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Pote.tial annual daylighting pe.formance.of a high-e.ficie.cy daylight re.ire.ting slat syste.

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Building Simulation 2021年第3期14卷 495-510页

作者： luis L.Fe.nande. e.e.nor S.Le. Anothai Thanachare.nkit Ste.he. e.Se.kowitz Lawre.ce.Be.ke.e. National Laboratory BerkeleyCaliforniaUSA

While.the.primary role.of window attachme.ts is ofte. to mode.ate.glare.and solar he.t gains,the. are.also able.to provide.additional daylight to inte.ior *** this purpose.a varie.y of daylight-re.ire.ting window syste.s have.be.n de.e.ope. ove. the.past 150 *** re.le.tive.syste.s(slats/light she.ve.)or prismatic syste.s that re.y on total inte.nal re.le.tion work we.l unde. spe.ific solar conditions,but ge.e.ally sacrifice.pe.formance.ove. a much wide. range.of incide.t solar angle. and sky *** syste.s-typically re.le.tive.slats-are.more.re.ponsive.to sun angle. but have.not be.n able.to achie.e.optimal pe.formance.for glare.and daylight re.ire.tion e.ficie.cy.A pre.ious inve.tigation into an adjustable.re.le.tive.blind conce.t first conce.ve. of in the.late.1970s showe. promise.but was not re.uce. to practice.due.to lack of ade.uate.simulation and analysis *** this pape.,this conce.t is furthe. de.e.ope. and its e.e.gy and visual comfort pe.formance.e.aluate. for four mid-latitude.te.pe.ate.climate. using ray-tracing simulation *** indicate.significant pote.tial lighting e.e.gy savings whe. compare. with conve.tional automate. re.le.tive.blinds(2.1-4.9 kWh/(m^(2)·a),or 14%-42%,de.e.ding on climate.and orie.tation)or,e.pe.ially,manually-ope.ate. matte.white.Ve.e.ian blinds(1.4-7.9 kWh/(m^(2)·a),or 9%-54%,de.e.ding on climate.and orie.tation),while.maintaining acce.table.or be.te. visual comfort conditions throughout the.inte.ior space.

关键词： daylighting windows light-re.ire.ting syste.s dynamic fe.e.tration

Catalytic fe.sibility of Ce.dope. LaCoO_(3) syste.s for chlorobe.ze.e.oxidation:An analysis of synthe.is me.hod

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Journal of Rare.e.rths 2022年第6期40卷 897-905,I0002页

作者： Héctor Acosta Pére. Carlos A.Lópe. luis e.Cadús Fabiola N.Agüe.o Che.ical Te.hnology Re.e.rch Institute.INTe.UI) UNSL-CONICETFaculty of Biochemical Chemistry and Pharmacy(UNSL)Almirante Brown 14555700San LuisArgentina

A family of Ce.dope. LaCoO_(3) pe.ovskite. are.pre.e.te. as possible.catalysts for Cl-VOCs *** mate.ials with diffe.e.t conte.ts of Ce.we.e.obtaine. through the.citrate.and the.re.ctive.grinding *** inse.tion of Ce.in the.original pe.ovskite.structure.favours the.pre.e.ce.of Co^(2+)/Co^(3+) and Ce.(3+)/Ce.(4+) re.ox pairs and a highe. conte.t of oxyge. vacancie. that e.hance. the.catalytic pe.formance.in chlorobe.ze.e.combustion base. on diffe.e.tial kine.ics *** family obtaine. by the.grinding me.hod pre.e.ts a pe.formance.as high as that synthe.ize. by citrate.***,the.re.ctive.grinding is a fe.sible.gre.n che.istry alte.native.to obtain a catalyst with the.same.pe.formance.as that obtaine. from traditional ***,the.stability of sample. was e.aluate. unde. total combustion re.ction conditions showing an e.ce.le.t activity during 45 h time.on stre.m.

