia-Roman Alma D.Campos-parra Posgrado e. Cie.cias Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unidad Acade.ica Multidisciplinaria Re.ion Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Se.vicio de.Anatomia Patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto de.Salud Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-coding RNAs(lncRNAs)are.non-coding RNAs longe. than 200 nucle.tide. with dynamic re.ulatory *** inte.act with a wide.range.of mole.ule. such as DNA,RNA,and prote.ns to modulate.dive.se.ce.lular functions through se.e.al me.hanisms and,if de.e.ulate.,the. can le.d to cance. de.e.opme.t and ***,it has be.n de.cribe. that IncRNAs are.susce.tible.to form ge.e.fusions with mRNAs or othe. IncRNAs,bre.king the.paradigm of ge.e.fusions consisting mainly of prote.n-coding ***,the.r biological significance.in the.tumor phe.otype.is still ***,the.r re.e.t ide.tification ope.s a ne. line.of re.e.rch to study the.r biological role.in tumor-ige.e.is,and the.r pote.tial as biomarke.s with clinical re.e.ance.or as the.ape.tic *** pre.e.t study aime. to re.ie. the.IncRNA fusions ide.tifie. so far and to know which of the. have.be.n associate. with a pote.tial *** addre.s the.curre.t challe.ge. to de.pe. the.r study as we.l as the.re.sons why the. re.re.e.t a future.the.ape.tic window incance..

关键词： Cance. Ge.e.usions IncRNAs ncRNAs The.apy

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Ne.roge.ic pote.tial of NG2 in ne.rotrauma:a syste.atic re.ie.

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Ne.ral Re.e.e.ation Re.e.rch 2024年第12期19卷 2673-2683页

作者： Yuri R.Rigo Radharani Be.ve.utti luis V.Porte.a Nathan R.Strogulski De.artame.to de.Bioquímica Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul(UFRGS)Porto AlegreBrazil School of Pharmacy and Biomole.ular Scie.ce. RCSI University of Medicine and Health SciencesDublinIreland School of Bioche.istry and Immunology Trinity Biomedical Sciences InstituteTrinity College DublinUniversity of DublinDublinIreland

Re.e.e.ative.approache. towards ne.ronal loss following traumatic brain or spinal cord injury have.long be.n conside.e. a dogma in ne.roscie.ce.and re.ain a cutting-e.ge.are. of *** is re.le.te. in a large.disparity be.we.n the.numbe. of studie. inve.tigating primary and se.ondary injury as the.ape.tic to rge.s in spinal co rd and traumatic brain *** advance. in biote.hnology may have.the.pote.tial to re.hape.the.curre.t state.of-the.art and bring focus to primary injury ne.rotrauma *** studie. using ne.ral-glial factor/antige. 2(NG2)ce.ls indicate.that the. may diffe.e.tiate.into ne.rons e.e. in the.de.e.ope. *** the.e.ce.ls show gre.t pote.tial to play a re.e.e.ative.role.studie. have.be.n conducte. to te.t various manipulations in ne.rotrauma mode.s aime. at e.iciting a ne.roge.ic re.ponse.from *** the.pre.e.t study,we.syste.atically re.ie.e. the.e.pe.ime.tal protocols and findings de.cribe. in the.scie.tific lite.ature.which we.e.pe.r-re.ie.e. original re.e.rch article.(1)de.cribing pre.linical e.pe.ime.tal studie.,(2)inve.tigating NG2 ce.ls,(3)associate. with ne.roge.e.is and ne.rotrauma,and(4)in vitro and/or in vivo,available.in PubMe./Me.LINe.We. of Scie.ce.or SCOPUS,from 1998 to ***,we.have.re.ie.e. a total of 1504 pape.s,and summarize. findings that ultimate.y sugge.t that NG2 ce.ls posse.s an inducible.ne.roge.ic pote.tial in animal mode.s and in *** also discriminate.findings of NG2 ne.roge.e.is promote. by diffe.e.t pharmacological and ge.e.ic approache. ove. functional and bioche.ical outcome. of traumatic brain injury and spinal co rd injury mode.s,and provide.mounting e.ide.ce.for the.pote.tial be.e.its of manipulate. NG2 ce.l e. vivo transplantation in primary injury *** findings indicate.the.fe.sibility of NG2 ce.l ne.roge.e.is strate.ie. and add ne. playe.s in the.de.e.opme.t of the.ape.tic alte.native. for ne.rotrauma.

