Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk： an exploratory genotype-environment interaction study

作     者：Luis A. Quinones Carlos E. Irarrázabal Claudio R. Rojas Cristian E. Orellana Cristian Acevedo Christian Huidobro Nelson E. Varela Dante D. Cáiceres 

作者机构：Laboratory of Chemical Carcinogenesis and Pharmacogenetics Faculty of Medicine Biomedical Science Institute（ICBM） University of Chile lndependencia 1027 Santiago Chile Department of Urology National Cancer Corporation Chile Capellán Abarzúa 027 Providencia Santiago Chile Epidemiology Division School of Public Health Faculty of Medicine University of Chile lndependencia 939Santiago Chile 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2006年第8卷第A3期

页      面：349-355页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：p53cd72 GSTM1 CYP1A1 genetic polymorphism prostate cancer risk smoking 

摘      要：Aim： To assess the role of several genetic factors in combination with an environmental factor as modulators of prostate cancer risk. We focus on allele variants of low-penetrance genes associated with cell control, the detoxification processes and smoking. Methods： In a case-control study we compared people carrying p53cd72 Pro allele, CYP1A1 M1 allele and GSTM1 null genotypes with their prostate cancer risk. Results： The joint risk for smokers carrying Pro^＊ and MI^＊, Pro^＊ and GSTM1null or GSTM1 null and CYP1A1 MI^＊ variants was significantly higher （odds ratio [OR]： 13.13, 95% confidence interval [CI]： 2.41-71.36; OR： 3.97, 95% CI： 1.13-13.95 and OR： 6.87, 95% CI： 1.68-27.97, respectively） compared with that for the reference group, and for non-smokers was not significant. OR for combinations among p53cd72, GSTM1 and CYP1A1 M1 in smokers were positively and significantly associated with prostate cancer risk compared with non-smokers and compared with the putative lowest risk group （OR： 8.87, 95% CI： 1.25-62.71）. Conclusion： Our results suggest that a combination of p53cd72, CYP1A1, GSTM1 alleles and smoking plays a significant role in modified prostate cancer risk on the study population, which means that smokers carrying susceptible genotypes might have a significantly higher risk than those carrying non-susceptible genotypes.