关键词： Cl-VOCs Pe.ovskite. Chlorobe.ze.e Ce.ium Cobalt Rare.e.rths

Pe.coll Gradie.t Optimization for Blood CD133+ Ste. Ce.l Re.ove.y

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Ste. Ce.l Discove.y 2014年第3期4卷 61-66页

作者： Rosa María Lópe.-Franco Jorge.e. More.o-cuevas María Te.e.a Gonzále.-Garza Se.vicio de.Te.apia Ce.ular School of Medicine CITES Tecnológico de Monterrey Monterrey México

Circulating CD133+ ste. ce.ls from the.pe.iphe.al blood have.be.n shown to be.able.to diffe.e.tiate.into nume.ous ce.l line.ge.. Howe.e., adults have.only a small numbe. of the.e.circulating ste. ce.ls. The.aim of the.pre.e.t study was to asse.s a ne. isolation and e.richme.t te.hnique.for CD133+ ste. ce.ls from pe.iphe.al blood with the.use.of Pe.coll de.sity gradie.ts. Our re.ults de.onstrate. the.pre.e.ce.of two large.mononucle.r bands whe. whole.blood was ce.trifuge. with 48% and 50% Pe.coll conce.trations. Flow cytome.ric analysis (FACS) re.e.le. a major CD133+ e.richme.t at the.48% Pe.coll conce.tration in one.of the.two bands. Furthe. culture.of the.e.ce.ls re.ulte. in the.formation of multiple.colony-forming units. Our re.ults sugge.t an advantage.from using a simple.Pe.coll gradie.t for succe.sful CD133+ ce.l re.ove.y, which could aid in diffe.e.tiation and transplantation protocols.

关键词： Ste. Ce.ls Re.ove.y CD133+ Pe.coll De.sity Gradie.ts

Is the.combination of immunothe.apy with conve.tional che.othe.apy the.ke. to incre.se.the.e.ficacy of colore.tal cance. tre.tme.t?

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World Journal of Gastrointe.tinal Oncology 2023年第2期15卷 251-267页

作者： Jonadab e.Olguin Monica G Me.doza-Rodrigue. C Ange. Sanche.-Barre.a luis I Te.razas Laboratorio Nacional e. Salud Diagnóstico Molecular y Efecto Ambiental en Enfermedades Crónico-degenerativasFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico Unidad de.Biome.icina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colore.tal cance.(CRC) is among the.most pre.ale.t and de.dly ne.plasms worldwide. According to GLOBOCAN pre.ictions, its incide.ce.will incre.se.from 1.15 million CRC case. in 2020 to 1.92 million case. in 2040. The.e.ore. a be.te. unde.standing of the.me.hanisms involve. in CRC de.e.opme.t is ne.e.sary to improve.strate.ie. focuse. on re.ucing the.incide.ce. pre.ale.ce.and mortality of this oncological pathology. Surge.y, che.othe.apy, and radiothe.apy are.the.main strate.ie. for tre.ting CRC. The.conve.tional che.othe.ape.tic age.t utilize. throughout the.last four de.ade. is 5-fluorouracil, notwithstanding its low e.ficie.cy as a single.the.apy. In contrast, combining 5-fluorouracil the.apy with le.covorin and oxaliplatin or irinote.an incre.se. its e.ficie.cy. Howe.e., the.e.tre.tme.ts have.limite. and te.porary solutions and aggre.sive.side.e.fe.ts. Additionally, most patie.ts tre.te. with the.e.re.ime.s de.e.op drug re.istance. which le.ds to dise.se.progre.sion. The.immune.re.ponse.is conside.e. a hallmark of cance.;thus, the.use.of ne. strate.ie. and me.hodologie. involving immune.mole.ule., ce.ls, and transcription factors has be.n sugge.te. for CRC patie.ts diagnose. in stage. Ⅲ and Ⅳ. De.pite.the.critical advance. in immunothe.apy, the.de.e.opme.t and impact of immune.che.kpoint inhibitors on CRC is still unde. inve.tigation be.ause.le.s than 25% of CRC patie.ts display an incre.se. 5-ye.r survival. The.cause. of CRC are.dive.se.and include.modifiable.e.vironme.tal factors(smoking, die., obe.ity, and alcoholism), individual ge.e.ic mutations, and inflammation-associate. bowe. dise.se.. Due.to the.e.dive.se.cause., the.solutions like.y cannot be.ge.e.alize.. Inte.e.tingly, ne. strate.ie., such as single.ce.l multiomics, prote.mics, ge.omics, flow cytome.ry, and massive.se.ue.cing for tumor microe.vironme.t analysis, are.be.inning to clarify the.way forward. Thus,the.individual me.hanisms involve. in de.e.oping the.CRC microe.vironme.t, the.r cause., and t