关键词： ne.ral-glial antige. 2 ne.ral-glial factor 2 ne.ron diffe.e.tiation NG2 ce.l re.e.e.ation spinal cord injury(SCI) traumatic brain injury(TBI)

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Towards an inte.rate. risk analysis se.urity frame.ork according to a syste.atic analysis of e.isting proposals

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Frontie.s of Compute. Scie.ce 2024年第3期18卷 199-216页

作者： Antonio SANTOS-OLMO luis e.rique.SÁNCHe. David G.ROSADO Manue. A.Se.RANO Carlos BLANCO Haralambos MOURATIDIS e.uardo Fe.NÁNDe.-Me.INA GSyA Re.e.rch Group University of Castilla-La ManchaCiudad Real 13071Spain Institute.for Analytics and Data Scie.ce University of EssexColchester CO43SQUK Alarcos Re.e.rch Group University of Castilla-La ManchaCiudad Real 13071Spain ISTR Re.e.rch group Department of Computer Science and ElectronicsUniversity of CantabriaSantander 39005Spain

The.information socie.y de.e.ds incre.singly on risk asse.sme.t and manage.e.t syste.s as me.ns to ade.uate.y prote.t its ke. information *** availability of the.e.syste.s is now vital for the.prote.tion and e.olution of ***,se.e.al factors have.le. to an incre.sing ne.d for more.accurate.risk analysis *** are.the.spe.d at which te.hnologie. e.olve.the.r global impact and the.growing re.uire.e.t for companie. to *** analysis proce.se. must conse.ue.tly adapt to the.e.ne. circumstance. and ne. te.hnological *** obje.tive.of this pape. is,the.e.ore.to pre.e.t the.re.ults of an e.haustive.analysis of the.te.hnique. and me.hods offe.e. by the.scie.tific community with the.aim of ide.tifying the.r main we.kne.se. and providing a ne. risk asse.sme.t and manage.e.t *** analysis was carrie. out using the.syste.atic re.ie. protocol and found that the.e.proposals do not fully me.t the.e.ne. *** pape. also pre.e.ts a summary of MARISMA,the.risk analysis and manage.e.t frame.ork de.igne. by our re.e.rch *** basis of our frame.ork is the.main e.isting risk standards and proposals,and it se.ks to addre.s the.we.kne.se. found in the.e.*** is in a proce.s of continuous improve.e.t,as is be.ng applie. by custome.s in se.e.al e.rope.n and Ame.ican *** consists of a risk data manage.e.t module.a me.hodology for its syste.atic application and a tool that automate. the.proce.s.

关键词： information se.urity manage.e.t se.urity syste. se.urity risk asse.sme.t and manage.e.t

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HVOF-spraye. HAp/S53P4 BG composite.coatings on an AZ31 alloy for pote.tial applications in te.porary implants

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Journal of Magne.ium and Alloys 2024年第1期12卷 345-360页

作者： Carlos A.Poblano-Salas John He.ao Astrid L.Giraldo-Be.ancur Paola Fore.o-Sossa Die.o Ge.man e.pinosa-Arbe.ae. Jorge.A.Gonzále.-Sánche. luis R.Dzib-Pére. Susana T.e.trada-Moo Ide.fonso e.Pe.h-Pe.h CIATe. A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-CIATe. A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-Cinve.tav Libramiento Norponiente#2000.Fraccionamiento Real de JuriquillaQuerétaro 76230Mexico Unive.sidad Te.nológica de.Que.étaro Av.Pie de la Cuesta N°2501Querétaro 76148Mexico CIDe.I Av.Playa Pie de la Cuesta No 702Col.San PabloQuerétaro 76125Mexico Ce.te. for Corrosion Re.e.rch Autonomous University of CampecheAv.Héroe de Nacozari No.480P.C.24070San Francisco de CampecheCam.Mexico

Bioactive.the.mal spray coatings produce. via high-ve.ocity oxyge. fue. spray(HVOF)from hydroxyapatite.HAp)and bioactive.glasse.(BG)have.the.pote.tial to be.e.ploye. on te.porary implants due.to the.ability of both HAp and BG to dissolve.and promote.osse.inte.ration,conside.ing that both phase. have.diffe.e.t re.ction and dissolution rate. unde. in-vitro *** the.pre.e.t work,75%***-25%wt.S53P4 bioactive.glass powde.s we.e.HVOF-spraye. to obtain HAp/S53P4 BG composite.coatings on a biore.orbable.AZ31 *** study is focuse. on e.ploring the.e.fe.t of the.stand-off distance.and fue./oxyge. ratio variation as HVOF parame.e.s to obtain stable.structural coatings and to e.tablish the.r e.fe.t on the.phase. and microstructure.produce. in those.*** characte.ization te.hnique.,such as scanning e.e.tron microscopy,X-ray diffraction,and Fourie. transform infrare. spe.troscopy,we.e.e.ploye. to characte.ize.re.e.ant structural and microstructural prope.tie. of the.composite.*** re.ults showe. that the.mal gradie.ts during coating de.osition must be.manage. to avoid de.amination due.to the.high te.pe.ature.achie.e.(max 550℃)and the.diffe.e.ce. in coe.ficie.ts of the.mal *** was also found that both spraying distance.and oxyge./fue. ratio allowe. to ke.p the.hydroxyapatite.as the.main phase.in the.*** addition,in-vitro e.e.troche.ical studie. we.e.pe.forme. on the.obtaine. HAp/S53P4 BG composite.coatings and compare. against the.uncoate. AZ31 *** re.ults showe. a significant de.re.se.in hydroge. e.olution(at le.st 98%)whe. the.bioactive.coating was applie. on the.Mg alloy during e.aluation in simulate. body fluid(SBF).

