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Importance of ROS1 gene fusions in non-small cell lung cancer

Cancer Drug Resistance 2023年第2期6卷 332-344页

作者： Meri Muminovic carlos Rodrigo Carracedo Uribe Andres Alvarez-Pinzon Khine Shan luis E.Raez Department of Hematology-Oncology Memorial Cancer Institute/Memorial Health Care SystemFlorida International UniversityPembroke PinesFL 33028USA Department of Internal Medicine Memorial Health Care SystemFlorida International UniversityPembroke PinesFL 33028USA Office of Human Research Memorial Healthcare SystemPembroke PinesFL 33028USA

Targeted therapy has become one of the standards of care for advanced lung *** than 10 genetic aberrations have been discovered that are actionable and several tyrosine kinase inhibitors(TKIs)have been approved to target each of *** several genetic aberrations that are actionable in non-small cell lung cancer(NSCLC),ROS1 translocations also known as gene fusion proteins,are found in only 1%-2%of the patient ***1 mutations can usually be detected using a combination of techniques such as immunohistochemistry(IHC),Fluorescence in-situ testing(FISH),polymerase chain reaction(PCR),and nextgeneration sequencing(NGS).However,RNA NGS and ctDNA NGS(liquid biopsies)also contribute to the *** are currently numerous FDA-approved agents for these tumors,including crizotinib and entrectinib;however,there is in-vitro sensitivity data and clinical data documenting responses to ceritinib and *** responses and survival rates with these agents are frequently among the best compared to other TKIs with genetic aberrations;however,intrinsic or extrinsic mechanisms of resistance may develop,necessitating research for alternative treatment *** combat the mechanisms of resistance,novel agents such as repotrectenib,cabozantinib,talotrectinib,and others are being *** this article,we examine the literature pertaining to patients with ROS1 tumors,including epidemiology,clinical outcomes,resistance mechanisms,and treatment options.

关键词： ROS1 targeted therapy non-small cell lung cancer

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Journal of Intensive Medicine 2022年第2期2卷 103-109页

作者： Diego Gil carlos Tiscar Maria Gómez Javier Felices luis Gajate Patricia Fernandez David Pestaña Tommaso Bardi Department of Anaesthesiology and Critical Care Ramón y Cajal Hospital28034 MadridSpain Department of Psychology Ramón y Cajal Hospital28034 MadridSpain

Background:There are insufficient data regarding the impact of acute respiratory distress syndrome related to coronavirus disease 2019(C-ARDS)–caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)–on health-related quality of life(HRQoL)and the occurrence of stress-related disorders in coronavirus disease 2019(COVID-19)intensive care unit(ICU)*** aim of this study is to assess HRQoL and the occurrence of stress-related disorders(acute stress disorder[ASD]and post-traumatic stress disorder[PTSD])in C-ARDS ICU survivors at 1 and 6 months following hospital ***:This prospective observational study included 90 patients treated for C-ARDS between March and May 2020 in the ICU and discharged alive from the *** patients included in the study were contacted by telephone 1 month and 6 months post-hospital discharge to assess the presence of symptoms of stress-related disorders and HRQoL using the 8-item Treatment Outcome Post-traumatic Stress Disorder scale(TOP-8)and 36-item Short Form survey(SF-36).We performed univariate analyses to evaluate differences between patients who developed stress and those who did *** also compared SF-36 scores in our sample with data from the general Spanish population and from cohorts of non–C-ARDS and severe acute respiratory syndrome coronavirus-1(SARS-CoV-1)***:There are 24.1%of patients showed symptoms of ASD;in 13.5%of cases the symptoms persisted 6 months *** factors for the development of symptoms of ASD and PTSD are younger age,female sex,obesity,a previously diagnosed psychiatric disease and disease severity at ICU admission(P<0.05).HRQoL was greatly affected by C-ARDS;however,there was improvement on all scales of the SF-36 at the 6-month follow-up(P<0.05).The mean SF-36 score of our sample was higher than those previously reported in non–C-ARDS survivors(P<0.05)for physical functioning(78.0 vs.52.0),role functioning/physical(51.0 vs.31.0),bodily pain(76.1 vs.57