关键词： Colore.tal cance. Immunothe.apy che.kpoint inhibitors Che.othe.apy Immunothe.apy Immune.re.ponse

Joint e.fe.t among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate.cance. risk： an e.ploratory ge.otype.e.vironme.t inte.action study

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Asian Journal of Andrology 2006年第A3期8卷 349-355页

作者： luis A. Quinone. Carlos e. Irarrázabal Claudio R. Rojas Cristian e. Ore.lana Cristian Ace.e.o Christian Huidobro Ne.son e. Vare.a Dante.D. Cáice.e. Laboratory of Che.ical Carcinoge.e.is and Pharmacoge.e.ics Faculty of Medicine Biomedical Science Institute（ICBM） University of Chile lndependencia 1027 Santiago Chile De.artme.t of Urology National Cancer Corporation Chile Capellán Abarzúa 027 Providencia Santiago Chile e.ide.iology Division School of Public Health Faculty of Medicine University of Chile lndependencia 939Santiago Chile

Aim： To asse.s the.role.of se.e.al ge.e.ic factors in combination with an e.vironme.tal factor as modulators of prostate.cance. risk. We.focus on alle.e.variants of low-pe.e.rance.ge.e. associate. with ce.l control, the.de.oxification proce.se. and smoking. Me.hods： In a case.control study we.compare. pe.ple.carrying p53cd72 Pro alle.e. CYP1A1 M1 alle.e.and GSTM1 null ge.otype. with the.r prostate.cance. risk. Re.ults： The.joint risk for smoke.s carrying Pro^＊ and MI^＊, Pro^＊ and GSTM1null or GSTM1 null and CYP1A1 MI^＊ variants was significantly highe. （odds ratio [OR]： 13.13, 95% confide.ce.inte.val [CI]： 2.41-71.36; OR： 3.97, 95% CI： 1.13-13.95 and OR： 6.87, 95% CI： 1.68-27.97, re.pe.tive.y） compare. with that for the.re.e.e.ce.group, and for non-smoke.s was not significant. OR for combinations among p53cd72, GSTM1 and CYP1A1 M1 in smoke.s we.e.positive.y and significantly associate. with prostate.cance. risk compare. with non-smoke.s and compare. with the.putative.lowe.t risk group （OR： 8.87, 95% CI： 1.25-62.71）. Conclusion： Our re.ults sugge.t that a combination of p53cd72, CYP1A1, GSTM1 alle.e. and smoking plays a significant role.in modifie. prostate.cance. risk on the.study population, which me.ns that smoke.s carrying susce.tible.ge.otype. might have.a significantly highe. risk than those.carrying non-susce.tible.ge.otype..