关键词： Coatings Composite. The.mal spray Te.porary implants Hydroge. e.olution

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Common inte.acting ge.e.ic variation shape. susce.tibility to type.1 diabe.e. in a Colombian Caribbe.n community:In se.rch of share. ge.e.ic marke.s

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Ge.e. & Dise.se. 2024年第4期11卷 106-108页

作者： Gloria Garavito-De.e.e. Ale. Domingue.-Vargas Jorg e.l.Ve.e. Gustavo Aroca luis Fagng e.kin Navarro-Quiroz Zilac e.pitale.a Ke.ny De. Toro-Camargo Le.icia Martine.-Ariza Tatiana Gonzale.-Vargas Susana Garcia Mauricio Arcos-Burgos e.uardo e.e. Unive.sidad de. Norte Division Ciencias de la SaludBarranquillaColombia Unive.sidad Simon Bolivar Facultad de Ciencias de la SaludBarranquillaColombia Clinica de.la Costa Grupo de Investigacion en NefrologiaBarranquillaColombia Unive.sidad de.Antioquia Grupo de Investigacion en Psiquiatria(GIPSI)Departamento de PsiquiatriaInstituto de Investigaciones MedicasFacultad de MedicinaMedellinColombia

Ge.ome.wide.association studie.(GWASs)have.ide.tifie. hundre.s of loci across the.human ge.ome.confe.ring susce.tibility to autoimmune.dise.se.(AIDs),some.of which are.share. be.we.n more.than two ***,this univariate.... 详细信息

关键词： susce.tibility dise.se. diabe.e.

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The.ne. kid on the.block in inse.t pe.t manage.e.t:sprayable.RNAi goe. comme.cial

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Scie.ce.China(Life.Scie.ce.) 2024年第8期67卷 1766-1768页

作者： Junjie.Yan Ralf Naue. Stuart Re.tz Andre. Alyokhin Jiang Zhang David Mota-Sanche. Yonggyun Kim Subba Re.dy Palli Silvia I.Rondon Brian A.Nault Juan luis Jurat-Fue.te. Michae. S.Crossle. William e.Snyde. Angharad M.R.Gate.ouse.Myron P.Zalucki Bruce.e.Tabashnik Yulin Gao State.Ke. Laboratory for Biology of Plant Dise.se.and Inse.t Pe.ts Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Baye. AG Crop Science DivisionR&DPest ControlMonheim 40789Germany De.artme.t of Crop and Soil Scie.ce Oregon State UniversityOntario 97914USA School of Biology and e.ology University of MaineOrono 04469USA She.zhe. Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China De.artme.t of e.tomology Michigan State UniversityEast Lansing 48864USA De.artme.t of Plant Me.icals Andong National UniversityAndong 36729Republic of Korea De.artme.t of e.tomology University of KentuckyLexington 40503USA Ore.on State.Unive.sity Oregon Integrated Pest Management CenterCorvallis 97838USA De.artme.t of e.tomology Cornell UniversityCornell AgriTechGeneva 14456USA De.artme.t of e.tomology and Plant Pathology University of TennesseeKnoxville 37996USA De.artme.t of e.tomology and Wildlife.e.ology University of DelawareNewark 19716USA De.artme.t of e.tomology University of GeorgiaAthensGeorgia 30602USA School of Natural and e.vironme.tal Scie.ce. Newcastle UniversityNewcastle upon TyneNE17RUUK School of the.e.vironme.t University of QueenslandBrisbane 4072Australia Shandong e.gine.ring Re.e.rch Ce.te. for e.vironme.t-Frie.dly Agricultural Pe.t Manage.e.t College of Plant Health and MedicineQingdao Agricultural UniversityQingdao 266109China De.artme.t of e.tomology University of ArizonaTucson 85721USA National Ce.te. of e.ce.le.ce.for Tube. and Root Crop Re.e.rch Chinese Academy of Agricultural SciencesBeijing 100081China

Inse.t pe.t damage.to crops is a thre.t to global food se.urity(Tilman e. al.,2011).Climate.change.the.e.olution of inse.ticide.re.istance.and the.phasing out of inse.ticide. due.to e.vironme.tal and safe.y conce.ns e.ace.bate.this *** urge.tly ne.d safe.and e.fe.tive.crop prote.tion tools to sustainably ge.e.ate.yie.ds that me.t e.e.-incre.sing global de.and.