关键词： COVID-19 Post-intensive care syndrome Respiratory distress syndrome,Adult Health-related quality of life Post-traumatic stress disorder

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Perpendicularly Self-Oriented and Shape-Controlled L10-FePt Nanorods Directly Synthesized by a Temperature-Modulated Process

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Nano Research 2011年第7期4卷 666-674页

作者： Tiago luis da Silva Laudemir carlos Varanda Colloidal Materials Group Instituto de Quimica de Sao Carlos Universidade de Sao Paulo--USP Sao Carlos PO Box 780 13566-590 Brazil

合成并且有高强制的地的四角形的包含阶段的 L10-Fe55Pt45 nanorods 自己组装被描述。试验性的过程为同样综合的 nanoparticles 导致了四角形 / 立方的阶段比率结束到 1:1。在这进程使用不同表面活化剂 / 溶剂比例从 nanospheres 允许... 详细信息

合成并且有高强制的地的四角形的包含阶段的 L10-Fe55Pt45 nanorods 自己组装被描述。试验性的过程为同样综合的 nanoparticles 导致了四角形 / 立方的阶段比率结束到 1:1。在这进程使用不同表面活化剂 / 溶剂比例从 nanospheres 允许粒子形态学的控制到 nanowires。有一些 60 的 Monodisperse

关键词：直接合成形状控制纳米棒垂直面调制过程自组装材料表面活性剂温度

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Effect of Exogenous Melatonin on Seed Germination and Seedling Growth in Melon(Cucumis melo L.) Under Salt Stress

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Horticultural Plant Journal 2019年第2期5卷 79-87页

作者： José luis Casta?ares carlos Alberto Bouzo Plant Physiology Laboratory Department of Basic Sciences Universidad Nacional de Luján Laboratory of Research in Physiology and Plant Molecular Biology Facultad de Ciencias Agrarias Universidad Nacional del Litoral

An investigation was carried out to evaluate the effect of different application forms and concentrations of melatonin on germination and initial growth of melon plants in several different salinity conditions. We evaluated germination percentage and growth of seedlings and measured total chlorophyll content, relative electrolyte leakage, peroxidase activity, root viability, proline concentration, relative water content,Na^+/K^+ratio in green parts and K^+leakage from roots. Seed germination percentage under salt stress increased with treatments of 10 and50 μmol·L^(-1) melatonin. Seed treatment and plant watering with melatonin at 50 μmol·L^(-1) improved growth parameters and plants showed higher chlorophyll content as well as better biochemical parameters than non-treated plants. Results suggest that melatonin can alleviate the effect of salt stress during seed germination and first stages of plant development.

关键词： melon melatonin salt stress germination antioxidation

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Fluidization of binary mixtures of sisal residue and sand:A new model for deriving the final fluidization velocity

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Particuology 2018年第5期16卷 10-22页

作者： David Vasconcelos Gabriele Batalha luis Gabriel Pereira carlos Augusto Pires Chemical Reaction Engineering Laboratory Federal University of Bahia40.210-910SalvadorBABrazil

The influence of different factors on the fiuidization of a binary mixture of sisal residue and sand was *** particle sizes of the sand and sisal residue were varied from 0.2to 0.8mm and the biomass mass fractions from 2% to 9%.Some segregation was noted,and a significant relationship was found among the final fluidization velocity (Uff),the biomass and sand sizes,and the biomass mass fraction.A novel model was developed for predicting Uff,leading to an average discrepancy of 12.69% between the measured and predicted Uff compared with the best match of 15.32% when using a model from a previous *** new model was applied to data from studies using other biomass and a broad range of particle *** average divergences from measured values when using the new model were 7.9% for corn cob and walnut shell,and 20.5% for sweet sorghum bagasse,tobacco residue, and soy *** were superior to the values derived using other *** results confirm the accuracy of the model developed in this work and show that it represents a viable alternative way to calculate Uff for a binary mixture of sand and biomass.