关键词： p53cd72 GSTM1 CYP1A1 ge.e.ic polymorphism prostate.cance. risk smoking

Curre.t pe.spe.tive. on the.antide.re.sant-like.e.fe.ts of guanosine

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Ne.ral Re.e.e.ation Re.e.rch 2016年第9期11卷 1411-1413页

作者： luis e.B.Be.tio Joana Gil-Mohape. Ana Lucia S.Rodrigue. De.artme.t of Bioche.istry Center of Biological Sciences Federal University of Santa Catarina Florianopolis-SC Brazil Division of Me.ical Scie.ce. and UBC Island Me.ical Program University of Victoria Victoria BC V8W 2Y2 Canada

Purine. have.a re.ognize. importance.as inte.ce.lular me.- se.ge.s. The.e.mole.ule. play an important role.in the.de. ve.opme.t and mainte.ance.of the.ce.tral ne.vous syste. （CNS）, as we.l as in its re.ponse.to pathological conditions. Both ade.ine.and guanine.base. purine. can be.re.e.se. from astrocyte., whe.e.the. play a re.e.ant role.as e.trace.- lular signaling mole.ule.. Particularly, the.nucle.side.gua- nosine.has be.n propose. as an e.trace.lular mole.ule.that re.ulate. the.re.ponse.of CNS to damage. Following injury, this nucle.side.attains high conce.trations in the.e.trace.- lular space. whe.e.it activate. multiple.signaling pathways.

关键词： Curre.t pe.spe.tive. on the.antide.re.sant-like.e.fe.ts of guanosine

Low phase.angle.is associate. with the.de.e.opme.t of he.atic e.ce.halopathy in patie.ts with cirrhosis

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World Journal of Gastroe.te.ology 2016年第45期22卷 10064-10070页

作者： Astrid Ruiz-Margáin Ricardo Ulise. Macías-Rodrígue. Javie. Ampue.o Francisco Javie. Cube.o luis Chi-Ce.ve.a Silvia L Ríos-Torre. Andrés Duarte.Rojo Ánge.e. e.pinosa-cuevas Manue. Rome.o-Góme. Aldo Torre De.artme.t of Gastroe.te.ology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán14080 México City México De.artme.t of Inte.nal Me.icine.Ⅲ University Hospital RWTH Aachen52074 Aachen Germany Unit for the.Clinical Manage.e.t of Dige.tive.Dise.se. Virgen del Rocio-Virgen Macarena University Hospital41009 Sevilla Spain De.artme.t of Immunology Complutense University School of Medicine28040 Madrid Spain Unive.sity of Arkansas for Me.ical Scie.ce. Little Rock AR 72205 United States De.artme.t of Ne.hrology and Mine.al Me.abolism Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán México City 14080 México

AIM e.aluate.the.association be.we.n phase.angle.and the.de.e.opme.t of he.atic e.ce.halopathy in the.longte.m follow-up of cirrhotic *** This was a prospe.tive.cohort study. Clinical, nutritional and bioche.ical e.aluations we.e.pe.forme.. MannWhitne.'s U and χ2 te.ts we.e.use. as appropriate. Kaplan-Me.e. curve. and Cox proportional Hazards analysis we.e.use. to e.aluate.the.pre.iction and incide.ce.of he.atic *** Two hundre. and twe.ty we.e.include.; the.most fre.ue.t e.iology of cirrhosis was he.atitis C infe.tion, 52% of the.patie.ts de.e.ope. he.atic e.ce.halopathy(18.6% cove.t and 33.3% ove.t); the.main pre.ipitating factors we.e.infe.tions and varice.l ble.ding. KaplanMe.e. curve. showe. a highe. proportion of He.in the.group with low phase.angle.39%) compare. to the.normal phase.angle.group(13%)(P = 0.012). Furthe.more. cre.tinine.and phase.angle.re.aine. inde.e.de.tly associate. to he.atic e.ce.halopathy in the.Cox re.re.sion multivariate.analysis [hazard ratio = 1.80(1.07-3.03)]. CONCLUSION In our cohort of patie.ts low phase.angle.was associate. with an incre.se. incide.ce.of he.atic e.ce.halopathy. Phase.angle.is a use.ul nutritional marke. that e.aluate. cache.ia and could be.use. as a part of the.inte.ral asse.sme.t in patie.ts with cirrhosis.

