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Prenatal programing of motivated behaviors:can innate immunity prime behavior?

Neural Regeneration Research 2023年第2期18卷 280-283页

作者： Larisa Montalvo-Martínez Gabriela Cruz-Carrillo Roger Maldonado-Ruiz luis atrujillo-villarreal Eduardo AGarza-villarreal Alberto Camacho-Morales Universidad Autónoma de Nuevo León Department of BiochemistryCollege of MedicineMonterreyMéxico Universidad Autónoma de Nuevo León Neurometabolism UnitCenter for Research and Development in Health SciencesMonterreyMéxico Universidad Nacional Autónoma de México Campus Juriquilla Instituto de NeurobiologíaQueretaroMéxico

Prenatal programming during pregnancy sets physiological outcomes in the offspring by integrating external or internal ***,pregnancy is an important stage of physiological adaptations to the environment where the fetus becomes exposed and adapted to the maternal *** exposure to high-energy dense diets can affect motivated behavior in the offs p ring leading to addiction and impaired sociability.A high-energy dense exposure also increases the pro-inflammatory cytokines profile in plasma and brain and favors microglia activation in the *** still under investigation,prenatal exposure to high-energy dense diets promotes structural abnormalities in selective brain regions regulating motivation and social behavior in the *** current review addresses the role of energy-dense foods programming central and peripheral inflammatory profiles during embryonic development and its effect on motivated behavior in the *** provide preclinical and clinical evidence that supports the contribution of prenatal programming in shaping immune profiles that favor structural and brain circuit disruption leading to aberrant motivated behaviors after *** hope this minireview encourages future research on novel insights into the mechanisms underlying maternal programming of motivated behavior by central immune networks.

关键词： addiction autism behavior cytokines diet maternal immune activation prenatal programming sociability trained immunity western-diets

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Dermatoscopy in the Diagnosis of Vulvar Basal Cell Carcinoma:A Case Report

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International Journal of Dermatology and Venereology 2022年第2期5卷 107-109页

作者： Diego Adolfo de los Cobos Davaios Rodrigo Cepeda-Valdes luis Fernando Favela-Fernandez Claudia villarreal-Carrillo Julio Cesar Salas-Alanis Debra Mexico GuadalupeNuevo León 67150Mexico Julio Salas Dermatology GuadalupeNuevo León 67150Mexico Facultad de Medicina Universidad Autónoma de Nuevo LeónMonterreyNuevo León 67150México.

Introduction: Basal cell carcinoma (BCC) is the most common human malignancy commonly in white people, but in less than 1% of cases it may appear on unexposed areas, like the perineal and anal regions. Vulvar BCC is often diagnosed late because it grows slowly and tends to be asymptomatic, with no specific physical findings. Here, we present a rare Latin patient with a 10-year history of vulvar BCC with dermatoscopic and histopathologic *** report: A 65-year-old Latin woman presented with a nodule on her left labium majus, which she first noted 10 years ago, and that had grown slowly but constantly. She also reported a 20-year history of pruritus and occasional pain. Physical examination showed a 3.5 cm × 3.0 cm erythematous lesion with a central rough without inguinal lymphadenopathy. Contact dermatoscopy (Dermalite DL3 Gen.) showed one blurred cluster of arborising vessels in a pinkish background with white homogeneous areas and lines radial converging. An incisional biopsy was realized, and histopathology diagnosed ***: Vulvar BCC is a rare malignancy that affects mainly Caucasian women over 70 years of age. The most common etiology for BCC is ultraviolet radiation, but as the vulva is unexposed its cause is unclear. Mutations in tumor suppressor and regulatory genes such as p53 are present in 50% of cases. Gorlin syndrome, chronic radiation, chronic arsenic exposure, xeroderma pigmentosum, and immunosuppression have been considered as risk ***: Vulvar BCC characteristics are the same as other cutaneous forms, featuring blue ovoid nests and arborizing telangiectasia, confused with inflammatory diseases, such as eczema, psoriasis, and chronic infection (especially if it is accompanied by pruritus), this makes diagnosis complex, with a delay of 5 to 6 years on average, with an average size of 2.1 cm. Diagnosis is enhanced with dermatoscopy, as the preferred treatment for most BCC cases is wide surgical excision.