关键词： Fluidization Binary mixture Sisal residue Final fluidization velocity model

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Current advances in solid free-form techniques for osteochondral tissue engineering

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Bio-Design and Manufacturing 2018年第3期1卷 171-181页

作者： Joao Bebiano Costa Joana Silva-Correia Rui luis reis Joaquim Miguel Oliveira B's Research Group I3Bs - Research Institute onBiomaterials Biodegradables and Biomimetics University ofMinho Headquarters of the European Institute of Excellenceon Tissue Engineering and Regenerative Medicine AveParkParque de Ciencia e Tecnologia Zona Industrial da Gandra4805-017 Barco Guimaraes Portugal ICVS/3B's-PT Government Associate Laboratory Braga Guimarfies Portugal The Discoveries Centre for Regenerative and PrecisionMedicine Headquarters at University of MinhoAvepark 4805-017 Barco Guimaraes Portugal

Osteochondral (OC) lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments have increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds’ processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form (SFF) techniques. These techniques allow tuning different properties at the micro–macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.

关键词：软骨病变生物技术生物科学发展现状

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Exercise stress echocardiography:Where are we now?

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World Journal of Cardiology 2022年第2期14卷 64-82页

作者： carlos Alberto Cotrim Hugo Café Isabel João Nuno Cotrim Jorge Guardado Pedro Cordeiro Hortense Cotrim luis Baquero Heart Center Hospital da Cruz Vermelha PortuguesaLisboa 1549-008Portugal Faculdade de Medicina Algarve UniversityFaro 8005-139Portugal Department of Cardiology Garcia de Orta HospitalAlmada 2805-267Portugal Department of Medicine Garcia de Orta HospitalAlmada 2805-267Portugal Cardiovascular Unit UCARDIOCentro ClinicoRiachos 2350-325Portugal Department of Cardiology Hospital Particular do AlgarveFaro 8005-226Portugal

Exercise stress echocardiography(ESE)is a widely used diagnostic test in cardiology *** is mainly used to study patients with coronary artery disease;however,it has increasingly been used in other clinical scenarios including valve pathology,congenital heart disease,hypertrophic and dilated cardiomyopathies,athlete evaluations,diastolic function evaluation,and pulmonary circulation *** our laboratories,we use an established methodology in which cardiac function is evaluated while exercising on a *** completing the exercise regimen,patients remain in a standing position or lie down on the left lateral decubitus,depending on the clinical questions to be answered for further *** method increases the quality and quantity of information ***,we present the various methods of exercise stress echocardiography and our experience in many clinical arenas in *** also present alternatives to ESE that may be used and their advantages and *** review recent advances in ESE and future directions for this established method in the study of cardiac patients and underline the advantage of using a diagnostic tool that is radiation-free.

关键词： Exercise stress echocardiography Coronary artery disease Valve disease Athletes Intraventricular gradients Children

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Experimental analysis of infragravity waves in two eroded microtidal beaches

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Acta Oceanologica Sinica 2017年第5期36卷 31-43页

作者： MARIO Conde-Frias luis Otero JUAN Camilo Restrepo JUAN carlos Ortiz Geosciences Research Group GE04 Department of PhysicsUniversidad del NorteBarranquilla 081007Colombia

This work aims to contribute to the characterization and understanding ofinfragravity waves on two beaches with erosion problems. For this reason, we have used an array of ADCP and a pressure sensor to measure wave parameters and pressure inside and outside of the surf zone during the dry and rainy period in the beaches of Galerazamba and Manzanillo del Mar （both dissipative and eroded beaches） located in the Colombian Caribbean coast. Based on these measurements, we have carried out a spectral analysis in order to identify the frequency components that characterize the wave and its energy; thus, we identified the characteristic frequencies of iufragravity waves to finally filter the infragravity signal on each beach in different seasonal periods. Among the results of the Welch spectrum applied to surface elevation time series, we found that, the frequencies＇ energy of the sea-swell band decreases due to bottom friction and wave breaking as the wave approaches the shore, while the frequencies＇ energy of the infragravity band increases significantly. In addition, for the wavelet analysis, we could observe how the energy of the infragravity band, especially the lowest frequencies gain energy as the waves approaches the coast. Furthermore, based on the infragravity wave obtained from the extreme wave event registered during the field campaign we can conclude that the contribution of this signal is important in the erosion problems presented in the beaches of Galerazamba and Manzanillo del Mar. Finally, these results show the need to realize other studies that allow us to understand deeply, the role of infragravity waves on the morphological changes that occurs in these beaches.