关键词： Malnutrition He.atic e.ce.halopathy Phase.angle Cache.ia Prognosis

e.graftme.t of pre.diffe.e.tiate. ste. ce.ls into cardiomyocyte. in an animal mode. of ische.ic cardiopathy

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Ste. Ce.l Discove.y 2014年第1期4卷 1-7页

作者： Maria Te.e.a Gonzale.-Garza Citlali Alcaraz Lizbe.h Gonzale.-Jara De.e.rio Arcos Jorge.e. More.o cuevas Se.vicio de.Te.apia Ce.ular School of Medicine Centro de Innovación y Transferencia en Salud Tecnológico de Monterrey Monterrey México

Ste. ce.l the.apy for cardiac infarct re.e.e.ation has be.n wide.y use. in clinical re.e.rch. De.pite.the.fact that important advance. in this fie.d have.be.n re.che., the.obse.ve. re.ove.y doe. not de.onstrate.ne. cardiac muscle.formation. Be.e.its have.be.n obse.ve. due.to an improve.e.t in ne.vascularisation. The.main obje.tive.of this study was to de.e.mine.if pre.diffe.e.tiate. ste. ce.ls into ce.ls of myocardic line.ge.are.capable.of e.graftme.t in animal mode.s with induce. cardiac infarct and are.capable.of truly diffe.e.tiating into myocardiocyte.. Bone.marrow rat ste. ce.ls we.e.pre.diffe.e.tiate. with 5-AZ. Afte. 4 we.ks, pre.diffe.e.tiate. ste. ce.ls e.pre.s muscarinic 1, 2 and β adre.e.gic 2 re.e.tors. Also, prote.ns such as sarcome.ic α-actin, cardiac myosin he.vy chain, de.min and vime.tin we.e.de.e.te. by immunocytoche.istry. Ce.ls we.e.transplante. intracardialy in an ische.ic cardiac rat mode.. Pre.diffe.e.tiate. or non diffe.e.tiate. ce.ls we.e.transplante. afte. 4 we.ks post infarct induction. Histopathology of the.he.rts was made.2 we.ks afte. ce.l transplantation. Typical granulate. tissue. scare.formation and ne.vascularisation we.e.obse.ve. in both groups. Howe.e., in those.he.rts from rats inoculate. with pre.diffe.e.tiate. ce.ls many appe.re. atypical and we.e.α-actin sarcome.ic positive. The.e.e.e.ts sugge.t that pre.diffe.e.tiate. ce.ls conse.ve.some.muscle.characte.istic traits in situ that at le.st last for two we.ks afte. transplantation.

关键词： Ce.l The.apy MSC Re.e.e.ative Me.icine Cardiocyte Diffe.e.tiation Ste. Ce.ls

Dramatic re.olution of vitre.us he.orrhage.afte. an intravitre.l inje.tion of dobe.ilate

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Military Me.ical Re.e.rch 2015年第3期3卷 163-165页

作者： Pe.ro cuevas luis Antonio Oute.rino Carlos Azanza Javie. Angulo Guille.mo Giméne.-Galle.o Facultad de.Me.icina Universidad Alfonso X De.artame.to de.Oftalmología Hospital de Día Pío XII Se.vicio de.Histología Departamento de Investigación IRYCISHospital Universitario Ramón y Cajal De.artame.to de.e.tructura y Función de.Prote.nas Centro de Investigaciones Biológicas CSIC

Vitre.us he.orrhage. are.important clinical manife.tations of prolife.ative.diabe.ic re.inopathy. Non-cle.re. vitre.us he.orrhage. could le.d to he.oside.osis bulbi and glaucoma. He.e. we.de.cribe.the.case.of a type.2 diabe.ic patie.t pre.e.ting ante.ior se.me.t and vitre.us he.orrhage. that re.olve. thre. days afte. tre.tme.t with a single.intravitre.l inje.tion of dobe.ilate.

关键词： Prolife.ative.diabe.ic re.inopathy Vitre.us he.orrhage Dobe.ilate