关键词： basal cell carcinoma cancer case report latino tumors woman

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Rethinking quasispecies theory: From fittest type to cooperative consortia

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World Journal of Biological Chemistry 2013年第4期4卷 79-90页

作者： luis P villarreal Guenther Witzany Department of Molecular Biology and Biochemistry University of California Telos-Philosophische Praxis

Recent investigations surprisingly indicate that single RNA "stem-loops" operate solely by chemical laws that act without selective forces, and in contrast, self-ligated consortia of RNA stem-loops operate by biological selection. To understand consortial RNA selection, the concept of single quasi-species and its mutant spectra as drivers of RNA variation and evolution is rethought here. Instead, we evaluate the current RNA world scenario in which consortia of cooperating RNA stem-loops(not individuals) are the basic players. We thus redefine quasispecies as RNA quasispecies consortia(qs-c) and argue that it has essential behavioral motifs that are relevant to the inherent variation, evolution and diversity in biology. We propose that qs-c is an especially innovative force. We apply qs-c thinking to RNA stem-loops and evaluate how it yields altered bulges and loops in the stem-loop regions, not as errors, but as a natural capability to generate diversity. This basic competencenot error-opens a variety of combinatorial possibilities which may alter and create new biological interactions, identities and newly emerged self identity(immunity) functions. Thus RNA stem-loops typically operate as cooperative modules, like members of social groups. Fromsuch qs-c of stem-loop groups we can trace a variety of RNA secondary structures such as ribozymes, viroids, viruses, mobile genetic elements as abundant infection derived agents that provide the stem-loop societies of small and long non-coding RNAs.

关键词： Quasispecies RNA stem-loops Infectious agents Cooperative interactions Evolution

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Inflammatory effect on the gastrointestinal system associated with COVID-19

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World Journal of Gastroenterology 2021年第26期27卷 4160-4171页

作者： Paulina Delgado-Gonzalez Carlos A Gonzalez-villarreal Jorge A Roacho-Perez Adriana G Quiroz-Reyes Jose Francisco Islas Juan luis Delgado-Gallegos Daniel Arellanos-Soto Kame A Galan-Huerta Elsa N Garza-Treviño Departamento de Bioquimica y Medicina Molecular UANLMonterrey 64610Nuevo LeónMexico Universidad de Monterrey UDEM Vicerrectoria de Ciencias de la SaludMonterrey 66238Nuevo LeonMexico

The severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)that causes coronavirus disease-2019(COVID-19)has provoked a global pandemic,mainly affecting the respiratory tract;however,a percentage of infected individuals can develop gastrointestinal(GI)*** studies describe the development of GI symptoms and how they affect the progression of *** this review,we summarize the main mechanisms associated with gut damage during infection by SARS-CoV-2 as well as other organs such as the liver and *** only are host factors associated with severe COVID-19 but intestinal microbiota dysbiosis is also observed in patients with severe disease.

关键词： SARS-CoV-2 Gastrointestinal symptoms COVID-19 Gastrointestinal system

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Tibial tuberosity avulsion-fracture associated with complete distal rupture of the patellar tendon:A case report and review of literature

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World Journal of Orthopedics 2020年第12期11卷 615-626页

作者： Rodolfo Morales-Avalos luis E Martinez-Manautou Santiago de la Garza-Castro Alejandra J Pozos-Garza Gregorio A villarreal-Villareal Victor M Pena-Martinez Felix Vilchez-Cavazos Department of Orthopedic Surgery and Traumatology University Hospital"Dr.JoseEleuterio Gonzalez"Universidad Autonoma de Nuevo LeonMonterrey 66434Nuevo LeonMexico Department of Orthopaedics and Traumatology University Hospital“Dr.JoseEleuterio Gonzalez”Universidad Autónoma de Nuevo LeonMonterrey 66460Nuevo LeonMexico

BACKGROUND Few cases of avulsion fractures of the tibial tuberosity with simultaneous rupture of the patellar tendon have been reported in the ***,its mechanism and incidence have not been determined *** type of fracture is considered a serious injury that requires prompt diagnosis and early surgical *** is no therapeutic algorithm or standard method of treatment due to the infrequency of the *** this case report,we conducted an exhaustive review and synthesis of the existing literature including all previously reported *** SUMMARY We present a 16-year-old male soccer player with a case of a tibial tuberosity fracture with distal avulsion of the patellar tendon 5 d prior to surgical *** patient presented with a loss of the extensor mechanism of the knee,edema,the inability to walk,and pain.X-rays showed a high patella and a 180-degree avulsion of the tibial *** diagnosis was confirmed by magnetic resonance imaging and computed *** patient underwent open reduction and internal fixation of the fracture with a cannulated screw and washer as well as patellar tendon repair with two metallic *** rehabilitation protocol consisted of initial immobilization in extension followed by passive mobility and muscle strengthening *** patient demonstrated excellent postoperative outcomes and returned to regular activity without *** This case presentation and literature review comprise the most relevant clinical,radiographic,and treatment details described in the international literature to date,providing the reader with an overview of this rare condition.