关键词： infragravity waves long waves experimental analysis fourier analysis wavelet transform

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Water-soluble hollow nanocrystals from self-assembly of AIEEactive Pt(II)metallomesogens

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Nano Research 2021年第1期14卷 245-254页

作者： Cristian Cuerva Javier Fernandez-Lodeiro Mercedes Cano Jose luis Capelo-Martinez carlos Lodeiro BIOSCOPE Research Group LAQV@REQUIMTE Chemistry DepartmentNOVA School of Science and TechnologyNOVA University Lisbon2829-516 CaparicaPortugal PROTEOMASS Scientific Society Rua dos InventoresMadam ParqueCaparica Campus2829-516 CaparicaPortugal Department of Inorganic Chemistry Complutense University of MadridCiudad Universitaria28040 MadridSpain

Luminescent hollow micro-and nanocrystals have been successfully obtained taking advantage of the self-assembly behavior and the aggregation-induced emission enhancement properties of several bispyrazolate Pt(II)metallomesogens decorated with four terminal alkyl ***-in-water droplets have been used to confine the Pt(II)compounds and drive them to be self-assembled via intermolecular Pt…Pt interactions into spherical aggregates of about 200 or 50 *** of the oil phase generates highly-stable aqueous dispersions of nanocrystals that emit a bright orange light as a result of the existence of^(3)MMLCT excited *** methods and conditions have been tested for studying the effect of several parameters such as the temperature and the stirring speed in the final particle size and in the polydispersity ***,the micro-and nanocrystals are able to entrap hydrophobic drugs between the alkyl chains of the compounds,forming stable dispersions of drug-loaded capsules in *** droplet method is applied in the area of metallomesogens for the first time to synthesize self-assembled Pt(II)nanocapsules,which opens a new field of study that could allow the use of these liquid crystal materials in biomedical applications.

关键词： R(II)metallomesogens self-assembly luminescent nanomaterials droplets nanocapsules

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Factors affecting the dominance hierarchy dynamics in a hummingbird assemblage

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Current Zoology 2019年第3期65卷 261-268页

作者： Ubaldo MARQUEZ-LUNA carlos Lara Pablo CORCUERA Pedro luis VALVERDE Doctorado en Ciencias Biologicas y de la Salud Universidad Autonoma Metropolitana-lztapalapa Ciudad de Mexico Mexico Centro de Investigacion en Ciencia Biologicas Universidad Autonoma de Tlaxcala. Km 10.5 Autopista Tlaxcala-San Martin Texmelucan San Felipe Ixtacuixtla Tlaxcala Mexico Departamento de Biologia Universidad Autonoma Metropolitana-lztapalapa Ciudad de Mexico

Intra and in terspecific competiti on for n ectar play an imports nt role in hummingbird communities. Larger sized species usually exclude smaller species from the rich floral resources. However, it has been recently postulated that the competitive advantages of a large body size decline as the evolutionary distance between the contending species in creases. In this study, we analyzed dominance hierarchy dynamics in a hummingbird assemblage in central Mexico. By monitoring hummingbird territories established in three plant species through 1 year, we assessed the effects of energy within territories and the territory owners identity in the frequency of inter and intraspecific encounters. We also evaluated if these factors affect the dominance of larger species when they compete against smaller distantly related contenders. Our results show that their frequency of intraspecific encounters was related with the identity of the territory's owner. On the contrary, the frequency of interspecific encounters was related with both the territory and the identity of the territory's owner. We did not find a significant difference between the number of encounters dominated by larger and smaller species and their conte nders. However, the in crease in genetic dista nee between contenders was positively associated with a higher frequency of encounters dominated by small *** results showed that the ecological factors and evolutionary relationships among contenders play important roles in the dominance hierarchy dynamics.

关键词： agonistic behavior competition hummingbirds resource quality territoriality

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