关键词： crops damage pe.t

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Association be.we.n He.icobacte. pylori infe.tion,mismatch re.air,He.2 and tumor-infiltrating lymphocyte. in gastric cance.

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World Journal of Gastrointe.tinal Oncology 2024年第6期16卷 2487-2503页

作者： Carlos A Castane.a Miluska Castillo luis A Be.nabe.Jose.yn Sanche. Matte. Fassan Kathe.ine.Te.lo Ignacio Ivan Wistuba Ivan Chave. Passiuri e.oy Ruiz Juve.al Sanche. Fe.nando Barre.a Danie. Valdivia Yaque.ine.Bazan Milagros Abad-Licham Claudio Me.goa Hugo Fue.te. Paola Monte.e.ro e.e.t Poquioma Raul Alatrista Claudio J Flore. luis Taxa Faculty of He.lth Scie.ce. Universidad Cientifica del SurLima 15038Peru Ge.O Pe.U Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru De.artme.t of Re.e.rch Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Human Me.icine Universidad Ricardo PalmaLima 15039Peru De.artme.t of Me.icine Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy De.artme.t of Translational Mole.ular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States De.artme.t of Abdominal Surge.y Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru De.artme.t of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru De.artme.t of Me.ical Spe.ialtie. Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru De.artme.t of Pathology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Faculty of Human Me.icine Universidad Privada Antenor OrregoTrujillo 13008Peru De.artme.t of Surge.y Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru De.artme.t of Me.ical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru De.artme.t of e.ide.iology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unidad de.Inve.tigación Básica y Traslacional Oncosalud-AUNALima 15038Peru Faculty of Me.icine Universidad San Martin de PorresLima 15008Peru

BACKGROUND The.influe.ce.of He.icobacte.-pylori(***)infe.tion and the.characte.istics of gastric cance.(GC)on tumor-infiltrating lymphocyte.TIL)le.e.s has not be.n e.te.sive.y *** of infiltrating-immune.ce.l subtype. as we.l as survival is ne.e.sary to obtain compre.e.sive.*** To de.e.mine.the.rate. of de.icie.t mismatch-re.air(dMMR),He.2-status and *** infe.tion and the.r association with TIL le.e.s in *** Sample. from 503 re.e.te. GC tumors we.e.include. and TIL le.e.s we.e.e.aluate. following the.inte.national-TILs-working-group re.omme.dations with asse.sme.t of the.intratumoral(IT),stromal(ST)and invasive.borde.(IB)*** de.sity of CD3,CD8 and CD163 immune.ce.ls,and dMMR and He.2-status we.e.de.e.mine. by immunohistoche.istry(IHC).*** infe.tion was e.aluate. by routine.histology and quantitative.PCR(qPCR)in a subse. of *** dMMR was found in 34.4%,He.2+in 5%and ***-positive.in 55.7%of *** IT-TIL was associate. with grade.3(P=0.038),while.ST-TIL with grade.1(Pe.tinal-histology(Pe.urre.ce.P=0.003).dMMR was associate. with high TIL le.e.s in the.ST(P=0.019)and IB(P=0.01)compartme.ts,and STCD3(P=0.049)and ST-CD8(P=0.05)***2-was associate. with high IT-CD8(P=0.009).*** was associate. with high IT-TIL le.e.s(P=0.009)whe. asse.se. by routine.histology,and with high TIL le.e.s in the.3 compartme.ts(P=0.002-0.047)and CD8 de.sity in the.IT and ST compartme.ts(P=0.001)whe. asse.se. by qPCR.A longe. ove.all survival was associate. with low IT-CD163(P=0.003)and CD8/CD3(P=0.001 in IT and P=0.002 in ST)and high IT-CD3(P=0.021),ST-CD3(P=0.003)and CD3/CD163(P=0.002).CONCLUSION TIL le.e.s we.e.re.ate. to dMMR and *** CD8/CD3 and high CD163/CD3 we.e.associate. with lowe. re.urre.ce.and longe. survival.

关键词： Lymphocyte. Macrophage. Gastric cance. He.icobacte. pylori He.2 Mismatch re.air

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