关键词： Avulsion Case report Patellar tendon Rupture Simultaneous Tibial tuberosity

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Hidden in plain sight:Morphological and phylogenetic evidence for Bouteloua arizonica,a species distinct from Bouteloua aristidoides(Poaceae,Chloridoideae)

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Plant Diversity 2021年第2期43卷 125-133页

作者： luis Fernando Cuellar-Garrido Maria Elena Siqueiros-Delgado Herbario Luz Maria villarreal de Puga Del Instituto de Botanica(IBUG) Departamento de Botanica y ZoologíaCentro Universitario de Ciencias Biologicas y AgropecuariasUniversidad de GuadalajaraCamino Ing.Ramon Padilla Sanchez 2100CP 45200ZapopanJaliscoMexico Departamento de Biologia Centro de Ciencias BioasicasUniversidad Autonoma de AguascalientesAvenida Universidad 940CP 20131AguascalientesMexico

Two varieties of Bouteloua aristidoides have been recognized,the widespread *** and the more narrowly distributed *** two varieties differ in inflorescence form even more than that seen between many other closely related species of *** therefore asked whether these taxa might be better regarded as distinct species.A total of 93 vouchers were studied by using morphometry(principal components analysis and statistical tests),leaf micromorphology,ancestral state reconstruction,and/or molecular(ITS,trnC-rpoB and trnT-L-F)phylogenetic *** from the ITS tree,all results supported elevation of *** *** to the rank of species,thus the new combination Bouteloua arizonica(***)***&Columbus *** ***.,is *** and combined chloroplast-nuclear molecular trees depicted *** as monophyletic(even in sympatric populations with ***)and reveals phylogenetic structure within *** for which the presence of new undescribed varieties of ***(different from ***)is *** differs from *** in having fewer branches per inflorescence,a bigger branch with more spikelets,and a shorter branch *** electron microscopy revealed the presence of papillae on leaves of *** as a clear *** mature plants of *** from seeds in a greenhouse revealed a strong cleistogamous nature for this species for which gene flow in sympatric populations with *** seems unlikely.A taxonomic treatment and distribution map for identification of *** is provided.

关键词： Ancestral state reconstruction Bouteloua arizonica Cleistogamy Morphology Phylogeny Sympatry

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Evaluation of the Essential Oil of <i>Citrus paradisi</i>as an Alternative Treatment against <i>Candida albicans</i>

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Open Journal of Stomatology 2020年第9期10卷 258-270页

作者： Ameyalli J. Martinez Delgado Uziel Castillo Velázquez Juan G. Báez González Abelardo Chávez Montes Sonia M. López villarreal Laura Elena villarreal García Rosa María Sánchez Casas Osvelia E. Rodríguez luis Universidad Autónoma de Nuevo León Facultad de Odontología Monterrey NL México Universidad Autónoma de Nuevo León Facultad de Medicina Veterinaria y Zootecnia General Escobedo NL México Universidad Autónoma de Nuevo León Facultad de Ciencias Biológicas San Nicolás de los Garza NL México

Introduction: The World Health Organization establishes that 80% of the world’s population uses traditional medicine for their primary care, because they contain compounds responsible for their properties. Objective: To evaluate the antifungal effect of the essential oil of Citrus paradisi against C. albicans and the cytotoxic effect in three cell lines in vitro. Methods: The phytochemical characterization of the oil was carried out by chemical methods and Gas chromatography (GC-MS) and the antifungal effect against C. albicans (ATCC 90029) was evaluated by the Kirby-Bauer method, which evaluated concentrations of 0.75 - 20 μg/mL and compared with nystatin 100,000 Ul/mL as a positive control. The percentage of the relative inhibitory effect was calculated. The minimum inhibitory concentration (MIC) was determined at 24 hours. Moreover, the cytotoxic effect on C. albicans and cell lines was determined by the colorimetric MTT tetrazolium assay. Finally, the antifungal effect against Candida strains isolated from clinical samples was evaluated at a concentration of 20 μg/mL. Results: The essential oil showed an antifungal effect with a percentage of inhibition of 123%. The MIC was 2.5 μg/mL, and the cytotoxicity index was 5.44 μg/mL for C. albicans. The IC50 values were 21.060, 9.482 and 4.176 μg/mL for Vero E6, J774A.1 and MDBK cells respectively. Conclusion: These results show the use of C. paradisi essential oil as an alternative treatment in oral antifungal therapy, it is beneficial due to its antifungal effect and its low toxicity on cell cultures.

关键词： Citrus Candida Candidiasis Essential Oil Herbal Medicine

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Polymerization Reactor Monitoring by In-line Raman Spectrometry

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材料科学与工程（中英文A版） 2017年第6期7卷 303-310页

作者： Ramiro Infante Martinez Andre Olivos Ramirez Ricardo Lopez Gonzalez Ramon Diaz de Leon luis villarreal Cardenas Esther Trevino Martinez Alejandro Diaz Elizondo Beatriz Reyes Vielma Procesos de polimerizacion Centro de Investigacion de Qulmica Aplicada Saltillo Coahuila 25294 Mexico

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Interferon Regulatory Factor 5 and Renin-Angiotensin-Aldosterone System Polymorphisms in Coronary Artery Disease: An Overview of Experimental and Clinical Studies

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World Journal of Cardiovascular Diseases 2021年第7期11卷 332-341页

作者： Jorge luis Bermudez-Gonzalez Rodrigo Dagio-Cuellar Cristina villarreal-Guerrero Ana Gilabert-Garcia luis Angel Ferral-Barbabosa Joaquin Berarducci Jose luis Siller-Nava Jose Antonio Luna-Alvarez-Amezquita Javier Iván Armenta-Moreno Nilda Espínola-Zavaleta Erick Alexanderson-Rosas Juan Ignacio Straface National Institute of Cardiology Ignacio Chavez Mexico City Mexico Medicine Faculty of National Autonomous University of Mexico Mexico City Mexico

Heart diseases are the main cause of mortality in Mexico, being coronary heart disease the most frequent in the country. Its high prevalence makes important the study of the pathophysiology and the search for prognostic factors. Different genes and polymorphisms promote atherogenesis and coronary artery disease, they affect inflammatory and vascular pathological processes. Interferon regulatory factor 5 (IRF5) is associated with coronary heart disease, it promotes chronic inflammation and cytokines release;it could trigger immune reactions and its activating receptors express in the vascular endothelium. Besides, polymorphisms in the renin-angiotensin-aldosterone system (RAAS) are implied with coronary disease, they are found in angiotensinogen (AGT), angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), and angiotensin-converting enzyme (ACE) genes. These genetic polymorphisms are associated with a prothrombotic state, endothelial dysfunction, and immune activation. Multiple experimental studies showed that chronic activation of RAAS and chronic expression of IRF5 generates an environment prone to the development of atherosclerosis, and autoimmune and cardiovascular diseases. Studying these specific genes and their relationship with coronary heart disease will allow a better understanding of the pathological process and possibly the quest for new treatments.

关键词： Interferon Regulatory Factor 5 (IRF5) Angiotensin-Converting Enzyme (ACE) Angiotensinogen (AGT) Angiotensin II Type 1 Receptor (AT1R) Angiotensin II Type 2 Receptor (AT2R) Polymorphisms

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Managament Wound Healing: The Importance of a Wound Clinic in Hospital Centers

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Modern Plastic Surgery 2023年第4期13卷 118-125页

作者： Alfredo Chama Naranjo Cuahutémoc Márquez Espriella Alberto Ignacio Cahuana Quispe Barbosa villarreal Fernando Ana Priscila Campollo López Mauricio Gutiérrez Álvarez Carlos Emiliano García Córdova Jesús Ricardo García Corral Cuervo Vergara Marco Antonio Jorge luis Rosales Becerra Dávila Díaz Rodrigo Edgar Alan Guillen Martínez Marín Canto Miguel Eduardo luis Arturo Herrera Lozano Ochoa Contreras Erick Cesar Martinez Villalobos Claudia Nallely Cruz Soto Randall Camacho Rodriguez Hayah Ricardo Alberto Pulido López Edwing Michel Jaimes Durán Department of Plastic and Restrictive Surgery Hospital Central Sur de Alta Especialidad Pemex Mexico City Mexico

Background: In clinical practice, acute and chronic wounds continue to be a challenge. Unfortunately, wound care is often inadequate or inappropriate. The implementation of wound clinics involving an interdisciplinary team for wound care and treatment yields favorable clinical outcomes as well as a reduction in economic expenses due to a higher rate of healing, a decrease in hospital stays, and a reduction in the number of readmissions. The establishment of wound clinics enhances the utilization of diagnostic, preventive, and therapeutic resources, improving the quality of life of patients and facilitating their reintegration into their normal lives. The objective is solely to describe the importance of wound clinics in the medical profession. Methods: A retrospective literature search was conducted to include articles no more than 10 years old that reported measures or results of the study in order to perform a literature review and describe the importance of wound clinics in medical practice. Results: A total of 7 articles were obtained with the inclusion criteria, the most recent being from the year 2023 and the oldest from 2013. Conclusion: An important area for improvement in the healthcare industry is the management and treatment of complex wounds. The establishment of wound clinics offers comprehensive and specialized care for both acute and chronic complex wounds with the goal of enhancing secondary illness patients’ prevention, treatment, and rehabilitation.

关键词： Wound Clinic Pressure Ulcer Chronic Wound Wound Healing Quality of Life

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